| Identification |
|---|
| HMDB Protein ID
| HMDBP07445 |
| Secondary Accession Numbers
| |
| Name
| Anoctamin-7 |
| Synonyms
|
- D-TMPP
- Dresden transmembrane protein of the prostate
- IPCA-5
- New gene expressed in prostate
- Prostate cancer-associated protein 5
- Transmembrane protein 16G
|
| Gene Name
| ANO7 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| May act as a calcium-activated chloride channel. May play a role in cell-cell interactions |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Isoform 2:Cytoplasm
- cytosol
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q37.3 |
| SNPs
| ANO7 |
| Gene Sequence
|
>2802 bp
ATGCGAATGGCTGCCACTGCCTGGGCGGGGCTCCAAGGGCCACCCCTCCCCACCCTCTGT
CCCGCAGTGAGGACGGGACTCTACTGCCGAGACCAGGCTCACGCTGAGAGGTGGGCCATG
ACCTCCGAGACCTCTTCCGGAAGCCACTGTGCCAGGAGCAGGATGCTGCGGCGACGGGCC
CAGGAAGAGGACAGCACCGTCCTGATCGATGTGAGCCCCCCTGAGGCAGAGAAGAGGGGC
TCTTACGGGAGCACAGCCCACGCCTCGGAGCCAGGTGGACAGCAAGCGGCCGCCTGCAGA
GCTGGGAGTCCTGCCAAGCCCCGGATCGCAGACTTCGTCCTCGTTTGGGAGGAGGACCTG
AAGCTAGACAGGCAGCAGGACAGTGCCGCCCGGGACAGAACAGACATGCACAGGACCTGG
CGGGAGACTTTTCTGGATAATCTTCGTGCGGCTGGGCTGTGTGTAGACCAGCAGGACGTC
CAGGACGGGAACACCACAGTGCACTACGCCCTCCTCAGCGCCTCCTGGGCTGTGCTCTGC
TACTACGCCGAAGACCTGCGCCTGAAGCTGCCCTTGCAGGAGTTACCCAACCAGGCCTCC
AACTGGTCGGCCGGCCTGCTGGCATGGCTGGGCATCCCCAACGTCCTGCTGGAGGTTGTG
CCAGACGTACCCCCCGAGTACTACTCCTGCCGGTTCAGAGTGAACAAGCTGCCACGCTTC
CTCGGGAGTGACAACCAGGACACCTTCTTCACAAGCACCAAGAGGCACCAAATTCTGTTT
GAGATCCTGGCCAAGACCCCGTATGGCCACGAGAAGAAAAACCTGCTTGGGATCCACCAG
CTGCTGGCAGAGGGTGTCCTCAGTGCCGCCTTCCCCCTGCATGACGGCCCCTTCAAGACG
CCCCCAGAGGGCCCGCAGGCTCCACGCCTCAACCAGCGCCAAGTCCTTTTCCAGCACTGG
GCGCGCTGGGGCAAGTGGAACAAGTACCAGCCCCTGGACCACGTGCGCAGGTACTTCGGG
GAGAAGGTGGCCCTCTACTTCGCCTGGCTCGGGTTTTACACAGGCTGGCTCCTGCCAGCG
GCAGTGGTGGGCACACTGGTGTTCCTGGTGGGCTGCTTCCTGGTGTTCTCAGACATACCC
ACGCAGGAACTGTGTGGCAGCAAGGACAGCTTCGAGATGTGCCCACTTTGCCTCGACTGC
CCTTTCTGGCTGCTCTCCAGCGCCTGTGCCCTGGCCCAGGCCGGCCGGCTGTTCGACCAC
GGCGGCACCGTGTTCTTCAGCTTGTTCATGGCACTGTGGGCCGTGCTGCTGCTGGAGTAC
TGGAAGCGGAAGAGCGCCACGCTGGCCTACCGCTGGGACTGCTCTGACTACGAGGACACT
GAGGAGAGGCCTCGGCCCCAGTTTGCCGCCTCAGCCCCCATGACAGCCCCGAACCCCATC
ACGGGTGAGGACGAGCCCTACTTCCCTGAGAGGAGCCGCGCGCGCCGCATGCTGGCCGGC
TCTGTGGTGATCGTGGTGATGGTGGCCGTGGTGGTCATGTGCCTCGTGTCTATCATCCTG
TACCGTGCCATCATGGCCATCGTGGTGTCCAGGTCGGGCAACACCCTTCTCGCAGCCTGG
GCCTCTCGCATCGCCAGCCTCACGGGGTCTGTAGTGAACCTCGTCTTCATCCTCATCCTC
TCCAAGATCTATGTATCCCTGGCCCACGTCCTGACACGATGGGAAATGCACCGCACCCAG
ACCAAGTTCGAGGACGCCTTCACCCTCAAGGTGTTCATCTTCCAGTTCGTCAACTTCTAC
TCCTCACCCGTCTACATTGCCTTCTTCAAGGGCAGGTTTGTGGGATACCCAGGCAACTAC
CACACCTTGTTTGGAGTCCGCAATGAGGAGTGCGCGGCTGGAGGCTGCCTGATCGAGCTG
GCACAGGAGCTCCTGGTCATCATGGTGGGCAAGCAGGTCATCAACAACATGCAGGAGGTC
CTCATCCCGAAGCTAAAGGGCTGGTGGCAGAAGTTCCGGCTTCGCTCCAAGAAGAGGAAG
GCGGGAGCTTCTGCAGGGGCTAGCCAGGGGCCCTGGGAGGACGACTATGAGCTTGTGCCC
TGTGAGGGTCTGTTTGACGAGTACCTGGAAATGGTGCTGCAGTTCGGCTTCGTCACCATC
TTCGTGGCCGCCTGTCCGCTCGCGCCGCTCTTCGCCCTGCTCAACAACTGGGTGGAGATC
CGCTTGGACGCGCGCAAGTTCGTCTGCGAGTACCGGCGCCCTGTGGCCGAGCGCGCCCAG
GACATCGGCATCTGGTTCCACATCCTGGCGGGCCTCACGCACCTGGCGGTCATCAGCAAC
GCCTTCCTCCTGGCCTTCTCGTCCGACTTCCTGCCGCGCGCCTACTACCGGTGGACCCGC
GCCCACGACCTGCGCGGCTTCCTCAACTTCACGCTGGCGCGAGCCCCGTCCTCCTTCGCC
