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Showing Protein Di-N-acetylchitobiase (HMDBP07355)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP07355
Secondary Accession Numbers
  • 12981
Name Di-N-acetylchitobiase
Synonyms Not Available
Gene Name CTBS
Protein Type Enzyme
Biological Properties
General Function Involved in chitinase activity
Specific Function Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing o-glycosyl compounds
chitinase activity
Process
polysaccharide metabolic process
metabolic process
primary metabolic process
carbohydrate metabolic process
polysaccharide catabolic process
aminoglycan catabolic process
chitin catabolic process
Cellular Location
  1. Lysosome
Gene Properties
Chromosome Location Chromosome:1
Locus 1p22
SNPs CTBS
Gene Sequence 
>1158 bp
ATGTCCCGGCCGCAGCTTCGACGCTGGCGCCTCGTCTCTAGCCCGCCGAGCGGCGTCCCG
GGTCTAGCGCTGCTGGCGCTGCTGGCGCTGCTGGCGCTGCGGCTCGCGGCCGGGACCGAC
TGCCCATGCCCGGAGCCTGAGCTCTGCCGCCCGATTCGCCACCATCCAGATTTCGAGGTC
TTTGTGTTTGATGTTGGACAGAAAACTTGGAAATCTTATGATTGGTCACAGATTACAACT
GTGGCAACATTTGGAAAATATGACTCAGAACTTATGTGCTACGCTCATTCAAAAGGAGCC
AGAGTAGTACTTAAAGGAGATGTATCCTTAAAGGATATCATTGATCCTGCTTTCAGAGCA
TCCTGGATAGCTCAAAAACTTAATTTGGCCAAAACACAATATATGGATGGAATTAATATA
GATATAGAGCAAGAAGTTAATTGTTTATCACCTGAATATGATGCATTAACTGCTTTAGTC
AAAGAAACTACAGACTCTTTCCATCGTGAAATTGAGGGATCACAGGTAACCTTTGATGTA
GCTTGGTCTCCAAAGAACATAGACAGAAGATGCTATAATTATACTGGAATCGCAGATGCT
TGTGACTTCCTCTTTGTGATGTCTTATGATGAACAAAGTCAGATCTGGTCAGAATGTATT
GCAGCAGCCAATGCTCCCTATAATCAGACATTAACTGGATATAATGACTACATCAAGATG
AGCATTAATCCTAAGAAACTTGTAATGGGTGTTCCTTGGTATGGTTATGATTATACCTGC
CTGAATCTGTCTGAGGATCATGTTTGTACCATTGCAAAAGTCCCTTTCCGGGGGGCTCCT
TGTAGTGACGCTGCAGGACGTCAGGTGCCCTACAAAACGATCATGAAGCAAATAAATAGT
TCTATTTCTGGAAACCTATGGGATAAAGATCAGCGGGCTCCTTATTATAACTATAAAGAT
CCTGCTGGCCACTTTCATCAAGTATGGTATGATAACCCTCAGAGTATTTCTTTAAAGGCA
ACATATATACAAAACTATCGCTTACGGGGCATTGGCATGTGGAATGCAAACTGTCTTGAC
TACTCTGGAGATGCTGTAGCCAAACAGCAAACTGAAGAAATGTGGGAAGTCTTAAAGCCA
AAGCTGTTACAGAGATGA
Protein Properties
Number of Residues 385
Molecular Weight 43759.4
Theoretical pI 6.61
Pfam Domain Function
Signals
  • 1-38
Transmembrane Regions
  • None
Protein Sequence 
>Di-N-acetylchitobiase
MSRPQLRRWRLVSSPPSGVPGLALLALLALLALRLAAGTDCPCPEPELCRPIRHHPDFEV
FVFDVGQKTWKSYDWSQITTVATFGKYDSELMCYAHSKGARVVLKGDVSLKDIIDPAFRA
SWIAQKLNLAKTQYMDGINIDIEQEVNCLSPEYDALTALVKETTDSFHREIEGSQVTFDV
AWSPKNIDRRCYNYTGIADACDFLFVMSYDEQSQIWSECIAAANAPYNQTLTGYNDYIKM
SINPKKLVMGVPWYGYDYTCLNLSEDHVCTIAKVPFRGAPCSDAAGRQVPYKTIMKQINS
SISGNLWDKDQRAPYYNYKDPAGHFHQVWYDNPQSISLKATYIQNYRLRGIGMWNANCLD
YSGDAVAKQQTEEMWEVLKPKLLQR
GenBank ID Protein 3603439
UniProtKB/Swiss-Prot ID Q01459
UniProtKB/Swiss-Prot Entry Name DIAC_HUMAN
PDB IDs Not Available
GenBank Gene ID AF085706
GeneCard ID CTBS
GenAtlas ID CTBS
HGNC ID HGNC:2496
References
General References
  1. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [PubMed:19159218 ]
  2. Fisher KJ, Aronson NN Jr: Cloning and expression of the cDNA sequence encoding the lysosomal glycosidase di-N-acetylchitobiase. J Biol Chem. 1992 Sep 25;267(27):19607-16. [PubMed:1527079 ]
  3. Liu B, Ahmad W, Aronson NN Jr: Structure of the human gene for lysosomal di-N-acetylchitobiase. Glycobiology. 1999 Jun;9(6):589-93. [PubMed:10336991 ]