Hmdb loader
Identification
HMDB Protein ID HMDBP07448
Secondary Accession Numbers
  • 13156
Name Ankyrin repeat and sterile alpha motif domain-containing protein 1B
Synonyms
  1. AIDA-1
  2. Amyloid-beta protein intracellular domain-associated protein 1
  3. E2A-PBX1-associated protein
  4. EB-1
Gene Name ANKS1B
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Isoform 6:Nucleus
Gene Properties
Chromosome Location Chromosome:1
Locus 12q23.1
SNPs ANKS1B
Gene Sequence
>3750 bp
ATGGGGAAGGACCAGGAGCTGCTGGAAGCTGCTCGCACTGGAAATGTGGCTCTGGTGGAG
AAACTCCTGTCTGGCAGGAAAGGAGGGATCCTGGGCGGTGGATCCGGACCCCTGCCCCTG
TCTAATCTGCTAAGCATCTGGCGAGGCCCCAATGTGAACTGCACAGACAGTTCGGGTTAC
ACTGCTTTACACCACGCAGCCTTAAATGGACATAAGGACATAGTTCTCAAACTACTTCAG
TATGAGGCATCAACAAATGTAGCAGACAACAAAGGGTATTTTCCTATTCACCTGGCTGCC
TGGAAAGGAGATGTGGAAATTGTGAAGATTCTTATTCATCATGGACCATCACATTCCAGG
GTCAATGAACAGAACAATGAAAATGAAACTGCCCTACACTGTGCAGCTCAATATGGACAC
TCAGAAGTAGTTGCTGTTCTCCTAGAAGAGCTCACTGACCCGACAATTAGAAATAGCAAG
CTGGAAACACCTTTGGACTTGGCGGCACTCTACGGACGGCTTAGAGTGGTAAAAATGATC
ATCAGTGCACATCCTAACTTAATGAGCTGCAACACTCGCAAGCACACGCCACTTCACCTT
GCTGCGCGCAATGGCCACAAAGCAGTCGTGCAGGTGCTGCTGGAGGCAGGAATGGATGTG
AGCTGTCAAACAGAAAAGGGGAGTGCACTTCATGAAGCAGCTTTGTTTGGAAAGGTGGAT
GTTGTACGAGTTCTGTTAGAAACAGGAATTGATGCCAACATAAAGGATAGCTTAGGTAGA
ACTGTCTTGGACATTCTGAAAGAACATCCATCTCAGAAATCTCTCCAGATTGCAACACTC
TTACAAGAGTATTTAGAAGGCGTGGGTAAGTATGCTACAGTCCTCGAAGAGCCTGTACAG
GAAGATGCAACACAAGAAACACACATTTCATCTCCTGTTGAGTCTCCTTCCCAAAAGACC
AAAAGTGAAACCGTCACTGGAGAATTATCAAAACTCTTGGATGAAATAAAACTCTGTCAA
GAAAAGGATTATTCGTTTGAAGACTTGTGCCACACAATATCAGACCACTACTTAGATAAT
TTGAGCAAGATTTCAGAGGAAGAACTTGGGAAAAATGGAAGCCAGAGTGTAAGAACCTCA
TCTACAATCAATTTGTCACCAGGAGAAGTGGAAGAAGAGGATGATGATGAAAATACGTGT
GGGCCATCAGGACTTTGGGAAGCATTAACTCCGTGTAATGGATGTAGGAACCTTGGCTTC
CCCATGCTTGCCCAGGAGTCCTATCCAAAGAAGAGAAATTACACTATGGAAATTGTACCA
TCTGCTTCTCTGGATACATTTCCTTCAGAAAATGAGAACTTTCTGTGTGATCTCATGGAC
ACAGCTGTTACAAAGAAACCTTGCTCCTTAGAAATTGCAAGGGCACCTTCCCCAAGAACT
GATAATGCCTCTGAGGTAGCAGTTACTACTCCAGGAACTAGTAACCATAGAAACAGCTCA
ACAGGCCCAACACCTGATTGTTCACCTCCATCCCCTGATACTGCCCTCAAAAATATTGTA
AAAGTCATTCGACCCCAGCCTAAACAGCGAACATCCATTGTGTCTTCTCTGGATTTTCAC
CGAATGAATCACAACCAAGAATATTTTGAAATCAACACATCTACAGGGTGCACAAGCTTT
ACTGCCAGTCCTCCTGCTAGTCCACCCACCTCTTCTGTGGGAACCACAGAAGTCAAGAAT
GAGGGAACTAACCATACAGATGACCTCTCCCGACAGGATGACAATGATCCCCCAAAAGAA
TATGATCCTGGGCAATTTGCAGGCCTGCTCCATGGATCCTCTCCAGCCTGTGAGTCCCCT
