| Identification |
|---|
| HMDB Protein ID
| HMDBP07441 |
| Secondary Accession Numbers
| |
| Name
| Anoctamin-3 |
| Synonyms
|
- Transmembrane protein 16C
|
| Gene Name
| ANO3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| May act as a calcium-activated chloride channel |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11p14.2 |
| SNPs
| ANO3 |
| Gene Sequence
|
>2946 bp
ATGGTCCACCATTCAGGCTCCATTCAGTCCTTTAAACAGCAAAAAGGTATGAATATAAGC
AAGAGTGAGATAACAAAAGAAACTTCGTTAAAACCGTCTCGGAGATCCCTGCCTTGCCTC
GCCCAGAGCTACGCTTACTCAAAGAGCTTGAGCCAGTCTACTTCCCTCTTCCAGTCAACC
GAGAGTGAATCTCAGGCTCCCACATCTATAACCTTAATCTCCACTGACAAAGCAGAGCAA
GTTAATACTGAGGAGAATAAAAACGACTCTGTGCTGAGATGTTCATTTGCTGACCTCAGC
GATTTTTGTTTGGCCCTAGGAAAAGATAAGGATTACACGGATGAATCAGAACACGCTACT
TATGACCGATCTCGTCTCATTAATGACTTTGTTATCAAAGATAAATCTGAATTCAAGACA
AAATTATCTAAGAATGACATGAATTACATAGCATCCAGTGGACCTCTGTTCAAAGATGGC
AAAAAGAGAATTGATTACATCTTGGTTTATAGAAAGACAAATATACAATATGATAAAAGA
AACACATTTGAAAAGAACCTCAGAGCAGAAGGCTTGATGTTGGAGAAGGAGCCAGCTATT
GCAAGCCCCGATATCATGTTTATTAAAATTCACATTCCATGGGACACGCTGTGCAAGTAT
GCAGAGAGGCTGAATATCAGGATGCCCTTCAGGAAAAAATGCTATTACACTGACGGGAGG
AGCAAATCAATGGGCAGGATGCAAACTTATTTTAGAAGAATCAAAAACTGGATGGCCCAA
AACCCAATGGTTCTTGACAAGTCAGCTTTTCCAGACCTAGAGGAGTCAGACTGCTATACT
GGCCCCTTCAGCCGTGCACGGATTCACCACTTCATAATAAATAATAAAGACACCTTCTTC
AGCAATGCTACTCGAAGCAGAATAGTCTATCACATGCTGGAACGCACCAAATATGAAAAT
GGAATATCAAAAGTGGGTATCCGTAAACTTATAAACAATGGCTCATACATAGCAGCGTTT
CCACCACATGAGGGAGCCTACAAAAGTAGCCAGCCCATTAAAACCCATGGACCTCAGAAT
AACAGACATCTATTATATGAGCGCTGGGCACGCTGGGGAATGTGGTATAAGCATCAGCCT
CTGGATTTAATCAGGCTATACTTTGGTGAGAAGATTGGACTATACTTTGCTTGGCTGGGA
TGGTATACTGGAATGTTGATTCCTGCAGCAATTGTTGGTTTGTGCGTTTTCTTCTATGGA
TTATTTACAATGAATAATAGTCAAGTAAGCCAAGAAATTTGTAAAGCCACTGAAGTCTTT
ATGTGCCCTCTCTGTGACAAGAACTGCTCCCTGCAGAGACTCAACGACAGCTGTATCTAT
GCCAAGGTGACATATTTGTTCGATAATGGAGGGACAGTCTTCTTTGCTATTTTTATGGCA
ATATGGGCCACAGTCTTCCTGGAGTTTTGGAAAAGGAGAAGGAGTATACTGACCTATACT
TGGGACCTTATCGAATGGGAAGAAGAGGAGGAAACACTTCGTCCCCAGTTTGAAGCCAAG
TATTACAAGATGGAGATTGTAAATCCCATCACGGGAAAACCTGAACCACATCAGCCTTCC
TCAGACAAAGTCACTCGTCTTCTTGTTTCTGTCTCAGGAATATTCTTCATGATATCCTTG
GTGATCACTGCAGTGTTTGGAGTTGTGGTGTACCGCCTGGTTGTCATGGAACAGTTTGCA
TCATTCAAGTGGAATTTCATCAAACAATACTGGCAGTTTGCAACATCTGCTGCTGCTGTC
TGTATCAATTTCATAATCATTATGTTGCTGAATCTTGCTTATGAAAAAATTGCTTACCTC
CTCACCAATTTAGAATATCCTCGAACAGAATCAGAGTGGGAAAACAGCTTCGCCCTGAAG
ATGTTCCTCTTCCAGTTTGTCAATTTAAACAGTTCCATCTTCTATATCGCTTTCTTTTTG
GGAAGATTCGTAGGCCACCCAGGAAAATACAATAAACTTTTTGACCGGTGGAGACTGGAG
GAATGTCATCCTAGTGGCTGTTTGATAGACCTCTGCCTCCAGATGGGTGTCATCATGTTT
TTGAAGCAAATATGGAACAACTTCATGGAACTAGGATACCCGTTGATCCAGAACTGGTGG
TCACGACATAAAATCAAGCGGGGAATACATGATGCTTCCATACCTCAGTGGGAAAATGAT
TGGAATCTGCAGCCCATGAACCTTCATGGACTGATGGATGAGTACTTAGAAATGGTTTTG
