Hmdb loader
Identification
HMDB Protein ID HMDBP07455
Secondary Accession Numbers
  • 13163
Name Annexin A7
Synonyms
  1. Annexin VII
  2. Annexin-7
  3. Synexin
Gene Name ANXA7
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
calcium-dependent phospholipid binding
calcium ion binding
lipid binding
phospholipid binding
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 10q22.2
SNPs ANXA7
Gene Sequence
>1467 bp
ATGTCATACCCAGGCTATCCCCCAACAGGCTACCCACCTTTCCCTGGATATCCTCCTGCA
GGTCAGGAGTCATCTTTTCCCCCTTCTGGTCAGTATCCTTATCCTAGTGGCTTTCCTCCA
ATGGGAGGAGGTGCCTACCCACAAGTGCCAAGTAGTGGCTACCCAGGAGCTGGAGGCTAC
CCTGCGCCTGGAGGTTATCCAGCCCCTGGAGGCTATCCTGGTGCCCCACAGCCAGGGGGA
GCTCCATCCTATCCCGGAGTTCCTCCAGGCCAAGGATTTGGAGTCCCACCAGGTGGAGCA
GGCTTTTCTGGGTATCCACAGCCACCTTCACAGTCTTATGGAGGTGGTCCAGCACAGGTT
CCACTACCTGGTGGCTTTCCTGGAGGACAGATGCCTTCTCAGTATCCTGGAGGACAACCT
ACTTACCCTAGTCAGATCAATACAGATTCTTTTTCTTCCTATCCTGTTTTCTCTCCTGTT
TCTTTGGATTATAGCAGTGAACCTGCCACAGTGACTCAGGTCACTCAAGGAACTATCCGA
CCAGCTGCCAACTTCGATGCTATAAGAGATGCAGAAATTCTTCGTAAGGCAATGAAGGGT
TTTGGGACAGATGAGCAGGCAATTGTGGATGTGGTGGCCAACCGTTCCAATGATCAGAGG
CAAAAAATTAAAGCAGCATTTAAGACCTCCTATGGCAAGGATTTAATCAAAGATCTCAAA
TCAGAGTTAAGTGGAAATATGGAAGAACTGATCCTGGCCCTCTTCATGCCTCCTACGTAT
TACGATGCCTGGAGCTTACGGAAAGCAATGCAGGGAGCAGGAACTCAGGAACGTGTATTG
ATTGAGATTTTGTGCACAAGAACAAATCAGGAAATCCGAGAAATTGTCAGATGTTATCAG
TCAGAATTTGGACGAGACCTTGAAAAGGACATTAGGTCAGATACATCAGGACATTTTGAA
CGTTTACTTGTGTCCATGTGCCAGGGAAATCGTGATGAGAACCAGAGTATAAACCACCAA
ATGGCTCAGGAAGATGCTCAGCGTCTCTATCAAGCTGGTGAGGGGAGACTAGGGACCGAT
GAATCTTGCTTTAACATGATCCTTGCCACAAGAAGCTTTCCTCAGCTGAGAGCTACCATG
GAGGCTTATTCTAGGATGGCTAATCGAGACTTGTTAAGCAGTGTGAGCCGTGAGTTTTCC
GGATATGTAGAAAGTGGTTTGAAGACCATCTTGCAGTGTGCCCTGAACCGCCCTGCCTTC
TTTGCTGAGAGGCTCTACTATGCTATGAAAGGTGCTGGCACAGATGACTCCACCCTGGTC
CGGATTGTGGTCACTCGAAGTGAGATTGACCTTGTACAAATAAAACAGATGTTCGCTCAG
ATGTATCAGAAGACTCTGGGCACAATGATTGCAGGTGACACGAGTGGAGATTACCGAAGA
CTTCTTCTGGCTATTGTGGGCCAGTAG
Protein Properties
Number of Residues 488
Molecular Weight 52738.9
Theoretical pI 5.32
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Annexin A7
MSYPGYPPTGYPPFPGYPPAGQESSFPPSGQYPYPSGFPPMGGGAYPQVPSSGYPGAGGY
PAPGGYPAPGGYPGAPQPGGAPSYPGVPPGQGFGVPPGGAGFSGYPQPPSQSYGGGPAQV
PLPGGFPGGQMPSQYPGGQPTYPSQINTDSFSSYPVFSPVSLDYSSEPATVTQVTQGTIR
PAANFDAIRDAEILRKAMKGFGTDEQAIVDVVANRSNDQRQKIKAAFKTSYGKDLIKDLK
SELSGNMEELILALFMPPTYYDAWSLRKAMQGAGTQERVLIEILCTRTNQEIREIVRCYQ
SEFGRDLEKDIRSDTSGHFERLLVSMCQGNRDENQSINHQMAQEDAQRLYQAGEGRLGTD
ESCFNMILATRSFPQLRATMEAYSRMANRDLLSSVSREFSGYVESGLKTILQCALNRPAF
FAERLYYAMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFAQMYQKTLGTMIAGDTSGDYRR
LLLAIVGQ
GenBank ID Protein 4809279
UniProtKB/Swiss-Prot ID P20073
UniProtKB/Swiss-Prot Entry Name ANXA7_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_004034.2
GeneCard ID ANXA7
GenAtlas ID ANXA7
HGNC ID HGNC:545
References
General References
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  2. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  3. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [PubMed:15164054 ]
  4. Shibata H, Suzuki H, Kakiuchi T, Inuzuka T, Yoshida H, Mizuno T, Maki M: Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. J Biol Chem. 2008 Apr 11;283(15):9623-32. doi: 10.1074/jbc.M800717200. Epub 2008 Feb 6. [PubMed:18256029 ]
  5. Burns AL, Magendzo K, Shirvan A, Srivastava M, Rojas E, Alijani MR, Pollard HB: Calcium channel activity of purified human synexin and structure of the human synexin gene. Proc Natl Acad Sci U S A. 1989 May;86(10):3798-802. [PubMed:2542947 ]
  6. Shirvan A, Srivastava M, Wang MG, Cultraro C, Magendzo K, McBride OW, Pollard HB, Burns AL: Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10. Biochemistry. 1994 Jun 7;33(22):6888-901. [PubMed:7515686 ]
  7. Magendzo K, Shirvan A, Cultraro C, Srivastava M, Pollard HB, Burns AL: Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain. J Biol Chem. 1991 Feb 15;266(5):3228-32. [PubMed:1825209 ]