Hmdb loader
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Identification
HMDB Protein ID HMDBP07386
Secondary Accession Numbers
  • 13046
Name UDP-glucose:glycoprotein glucosyltransferase 2
Synonyms
  1. UDP--Glc:glycoprotein glucosyltransferase 2
  2. UDP-glucose ceramide glucosyltransferase-like 1
  3. UGT2
  4. hUGT2
Gene Name UGGT2
Protein Type Unknown
Biological Properties
General Function Involved in transferase activity, transferring glycosyl groups
Specific Function Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation
Pathways Not Available
Reactions Not Available
GO Classification
Function
udp-glucose:glycoprotein glucosyltransferase activity
catalytic activity
transferase activity
udp-glycosyltransferase activity
transferase activity, transferring glycosyl groups
udp-glucosyltransferase activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid glycosylation
Cellular Location
  1. Endoplasmic reticulum lumen
  2. Endoplasmic reticulum-Golgi intermediate compartment
Gene Properties
Chromosome Location Chromosome:1
Locus 13q32.1
SNPs UGGT2
Gene Sequence
>4551 bp
ATGGCGCCAGCGAAAGCCACGAACGTGGTGCGGCTGCTACTAGGCTCCACAGCGCTGTGG
CTTTCGCAGCTCGGCTCCGGGACGGTCGCCGCGTCCAAGTCGGTGACTGCCCACTTGGCC
GCGAAGTGGCCCGAGACCCCGCTGCTGCTGGAGGCAAGTGAATTTATGGCAGAAGAAAGT
AATGAAAAATTTTGGCAGTTTTTGGAAACTGTGCAAGAATTAGCAATTTATAAGCAAACA
GAATCAGATTATTCTTATTACAACTTAATCCTGAAGAAAGCTGGACAGTTTCTAGACAAT
TTACACATCAACCTTTTAAAGTTTGCTTTCTCTATAAGGGCATACTCCCCAGCTATTCAG
ATGTTTCAGCAGATTGCAGCTGATGAGCCACCACCAGATGGTTGTAATGCATTTGTGGTT
ATTCATAAGAAGCACACCTGTAAAATTAATGAGATTAAAAAGCTGCTGAAGAAAGCTGCT
TCAAGGACTAGACCTTATCTATTTAAAGGAGATCACAAATTTCCTACAAACAAAGAGAAC
TTACCAGTGGTGATTCTCTATGCCGAAATGGGTACTAGAACATTTAGTGCATTTCACAAA
GTATTGTCTGAAAAAGCTCAAAATGAGGAAATTCTGTATGTTCTTCGCCATTATATTCAG
AAACCAAGCTCACGGAAAATGTACTTATCTGGGTATGGTGTGGAGCTAGCAATTAAGAGT
ACAGAATACAAAGCACTGGATGATACCCAAGTTAAAACTGTGACTAATACTACTGTAGAG
GATGAGACTGAAACAAATGAAGTTCAAGGATTTCTCTTTGGGAAACTAAAAGAAATATAT
TCAGATCTTAGAGATAATCTGACAGCATTCCAAAAATACCTGATTGAGAGTAACAAACAA
ATGATGCCTTTGAAAGTCTGGGAACTACAAGATCTTAGTTTTCAAGCAGCTTCTCAAATA
