Human Metabolome Database: Showing Protein Cadherin-20 (HMDBP07512)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07512

Secondary Accession Numbers

13220

Name

Cadherin-20

Synonyms

Not Available

Gene Name

CDH20

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Chromosome:1

Locus

18q21.33

SNPs

CDH20

Gene Sequence

>2406 bp
ATGTGGACTTCTGGTAGAATGAGCAATGCAAAGAACTGGCTTGGACTTGGCATGTCCTTG
TACTTCTGGGGGCTGATGGACCTTACGACCACCGTTCTCTCGGACACCCCAACACCACAA
GGTGAATTAGAAGCACTCCTGTCAGACAAGCCACAGTCACATCAGCGGACCAAGAGGAGC
TGGGTTTGGAACCAGTTTTTCGTTCTGGAAGAGTACACTGGGACCGACCCTTTGTATGTC
GGCAAGCTTCATTCAGATATGGACAGGGGAGACGGATCCATCAAATACATCCTCTCGGGA
GAAGGTGCTGGCATCGTGTTTACCATCGACGACACCACTGGAGACATCCACGCCATTCAG
AGGCTCGACCGAGAGGAAAGAGCCCAGTATACTCTAAGGGCTCAAGCCCTAGACAGGCGG
ACGGGCAGGCCAATGGAGCCCGAGTCAGAGTTCATCATCAAAATTCAAGACATCAATGAC
AATGAGCCCAAGTTCCTGGACGGACCTTATGTGGCCACTGTGCCAGAAATGTCCCCTGTG
GGTACCTCCGTCATCCAAGTGACAGCCACAGATGCAGATGACCCGACCTACGGCAACAGT
GCCAGGGTGGTGTACAGCATTCTTCAGGGCCAGCCATATTTTTCTGTGGACTCTAAAACA
GGTGTAATTAGGACAGCGCTCATGAACATGGACAGAGAAGCCAAAGAATACTACGAAGTG
ATTATCCAAGCCAAGGACATGGGAGGGCAGCTTGGAGGATTAGCTGGGACCACAACAGTC
AACATCACCCTCTCAGATGTCAATGATAACCCACCCCGCTTTCCCCAGAAACATTACCAG
ATGAGTGTGTTGGAATCAGCTCCAATTAGCTCCACTGTCGGGAGAGTGTTTGCCAAGGAC
TTGGATGAAGGCATCAATGCAGAGATGAAATATACTATTGTGGATGGAGATGGTGCAGAT
GCCTTTGACATTAGCACAGATCCCAATTTCCAAGTTGGTATCATAACTGTGAAGAAGCCC
CTGAGTTTTGAAAGCAAGAAAAGCTACACCTTAAAGGTGGAGGGAGCCAATCCTCACCTA
GAGATGCGTTTTCTGAACTTGGGCCCATTTCAGGACACAACAACAGTGCACATCAGTGTG
GAAGACGTGGACGAGCCCCCTGTGTTTGAACCTGGCTTTTACTTTGTGGAGGTGCCTGAG
GATGTGGCGATTGGAACAACCATACAGATCATTTCTGCCAAGGACCCAGATGTGACCAAC
AACTCAATCAGATACTCCATTGATAGAAGCAGTGACCCTGGAAGATTTTTCTATGTTGAC
ATTACAACAGGTGCCCTAATGACAGCAAGACCCCTAGACCGGGAAGAATTTTCTTGGCAT
AATATCACTGTCCTTGCTATGGAAATGAACAATCCCTCCCAGGTTGGAAGTGTTCCTGTC
ACAATCAAAGTCTTAGATGTGAATGACAATGCTCCAGAGTTCCCCAGATTCTATGAAGCT
TTTGTCTGTGAGAACGCCAAGGCAGGACAGCTGATCCAGACAGTGAGTGCGGTGGACCAA
GATGACCCACGCAATGGTCAGCATTTCTACTACAGCTTGGCTCCTGAGGCTGCTAACAAC
CCCAACTTTACCATAAGGGACAACCAAGATAACACAGCACGGATTCTAACCAGGAGGTCT
GGTTTCCGGCAGCAGGAGCAGAGTGTCTTTCACCTGCCTATCCTGATAGCAGATAGCGGG
CAGCCCGTGCTGAGCAGCACAGGCACACTGACCATCCAAGTGTGCAGCTGTGATGACGAC
GGCCACGTCATGTCCTGCAGCCCAGAGGCCTACATGCTCCCAGTCAGTTTGAGCCGGGGC
CCCCTCATTGCCATCCTCGCCTGCATCTTTGTCCTCCTAGTGCTGGTGTTGCTCATTTTG
TCCATGAGGCGGCACCGGAAACAACCATACATCATCGACGACGAGGAAAACATCCACGAG
AACATCGTCCGCTACGACGACGAGGGCGGCGGCGAGGAGGACACCGAGGCCTTCGACATC
GCGGCCATGTGGAACCCCCGGGAGGCGCAGGCGGGGGCCGGCCCCAAGACGCGGCAGGAC
ATGCTGCCCGAGATCGAGAGCCTCTTCCGCTACGTGCCTCAGACGTGCGCAGTGAACAGC
ACTGTCCACAGCTACGTGCTGGCCAAGCTCTACGAGGCCGACATGGACCTGTGGACACCG
CCCTTCGACTCCCTCCAGACGTATATGTTCGAGGGGGACGGCCCTGTGGCGGGGTCGCTG
AGCTCCCTGCAGTCGGCCACGTCGGACTCGGAACAGAGCTTCGACTTCCTGACGGACTGG
GGGCCCCGCTTCCGGAAGCTGGCCGAGCTCTACGGGGCGTCGGAGGGACCCGCGCCGCTG
TGGTGA

Protein Properties

Number of Residues

801

Molecular Weight

88992.0

Theoretical pI

4.3

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_C (PF01049 )

Signals

1-34

Transmembrane Regions

620-640

Protein Sequence

>Cadherin-20
MWTSGRMSNAKNWLGLGMSLYFWGLMDLTTTVLSDTPTPQGELEALLSDKPQSHQRTKRS
WVWNQFFVLEEYTGTDPLYVGKLHSDMDRGDGSIKYILSGEGAGIVFTIDDTTGDIHAIQ
RLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPV
GTSVIQVTATDADDPTYGNSARVVYSILQGQPYFSVDSKTGVIRTALMNMDREAKEYYEV
IIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMSVLESAPISSTVGRVFAKD
LDEGINAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKPLSFESKKSYTLKVEGANPHL
EMRFLNLGPFQDTTTVHISVEDVDEPPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTN
NSIRYSIDRSSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPV
TIKVLDVNDNAPEFPRFYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANN
PNFTIRDNQDNTARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDD
GHVMSCSPEAYMLPVSLSRGALIAILACIFVLLVLVLLILSMRRHRKQPYIIDDEENIHE
NIVRYDDEGGGEEDTEAFDIAAMWNPREAQAGAAPKTRQDMLPEIESLSRYVPQTCAVNS
TVHSYVLAKLYEADMDLWAPPFDSLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFLTDW
GPRFRKLAELYGASEGPAPLW

External Links

GenBank ID Protein

10834607

UniProtKB/Swiss-Prot ID

Q9HBT6

UniProtKB/Swiss-Prot Entry Name

CAD20_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
Kools P, Van Imschoot G, van Roy F: Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7. Genomics. 2000 Sep 15;68(3):283-95. [PubMed:10995570 ]