| Identification |
|---|
| HMDB Protein ID
| HMDBP07511 |
| Secondary Accession Numbers
| |
| Name
| Cadherin-19 |
| Synonyms
|
Not Available
|
| Gene Name
| CDH19 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18q22.1 |
| SNPs
| CDH19 |
| Gene Sequence
|
>2319 bp
ATGAACTGTTATTTACTGCTGCGTTTTATGTTGGGAATTCCTCTCCTATGGCCTTGTCTT
GGAGCAACAGAAAACTCTCAAACAAAGAAAGTCAAGCAGCCAGTGCGATCTCATTTGAGA
GTGAAGCGTGGCTGGGTGTGGAACCAATTTTTTGTACCAGAGGAAATGAATACGACTAGT
CATCACATCGGCCAGCTAAGATCTGATTTAGACAATGGAAACAATTCTTTCCAGTACAAG
CTTTTGGGAGCTGGAGCTGGAAGTACTTTTATCATTGATGAAAGAACAGGTGACATATAT
GCCATACAGAAGCTTGATAGAGAGGAGCGATCCCTCTACATCTTAAGAGCCCAGGTAATA
GACATCGCTACTGGAAGGGCTGTGGAACCTGAGTCTGAGTTTGTCATCAAAGTTTCGGAT
ATCAATGACAATGAACCAAAATTCCTAGATGAACCTTATGAGGCCATTGTACCAGAGATG
TCTCCAGAAGGAACATTAGTTATCCAGGTGACAGCAAGTGATGCTGACGATCCCTCAAGT
GGTAATAATGCTCGTCTCCTCTACAGCTTACTTCAAGGCCAGCCATATTTTTCTGTTGAA
CCAACAACAGGAGTCATAAGAATATCTTCTAAAATGGATAGAGAACTGCAAGATGAGTAT
TGGGTAATCATTCAAGCCAAGGACATGATTGGTCAGCCAGGAGCGTTGTCTGGAACAACA
AGTGTATTAATTAAACTTTCAGATGTTAATGACAATAAGCCTATATTTAAAGAAAGTTTA
TACCGCTTGACTGTCTCTGAATCTGCACCCACTGGGACTTCTATAGGAACAATCATGGCA
TATGATAATGACATAGGAGAGAATGCAGAAATGGATTACAGCATTGAAGAGGATGATTCG
CAAACATTTGACATTATTACTAATCATGAAACTCAAGAAGGAATAGTTATATTAAAAAAG
AAAGTGGATTTTGAGCACCAGAACCACTACGGTATTAGAGCAAAAGTTAAAAACCATCAT
GTTCCTGAGCAGCTCATGAAGTACCACACTGAGGCTTCCACCACTTTCATTAAGATCCAG
GTGGAAGATGTTGATGAGCCTCCTCTTTTCCTCCTTCCATATTATGTATTTGAAGTTTTT
GAAGAAACCCCACAGGGATCATTTGTAGGCGTGGTGTCTGCCACAGACCCAGACAATAGG
AAATCTCCTATCAGGTATTCTATTACTAGGAGCAAAGTGTTCAATATCAATGATAATGGT
ACAATCACTACAAGTAACTCACTGGATCGTGAAATCAGTGCTTGGTACAACCTAAGTATT
ACAGCCACAGAAAAATACAATATAGAACAGATCTCTTCGATCCCACTGTATGTGCAAGTT
CTTAACATCAATGATCATGCTCCTGAGTTCTCTCAATACTATGAGACTTATGTTTGTGAA
AATGCAGGCTCTGGTCAGGTAATTCAGACTATCAGTGCAGTGGATAGAGATGAATCCATA
GAAGAGCACCATTTTTACTTTAATCTATCTGTAGAAGACACTAACAATTCAAGTTTTACA
ATCATAGATAATCAAGATAACACAGCTGTCATTTTGACTAATAGAACTGGTTTTAACCTT
CAAGAAGAACCTGTCTTCTACATCTCCATCTTAATTGCCGACAATGGAATCCCGTCACTT
ACAAGTACAAACACACTTACCATCCATGTCTGTGACTGTGGTGACAGTGGGAGCACACAG
ACCTGCCAGTACCAGGAGCTTGTGCTTTCCATGGGATTCAAGACAGAAGTCATCATTGCT
ATTCTCATTTGCATTATGATCATATTTGGGTTTATTTTTTTGACTTTGGGTTTAAAACAA
CGGAGAAAACAGATTCTATTTCCTGAGAAAAGTGAAGATTTCAGAGAGAATATATTCCAA
TATGATGATGAAGGGGGTGGAGAAGAAGATACAGAGGCCTTTGATATAGCAGAGCTGAGG
AGTAGTACCATAATGCGGGAACGCAAGACTCGGAAAACCACAAGCGCTGAGATCAGGAGC
CTATACAGGCAGTCTTTGCAAGTTGGCCCCGACAGTGCCATATTCAGGAAATTCATTCTG
GAAAAGCTCGAAGAAGCTAATACTGATCCGTGTGCCCCTCCTTTTGATTCCCTCCAGACC
TACGCTTTTGAGGGAACAGGGTCATTAGCTGGATCCCTGAGCTCCTTAGAATCAGCAGTC
TCTGATCAGGATGAAAGCTATGATTACCTTAATGAGTTGGGACCTCGCTTTAAAAGATTA
GCATGCATGTTTGGTTCTGCAGTGCAGTCAAATAATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 772 |
| Molecular Weight
| 87001.6 |
| Theoretical pI
| 4.35 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cadherin-19
MNCYLLLRFMLGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTTS
HHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVI
DIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSS
GNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTT
SVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDS
QTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQ
VEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNINDNG
TITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCE
NAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNL
QEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIA
ILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELR
SSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQT
YAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN
|
| External Links |
|---|
| GenBank ID Protein
| 10803406 |
| UniProtKB/Swiss-Prot ID
| Q9H159 |
| UniProtKB/Swiss-Prot Entry Name
| CAD19_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ007607 |
| GeneCard ID
| CDH19 |
| GenAtlas ID
| CDH19 |
| HGNC ID
| HGNC:1758 |
| References |
|---|
| General References
| - Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]
- Kools P, Van Imschoot G, van Roy F: Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7. Genomics. 2000 Sep 15;68(3):283-95. [PubMed:10995570 ]
|