CAATTTGGTTTTACCACCATCTTTGTTGCGGCTTTTCCTCTAGCCCCTCTTTTGGCTTTG
TTAAACAATATCATTGAAATCAGGCTGGATGCATACAAATTTGTCACTCAATGGCGGAGG
CCTTTGCCAGCCCGAGCAACTGACATAGGTATCTGGCTTGGAATTCTCGAAGGAATCGGT
ATATTGGCTGTGATCACCAATGCATTTGTAATTGCTATTACTTCTGATTACATCCCACGT
TTTGTTTATGAATACAAATATGGCCCCTGTGCAAATCATGTAGAACCAAGTGAAAATTGC
TTGAAGGGATATGTCAACAATAGCCTATCCTTCTTTGACCTGAGTGAGCTTGGTATGGGA
AAATCTGGTTATTGCAGGTACAGAGACTACAGAGGCCCGCCCTGGAGTTCCAAACCCTAT
GAGTTTACTTTACAATACTGGCATATCCTTGCTGCTAGATTGGCCTTCATTATTGTGTTT
GAGCACCTTGTTTTTGGGATTAAGTCATTCATCGCATACCTGATTCCAGACGTACCAAAG
GGTCTACATGACCGAATACGACGAGAGAAGTACTTAGTTCAAGAAATGATGTATGAGGCT
GAACTGGAACATTTGCAACAACAACGGAGAAAAAGTGGTCAGCCTGTTCACCATGAATGG
CCTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 981 |
| Molecular Weight
| 114655.5 |
| Theoretical pI
| 8.84 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 404-424
- 470-490
- 551-571
- 593-613
- 641-661
- 762-782
- 811-831
- 915-935
|
| Protein Sequence
|
>Anoctamin-3
MVHHSGSIQSFKQQKGMNISKSEITKETSLKPSRRSLPCLAQSYAYSKSLSQSTSLFQST
ESESQAPTSITLISTDKAEQVNTEENKNDSVLRCSFADLSDFCLALGKDKDYTDESEHAT
YDRSRLINDFVIKDKSEFKTKLSKNDMNYIASSGPLFKDGKKRIDYILVYRKTNIQYDKR
NTFEKNLRAEGLMLEKEPAIASPDIMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGR
SKSMGRMQTYFRRIKNWMAQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFF
SNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQN
NRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYG
LFTMNNSQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMA
IWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPS
SDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFASFKWNFIKQYWQFATSAAAV
CINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFL
GRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWW
SRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLAL
LNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPR
FVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPY
EFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQEMMYEA
ELEHLQQQRRKSGQPVHHEWP
|
| External Links |
|---|
| GenBank ID Protein
| 156766084 |
| UniProtKB/Swiss-Prot ID
| Q9BYT9 |
| UniProtKB/Swiss-Prot Entry Name
| ANO3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_031418.2 |
| GeneCard ID
| ANO3 |
| GenAtlas ID
| ANO3 |
| HGNC ID
| HGNC:14004 |
| References |
|---|
| General References
| - Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [PubMed:16554811 ]
- Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, Park SP, Lee J, Lee B, Kim BM, Raouf R, Shin YK, Oh U: TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature. 2008 Oct 30;455(7217):1210-5. doi: 10.1038/nature07313. Epub 2008 Aug 24. [PubMed:18724360 ]
|
