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Identification
HMDB Protein ID HMDBP07594
Secondary Accession Numbers
  • 13303
Name Claudin-10
Synonyms
  1. OSP-like protein
Gene Name CLDN10
Protein Type Unknown
Biological Properties
General Function Involved in structural molecule activity
Specific Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell-cell junction
occluding junction
tight junction
membrane
cell part
membrane part
plasma membrane part
cell junction
Function
structural molecule activity
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
  3. Cell junction
  4. tight junction
Gene Properties
Chromosome Location Chromosome:1
Locus 13q31-q34
SNPs CLDN10
Gene Sequence
>687 bp
ATGGCTAGCACGGCTTCGGAGATCATCGCCTTCATGGTCTCCATCTCAGGCTGGGTACTG
GTGTCCTCCACGCTGCCCACCGACTACTGGAAGGTGTCTACCATCGACGGCACGGTCATC
ACAACCGCCACCTATTGGGCCAACCTGTGGAAGGCGTGCGTTACCGACTCCACGGGCGTC
TCCAACTGCAAGGACTTCCCCTCCATGCTGGCGCTGGACGGTTATATACAGGCATGTAGA
GGACTTATGATCGCTGCTGTCAGCCTGGGCTTCTTTGGTTCCATATTTGCGCTCTTTGGA
ATGAAGTGTACCAAAGTCGGAGGCTCCGATAAAGCCAAAGCTAAAATTGCTTGTTTGGCT
GGGATTGTATTCATACTGTCAGGGCTGTGCTCAATGACTGGATGTTCCCTATATGCAAAC
AAAATCACAACGGAATTCTTTGATCCTCTCTTTGTTGAGCAAAAGTATGAATTAGGAGCC
GCTCTGTTTATTGGATGGGCAGGAGCCTCACTGTGCATAATTGGTGGTGTCATATTTTGC
TTTTCAATATCTGACAACAACAAAACACCCAGATACACATACAACGGGGCCACATCTGTC
ATGTCTTCTCGGACAAAGTATCATGGTGGAGAAGATTTTAAAACAACAAACCCTTCAAAA
CAGTTTGATAAAAATGCTTATGTCTAA
Protein Properties
Number of Residues 228
Molecular Weight 24488.1
Theoretical pI 8.12
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 1-21
  • 81-101
  • 116-136
  • 161-181
Protein Sequence
>Claudin-10
MASTASEIIAFMVSISGWVLVSSTLPTDYWKVSTIDGTVITTATYWANLWKACVTDSTGV
SNCKDFPSMLALDGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLA
GIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFC
FSISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV
GenBank ID Protein 15012045
UniProtKB/Swiss-Prot ID P78369
UniProtKB/Swiss-Prot Entry Name CLD10_HUMAN
PDB IDs Not Available
GenBank Gene ID BC010920
GeneCard ID CLDN10
GenAtlas ID CLDN10
HGNC ID HGNC:2033
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y: Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Anal Sci. 2008 Jan;24(1):161-6. [PubMed:18187866 ]