Hmdb loader
Identification
HMDB Protein ID HMDBP07430
Secondary Accession Numbers
  • 13138
Name Sodium/hydrogen exchanger 10
Synonyms
  1. NHE-10
  2. Na(+)/H(+) exchanger 10
  3. Solute carrier family 9 member 10
  4. Sperm-specific Na(+)/H(+) exchanger
  5. sNHE
Gene Name SLC9A10
Protein Type Unknown
Biological Properties
General Function Involved in solute:hydrogen antiporter activity
Specific Function Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC)
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
solute:cation antiporter activity
solute:hydrogen antiporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
transporter activity
Process
establishment of localization
transport
transmembrane transport
ion transport
cation transport
Cellular Location
  1. Multi-pass membrane protein
  2. Cell projection
  3. cilium
  4. flagellum membrane
Gene Properties
Chromosome Location Chromosome:3
Locus 3q13.2
SNPs SLC9A10
Gene Sequence
>3534 bp
ATGGCTGGAATATTTAAGGAGTTTTTTTTCAGTACTGAGGACCTCCCTGAAGTCATTCTA
ACATTGTCTTTGATCAGCTCCATTGGAGCATTTTTGAACCGGCACTTGGAAGACTTTCCA
ATTCCTGTCCCTGTGATATTATTTTTACTTGGATGCAGTTTTGAAGTATTAAGCTTTACA
TCTTCACAGGTCCAAAGATACGCAAACGCCATACAATGGATAAGTCCAGACTTATTTTTT
CGTATATTTACACCAGTAGTTTTCTTTACTACTGCATTTGACATGGATACGTACATGCTT
CAAAAGTTATTTTGGCAGATACTTTTAATTTCAATTCCCGGCTTTTTGGTTAATTATATC
TTAGTTCTTTGGCATCTGGCATCTGTAAATCAATTACTTTTGAAGCCTACCCAATGGTTA
TTATTTTCAGCTATCCTTGTGAGTTCAGATCCCATGCTAACCGCAGCTGCTGTAAGAGAC
CTTGGGCTTTCTAGAAGCCTCATCAGTTTAATTAATGGAGAAAGTCTGATGACCTCTGTT
ATATCATTAATTACATTTACTAGTATTATGGATTTTGACCAAAGACTACAAAGTAAAAGA
AACCATACCTTAGCTGAAGAGATCGTGGGTGGAATTTGTTCATATATTATAGCAAGTTTC
TTGTTTGGAATTCTAAGTTCAAAACTGATTCAATTTTGGATGTCAACTGTTTTTGGTGAT
GATGTCAATCATATAAGTCTCATCTTTTCAATTCTGTATCTCATCTTTTATATTTGTGAG
TTAGTTGGAATGTCAGGAATATTTACTCTGGCCATTGTGGGACTTCTTTTAAATTCTACA
AGTTTTAAAGCAGCAGTTGAAGAAACACTTCTTCTTGAATTCTGGACTTTTCTATCACGT
ATTGCTTTTCTCATGGTGTTTACTTTCTTTGGACTTCTAATTCCTGCACATACATATTTG
TATATAGAATTTGTTGATATATACTATTCATTAAATATCTACTTAACATTGATTGTTTTA
AGATTTCTGACCCTTCTTTTAATGAGCCCTGTTTTGTCTCGAGTTGGTCATGAGTTCAGT
TGGCGCTGGGTATTCATAATGGTCTGTAGTGAAATGAAAGGGATGCCTAATATAAACATG
GCCCTTCTGCTTGCCTACTCTGATCTTTATTTTGGATCTGACAAAGAAAAATCTCAAATA