GAAAATCCATTTCATCTCTATGGGAAAAGAGAACAATGTGAAAAAGGACAAGATGAAGTC
AGTTTGGCAAACAGTCCTTTGCCTTTCAAGCAGTCTCCAATAGAAAATAACTCAGAACCT
TTGGTAAAGAAAATTAAACCCAAAGTGGTCAGTAGAACAATTTTTCACAAAAAAAGCAAC
CAACTCGAAAACCATACCATTGTTGGCACAAGATCAACCAGGAGTGGATCTCGGAATGGG
GACCAGTGGGTTATGAACGCAGGGGGATTTGTGGAGAGAGCCTGTACTCTGGGGAGAATA
AGGTCATTGCCTAAAGCCTTGATCGACATGCATTTGTCAAAAAGTGTCTCTAAATCTGAT
TCTGATCTCATTGCCTATCCTTCCAATGAGAAAACATCAAGAGTTAACTGGAGTGAATCT
TCCACTGCTGAACACAGTTCTAAAGGGAATTCTGAAAGAACACCATCCTTCACATCGGAA
TGGGAAGAAATTGACAAAATAATGAGTTCCATAGATGTTGGAATCAACAACGAACTTAAA
GAGATGAATGGTGAGACCACAAGACCCAGATGCCCTGTCCAAACAGTGGGACAATGGTTG
GAAAGCATTGGGCTACCTCAGTACGAGAACCACCTGATGGCTAATGGATTTGACAATGTG
CAGTTTATGGGAAGCAATGTTATGGAAGATCAGGATTTGTTGGAAATTGGAATCCTTAAT
TCTGGGCACAGACAAAGAATTCTACAGGCAATCCAGCTCCTTCCAAAGATGAGACCCATT
GGGCATGATGGCTACCATCCCACCTCTGTAGCTGAGTGGCTGGATTCCATTGAACTGGGC
GACTACACCAAAGCCTTTCTAATTAATGGCTACACTTCGATGGACCTGTTGAAAAAAATC
TGGGAGGTTGAACTTATTAATGTTTTAAAAATCAATTTGATTGGCCACAGGAAACGTATT
TTGGCATCTCTGGGAGACAGGCTGCACGACGATCCCCCACAGAAGCCCCCTCGGTCCATC
ACCCTCAGGGAACCCAGTGGTAATCACACTCCTCCTCAGTTGTCTCCATCACTTAGCCAA
AGCACTTACACCACTGGTGGCTCCCTAGACGTTCCTCACATTATCATGCAGGGCGATGCA
AGGAGGAGAAGAAATGAAAACTACTTTGATGATATTCCCCGATCAAAACTGGAGAGGCAG
ATGGCTCAGACAGGAGACTGGGGAGAACCTTCCATTACCTTGCGACCTCCGAATGAAGCC
ACAGCCTCTACCCCGGTACAGTACTGGCAGCATCACCCAGAAAAGCTTATCTTCCAGTCG
TGTGATTACAAAGCTTTTTATTTAGGTTCTATGCTGATAAAAGAGCTTAGGGGGACAGAA
TCAACCCAAGATGCTTGTGCAAAAATGCGGGCTAACTGTCAGAAGTCTACAGAGCAAATG
AAGAAGGTCCCTACTATTATTCTTTCTGTCTCATATAAAGGAGTCAAATTTATTGATGCA
ACAAATAAGAACATAATTGCTGAGCATGAAATTCGTAATATCTCCTGTGCTGCCCAGGAC
CCAGAAGACCTCTCAACATTTGCCTATATCACAAAAGATTTGAAGTCTAATCACCACTAC
TGTCATGTGTTTACTGCCTTTGATGTGAATTTAGCCTATGAAATCATCCTAACCCTGGGA
CAGGCATTCGAAGTCGCTTACCAGCTAGCACTACAAGCAAGAAAAGGGGGACACTCCTCC
ACACTTCCAGAAAGCTTTGAAAACAAACCCTCCAAACCCATCCCCAAGCCCCGCGTTAGC
ATTCGCAAGTCCGTGGATCTTCTTCATGCCAGCCATACCGGGCAGGAACCATCAGAGAGA
CACACTGAGGAGGCACTCAGAAAATTTTGA
Protein Properties
Number of Residues 1249
Molecular Weight 138184.2
Theoretical pI 6.33
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Ankyrin repeat and sterile alpha motif domain-containing protein 1B
MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGY
TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR
VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI
ISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVD
VVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGKYATVLEEPVQ
EDATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDN
LSKISEEELGKNGSQSVRTSSTINLSPGEVEEEDDDENTCGPSGLWEALTPCNGCRNLGF
PMLAQESYPKKRNYTMEIVPSASLDTFPSENENFLCDLMDTAVTKKPCSLEIARAPSPRT
DNASEVAVTTPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFH
RMNHNQEYFEINTSTGCTSFTASPPASPPTSSVGTTEVKNEGTNHTDDLSRQDDNDPPKE
YDPGQFAGLLHGSSPACESPENPFHLYGKREQCEKGQDEVSLANSPLPFKQSPIENNSEP
LVKKIKPKVVSRTIFHKKSNQLENHTIVGTRSTRSGSRNGDQWVMNAGGFVERACTLGRI
RSLPKALIDMHLSKSVSKSDSDLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSE
WEEIDKIMSSIDVGINNELKEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNV
QFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELG
DYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSI
TLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQ
MAQTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTE
STQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQD
PEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSS
TLPESFENKPSKPIPKPRVSIRKSVDLLHASHTGQEPSERHTEEALRKF
GenBank ID Protein 31746739
UniProtKB/Swiss-Prot ID Q7Z6G8
UniProtKB/Swiss-Prot Entry Name ANS1B_HUMAN
PDB IDs Not Available
GenBank Gene ID AY281131
GeneCard ID ANKS1B
GenAtlas ID ANKS1B
HGNC ID HGNC:24600
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9543-8. [PubMed:10931946 ]
  4. Ghersi E, Noviello C, D'Adamio L: Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner. J Biol Chem. 2004 Nov 19;279(47):49105-12. Epub 2004 Sep 3. [PubMed:15347684 ]
  5. Ghersi E, Vito P, Lopez P, Abdallah M, D'Adamio L: The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing. J Alzheimers Dis. 2004 Feb;6(1):67-78. [PubMed:15004329 ]
  6. Xu H, Hebert MD: A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. BMC Cell Biol. 2005 Apr 29;6(1):23. [PubMed:15862129 ]
  7. Fu X, McGrath S, Pasillas M, Nakazawa S, Kamps MP: EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1. Oncogene. 1999 Sep 2;18(35):4920-9. [PubMed:10490826 ]
  8. Casagrande G, te Kronnie G, Basso G: The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line. Haematologica. 2006 Jun;91(6):765-71. [PubMed:16769578 ]
  9. Shin J, Gu C, Park E, Park S: Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function. Mol Cell Biol. 2007 Dec;27(23):8113-26. Epub 2007 Sep 17. [PubMed:17875921 ]