Human Metabolome Database: Showing Protein Cadherin-9 (HMDBP07525)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07525

Secondary Accession Numbers

13233

Name

Cadherin-9

Synonyms

Not Available

Gene Name

CDH9

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein (Potential)

Gene Properties

Chromosome Location

Chromosome:5

Locus

5p14

SNPs

CDH9

Gene Sequence

>2370 bp
ATGAGGACTTACCATTATATACCATTATTCATCTGGACCTATATGTTCCATATAGTTGAC
ACCATCCTATTACAAGAAAAACCTAACAGTTATTTATCAAGCAAAAAGATAGCGGGTCTG
ACAAAAGATGACGGTAAAATGCTACGTCGCACCAAGCGTGGCTGGATGTGGAATCAGTTC
TTCTTATTGGAAGAGTACACAGGTACTGACACACAATATGTAGGCAAGCTTCACACTGAC
CAAGATAAAGGAGATGGAAATTTAAAATACATACTAACAGGAGATGGGGCTGGCAGTCTA
TTTGTTATAGATGAAAATACAGGAGACATTCATGCTGCAAAGAAACTAGACAGAGAAGAA
AAATCTCTGTACATTCTTCGTGCCAAGGCTATAGACAGAAAAACTGGGCGGCAGGTGGAA
CCGGAATCGGAATTTATCATTAAAATACATGATATCAATGACAATGAGCCAAAATTTACA
AAAGACTTATACACTGCCAGTGTTCCTGAAATGTCTGGAGTCGGTACATCTGTTATACAA
GTAACTGCAACAGATGCAGATGACGCCAACTATGGAAATAGTGCCAAAGTGGTCTATAGC
ATATTGCAAGGACAGCCATATTTTTCAGTGGACCCAGAATCAGGCATAATAAAAACTGCA
TTACCAGACATGAGCAGAGAAAATAGAGAGCAGTACCAGGTTGTTATACAGGCCAAAGAC
ATGGGTGGCCAGATGGGAGGCCTTTCTGGAACCACCACAGTGAACATCACGCTGACAGAT
GTCAACAACAACCCTCCTCGATTTCCCCAGAGTACGTATCAATTTAATTCTCCTGAGTCT
GTACCTCTTGGAACTCATCTTGGAAGGATAAAAGCCAATGACCCTGACGTGGGGGAAAAT
GCAGAAATGGAGTATAGCATTGCTGAAGGAGATGGTGCAGACATGTTCGATGTCATCACT
GACAAGGATACACAGGAAGGGATTATAACTGTCAAACAGAATTTAGATTTTGAAAATCAA
ATGCTCTATACTTTAAGAGTGGATGCAAGTAACACTCACCCTGATCCACGATTCTTACAC
CTGGGACCTTTCAAAGATACAGCTGTGGTCAAAATATCTGTGGAAGATATAGATGAGCCT
CCTGTGTTCACTAAAGTCTCTTACTTGATAGAAGTAGATGAAGATGTAAAGGAGGGCAGT
ATCATTGGACAGGTTACAGCATACGATCCAGATGCCAGGAACAATTTAATAAAGTACTCT
GTTGATCGGCATACTGATATGGACCGTATTTTTGGTATTCACTCAGAAAATGGTTCTATT
TTCACTTTGAAAGCCCTTGACCGGGAATCATCTCCTTGGCATAACATCACTGTTACAGCC
ACAGAAATAAATAACCCAAAACAAAGTAGCCACATCCCTGTCTTCATCAGAATTCTAGAT
ATAAATGACCATGCTCCGGAATTTGCCATGTATTATGAAACATTTGTTTGTGAAAATGCA
AAACCTGGGCAGTTGATTCAGACTGTCAGTGTCATGGATAAGGATGACCCTCCCCGAGGT
CACAAATTCTTTTTTGAACCAGTGCCAGAATTTACTCTCAATCCGAATTTCACCATTGTA
GATAATAAAGATAATACAGCAGGAATCATGACTCGGAAAGATGGCTACAGTCGCAACAAA
ATGAGCACCTACTTATTGCCGATTTTAATCTTTGACAACGATTATCCAATTCAAAGCAGC
ACTGGTACACTCACTATCCGTGTGTGTGCCTGCGATAATCAAGGAAACATGCAATCCTGC
ACCGCAGAAGCCCTGATCCTTTCAGCCGGCCTGAGCACGGGAGCTCTCGTTGCGATTCTA
CTCTGTGTCCTCATACTGCTTATTTTAGTCGTGTTGTTTGCTGCATTGAAGAGGCAAAGA
AAAAAGGAACCTCTGATAATTTCAAAAGACGATGTCCGGGACAACATTGTGACCTACAAC
GATGAAGGCGGCGGGGAAGAAGATACCCAAGCTTTTGACATTGGCACATTAAGGAATCCA
GAGGCAAGAGAAGACAGTAAACTTAGACGGGATGTAATGCCTGAAACTATTTTTCAGATA
AGGAGGACTGTGCCTCTGTGGGAAAATATTGATGTACAAGATTTTATCCATCGAAGATTA
AAAGAAAACGACGCAGACCCAAGTGCACCTCCATATGATTCGCTGGCAACGTATGCCTAT
GAAGGGAATGATTCCATAGCAGATTCGCTCAGTTCTTTGGAATCTCTCACAGCTGATTGT
AACCAAGATTATGATTACCTCAGTGACTGGGGGCCTCGTTTCAAAAAACTTGCCGATATG
TATGGGGGTGATGATAGTGACCGAGACTAA

Protein Properties

Number of Residues

789

Molecular Weight

88688.6

Theoretical pI

4.49

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_C (PF01049 )

Signals

1-21

Transmembrane Regions

616-636

Protein Sequence

>Cadherin-9
MRTYHYIPLFIWTYMFHTVDTILLQEKPNSYLSSKKIAGLTKDDGKMLRRTKRGWMWNQF
FLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGSLFVIDENTGDIHAAKKLDREE
KSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVPEMSGVGTSVIQ
VTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSRENREQYQVVIQAKD
MGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPESVPLGTHLGRIKANDPDVGEN
AEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQMLYTLRVDASNTHPDPRFLH
LGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQVTAYDPDARNNLIKYS
VDRHTDMDRIFGIHSENGSIFTLKALDRESSPWHNITVTATEINNPKQSSHIPVFIRILD
INDHAPEFAMYYETFVCENAKPGQLIQTVSVMDKDDPPRGHKFFFEPVPEFTLNPNFTIV
DNKDNTAGIMTRKDGYSRNKMSTYLLPILIFDNDYPIQSSTGTLTIRVCACDNQGNMQSC
TAEALILSAGLSTGALVAILLCVLILLILVVLFAALKRQRKKEPLIISKDDVRDNIVTYN
DEGGGEEDTQAFDIGTLRNPEAREDSKLRRDVMPETIFQIRRTVPLWENIDVQDFIHRRL
KENDADPSAPPYDSLATYAYEGNDSIADSLSSLESLTADCNQDYDYLSDWGPRFKKLADM
YGGDDSDRD

External Links

GenBank ID Protein

6483296

UniProtKB/Swiss-Prot ID

Q9ULB4

UniProtKB/Swiss-Prot Entry Name

CADH9_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AB035302

GeneCard ID

CDH9

GenAtlas ID

Not Available

HGNC ID

Not Available

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Shimoyama Y, Tsujimoto G, Kitajima M, Natori M: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. Biochem J. 2000 Jul 1;349(Pt 1):159-67. [PubMed:10861224 ]