TTATTTCATGGAGTGTTAGTATGCCTAATAACCCTTGTTGTCAATAGATTTATTTTGCCA
GTGGCAGTTGCTATACTAGGTCTTCGTGATGCCACATCAACAAAATATAAATCGGTTTGT
TGCACATTTCAACACTTTCAAGAGCTAACCAAGTCTGCAGCCTCTGCCCTTAAATTTGAC
AAAGATCTTGCTAATGCTGATTGGAACATGATTGAGAAAGCAATTACACTTGAAAACCCA
TACATGTTGAACGAAGAAGAAACAACAGAACATCAGAAGGTGAAATGTCCACACTGTAAC
AAGGAAATAGATGAGATCTTTAACACTGAAGCAATGGAGCTGGCCAACAGGCGTCTCTTG
TCAGCACAAATAGCAAGCTACCAGAGACAATACAGGAATGAGATTCTGTCCCAGAGTGCT
GTCCAGGTGTTGGTTGGTGCAGCAGAAAGTTTTGGTGAGAAGAAGGGAAAATGTATGAGT
CTTGATACAATAAAGAATTATTCTGAAAGCCAAAAAACAGTTACCTTTGCTAGAAAACTA
CTACTTAATTGGGTGTATAATACCAGAAAGGAAAAAGAGGGCCCATCAAAATACTTCTTT
TTTCGTATATGCCATACAATAGTATTTACTGAGGAATTTGAACATGTTGGATACCTTGTG
ATATTAATGAATATATTTCCCTTTATAATCTCTTGGATATCCCAGTTAAATGTAATCTAC
CACAGCGAATTAAAACACACTAACTACTGTTTTCTTACACTTTATATTCTAGAGGCACTA
CTTAAGATAGCAGCAATGAGGAAGGACTTTTTTTCACATGCCTGGAACATATTCGAGTTA
GCAATTACATTAATTGGCATCTTACATGTAATACTTATTGAAATAGACACCATTAAGTAT
ATTTTTAATGAGATTGAAGTAATAGTCTTTATAAAAGTTGTTCAATTTTTTCGTATACTA
CGCATTTTCAAGCTCATAGCACCAAAGTTGCTGAAAATAATAGATAAAAGAATGAGTCAT
CAGAAGACCTTTTGGTATGGAATACTAAAAGGCTATGTCCAAGGCGAAGCAGACATAATG
ACCATAATTGATCAGATTACAATTTCTAAACAGATTAAACAGATGTTATTAAAGCAAGTG
ATAAGGAATATGGACCATGCTACAAAAGAGCTAGGCTACTTAGAGTATGATCACCCAGAA
ATTGCTGTCACTGTGAAAACAAAGGAAGAAATTAATGTTATGCTCAATATGGCTACAGAA
ATTCTTAAGGCTTTCAGCTTAAAAGGAATTATTAGTAAAACTGAAGGTGCTGGAATTAAT
AAGTTAATCATGGCCAAAAAGAAAGAGGTGCTTGATTCTCAATCTATTATCAGGCCTCTT
ACTGTTGAAGAAGTTCTATATCATATTCCGTGGCTAGATAAAAACAAAGATTATATAAAC
TTCATTCAGGAAAAAGCCAAAGTTGTAACATTTGATTGTGGAAATGATATATTTGAAGAA
GGTGATGAGCCCAAAGGAATCTATATCATTATTTCAGGCATGGTAAAGCTTGAAAAATCA
AAGCCAGGTTTAGGGATTGATCAAATGGTGGAGTCAAAGGAGAAAGATTTTCCGATAATT
GACACAGACTATATGCTCAGTGGAGAAATAATAGGAGAGATAAACTGCTTAACTAATGAA
CCTATGAAATATTCTGCCACCTGCAAAACTGTAGTGGAGACATGTTTTATTCCCAAAACT
CACTTGTATGATGCTTTTGAGCAATGCTCTCCTCTCATTAAACAAAAAATGTGGCTAAAA
CTTGGACTCGCTATTACAGCCAGAAAAATCAGAGAACACTTATCTTATGAGGATTGGAAC
TACAATATGCAACTAAAGCTCTCTAATATTTATGTAGTAGATATACCAATGAGTACCAAA
ACTGATATTTATGATGAAAATCTAATCTATGTTATCCTCATACATGGAGCTGTAGAAGAT
TGTCTGTTACGAAAAACTTATAGAGCACCTTTCTTAATTCCTATAACATGCCATCAGATA
CAAAGTATTGAAGATTTCACAAAAGTAGTGATTATTCAAACTCCGATTAACATGAAAACA
TTCAGAAGGAATATTAGAAAGTTTGTTCCTAAACATAAAAGTTATCTTACACCAGGATTA
ATAGGTTCAGTTGGAACATTGGAAGAAGGCATTCAAGAAGAAAGAAATGTTAAGGAGGAT
