Showing Protein CDGSH iron-sulfur domain-containing protein 2 (HMDBP07586)

• 13294

1. Endoplasmic reticulum intermembrane small protein
2. Miner1
3. MitoNEET-related 1 protein
4. NAF-1
5. Nutrient-deprivation autophagy factor-1

1. Endoplasmic reticulum membrane
2. Single-pass membrane protein
3. Single-pass membrane protein
4. Mitochondrion outer membrane

>408 bp
ATGGTGCTGGAGAGCGTGGCCCGTATCGTGAAGGTGCAGCTCCCTGCATATCTGAAGCGG
CTCCCAGTCCCTGAAAGCATTACCGGGTTCGCTAGGCTCACAGTTTCAGAATGGCTTCGG
TTATTGCCTTTCCTTGGTGTACTCGCACTTCTTGGCTACCTTGCAGTTCGTCCATTCCTC
CCGAAGAAGAAACAACAGAAGGATAGCTTGATTAATCTTAAAATACAAAAGGAAAATCCG
AAAGTAGTGAATGAAATAAACATTGAAGATTTGTGTCTTACTAAAGCAGCTTATTGTAGG
TGTTGGCGTTCTAAAACGTTTCCTGCCTGCGATGGTTCACATAATAAACACAATGAATTG
ACAGGAGATAATGTGGGTCCACTAATACTGAAGAAGAAAGAAGTATAA

• MitoNEET_N (PF10660 )
• zf-CDGSH (PF09360 )

• None

• 38-60

>CDGSH iron-sulfur domain-containing protein 2
MVLESVARIVKVQLPAYLKRLPVPESITGFARLTVSEWLRLLPFLGVLALLGYLAVRPFL
PKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNEL
TGDNVGPLILKKKEV

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3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
4. Amr S, Heisey C, Zhang M, Xia XJ, Shows KH, Ajlouni K, Pandya A, Satin LS, El-Shanti H, Shiang R: A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2. Am J Hum Genet. 2007 Oct;81(4):673-83. Epub 2007 Aug 20. [PubMed:17846994 ]
5. Wiley SE, Murphy AN, Ross SA, van der Geer P, Dixon JE: MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5318-23. Epub 2007 Mar 21. [PubMed:17376863 ]
6. Chang NC, Nguyen M, Germain M, Shore GC: Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. EMBO J. 2010 Feb 3;29(3):606-18. doi: 10.1038/emboj.2009.369. Epub 2009 Dec 10. [PubMed:20010695 ]
7. Conlan AR, Axelrod HL, Cohen AE, Abresch EC, Zuris J, Yee D, Nechushtai R, Jennings PA, Paddock ML: Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2. J Mol Biol. 2009 Sep 11;392(1):143-53. doi: 10.1016/j.jmb.2009.06.079. Epub 2009 Jul 4. [PubMed:19580816 ]