ATGTCCACTCCAGTTTATGATGCCATTAAATTAATGAAAGACATTTCACAGAACTTCCCC
ATAAAAGCCAGATCTCTAACCAGAATTGCTGTAAATCAACATATGAGAGAAGAAATAAAG
GAAAATCAAAAGGATCTTCAAGTTAGATTTAAAATTCAGCCAGGCGATGCTCGTCTATTT
ATAAATGGCCTTCGTGTTGATATGGATGTTTATGACGCTTTTAGTATTTTGGATATGCTG
AAATTAGAAGGAAAAATGATGAATGGCCTTCGCAATCTTGGGATCAATGGGGAAGATATG
AGCAAATTTTTAAAATTAAATTCACACATTTGGGAATATACTTATGTATTAGATATTCGA
CATTCTTCTATAATGTGGATTAATGACTTAGAAAATGATGATTTGTATATTACATGGCCT
ACAAGTTGCCAGAAACTTCTGAAGCCAGTATTTCCTGGAAGTGTACCTTCCATAAGGCGC
AATTTTCATAATTTGGTTCTGTTTATTGATCCGGCCCAAGAATATACCTTGGATTTTATA
AAACTTGCTGATGTTTTCTATTCTCACGAAGTTCCTCTTAGAATTGGTTTTGTGTTCATT
CTTAATACAGATGATGAAGTTGATGGAGCAAATGATGCTGGAGTTGCTCTCTGGCGAGCT
TTCAACTATATTGCAGAAGAATTTGATATATCAGAAGCATTTATTTCTATAGTACACATG
TACCAAAAAGTGAAGAAGGATCAAAATATACTCACTGTGGACAATGTGAAGAGTGTTCTC
CAAAATACATTTCCTCATGCTAATATTTGGGATATTTTGGGAATTCATTCTAAATATGAT
GAAGAAAGAAAGGCTGGAGCAAGCTTTTATAAGATGACTGGCCTGGGTCCTTTGCCTCAA
GCTCTTTATAATGGTGAACCCTTTAAACATGAAGAGATGAATATTAAAGAACTAAAAATG
GCTGTTCTTCAAAGAATGATGGATGCATCTGTATATTTACAAAGAGAAGTTTTTTTGGGC
ACATTAAATGATCGCACGAATGCAATTGATTTTCTAATGGATAGGAATAATGTTGTACCC
CGTATAAATACTTTGATTTTGCGTACTAACCAGCAGTACCTCAATTTAATATCTACATCA
GTAACTGCTGATGTTGAAGATTTCTCTACTTTCTTTTTCTTGGATTCACAAGATAAGAGT
GCTGTAATTGCAAAGAACATGTATTATTTAACCCAAGACGATGAGAGTATAATTTCTGCA
GTCACTCTCTGGATTATTGCAGATTTTGATAAGCCTTCTGGGAGAAAACTTCTTTTTAAT
GCATTAAAGCACATGAAAACAAGTGTTCATAGTCGGTTGGGGATTATTTATAATCCTACA
TCAAAAATAAATGAAGAGAACACAGCTATTTCTAGAGGGATTTTGGCAGCTTTTCTTACA
CAGAAGAACATGTTTTTGAGAAGCTTTCTTGGGCAACTGGCAAAGGAAGAAATTGCTACA
ACTATTTACTCTGGAGATAAAATTAAAACATTCCTTATTGAGGGGATGGATAAGAATGCT
TTTGAGAAAAAATATAATACTGTTGGAGTGAATATTTTTCGAACTCACCAGTTGTTCTGT
CAAGATGTACTTAAATTACGTCCTGGAGAAATGGGTATTGTCAGCAATGGGAGATTCTTA
GGACCTTTAGATGAAGATTTTTATGCAGAAGATTTTTACTTGTTGGAAAAGATAACATTT
AGTAATTTAGGAGAGAAAATTAAAGGCATTGTTGAAAATATGGGAATCAACGCAAATAAC
ATGAGTGACTTTATTATGAAAGTTGATGCCCTTATGTCCTCTGTGCCTAAGCGTGCATCT
CGATATGATGTCACATTTCTTAGGGAGAATCACAGTGTTATAAAGACGAATCCTCAAGAG
AATGATATGTTCTTCAATGTCATTGCTATTGTTGATCCATTAACAAGAGAAGCACAGAAA
ATGGCACAGTTGTTGGTTGTACTTGGCAAGATTATCAACCTGAAGATAAAGTTGTTCATG
