Hmdb loader
Identification
HMDB Protein ID HMDBP07513
Secondary Accession Numbers
  • 13221
Name Cadherin-22
Synonyms
  1. PB-cadherin
  2. Pituitary and brain cadherin
Gene Name CDH22
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:2
Locus 20q13.1
SNPs CDH22
Gene Sequence
>2487 bp
ATGAGGCCGAGGCCCGAAGGTAGGGGGCTCCGGGCGGGAGTCGCGCTGTCCCCCGCGCTA
CTGCTGCTGCTGCTGCTGCCGCCGCCGCCGACGCTGCTGGGGCGCCTGTGGGCAGCGGGC
ACACCCTCGCCGTCGGCGCCCGGAGCTCGGCAGGACGGCGCGCTGGGAGCCGGCCGCGTC
AAACGCGGCTGGGTGTGGAACCAGTTCTTCGTGGTAGAGGAGTACACGGGCACGGAGCCC
CTGTATGTGGGCAAGATCCACTCCGACTCAGACGAGGGTGACGGGGCCATCAAGTACACC
ATCTCAGGCGAGGGTGCTGGGACCATCTTCCTGATCGACGAGCTGACAGGCGACATTCAT
GCCATGGAGCGCCTGGACCGCGAGCAGAAAACCTTCTACACGCTGCGGGCCCAGGCTCGG
GATCGCGCCACCAACCGCCTACTGGAGCCCGAGTCGGAGTTCATCATCAAGGTGCAGGAC
ATCAATGACAGTGAGCCCCGCTTCCTGCACGGCCCCTATATTGGCAGCGTGGCCGAGCTC
TCACCTACAGGCACGTCGGTGATGCAGGTGATGGCCTCGGATGCGGATGACCCCACGTAC
GGCAGCAGCGCTCGGCTGGTGTACAGCGTGCTGGACGGCGAGCACCACTTCACCGTGGAC
CCCAAGACCGGCGTAATCCGGACGGCTGTGCCTGACCTTGACCGCGAGAGCCAGGAGCGC
TACGAGGTGGTGATCCAGGCCACAGACATGGCGGGTCAGCTGGGTGGCCTCTCGGGCTCC
ACTACCGTCACCATCGTAGTCACCGACGTCAATGACAACCCGCCCCGTTTCCCGCAGAAG
ATGTACCAGTTCAGCATCCAGGAGTCAGCCCCCATTGGAACGGCTGTGGGACGTGTGAAG
GCTGAGGACTCAGACGTGGGAGAGAACACAGACATGACTTACCACCTTAAGGACGAGAGC
AGCAGCGGCGGCGATGTGTTCAAGGTCACCACAGACAGCGACACTCAGGAGGCCATCATC
GTAGTGCAGAAGCGCCTGGACTTCGAATCCCAGCCCGTGCACACCGTGATCCTGGAGGCC
CTCAACAAGTTCGTGGACCCCCGCTTCGCCGACCTGGGCACGTTCCGCGACCAGGCGATC
GTGCGCGTGGCCGTGACCGACGTGGACGAGCCCCCCGAGTTCCGGCCGCCCTCCGGCCTC
CTGGAGGTGCAGGAGGACGCGCAGGTGGGCTCCCTGGTCGGCGTGGTGACGGCGCGGGAC
CCCGACGCCGCCAACCGGCCCGTCCGGTACGCCATTGACCGCGAATCAGATTTGGACCAG
ATCTTCGATATCGATGCGGACACAGGCGCCATCGTGACTGGCAAGGGGCTGGACCGCGAG
ACGGCCGGCTGGCACAACATCACAGTGCTGGCCATGGAGGCGGACAATCATGCACAGCTA
TCCCGGGCATCCCTAAGGATCCGAATCCTGGATGTGAACGACAATCCCCCAGAACTGGCC
ACACCCTACGAGGCAGCTGTATGCGAGGATGCCAAGCCAGGCCAGCTCATCCAGACCATC
AGCGTGGTGGACAGAGACGAGCCCCAAGGCGGGCACCGCTTCTATTTCCGCCTGGTGCCT
GAAGCTCCCAGCAACCCTCATTTCTCTCTGCTTGACATCCAAGACAACACCGCTGCAGTG
CACACGCAGCACGTGGGCTTCAACCGGCAGGAGCAGGACGTGTTCTTCCTGCCCATCCTG
GTGGTAGACAGTGGGCCGCCCACACTGAGCAGCACAGGCACGCTCACCATCCGCATCTGT
GGCTGCGACAGCTCCGGCACCATCCAGTCCTGCAACACCACGGCCTTTGTCATGGCCGCC
TCCCTCAGCCCCGGCGCCCTCATCGCCCTCTTGGTCTGCGTTCTCATCCTGGTTGTGCTG
GTGCTGCTGATCCTCACCCTCAGGCGCCACCACAAGAGCCACCTGAGCTCGGACGAGGAT
GAAGACATGCGGGACAACGTCATCAAATACAACGACGAAGGCGGCGGCGAGCAGGACACC
GAAGCCTACGACATGTCGGCGCTGCGGAGCCTCTACGACTTCGGCGAGCTCAAGGGCGGC
GACGGGGGCGGCAGCGCGGGCGGGGGAGCGGGCGGGGGCTCGGGCGGGGGCGCGGGCAGC
CCCCCGCAGGCCCACCTGCCCTCCGAGCGCCACTCGCTGCCGCAGGGGCCGCCGAGCCCC
GAGCCAGACTTCTCAGTGTTCAGGGACTTCATCAGCCGCAAGGTGGCACTGGCGGACGGG
GACCTGTCGGTGCCGCCCTACGACGCCTTCCAGACCTACGCCTTCGAGGGCGCGGACTCG
CCGGCCGCCTCGCTCAGCTCCCTGCACAGCGGCTCGTCGGGCTCCGAGCAGGACTTCGCC
TATCTCAGCAGCTGGGGTCCGCGCTTCCGGCCCCTGGCCGCGCTCTACGCCGGCCACCGC
GGGGACGACGAGGCCCAGGCCTCCTAG
Protein Properties
Number of Residues 828
Molecular Weight 89090.3
Theoretical pI 4.39
Pfam Domain Function
Signals
  • 1-34
Transmembrane Regions
  • 625-645
Protein Sequence
>Cadherin-22
MRPRPEGRGLRAGVALSPALLLLLLLPPPPTLLGRLWAAGTPSPSAPGARQDGALGAGRV
KRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIH
AMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAEL
SPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQER
YEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVK
AEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEA
LNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARD
PDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQL
SRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVP
EAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRIC
GCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDED
EDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGS
PPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADS
PAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGHRGDDEAQAS
GenBank ID Protein 16753221
UniProtKB/Swiss-Prot ID Q9UJ99
UniProtKB/Swiss-Prot Entry Name CAD22_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_021248.1
GeneCard ID CDH22
GenAtlas ID CDH22
HGNC ID HGNC:13251
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [PubMed:11780052 ]