| Identification |
|---|
| HMDB Protein ID
| HMDBP07523 |
| Secondary Accession Numbers
| |
| Name
| Cadherin-7 |
| Synonyms
|
Not Available
|
| Gene Name
| CDH7 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18q22.1 |
| SNPs
| CDH7 |
| Gene Sequence
|
>2358 bp
ATGAAGTTGGGCAAAGTGGAGTTCTGCCATTTTCTGCAGCTAATAGCTCTTTTCCTGTGT
TTTTCTGGGATGAGTCAAGCAGAACTCTCAAGGTCCAGATCAAAGCCCTATTTCCAATCA
GGGAGGTCCCGGACCAAGCGCAGCTGGGTGTGGAATCAGTTCTTTGTGCTGGAGGAATAC
ATGGGTTCAGACCCCCTCTATGTAGGAAAGCTTCACTCTGATGTTGATAAAGGAGATGGT
TCCATCAAATACATCTTGTCAGGCGAAGGGGCAAGTTCCATTTTCATTATTGATGAGAAC
ACTGGGGATATTCATGCCACCAAGAGACTGGATCGTGAGGAGCAGGCCTACTACACGCTC
CGAGCTCAAGCGCTGGATAGGCTCACCAACAAACCCGTGGAGCCCGAGTCGGAGTTTGTC
ATCAAAATTCAGGATATCAACGACAATGAACCCAAATTTTTGGATGGCCCATACACGGCA
GGAGTTCCCGAAATGTCTCCCGTGGGGACCTCAGTGGTACAAGTGACAGCGACGGATGCT
GATGATCCTACATATGGCAACAGTGCCAGAGTGGTCTACAGTATTCTGCAAGGACAGCCG
TACTTCTCAGTGGAGCCAAAGACAGGAGTCATCAAGACTGCCCTTCCAAACATGGATAGA
GAGGCTAAAGACCAGTATTTGCTTGTTATTCAGGCAAAGGATATGGTTGGTCAAAATGGA
GGACTGTCAGGAACTACATCAGTCACTGTGACCCTAACTGATGTCAACGATAATCCACCT
CGCTTTCCTCGAAGGTCTTATCAATATAACGTCCCAGAGTCATTACCTGTAGCCTCAGTT
GTGGCCAGAATTAAAGCTGCTGATGCAGATATTGGAGCTAATGCTGAAATGGAGTACAAG
ATTGTGGATGGTGATGGTTTGGGCATTTTTAAGATTTCTGTTGACAAAGAAACCCAGGAA
GGAATCATTACTATACAGAAGGAGCTGGATTTTGAAGCCAAAACAAGTTACACGCTACGG
ATAGAAGCTGCAAATAAAGATGCCGACCCTCGCTTTCTGAGCTTGGGTCCGTTCAGTGAC
ACGACAACTGTGAAGATAATTGTGGAAGATGTAGATGAGCCCCCTGTGTTCTCTTCACCC
TTGTACCCTATGGAGGTGTCGGAAGCTACCCAGGTTGGGAATATCATTGGCACTGTAGCA
GCTCATGACCCAGATTCTTCCAATAGCCCTGTGAGGTACTCAATTGACAGAAACACAGAC
TTGGAGAGATACTTCAATATTGATGCCAACAGTGGGGTCATCACAACTGCCAAGTCTTTG
GATCGAGAGACAAATGCTATTCACAATATCACAGTCCTTGCAATGGAGAGCCAGAATCCA
TCTCAAGTAGGAAGAGGCTATGTGGCCATCACTATACTTGACATCAATGATAACGCCCCT
GAATTTGCCATGGACTATGAGACCACCGTCTGTGAAAATGCCCAGCCGGGGCAGGTTATC
CAGAAAATCAGTGCTGTGGATAAAGATGAGCCATCCAATGGACACCAGTTTTACTTCAGC
TTAACAACGGATGCAACAAATAACCACAACTTTTCATTGAAAGATAACAAAGACAACACA
GCCTCAATACTGACCAGGAGAAACGGCTTCCGGAGACAGGAACAATCAGTTTACTATCTG
CCAATTTTCATTGTGGACAGTGGATCTCCCTCACTTAGCAGCACCAGCACCCTCACCATC
CGCGTGTGTGACTGTGATGCTGACGGCGTAGCCCAGACCTGCAATGCAGAGGCCTATGTC
CTACCTGCTGGCCTCAGTACAGGAGCCCTGATAGCCATACTCGCCTGTGTCTTGACATTA
TTGGTGTTGATCCTCCTTATCGTCACTATGAGAAGACGGAAAAAAGAGCCCCTTATTTTT
GACGAAGAAAGAGACATCAGAGAAAATATTGTGAGATACGATGACGAGGGCGGGGGAGAG
GAGGACACGGAAGCGTTTGACATGGCTGCACTGAGAAACCTCAACGTCATCCGAGACACC
AAGACCCGGAGGGATGTGACTCCAGAAATTCAATTCCTGAGTCGACCAGCTTTTAAAAGC
ATCCCAGATAATGTCATCTTTAGGGAATTTATTTGGGAAAGATTAAAAGAAGCCGATGTT
GATCCTGGTGCTCCTCCTTATGACTCCCTGCAGACATATGCTTTTGAAGGAAATGGCTCA
GTTGCTGAATCACTCAGCTCTTTAGATTCCATCAGCTCAAACTCTGATCAGAACTATGAC
TACCTAAGTGACTGGGGACCTCGCTTTAAACGACTCGCGGACATGTATGGGACTGGCCAA
GAGAGTTTGTACTCATAG
|
| Protein Properties |
|---|
| Number of Residues
| 785 |
| Molecular Weight
| 87085.5 |
| Theoretical pI
| 4.39 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cadherin-7
MKLGKVEFCHFLQLIALFLCFSGMSQAELSRSRSKPYFQSGRSRTKRSWVWNQFFVLEEY
MGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTL
RAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDA
DDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNG
GLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYK
IVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSD
TTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTD
LERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAP
EFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNT
ASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYV
LPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGE
EDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADV
DPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQ
ESLYS
|
| External Links |
|---|
| GenBank ID Protein
| 6483290 |
| UniProtKB/Swiss-Prot ID
| Q9ULB5 |
| UniProtKB/Swiss-Prot Entry Name
| CADH7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB035301 |
| GeneCard ID
| CDH7 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES: DNA sequence and analysis of human chromosome 18. Nature. 2005 Sep 22;437(7058):551-5. [PubMed:16177791 ]
- Shimoyama Y, Tsujimoto G, Kitajima M, Natori M: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. Biochem J. 2000 Jul 1;349(Pt 1):159-67. [PubMed:10861224 ]
- Kools P, Van Imschoot G, van Roy F: Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7. Genomics. 2000 Sep 15;68(3):283-95. [PubMed:10995570 ]
|