AACTGTAGGGGCAGGCTTTCAGAAGCCCCTTTAGAAAGCTTTTACCGTTTTGTTCTGGAA
CCAGAACTGATGTCAGGGGCTAATGACGTTTCTTCTCTTGGACCAGTGGCAAAATTTTTG
GATATTCCTGAATCACCCCTCCTAATCCTCAACATGATTACTCCAGAAGGCTGGTTGGTT
GAAACAGTGCACAGCAACTGTGACCTTGATAATATTCACTTAAAGGATACTGAGAAAACT
GTTACAGCAGAATATGAACTAGAATACTTACTACTGGAAGGACAATGCTTTGATAAAGTG
ACAGAACAGCCTCCTCGGGGTCTGCAGTTCACACTAGGCACAAAAAATAAACCTGCTGTG
GTTGATACAATAGTGATGGCACATCATGGGTATTTTCAATTAAAAGCAAACCCAGGTGCT
TGGATACTGAGGTTACACCAAGGAAAATCTGAAGATATTTATCAAATAGTTGGGCATGAA
GGAACTGACTCTCAAGCAGACCTAGAAGATATCATTGTTGTATTAAACAGCTTCAAAAGC
AAGATACTCAAAGTAAAAGTGAAAAAAGAAACAGACAAAATTAAGGAAGATATCCTTACC
GATGAAGATGAAAAAACAAAAGGACTGTGGGATTCCATTAAAAGTTTCACAGTAAGCTTG
CATAAAGAAAACAAAAAGGAAAAAGATGTCCTAAACATTTTTTCAGTTGCTTCTGGTCAT
TTATATGAACGTTTTTTAAGAATTATGATGCTTTCTGTTTTGCGTAACACCAAAACACCA
GTGAAATTCTGGTTGCTAAAAAATTATCTCTCACCGACATTTAAAGAAGTAATTCCTCAC
ATGGCTAAAGAGTATGGATTCCGATATGAACTAGTTCAATATAGGTGGCCCCGTTGGCTT
CGTCAACAGACTGAAAGACAGAGGATTATTTGGGGTTACAAAATTCTTTTCCTTGATGTT
CTTTTCCCACTAGCAGTGGACAAAATCATTTTTGTTGATGCTGACCAGATTGTGAGACAT
GATCTAAAAGAACTTCGAGATTTCGATCTGGATGGAGCTCCTTATGGGTATACTCCATTT
TGTGATAGCCGCAGGGAAATGGATGGATATCGTTTCTGGAAAACAGGATACTGGGCATCA
CATCTTTTAAGACGGAAATACCATATCAGTGCTTTATATGTAGTGGATCTCAAGAAGTTC
AGGAGAATTGGAGCAGGTGACAGGCTCAGGAGCCAGTATCAAGCTCTCAGTCAAGATCCA
AACAGTCTTTCAAACCTAGATCAGGATCTCCCCAATAATATGATTTACCAAGTCGCCATT
AAGTCTCTTCCTCAAGACTGGCTGTGGTGTGAAACCTGGTGTGATGATGAATCCAAACAA
AGAGCCAAAACAATTGATCTGTGCAATAATCCCAAAACAAAAGAATCCAAACTAAAAGCT
GCTGCCAGAATTGTCCCAGAATGGGTGGAGTATGATGCTGAGATAAGACAACTATTAGAT
CATCTTGAAAACAAGAAGCAAGATACAATTTTGACACATGATGAACTCTAG
Protein Properties
Number of Residues 1516
Molecular Weight 174717.7
Theoretical pI 6.88
Pfam Domain Function
Signals
  • 1-27
Transmembrane Regions
  • None
Protein Sequence
>UDP-glucose:glycoprotein glucosyltransferase 2
MAPAKATNVVRLLLGSTALWLSQLGSGTVAASKSVTAHLAAKWPETPLLLEASEFMAEES
NEKFWQFLETVQELAIYKQTESDYSYYNLILKKAGQFLDNLHINLLKFAFSIRAYSPAIQ
MFQQIAADEPPPDGCNAFVVIHKKHTCKINEIKKLLKKAASRTRPYLFKGDHKFPTNKEN
LPVVILYAEMGTRTFSAFHKVLSEKAQNEEILYVLRHYIQKPSSRKMYLSGYGVELAIKS
