| Identification |
|---|
| HMDB Protein ID
| HMDBP07504 |
| Secondary Accession Numbers
| |
| Name
| Cadherin-10 |
| Synonyms
|
- T2-cadherin
|
| Gene Name
| CDH10 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein (Potential)
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5p14.2 |
| SNPs
| CDH10 |
| Gene Sequence
|
>2367 bp
ATGACAATACATCAATTTTTGCTACTGTTTCTATTCTGGGTATGCCTGCCACATTTCTGC
TCTCCAGAAATAATGTTCAGAAGGACGCCTGTGCCACAGCAAAGAATTTTAAGTTCACGT
GTACCAAGGAGTGATGGCAAAATTCTCCATCGTCAAAAACGTGGTTGGATGTGGAATCAA
TTTTTCTTACTTGAAGAATATACAGGATCTGATTATCAGTACGTAGGCAAGCTACATTCA
GACCAAGATAAAGGAGATGGATCACTCAAATATATCTTATCTGGAGATGGAGCTGGTACT
CTTTTTATTATTGATGAAAAAACAGGTGATATTCATGCCACAAGGCGAATTGATAGGGAG
GAAAAGGCCTTTTATACTCTACGCGCACAAGCTATTAACAGAAGAACTCTGAGGCCAGTA
GAGCCAGAGTCAGAGTTTGTGATCAAAATTCATGATATCAATGACAATGAGCCAACGTTC
CCAGAAGAAATCTATACAGCTAGTGTTCCCGAAATGTCTGTTGTAGGTACTTCTGTGGTG
CAAGTCACAGCTACAGATGCCGATGACCCTTCATATGGGAACAGCGCCAGAGTCATTTAC
AGCATACTTCAAGGGCAGCCCTATTTCTCTGTGGAGCCTGAAACAGGTATCATCAGGACT
GCTTTACCGAACATGAACAGAGAAAACAGAGAGCAATACCAAGTGGTCATCCAGGCCAAA
GACATGGGCGGCCAGATGGGAGGCTTATCGGGGACAACCACTGTGAACATCACGCTGACA
GATGTCAATGACAACCCACCACGTTTCCCCCAGAACACTATTCATCTTCGAGTTCTTGAA
TCCTCCCCAGTTGGCACAGCCATTGGAAGTGTCAAAGCAACTGATGCTGACACTGGGAAA
AATGCTGAAGTAGAATACCGAATTATTGATGGTGACGGTACTGATATGTTTGACATCGTG
ACTGAGAAGGACACACAGGAAGGCATCATCACTGTGAAAAAGCCACTCGACTATGAGAGC
CGAAGACTTTATACTCTGAAAGTCGAAGCAGAAAACACCCATGTAGATCCCCGTTTTTAT
TACCTAGGACCATTTAAAGATACTACCATAGTGAAAATCTCTATAGAAGATGTGGATGAA
CCTCCTGTTTTTAGTAGGTCCTCCTATCTGTTTGAAGTTCATGAAGATATTGAAGTGGGC
ACAATCATTGGTACTGTAATGGCAAGGGACCCAGATTCTATTTCCAGCCCCATTAGATTT
TCCTTGGATCGCCATACTGACCTTGACAGAATCTTTAACATTCATTCAGGAAATGGATCT
CTTTATACATCAAAACCTCTTGACCGTGAACTATCTCAGTGGCATAATCTTACTGTTATT
GCTGCTGAAATCAACAATCCCAAAGAGACAACACGCGTGGCTGTTTTTGTGAGAATTTTG
GATGTTAATGACAATGCCCCACAGTTTGCTGTGTTCTATGACACTTTTGTATGTGAAAAT
GCCAGACCAGGGCAGCTAATACAGACTATAAGTGCAGTAGACAAAGATGACCCTTTAGGT
GGACAGAAATTTTTTTTCAGTTTAGCTGCTGTCAATCCAAACTTCACAGTACAGGATAAT
GAAGATAATACTGCCAGAATCTTAACCAGAAAAAATGGATTCAATAGACATGAAATCAGT
ACCTATCTCTTGCCTGTGGTGATATCAGACAATGATTACCCAATTCAGAGCAGCACAGGC
ACACTGACCATTCGAGTGTGTGCTTGTGACAGCCAAGGCAACATGCAATCCTGCAGTGCT
GAAGCCCTGCTCCTCCCTGCCGGCCTCAGCACTGGGGCCTTGATCGCCATCCTCCTCTGC
ATCATCATTCTACTGGTTATAGTAGTACTGTTTGCAGCTCTGAAAAGACAGCGAAAAAAA
GAGCCTCTGATCTTGTCAAAAGAAGATATCAGAGACAACATTGTGAGCTATAACGATGAG
GGTGGTGGAGAGGAGGACACCCAGGCCTTTGATATCGGCACCCTGAGGAATCCTGCAGCC
ATTGAGGAAAAAAAGCTCCGGCGAGATATTATTCCAGAAACGTTATTTATTCCTCGGAGG
ACTCCTACAGCTCCAGATAACACGGACGTCCGGGATTTCATTAATGAAAGGCTAAAAGAG
CATGATCTTGACCCCACCGCACCCCCCTACGACTCACTTGCAACCTATGCCTATGAAGGA
AATGATTCCATTGCTGAATCTCTGAGTTCATTAGAATCAGGTACTACTGAAGGAGACCAA
AACTACGATTACCTCCGAGAATGGGGCCCTCGGTTTAATAAGCTAGCAGAAATGTATGGT
GGTGGGGAAAGTGACAAAGACTCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 788 |
| Molecular Weight
| 88450.4 |
| Theoretical pI
| 4.59 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cadherin-10
MTIHQFLLLFLFWVCLPHFCSPEIMFRRTPVPQQRILSSRVPRSDGKILHRQKRGWMWNQ
FFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTLFIIDEKTGDIHATRRIDRE
EKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVV
QVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGIIRTALPNMNRENREQYQVVIQAK
DMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAIGSVKATDADTGK
NAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFY
YLGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSISSPIRF
SLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINNPKETTRVAVFVRIL
DVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSLAAVNPNFTVQDN
EDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSA
EALLLPAGLSTGALIAILLCIIILLVIVVLFAALKRQRKKEPLILSKEDIRDNIVSYNDE
GGGEEDTQAFDIGTLRNPAAIEEKKLRRDIIPETLFIPRRTPTAPDNTDVRDFINERLKE
HDLDPTAPPYDSLATYAYEGNDSIAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYG
GGESDKDS
|
| External Links |
|---|
| GenBank ID Protein
| 6483303 |
| UniProtKB/Swiss-Prot ID
| Q9Y6N8 |
| UniProtKB/Swiss-Prot Entry Name
| CAD10_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB035303 |
| GeneCard ID
| CDH10 |
| GenAtlas ID
| CDH10 |
| HGNC ID
| HGNC:1749 |
| References |
|---|
| General References
| - Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
- Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
- Kools P, Vanhalst K, Van den Eynde E, van Roy F: The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14. FEBS Lett. 1999 Jun 11;452(3):328-34. [PubMed:10386616 ]
- Shimoyama Y, Tsujimoto G, Kitajima M, Natori M: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. Biochem J. 2000 Jul 1;349(Pt 1):159-67. [PubMed:10861224 ]
|