GGAGCACACAGTGCCGCCACTGCCAGGAGTCCCCAGCCTTGCTCCCTGCTGGGGACAAAG
TTCAACTGTAAGGAGTCCCCTAGAATAAACCTAAGGAAAGTCAGGAAAGAGTAA
Protein Properties
Number of Residues 1177
Molecular Weight 135204.6
Theoretical pI 7.14
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 8-28
  • 39-59
  • 73-93
  • 103-123
  • 138-158
  • 167-187
  • 204-224
  • 248-268
  • 301-321
  • 333-353
  • 364-384
  • 405-425
  • 613-633
  • 646-666
  • 675-695
  • 707-727
Protein Sequence
>Sodium/hydrogen exchanger 10
MAGIFKEFFFSTEDLPEVILTLSLISSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLSFT
SSQVQRYANAIQWMSPDLFFRIFTPVVFFTTAFDMDTYMLQKLFWQILLISIPGFLVNYI
LVLWHLASVNQLLLKPTQWLLFSAILVSSDPMLTAAAIRDLGLSRSLISLINGESLMTSV
ISLITFTSIMDFDQRLQSKRNHTLAEEIVGGICSYIIASFLFGILSSKLIQFWMSTVFGD
DVNHISLIFSILYLIFYICELVGMSGIFTLAIVGLLLNSTSFKAAIEETLLLEFWTFLSR
IAFLMVFTFFGLLIPAHTYLYIEFVDIYYSLNIYLTLIVLRFLTLLLISPVLSRVGHEFS
WRWIFIMVCSEMKGMPNINMALLLAYSDLYFGSDKEKSQILFHGVLVCLITLVVNRFILP
VAVTILGLRDATSTKYKSVCCTFQHFQELTKSAASALKFDKDLANADWNMIEKAITLENP
YMLNEEETTEHQKVKCPHCNKEIDEIFNTEAMELANRRLLSAQIASYQRQYRNEILSQSA
VQVLVGAAESFGEKKGKCMSLDTIKNYSESQKTVTFARKLLLNWVYNTRKEKEGPSKYFF
FRICHTIVFTEEFEHVGYLVILMNIFPFIISWISQLNVIYHSELKHTNYCFLTLYILEAL
LKIAAMRKDFFSHAWNIFELAITLIGILHVILIEIDTIKYIFNETEVIVFIKVVQFFRIL
RIFKLIAPKLLQIIDKRMSHQKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQV
IRNMEHAIKELGYLEYDHPEIAVTVKTKEEINVMLNMATEILKAFGLKGIISKTEGAGIN
KLIMAKKKEVLDSQSIIRPLTVEEVLYHIPWLDKNKDYINFIQEKAKVVTFDCGNDIFEE
GDEPKGIYIIISGMVKLEKSKPGLGIDQMVESKEKDFPIIDTDYMLSGEIIGEINCLTNE
PMKYSATCKTVVETCFIPKTHLYDAFEQCSPLIKQKMWLKLGLAITARKIREHLSYEDWN
YNMQLKLSNIYVVDIPMSTKTDIYDENLIYVILIHGAVEDCLLRKTYRAPFLIPITCHQI
QSIEDFTKVVIIQTPINMKTFRRNIRKFVPKHKSYLTPGLIGSVGTLEEGIQEERNVKED
GAHSAATARSPQPCSLLGTKFNCKESPRINLRKVRKE
GenBank ID Protein 34535281
UniProtKB/Swiss-Prot ID Q4G0N8
UniProtKB/Swiss-Prot Entry Name S9A10_HUMAN
PDB IDs Not Available
GenBank Gene ID AK128084
GeneCard ID SLC9A10
GenAtlas ID SLC9A10
HGNC ID HGNC:31401
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Oduru S, Campbell JL, Karri S, Hendry WJ, Khan SA, Williams SC: Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. BMC Genomics. 2003 Jun 3;4(1):22. Epub 2003 Jun 3. [PubMed:12783626 ]