TEYKALDDTQVKTVTNTTVEDETETNEVQGFLFGKLKEIYSDLRDNLTAFQKYLIESNKQ
MMPLKVWELQDLSFQAASQIMSAPVYDAIKLMKDISQNFPIKARSLTRIAVNQHMREEIK
ENQKDLQVRFKIQPGDARLFINGLRVDMDVYDAFSILDMLKLEGKMMNGLRNLGINGEDM
SKFLKLNSHIWEYTYVLDIRHSSIMWINDLENDDLYITWPTSCQKLLKPVFPGSVPSIRR
NFHNLVLFIDPAQEYTLDFIKLADVFYSHEVPLRIGFVFILNTDDEVDGANDAGVALWRA
FNYIAEEFDISEAFISIVHMYQKVKKDQNILTVDNVKSVLQNTFPHANIWDILGIHSKYD
EERKAGASFYKMTGLGPLPQALYNGEPFKHEEMNIKELKMAVLQRMMDASVYLQREVFLG
TLNDRTNAIDFLMDRNNVVPRINTLILRTNQQYLNLISTSVTADVEDFSTFFFLDSQDKS
AVIAKNMYYLTQDDESIISAVTLWIIADFDKPSGRKLLFNALKHMKTSVHSRLGIIYNPT
SKINEENTAISRGILAAFLTQKNMFLRSFLGQLAKEEIATAIYSGDKIKTFLIEGMDKNA
FEKKYNTVGVNIFRTHQLFCQDVLKLRPGEMGIVSNGRFLGPLDEDFYAEDFYLLEKITF
SNLGEKIKGIVENMGINANNMSDFIMKVDALMSSVPKRASRYDVTFLRENHSVIKTNPQE
NDMFFNVIAIVDPLTREAQKMAQLLVVLGKIINMKIKLFMNCRGRLSEAPLESFYRFVLE
PELMSGANDVSSLGPVAKFLDIPESPLLILNMITPEGWLVETVHSNCDLDNIHLKDTEKT
VTAEYELEYLLLEGQCFDKVTEQPPRGLQFTLGTKNKPAVVDTIVMAHHGYFQLKANPGA
WILRLHQGKSEDIYQIVGHEGTDSQADLEDIIVVLNSFKSKILKVKVKKETDKIKEDILT
DEDEKTKGLWDSIKSFTVSLHKENKKEKDVLNIFSVASGHLYERFLRIMMLSVLRNTKTP
VKFWLLKNYLSPTFKEVIPHMAKEYGFRYELVQYRWPRWLRQQTERQRIIWGYKILFLDV
LFPLAVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCDSRREMDGYRFWKTGYWAS
HLLRRKYHISALYVVDLKKFRRIGAGDRLRSQYQALSQDPNSLSNLDQDLPNNMIYQVAI
KSLPQDWLWCETWCDDESKQRAKTIDLCNNPKTKESKLKAAARIVPEWVEYDAEIRQLLD
HLENKKQDTILTHDEL
GenBank ID Protein 11346464
UniProtKB/Swiss-Prot ID Q9NYU1
UniProtKB/Swiss-Prot Entry Name UGGG2_HUMAN
PDB IDs Not Available
GenBank Gene ID AF227906
GeneCard ID UGGT2
GenAtlas ID UGGT2
HGNC ID HGNC:15664
References
General References
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  2. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
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  5. Arnold SM, Fessler LI, Fessler JH, Kaufman RJ: Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. Biochemistry. 2000 Mar 7;39(9):2149-63. [PubMed:10694380 ]
  6. Arnold SM, Kaufman RJ: The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain. J Biol Chem. 2003 Oct 31;278(44):43320-8. Epub 2003 Aug 11. [PubMed:12913004 ]