GCCGCGCACAACCGCACGTGCAGGTATCGGGCTTTCCGGGATGACGATGGACATTATTCC
CAGACCTACTGGAATCTTCTTGCCATCCGCCTGGCCTTCGTCATTGTGTTTGAGCATGTG
GTTTTCTCCGTTGGCCGCCTCCTGGACCTCCTGGTGCCTGACATCCCAGAGTCTGTGGAG
ATCAAAGTGAAGCGGGAGTACTACCTGGCTAAGCAGGCACTGGCTGAGAATGAGGTTCTT
TTTGGAACGAACGGAACAAAGGATGAGCAGCCCAAGGGCTCAGAGCTCAGCTCCCACTGG
ACACCCTTCACGGTTCCCAAGGCCAGCCAGCTGCAGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 933 |
| Molecular Weight
| 105529.5 |
| Theoretical pI
| 8.1 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 356-376
- 421-441
- 500-520
- 551-571
- 589-609
- 715-735
- 764-784
- 844-864
|
| Protein Sequence
|
>Anoctamin-7
MRMAATAWAGLQGPPLPTLCPAVRTGLYCRDQAHAERWAMTSETSSGSHCARSRMLRRRA
QEEDSTVLIDVSPPEAEKRGSYGSTAHASEPGGQQAAACRAGSPAKPRIADFVLVWEEDL
KLDRQQDSAARDRTDMHRTWRETFLDNLRAAGLCVDQQDVQDGNTTVHYALLSASWAVLC
YYAEDLRLKLPLQELPNQASNWSAGLLAWLGIPNVLLEVVPDVPPEYYSCRFRVNKLPRF
LGSDNQDTFFTSTKRHQILFEILAKTPYGHEKKNLLGIHQLLAEGVLSAAFPLHDGPFKT
PPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLPA
AVVGTLVFLVGCFLVFSDIPTQELCGSKDSFEMCPLCLDCPFWLLSSACALAQAGRLFDH
GGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDTEERPRPQFAASAPMTAPNPI
TGEDEPYFPERSRARRMLAGSVVIVVMVAVVVMCLVSIILYRAIMAIVVSRSGNTLLAAW
ASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLKVFIFQFVNFY
SSPVYIAFFKGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEV
LIPKLKGWWQKFRLRSKKRKAGASAGASQGPWEDDYELVPCEGLFDEYLEMVLQFGFVTI
FVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVISN
AFLLAFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNRTCRYRAFRDDDGHYS
QTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAENEVL
FGTNGTKDEQPKGSELSSHWTPFTVPKASQLQQ
|
| External Links |
|---|
| GenBank ID Protein
| 48093524 |
| UniProtKB/Swiss-Prot ID
| Q6IWH7 |
| UniProtKB/Swiss-Prot Entry Name
| ANO7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY617079 |
| GeneCard ID
| ANO7 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, Park SP, Lee J, Lee B, Kim BM, Raouf R, Shin YK, Oh U: TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature. 2008 Oct 30;455(7217):1210-5. doi: 10.1038/nature07313. Epub 2008 Aug 24. [PubMed:18724360 ]
- Bera TK, Das S, Maeda H, Beers R, Wolfgang CD, Kumar V, Hahn Y, Lee B, Pastan I: NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3059-64. Epub 2004 Feb 23. [PubMed:14981236 ]
- Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T: Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes. Genome Res. 1999 Dec;9(12):1198-203. [PubMed:10613842 ]
- Katoh M, Katoh M: Characterization of human TMEM16G gene in silico. Int J Mol Med. 2004 Oct;14(4):759-64. [PubMed:15375614 ]
- Kiessling A, Weigle B, Fuessel S, Ebner R, Meye A, Rieger MA, Schmitz M, Temme A, Bachmann M, Wirth MP, Rieber EP: D-TMPP: a novel androgen-regulated gene preferentially expressed in prostate and prostate cancer that is the first characterized member of an eukaryotic gene family. Prostate. 2005 Sep 1;64(4):387-400. [PubMed:15761874 ]
- Das S, Hahn Y, Nagata S, Willingham MC, Bera TK, Lee B, Pastan I: NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells. Cancer Res. 2007 Feb 15;67(4):1594-601. [PubMed:17308099 ]
|
