Hmdb loader

Showing Protein Cadherin-24 (HMDBP07515)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP07515
Secondary Accession Numbers
  • 13223
Name Cadherin-24
Synonyms Not Available
Gene Name CDH24
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein (Potential)
Gene Properties
Chromosome Location Chromosome:1
Locus 14q11.2
SNPs CDH24
Gene Sequence 
>2460 bp
ATGTGGGGCCTGGTGAGGCTCCTGCTGGCCTGGCTGGGTGGCTGGGGCTGCATGGGGCGT
CTGGCAGCCCCAGCCCGGGCCTGGGCAGGGTCCCGGGAACACCCAGGGCCTGCTCTGCTG
CGGACTCGAAGGAGCTGGGTCTGGAACCAGTTCTTTGTCATTGAGGAATATGCTGGTCCA
GAGCCTGTTCTCATTGGCAAGCTGCACTCGGATGTTGACCGGGGAGAGGGCCGCACCAAG
TACCTGTTGACCGGGGAGGGGGCAGGCACCGTATTTGTGATTGATGAGGCCACAGGCAAT
ATTCATGTTACCAAGAGCCTTGACCGGGAGGAAAAGGCGCAATATGTGCTACTGGCCCAA
GCCGTGGACCGAGCCTCCAACCGGCCCCTGGAGCCCCCATCAGAGTTCATCATCAAAGTG
CAAGACATCAACGACAATCCACCCATTTTTCCCCTTGGGCCCTACCATGCCACCGTGCCC
GAGATGTCCAATGTCGGGACATCAGTGATCCAGGTGACTGCTCACGATGCTGATGACCCC
AGCTATGGGAACAGTGCCAAGCTGGTGTACACTGTTCTGGATGGACTGCCTTTCTTCTCT
GTGGACCCCCAGACTGGAGTGGTGCGTACAGCCATCCCCAACATGGACCGGGAGACACAG
GAGGAGTTCTTGGTGGTGATCCAGGCCAAGGACATGGGCGGCCACATGGGGGGGCTGTCA
GGCAGCACTACGGTGACTGTCACGCTCAGCGATGTCAACGACAACCCCCCCAAGTTCCCA
CAGAGCCTATACCAGTTCTCCGTGGTGGAGACAGCTGGACCTGGCACACTGGTGGGCCGG
CTCCGGGCCCAGGACCCAGACCTGGGGGACAACGCCCTGATGGCATACAGCATCCTGGAT
GGGGAGGGGTCTGAGGCCTTCAGCATCAGCACAGACTTGCAGGGTCGAGACGGGCTCCTC
ACTGTCCGCAAGCCCCTAGACTTTGAGAGCCAGCGCTCCTACTCCTTCCGTGTCGAGGCC
ACCAACACGCTCATTGACCCAGCCTATCTGCGGCGAGGGCCCTTCAAGGATGTGGCCTCT
GTGCGTGTGGCAGTGCAAGATGCCCCAGAGCCACCTGCCTTCACCCAGGCTGCCTACCAC
CTGACAGTGCCTGAGAACAAGGCCCCGGGGACCCTGGTAGGCCAGATCTCCGCGGCTGAC
CTGGACTCCCCTGCCAGCCCAATCAGATACTCCATCCTCCCCCACTCAGATCCGGAGCGT
TGCTTCTCTATCCAGCCCGAGGAAGGCACCATCCATACAGCAGCACCCCTGGATCGCGAG
GCTCGCGCCTGGCACAACCTCACTGTGCTGGCTACAGAGCTCGGCTGGAGCTGGGGGCCA
GAAAGGGGCTGGGTACCTCTTCTGGTTGCTGAGTGGAGTGCACCAGCAGCCCCACCCCAG
AGAAGCCCTGTTGGAAGCGCTGTGGGAATCCCCCAAGACAGTTCTGCACAGGCCTCGCGC
GTGCAAGTGGCCATCCAGACCCTGGATGAGAATGACAATGCTCCCCAGCTGGCTGAGCCC
TACGATACTTTTGTGTGTGACTCTGCAGCTCCTGGCCAGCTGATTCAGGTCATCCGGGCC
CTGGACAGAGATGAAGTTGGCAACAGTAGCCATGTCTCCTTTCAAGGTCCTCTGGGCCCT
GATGCCAACTTTACTGTCCAGGACAACCGAGATGGCTCCGCCAGCCTGCTGCTGCCCTCC
CGCCCTGCTCCACCCCGCCATGCCCCCTACTTGGTTCCCATAGAACTGTGGGACTGGGGG
CAGCCGGCGCTGAGCAGCACTGCCACAGTGACTGTTAGTGTGTGCCGCTGCCAGCCTGAC
