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Identification
HMDB Protein ID HMDBP07523
Secondary Accession Numbers
  • 13231
Name Cadherin-7
Synonyms Not Available
Gene Name CDH7
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 18q22.1
SNPs CDH7
Gene Sequence
>2358 bp
ATGAAGTTGGGCAAAGTGGAGTTCTGCCATTTTCTGCAGCTAATAGCTCTTTTCCTGTGT
TTTTCTGGGATGAGTCAAGCAGAACTCTCAAGGTCCAGATCAAAGCCCTATTTCCAATCA
GGGAGGTCCCGGACCAAGCGCAGCTGGGTGTGGAATCAGTTCTTTGTGCTGGAGGAATAC
ATGGGTTCAGACCCCCTCTATGTAGGAAAGCTTCACTCTGATGTTGATAAAGGAGATGGT
TCCATCAAATACATCTTGTCAGGCGAAGGGGCAAGTTCCATTTTCATTATTGATGAGAAC
ACTGGGGATATTCATGCCACCAAGAGACTGGATCGTGAGGAGCAGGCCTACTACACGCTC
CGAGCTCAAGCGCTGGATAGGCTCACCAACAAACCCGTGGAGCCCGAGTCGGAGTTTGTC
ATCAAAATTCAGGATATCAACGACAATGAACCCAAATTTTTGGATGGCCCATACACGGCA
GGAGTTCCCGAAATGTCTCCCGTGGGGACCTCAGTGGTACAAGTGACAGCGACGGATGCT
GATGATCCTACATATGGCAACAGTGCCAGAGTGGTCTACAGTATTCTGCAAGGACAGCCG
TACTTCTCAGTGGAGCCAAAGACAGGAGTCATCAAGACTGCCCTTCCAAACATGGATAGA
GAGGCTAAAGACCAGTATTTGCTTGTTATTCAGGCAAAGGATATGGTTGGTCAAAATGGA
GGACTGTCAGGAACTACATCAGTCACTGTGACCCTAACTGATGTCAACGATAATCCACCT
CGCTTTCCTCGAAGGTCTTATCAATATAACGTCCCAGAGTCATTACCTGTAGCCTCAGTT
GTGGCCAGAATTAAAGCTGCTGATGCAGATATTGGAGCTAATGCTGAAATGGAGTACAAG
ATTGTGGATGGTGATGGTTTGGGCATTTTTAAGATTTCTGTTGACAAAGAAACCCAGGAA
GGAATCATTACTATACAGAAGGAGCTGGATTTTGAAGCCAAAACAAGTTACACGCTACGG
ATAGAAGCTGCAAATAAAGATGCCGACCCTCGCTTTCTGAGCTTGGGTCCGTTCAGTGAC
ACGACAACTGTGAAGATAATTGTGGAAGATGTAGATGAGCCCCCTGTGTTCTCTTCACCC
TTGTACCCTATGGAGGTGTCGGAAGCTACCCAGGTTGGGAATATCATTGGCACTGTAGCA
GCTCATGACCCAGATTCTTCCAATAGCCCTGTGAGGTACTCAATTGACAGAAACACAGAC
TTGGAGAGATACTTCAATATTGATGCCAACAGTGGGGTCATCACAACTGCCAAGTCTTTG
GATCGAGAGACAAATGCTATTCACAATATCACAGTCCTTGCAATGGAGAGCCAGAATCCA
TCTCAAGTAGGAAGAGGCTATGTGGCCATCACTATACTTGACATCAATGATAACGCCCCT
GAATTTGCCATGGACTATGAGACCACCGTCTGTGAAAATGCCCAGCCGGGGCAGGTTATC
CAGAAAATCAGTGCTGTGGATAAAGATGAGCCATCCAATGGACACCAGTTTTACTTCAGC
TTAACAACGGATGCAACAAATAACCACAACTTTTCATTGAAAGATAACAAAGACAACACA
GCCTCAATACTGACCAGGAGAAACGGCTTCCGGAGACAGGAACAATCAGTTTACTATCTG
CCAATTTTCATTGTGGACAGTGGATCTCCCTCACTTAGCAGCACCAGCACCCTCACCATC
CGCGTGTGTGACTGTGATGCTGACGGCGTAGCCCAGACCTGCAATGCAGAGGCCTATGTC
CTACCTGCTGGCCTCAGTACAGGAGCCCTGATAGCCATACTCGCCTGTGTCTTGACATTA
TTGGTGTTGATCCTCCTTATCGTCACTATGAGAAGACGGAAAAAAGAGCCCCTTATTTTT
GACGAAGAAAGAGACATCAGAGAAAATATTGTGAGATACGATGACGAGGGCGGGGGAGAG
GAGGACACGGAAGCGTTTGACATGGCTGCACTGAGAAACCTCAACGTCATCCGAGACACC
AAGACCCGGAGGGATGTGACTCCAGAAATTCAATTCCTGAGTCGACCAGCTTTTAAAAGC
ATCCCAGATAATGTCATCTTTAGGGAATTTATTTGGGAAAGATTAAAAGAAGCCGATGTT
GATCCTGGTGCTCCTCCTTATGACTCCCTGCAGACATATGCTTTTGAAGGAAATGGCTCA
GTTGCTGAATCACTCAGCTCTTTAGATTCCATCAGCTCAAACTCTGATCAGAACTATGAC
TACCTAAGTGACTGGGGACCTCGCTTTAAACGACTCGCGGACATGTATGGGACTGGCCAA
GAGAGTTTGTACTCATAG
Protein Properties
Number of Residues 785
Molecular Weight 87085.5
Theoretical pI 4.39
Pfam Domain Function
Signals
  • 1-27
Transmembrane Regions
  • 608-628
Protein Sequence
>Cadherin-7
MKLGKVEFCHFLQLIALFLCFSGMSQAELSRSRSKPYFQSGRSRTKRSWVWNQFFVLEEY
MGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTL
RAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDA
DDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNG
GLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYK
IVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSD
TTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTD
LERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAP
EFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNT
ASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYV
LPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGE
EDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADV
DPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQ
ESLYS
GenBank ID Protein 6483290
UniProtKB/Swiss-Prot ID Q9ULB5
UniProtKB/Swiss-Prot Entry Name CADH7_HUMAN
PDB IDs Not Available
GenBank Gene ID AB035301
GeneCard ID CDH7
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES: DNA sequence and analysis of human chromosome 18. Nature. 2005 Sep 22;437(7058):551-5. [PubMed:16177791 ]
  2. Shimoyama Y, Tsujimoto G, Kitajima M, Natori M: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. Biochem J. 2000 Jul 1;349(Pt 1):159-67. [PubMed:10861224 ]
  3. Kools P, Van Imschoot G, van Roy F: Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7. Genomics. 2000 Sep 15;68(3):283-95. [PubMed:10995570 ]