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Showing Protein Annexin A11 (HMDBP07450)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP07450
Secondary Accession Numbers
  • 13158
Name Annexin A11
Synonyms
  1. 56 kDa autoantigen
  2. Annexin XI
  3. Annexin-11
  4. CAP-50
  5. Calcyclin-associated annexin 50
Gene Name ANXA11
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
calcium-dependent phospholipid binding
calcium ion binding
lipid binding
phospholipid binding
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. Cytoplasm
  4. Melanosome
  5. cytoskeleton
  6. Nucleus envelope
  7. spindle
  8. nucleoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 10q23
SNPs ANXA11
Gene Sequence 
>1518 bp
ATGAGCTACCCTGGCTATCCCCCGCCCCCAGGTGGCTACCCACCAGCTGCACCAGGTGGT
GGTCCCTGGGGAGGTGCTGCCTACCCTCCTCCGCCCAGCATGCCCCCCATCGGGCTGGAT
AACGTGGCCACCTATGCGGGGCAGTTCAACCAGGACTATCTCTCGGGAATGGCGGCCAAC
ATGTCTGGGACATTTGGAGGAGCCAACATGCCCAACCTGTACCCTGGGGCCCCTGGGGCT
GGCTACCCACCAGTGCCCCCTGGCGGCTTTGGGCAGCCCCCCTCTGCCCAGCAGCCTGTT
CCTCCCTATGGGATGTATCCACCCCCAGGAGGAAACCCACCCTCCAGGATGCCCTCATAT
CCGCCATACCCAGGGGCCCCTGTGCCGGGCCAGCCCATGCCACCCCCCGGACAGCAGCCC
CCAGGGGCCTACCCTGGGCAGCCACCAGTGACCTACCCTGGTCAGCCTCCAGTGCCACTC
CCTGGGCAGCAGCAGCCAGTGCCGAGCTACCCAGGATACCCGGGGTCTGGGACTGTCACC
CCCGCTGTGCCCCCAACCCAGTTTGGAAGCCGAGGCACCATCACTGATGCTCCCGGCTTT
GACCCCCTGCGAGATGCCGAGGTCCTGCGGAAGGCCATGAAAGGCTTCGGGACGGATGAG
CAGGCCATCATTGACTGCCTGGGGAGTCGCTCCAACAAGCAGCGGCAGCAGATCCTACTT
TCCTTCAAGACGGCTTACGGCAAGGATTTGATCAAAGATCTGAAATCTGAACTGTCAGGA
AACTTTGAGAAGACAATCTTGGCTCTGATGAAGACCCCAGTCCTCTTTGACATTTATGAG
ATAAAGGAAGCCATCAAGGGGGTTGGCACTGATGAAGCCTGCCTGATTGAGATCCTCGCT
TCCCGCAGCAATGAGCACATCCGAGAATTAAACAGAGCCTACAAAGCAGAATTCAAAAAG
ACCCTGGAAGAGGCCATTCGAAGCGACACATCAGGGCACTTCCAGCGGCTCCTCATCTCT
CTCTCTCAGGGAAACCGTGATGAAAGCACAAACGTGGACATGTCACTCGCCCAGAGAGAT
GCCCAGGAGCTGTATGCGGCCGGGGAGAACCGCCTGGGAACAGACGAGTCCAAGTTCAAT
GCGGTTCTGTGCTCCCGGAGCCGGGCCCACCTGGTAGCAGTTTTCAATGAGTACCAGAGA
ATGACAGGCCGGGACATTGAGAAGAGCATCTGCCGGGAGATGTCCGGGGACCTGGAGGAG
GGCATGCTGGCCGTGGTGAAATGTCTCAAGAATACCCCAGCCTTCTTTGCGGAGAGGCTC
AACAAGGCCATGAGGGGGGCAGGAACAAAGGACCGGACCCTGATTCGCATCATGGTGTCT
CGCAGCGAGACCGACCTCCTGGACATCAGATCAGAGTATAAGCGGATGTACGGCAAGTCG
CTGTACCACGACATCTCGGGAGATACTTCAGGGGATTACCGGAAGATTCTGCTGAAGATC
TGTGGTGGCAATGACTGA
Protein Properties
Number of Residues 505
Molecular Weight 54389.3
Theoretical pI 7.77
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Annexin A11
MSYPGYPPPPGGYPPAAPGGGPWGGAAYPPPPSMPPIGLDNVATYAGQFNQDYLSGMAAN
MSGTFGGANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSY
PPYPGAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPLPGQQQPVPSYPGYPGSGTVT
PAVPPTQFGSRGTITDAPGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILL
SFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDIYEIKEAIKGVGTDEACLIEILA
SRSNEHIRELNRAYKAEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLAQRD
AQELYAAGENRLGTDESKFNAVLCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEE
GMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSETDLLDIRSEYKRMYGKS
LYHDISGDTSGDYRKILLKICGGND
GenBank ID Protein 8671171
UniProtKB/Swiss-Prot ID P50995
UniProtKB/Swiss-Prot Entry Name ANX11_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ278463
GeneCard ID ANXA11
GenAtlas ID ANXA11
HGNC ID HGNC:535
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  3. Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190-203. [PubMed:18083107 ]
  4. Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J Proteome Res. 2006 Nov;5(11):3135-44. [PubMed:17081065 ]
  5. Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG 2nd, Smith RD, Wiley HS, Qian WJ: An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. J Proteome Res. 2009 Aug;8(8):3852-61. doi: 10.1021/pr900044c. [PubMed:19534553 ]
  6. Shibata H, Suzuki H, Kakiuchi T, Inuzuka T, Yoshida H, Mizuno T, Maki M: Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. J Biol Chem. 2008 Apr 11;283(15):9623-32. doi: 10.1074/jbc.M800717200. Epub 2008 Feb 6. [PubMed:18256029 ]
  7. Misaki Y, Pruijn GJ, van der Kemp AW, van Venrooij WJ: The 56K autoantigen is identical to human annexin XI. J Biol Chem. 1994 Feb 11;269(6):4240-6. [PubMed:7508441 ]
  8. Bances P, Fernandez MR, Rodriguez-Garcia MI, Morgan RO, Fernandez MP: Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms. Genomics. 2000 Oct 1;69(1):95-103. [PubMed:11013079 ]
  9. Satoh H, Shibata H, Nakano Y, Kitaura Y, Maki M: ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner. Biochem Biophys Res Commun. 2002 Mar 15;291(5):1166-72. [PubMed:11883939 ]
  10. Tomas A, Moss SE: Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope. J Biol Chem. 2003 May 30;278(22):20210-6. Epub 2003 Feb 24. [PubMed:12601007 ]
  11. Farnaes L, Ditzel HJ: Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display. J Biol Chem. 2003 Aug 29;278(35):33120-6. Epub 2003 Jun 11. [PubMed:12805373 ]
  12. Tomas A, Futter C, Moss SE: Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis. J Cell Biol. 2004 Jun 21;165(6):813-22. Epub 2004 Jun 14. [PubMed:15197175 ]