Hmdb loader

Showing Protein Bone morphogenetic protein 8B (HMDBP07473)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP07473
Secondary Accession Numbers
  • 13181
Name Bone morphogenetic protein 8B
Synonyms
  1. BMP-8
  2. BMP-8B
  3. OP-2
  4. Osteogenic protein 2
Gene Name BMP8B
Protein Type Unknown
Biological Properties
General Function Involved in growth factor activity
Specific Function Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis
Pathways Not Available
Reactions Not Available
GO Classification
Component
extracellular region
Function
binding
protein binding
receptor binding
growth factor activity
Process
growth
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Chromosome:1
Locus 1p35-p32
SNPs BMP8B
Gene Sequence 
>1209 bp
ATGACCGCGCTCCCCGGCCCGCTCTGGCTCCTGGGCCTGGCGCTATGCGCGCTGGGCGGG
GGCGGCCCCGGCCTGCGACCCCCGCCCGGCTGTCCCCAGCGACGTCTGGGCGCGCGCGAG
CGCCGGGACGTGCAGCGCGAGATCCTGGCGGTGCTCGGGCTGCCTGGGCGGCCCCGGCCC
CGCGCGCCACCCGCCGCCTCCCGGCTGCCCGCGTCCGCGCCGCTCTTCATGCTGGACCTG
TACCACGCCATGGCCGGCGACGACGACGAGGACGGCGCGCCCGCGGAGCGGCGCCTGGGC
CGCGCCGACCTGGTCATGAGCTTCGTTAACATGGTGGAGCGAGACCGTGCCCTGGGCCAC
CAGGAGCCCCATTGGAAGGAGTTCCGCTTTGACCTGACCCAGATCCCGGCTGGGGAGGCG
GTCACAGCTGCGGAGTTCCGGATTTACAAGGTGCCCAGCATCCACCTGCTCAACAGGACC
CTCCACGTCAGCATGTTCCAGGTGGTCCAGGAGCAGTCCAACAGGGAGTCTGACTTGTTC
TTTTTGGATCTTCAGACGCTCCGAGCTGGAGACGAGGGCTGGCTGGTGCTGGATGTCACA
GCAGCCAGTGACTGCTGGTTGCTGAAGCGTCACAAGGACCTGGGACTCCGCCTCTATGTG
GAGACTGAGGACGGGCACAGCGTGGATCCTGGCCTGGCCGGCCTGCTGGGTCAACGGGCC
CCACGCTCCCAACAGCCTTTCGTGGTCACTTTCTTCAGGGCCAGTCCGAGTCCCATCCGC
ACCCCTCGGGCAGTGAGGCCACTGAGGAGGAGGCAGCCGAAGAAAAGCAACGAGCTGCCG
CAGGCCAACCGACTCCCAGGGATCTTTGATGACGTCCACGGCTCCCACGGCCGGCAGGTC
TGCCGTCGGCACGAGCTCTACGTCAGCTTCCAGGACCTCGGCTGGCTGGACTGGGTCATC
GCTCCCCAAGGCTACTCGGCCTATTACTGTGAGGGGGAGTGCTCCTTCCCACTGGACTCC
TGCATGAATGCCACCAACCACGCCATCCTGCAGTCCCTGGTGCACCTGATGATGCCAGAC
GCAGTCCCCAAGGCGTGCTGTGCACCCACCAAGCTGAGCGCCACCTCTGTGCTCTACTAT
GACAGCAGCAACAATGTCATCCTGCGCAAGCACCGCAACATGGTGGTCAAGGCCTGCGGC
TGCCACTGA
Protein Properties
Number of Residues 402
Molecular Weight 44768.0
Theoretical pI 8.49
Pfam Domain Function
Signals
  • 1-19
Transmembrane Regions
  • None
Protein Sequence 
>Bone morphogenetic protein 8B
MTALPGPLWLLGLALCALGGGGPGLRPPPGCPQRRLGARERRDVQREILAVLGLPGRPRP
RAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADLVMSFVNMVERDRALGH
QEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLF
FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRA
PRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV
CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD
AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH
GenBank ID Protein 7018292
UniProtKB/Swiss-Prot ID P34820
UniProtKB/Swiss-Prot Entry Name BMP8B_HUMAN
PDB IDs Not Available
GenBank Gene ID AL033527
GeneCard ID BMP8B
GenAtlas ID BMP8B
HGNC ID HGNC:1075
References
General References
  1. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. [PubMed:16710414 ]
  2. Ozkaynak E, Schnegelsberg PN, Jin DF, Clifford GM, Warren FD, Drier EA, Oppermann H: Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. J Biol Chem. 1992 Dec 15;267(35):25220-7. [PubMed:1460021 ]