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Identification
HMDB Protein ID HMDBP07383
Secondary Accession Numbers
  • 13043
Name Thioredoxin domain-containing protein 12
Synonyms
  1. ER protein 18
  2. ER protein 19
  3. ERp18
  4. ERp19
  5. Endoplasmic reticulum resident protein 18
  6. Endoplasmic reticulum resident protein 19
  7. Thioredoxin-like protein p19
  8. hTLP19
Gene Name TXNDC12
Protein Type Enzyme
Biological Properties
General Function Involved in cell redox homeostasis
Specific Function Possesses significant protein thiol-disulfide oxidase activity.
Pathways
  • Glutathione metabolism
Reactions
Glutathione + protein-disulfide → Oxidized glutathione + protein-dithiol details
Insulin + Glutathione → Reduced insulin + Oxidized glutathione details
Protein dithiol + Oxidized glutathione → Protein disulfide + Glutathione details
GO Classification
Biological Process
cell redox homeostasis
Cellular Component
endoplasmic reticulum lumen
Molecular Function
protein-disulfide reductase (glutathione) activity
Process
cellular process
cellular homeostasis
cell redox homeostasis
Cellular Location
  1. Endoplasmic reticulum lumen
Gene Properties
Chromosome Location 1
Locus 1p32.3
SNPs TXNDC12
Gene Sequence
>519 bp
ATGGAGACGCGGCCTCGTCTCGGGGCCACCTGTTTGCTGGGCTTCAGTTTCCTGCTCCTC
GTCATCTCTTCTGATGGACATAATGGGCTTGGAAAGGGTTTTGGAGATCATATTCATTGG
AGGACACTGGAAGATGGGAAGAAAGAAGCAGCTGCCAGTGGACTGCCCCTGATGGTGATT
ATTCATAAATCCTGGTGTGGAGCTTGCAAAGCTCTAAAGCCCAAATTTGCAGAATCTACG
GAAATTTCAGAACTCTCCCATAATTTTGTTATGGTAAATCTTGAGGATGAAGAGGAACCC
AAAGATGAAGATTTCAGCCCTGACGGGGGTTATATTCCACGAATCCTTTTTCTGGATCCC
AGTGGCAAGGTGCATCCTGAAATCATCAATGAGAATGGAAACCCCAGCTACAAGTATTTT
TATGTCAGTGCCGAGCAAGTTGTTCAGGGGATGAAGGAAGCTCAGGAAAGGCTGACGGGT
GATGCCTTCAGAAAGAAACATCTTGAAGATGAATTGTAA
Protein Properties
Number of Residues 172
Molecular Weight 19205.615
Theoretical pI 5.405
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Thioredoxin domain-containing protein 12
METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVI
IHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDP
SGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL
GenBank ID Protein 4406577
UniProtKB/Swiss-Prot ID O95881
UniProtKB/Swiss-Prot Entry Name TXD12_HUMAN
PDB IDs
GenBank Gene ID AF131758
GeneCard ID TXNDC12
GenAtlas ID TXNDC12
HGNC ID HGNC:24626
References
General References
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  3. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]
  4. Zhang Z, Henzel WJ: Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. 2004 Oct;13(10):2819-24. Epub 2004 Aug 31. [PubMed:15340161 ]
  5. Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. DNA Res. 2005;12(2):117-26. [PubMed:16303743 ]
  6. Liu F, Rong YP, Zeng LC, Zhang X, Han ZG: Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein. Gene. 2003 Oct 2;315:71-8. [PubMed:14557066 ]
  7. Alanen HI, Williamson RA, Howard MJ, Lappi AK, Jantti HP, Rautio SM, Kellokumpu S, Ruddock LW: Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member. J Biol Chem. 2003 Aug 1;278(31):28912-20. Epub 2003 May 21. [PubMed:12761212 ]