Hmdb loader
Identification
HMDB Protein ID HMDBP07506
Secondary Accession Numbers
  • 13214
Name Cadherin-12
Synonyms
  1. BR-cadherin
  2. Brain cadherin
  3. N-cadherin 2
  4. Neural type cadherin 2
Gene Name CDH12
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:5
Locus 5p14.3
SNPs CDH12
Gene Sequence
>2385 bp
ATGCTTACAAGGAACTGTTTATCCCTGCTTCTCTGGGTTCTGTTTGATGGAGGTCTCCTA
ACACCACTACAACCACAGCCACAGCAGACTTTAGCCACAGAGCCAAGAGAAAATGTTATC
CATCTGCCAGGACAACGGTCACATTTCCAACGTGTTAAACGTGGCTGGGTATGGAATCAA
TTTTTTGTGCTGGAAGAATACGTGGGCTCCGAGCCTCAGTATGTGGGAAAGCTCCATTCC
GACTTAGACAAGGGAGAGGGCACTGTGAAATACACCCTCTCAGGAGATGGCGCTGGCACC
GTTTTTACCATTGATGAAACCACAGGGGACATTCATGCAATAAGGAGCCTAGATAGAGAA
GAGAAACCTTTCTACACTCTTCGTGCTCAGGCTGTGGACATAGAAACCAGAAAGCCCCTG
GAGCCTGAATCAGAATTCATCATCAAAGTGCAGGATATTAATGATAATGAGCCAAAGTTT
TTGGATGGACCTTATGTTGCTACTGTTCCAGAAATGTCTCCTGTGGGTGCATATGTACTC
CAGGTCAAGGCCACAGATGCAGATGACCCGACCTATGGAAACAGTGCCAGAGTCGTTTAC
AGCATTCTTCAGGGACAACCTTATTTCTCTATTGATCCCAAGACAGGTGTTATTAGAACA
GCTTTGCCAAACATGGACAGAGAAGTCAAAGAACAATATCAAGTACTCATCCAAGCCAAG
GATATGGGAGGACAGCTTGGAGGATTAGCCGGAACAACAATAGTCAACATCACTCTCACC
GATGTCAATGACAATCCACCTCGATTCCCCAAAAGCATCTTCCACTTGAAAGTTCCTGAG
TCTTCCCCTATTGGTTCAGCTATTGGAAGAATAAGAGCTGTGGATCCTGATTTTGGACAA
AATGCAGAAATTGAATACAATATTGTTCCAGGAGATGGGGGAAATTTGTTTGACATCGTC
ACAGATGAGGATACACAAGAGGGAGTCATCAAATTGAAAAAGCCTTTAGATTTTGAAACA
AAGAAGGCATACACTTTCAAAGTTGAGGCTTCCAACCTTCACCTTGACCACCGGTTTCAC
TCGGCGGGCCCTTTCAAAGACACAGCTACGGTGAAGATCAGCGTGCTGGACGTAGATGAG
CCACCGGTTTTCAGCAAGCCGCTCTACACCATGGAGGTTTATGAAGACACTCCGGTAGGG
ACCATCATTGGCGCTGTCACTGCTCAAGACCTGGATGTAGGCAGCAGTGCTGTTAGGTAC
TTCATAGATTGGAAGAGTGATGGGGACAGCTACTTTACAATAGATGGAAATGAAGGAACC
ATCGCCACTAATGAATTACTAGACAGAGAAAGCACTGCGCAGTATAATTTCTCCATAATT
GCGAGTAAAGTTAGTAACCCTTTATTGACCAGCAAAGTCAATATACTGATTAATGTCTTA
GATGTAAATGAATTTCCTCCAGAAATATCTGTGCCATATGAGACAGCCGTGTGTGAAAAT
GCCAAGCCAGGACAGATAATTCAGATAGTCAGTGCTGCAGACCGAGATCTTTCACCTGCT
GGGCAACAATTCTCCTTTAGATTATCACCTGAGGCTGCTATCAAACCAAATTTTACAGTT
CGTGACTTCAGAAACAACACAGCGGGGATTGAAACCCGAAGAAATGGATACAGCCGCAGG
CAGCAAGAGTTGTATTTCCTCCCTGTTGTAATAGAAGACAGCAGCTACCCTGTCCAGAGC
AGCACAAACACAATGACTATTCGAGTCTGTAGATGTGACTCTGATGGCACCATCCTGTCT
TGTAATGTGGAAGCAATTTTTCTACCTGTAGGACTTAGCACTGGGGCGTTGATTGCAATT
CTACTATGCATTGTTATACTCTTAGCCATAGTTGTACTGTATGTAGCACTGCGAAGGCAG
AAGAAAAAAGACACCCTGATGACCTCTAAAGAAGACATCAGAGACAACGTCATCCATTAC
GATGATGAAGGAGGTGGGGAGGAAGATACCCAGGCTTTCGACATCGGGGCTCTGAGAAAC
CCAAAAGTGATTGAGGAGAACAAAATTCGCAGGGATATAAAACCAGACTCTCTCTGTTTA
CCTCGTCAGAGACCACCCATGGAAGATAACACAGACATAAGGGATTTCATTCATCAAAGG
CTACAGGAAAATGACGTGGACCCAACTGCCCCACCATACGATTCACTGGCCACATATGCC
TACGAAGGGAGTGGGTCCGTGGCAGAGTCCCTCAGCTCTATAGACTCTCTCACCACAGAA
GCCGACCAGGACTATGACTATCTGACAGACTGGGGACCCCGCTTTAAAGTCTTGGCAGAC
ATGTTTGGCGAAGAAGAGAGTTATAACCCTGATAAAGTCACTTAA
Protein Properties
Number of Residues 794
Molecular Weight 88331.5
Theoretical pI 4.4
Pfam Domain Function
Signals
  • 1-23
Transmembrane Regions
  • 610-637
Protein Sequence
>Cadherin-12
MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQ
FFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDRE
EKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVL
QVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAK
DMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQ
NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFH
SAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRY
FIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVL
DVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTV
RDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILS
CNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHY
DDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQR
LQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLAD
MFGEEESYNPDKVT
GenBank ID Protein 189054555
UniProtKB/Swiss-Prot ID P55289
UniProtKB/Swiss-Prot Entry Name CAD12_HUMAN
PDB IDs Not Available
GenBank Gene ID AK314800
GeneCard ID CDH12
GenAtlas ID CDH12
HGNC ID HGNC:1751
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9. [PubMed:17924679 ]
  4. Tanihara H, Sano K, Heimark RL, St John T, Suzuki S: Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. Cell Adhes Commun. 1994 Apr;2(1):15-26. [PubMed:7982033 ]
  5. Selig S, Bruno S, Scharf JM, Wang CH, Vitale E, Gilliam TC, Kunkel LM: Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene. Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3702-6. [PubMed:7731968 ]