GGCTCTGTGGCATCCTGCTGGCCTGAGGCTCACCTCTCAGCTGCTGGGCTCAGCACCGGC
GCCCTGCTTGCCATCATCACCTGTGTGGGTGCCCTGCTTGCCCTGGTGGTGCTCTTCGTG
GCCCTGCGGCGGCAGAAGCAAGAAGCACTGATGGTACTGGAGGAGGAGGACGTCCGAGAG
AACATCATCACCTACGACGACGAGGGCGGCGGCGAGGAGGACACCGAGGCCTTCGACATC
ACGGCCTTGCAGAACCCGGACGGGGCGGCCCCCCCGGCGCCCGGCCCTCCCGCGCGCCGA
GACGTGTTGCCCCGGGCCCGGGTGTCGCGCCAGCCCAGACCCCCCGGCCCCGCCGACGTG
GCGCAGCTCCTGGCGCTGCGGCTCCGCGAGGCGGACGAGGACCCCGGCGTACCCCCGTAC
GACTCGGTGCAGGTGTACGGCTACGAGGGCCGCGGCTCCTCTTGCGGCTCCCTCAGCTCC
CTGGGCTCCGGCAGCGAAGCCGGCGGCGCCCCCGGCCCCGCGGAGCCGCTGGACGACTGG
GGTCCGCTCTTCCGCACCCTGGCCGAGCTGTATGGGGCCAAGGAGCCCCCGGCCCCCTGA
Protein Properties
Number of Residues 819
Molecular Weight 87751.5
Theoretical pI 4.4
Pfam Domain Function
Signals
  • 1-19
Transmembrane Regions
  • 642-662
Protein Sequence 
>Cadherin-24
MWGLVRLLLAWLGGWGCMGRLAAPARAWAGSREHPGPALLRTRRSWVWNQFFVIEEYAGP
EPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLAQ
AVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADDP
SYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLS
GSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGRLRAQDPDLGDNALMAYSILD
GEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSYSFRVEATNTLIDPAYLRRGPFKDVAS
VRVAVQDAPEPPAFTQAAYHLTVPENKAPGTLVGQISAADLDSPASPIRYSILPHSDPER
CFSIQPEEGTIHTAAPLDREARAWHNLTVLATELGWSWGPERGWVPLLVAEWSAPAAPPQ
RSPVGSAVGIPQDSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRA
LDRDEVGNSSHVSFQGPLGPDANFTVQDNRDGSASLLLPSRPAPPRHAPYLVPIELWDWG
QPALSSTATVTVSVCRCQPDGSVASCWPEAHLSAAGLSTGALLAIITCVGALLALVVLFV
ALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDITALQNPDGAAPPAPGPPARR
DVLPRARVSRQPRPPGPADVAQLLALRLREADEDPGVPPYDSVQVYGYEGRGSSCGSLSS
LGSGSEAGGAPGPAEPLDDWGPLFRTLAELYGAKEPPAP
GenBank ID Protein 32880206
UniProtKB/Swiss-Prot ID Q86UP0
UniProtKB/Swiss-Prot Entry Name CAD24_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_022478.3
GeneCard ID CDH24
GenAtlas ID CDH24
HGNC ID HGNC:14265
References
General References
  1. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  2. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]
  3. Katafiasz BJ, Nieman MT, Wheelock MJ, Johnson KR: Characterization of cadherin-24, a novel alternatively spliced type II cadherin. J Biol Chem. 2003 Jul 25;278(30):27513-9. Epub 2003 May 5. [PubMed:12734196 ]