Identification |
HMDB Protein ID
| HMDBP07376 |
Secondary Accession Numbers
| |
Name
| Dihydrofolate reductase |
Synonyms
|
- SubName: cDNA, FLJ93028, Homo sapiens dihydrofolate reductase (DHFR), mRNA
|
Gene Name
| DYR |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in dihydrofolate reductase activity |
Specific Function
| Not Available |
Pathways
|
- One carbon pool by folate
|
Reactions
| Not Available |
GO Classification
|
Function |
binding |
nucleotide binding |
catalytic activity |
oxidoreductase activity, acting on the ch-nh group of donors |
nadp or nadph binding |
oxidoreductase activity, acting on the ch-nh group of donors, nad or nadp as acceptor |
oxidoreductase activity |
dihydrofolate reductase activity |
Process |
metabolic process |
nitrogen compound metabolic process |
cellular nitrogen compound metabolic process |
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
nucleobase, nucleoside and nucleotide metabolic process |
nucleoside phosphate metabolic process |
nucleotide metabolic process |
nucleotide biosynthetic process |
cellular metabolic process |
serine family amino acid metabolic process |
glycine metabolic process |
oxidation reduction |
cellular amino acid and derivative metabolic process |
glycine biosynthetic process |
cellular amino acid metabolic process |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| DYR |
Gene Sequence
|
>564 bp
ATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAACATGGGCATCGGCAAGAAC
GGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTCCAGAGAATGACCACA
ACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGACCTGGTTCTCC
ATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAGAGAACTC
AAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAACTT
ACTGAACAACCAGAATTAGCAAATAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCT
GTTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATG
CAAGACTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTG
CCAGAATACCCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTT
GAAGTATATGAGAAGAATGATTAA
|
Protein Properties |
Number of Residues
| 187 |
Molecular Weight
| 21452.6 |
Theoretical pI
| 7.6 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Dihydrofolate reductase
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
External Links |
GenBank ID Protein
| 189069188 |
UniProtKB/Swiss-Prot ID
| B0YJ76 |
UniProtKB/Swiss-Prot Entry Name
| B0YJ76_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AK312642 |
GeneCard ID
| DYR |
GenAtlas ID
| DYR |
HGNC ID
| HGNC:2861 |
References |
General References
| - Kao TT, Wang KC, Chang WN, Lin CY, Chen BH, Wu HL, Shi GY, Tsai JN, Fu TF: Characterization and comparative studies of zebrafish and human recombinant dihydrofolate reductases--inhibition by folic acid and polyphenols. Drug Metab Dispos. 2008 Mar;36(3):508-16. Epub 2007 Dec 3. [PubMed:18056255 ]
|