Hmdb loader
Identification
HMDB Protein ID HMDBP07634
Secondary Accession Numbers
  • 13343
Name Calsyntenin-1
Synonyms
  1. Alc-alpha
  2. Alcadein-alpha
  3. Alzheimer-related cadherin-like protein
  4. C-terminal fragment 1-alpha
  5. CTF1-alpha
  6. Non-classical cadherin XB31alpha
  7. SAlc-alpha
  8. Soluble Alc-alpha
Gene Name CLSTN1
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Nucleus
  2. Golgi apparatus membrane
  3. Endoplasmic reticulum membrane
  4. Single-pass type I membrane protein
  5. Single-pass type I membrane protein
  6. Cell junction
  7. synapse
  8. Cell projection
  9. postsynaptic cell membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 1p36.22
SNPs CLSTN1
Gene Sequence
>2946 bp
ATGCTGCGCCGCCCCGCTCCCGCGCTGGCCCCGGCCGCCCGGCTGCTGCTGGCCGGGCTG
CTGTGCGGCGGCGGGGTCTGGGCCGCGCGAGTTAACAAGCACAAGCCCTGGCTGGAGCCC
ACCTACCACGGCATAGTCACAGAGAACGACAACACCGTGCTCCTCGACCCCCCACTGATC
GCGCTGGATAAAGATGCGCCTCTGCGATTTGCAGAGAGTTTTGAGGTGACAGTCACCAAA
GAAGGTGAGATTTGTGGATTTAAAATTCACGGGCAGAATGTCCCCTTTGATGCAGTGGTA
GTGGATAAATCCACTGGTGAGGGAGTCATTCGCTCCAAAGAGAAACTGGACTGTGAGCTG
CAGAAAGACTATTCATTCACCATCCAGGCCTATGATTGTGGGAAGGGACCTGATGGCACC
AACGTGAAAAAGTCTCATAAAGCAACTGTTCATATTCAGGTGAACGACGTGAATGAGTAC
GCGCCCGTGTTCAAGGAGAAGTCCTACAAAGCCACGGTCATCGAGGGGAAGCAGTACGAC
AGCATTTTGAGGGTGGAGGCCGTGGATGCCGACTGCTCCCCTCAGTTCAGCCAGATTTGC
AGCTACGAAATCATCACTCCAGACGTGCCCTTTACTGTTGACAAAGATGGTTATATAAAA
AACACAGAGAAATTAAACTACGGGAAAGAACATCAATATAAGCTGACCGTCACTGCCTAT
GACTGTGGGAAGAAAAGAGCCACAGAAGATGTTTTGGTGAAGATCAGCATTAAGCCCACC
TGCACCCCTGGGTGGCAAGGATGGAACAACAGGATTGAGTATGAGCCGGGCACCGGCGCG
TTGGCCGTCTTTCCAAATATCCACCTGGAGACATGTGACGAGCCAGTCGCCTCAGTACAG
GCCACAGTGGAGCTAGAAACCAGCCACATAGGGAAAGGCTGCGACCGAGACACCTACTCA
GAGAAGTCCCTCCACCGGCTCTGTGGTGCGGCCGCGGGCACTGCCGAGCTGCTGCCATCC
CCGAGTGGATCCCTCAACTGGACCATGGGCCTGCCCACCGACAATGGCCACGACAGCGAC
CAGGTGTTTGAGTTCAACGGCACCCAGGCAGTGAGGATCCCGGATGGCGTCGTGTCGGTC
AGCCCCAAAGAGCCGTTCACCATCTCGGTGTGGATGAGACATGGGCCATTCGGCAGGAAG
AAGGAGACAATTCTTTGCAGTTCTGATAAAACAGATATGAATCGGCACCACTACTCCCTC
TATGTCCACGGGTGCCGGCTGATCTTCCTCTTCCGTCAGGATCCTTCTGAGGAGAAGAAA
TACAGACCTGCAGAGTTCCACTGGAAGTTGAATCAGGTCTGTGATGAGGAATGGCACCAC
TACGTCCTCAATGTAGAATTCCCGAGTGTGACTCTCTATGTGGATGGCACGTCCCACGAG
CCCTTCTCTGTGACTGAGGATTACCCGCTCCATCCATCCAAGATAGAAACTCAGCTCGTG
GTGGGGGCTTGCTGGCAAGAGTTTTCAGGAGTTGAAAATGACAATGAAACTGAGCCTGTG
ACTGTGGCCTCTGCAGGTGGCGACCTGCACATGACCCAGTTTTTCCGAGGCAATCTGGCT
GGCTTAACTCTCCGTTCCGGGAAACTCGCGGATAAGAAGGTGATCGACTGTCTGTATACC
TGCAAGGAGGGGCTGGACCTGCAGGTCCTCGAAGACAGTGGCAGAGGCGTGCAGATCCAA
GCACACCCCAGCCAGTTGGTATTGACCTTGGAGGGAGAAGACCTCGGGGAATTGGATAAG
GCCATGCAGCACATCTCGTACCTGAACTCCCGGCAGTTCCCCACGCCCGGAATTCGCAGA
CTCAAAATCACCAGCACAATCAAGTGTTTTAACGAGGCCACCTGCATTTCGGTCCCCCCG
GTAGATGGCTACGTGATGGTTTTACAGCCCGAGGAGCCCAAGATCAGCCTGAGTGGCGTC
CACCATTTTGCCCGAGCAGCTTCTGAATTTGAAAGCTCAGAAGGGGTGTTCCTTTTCCCT
GAGCTTCGCATCATCAGCACCATCACGAGAGAAGTGGAGCCTGAAGGGGACGGGGCTGAG
GACCCCACAGTTCAAGAATCACTGGTGTCCGAGGAGATCGTGCACGACCTGGATACCTGT
GAGGTCACGGTGGAGGGAGAGGAGCTGAACCACGAGCAGGAGAGCCTGGAGGTGGACATG
GCCCGCCTGCAGCAGAAGGGCATTGAAGTGAGCAGCTCTGAACTGGGCATGACCTTCACA
GGCGTGGACACCATGGCCAGCTACGAGGAGGTTTTGCACCTGCTGCGCTATCGGAACTGG
CATGCCAGGTCCTTGCTTGACCGGAAGTTTAAGCTCATCTGCTCAGAGCTGAATGGCCGC
TACATCAGCAACGAATTTAAGGTGGAGGTGAATGTAATCCACACGGCCAACCCCATGGAA
CACGCCAACCACATGGCTGCCCAGCCACAGTTCGTGCACCCGGAACACCGCTCCTTTGTT
GACCTGTCAGGCCACAACCTGGCCAACCCCCACCCGTTCGCAGTCGTCCCCAGCACTGCG
ACAGTTGTGATCGTGGTGTGCGTCAGCTTCCTGGTGTTCATGATTATCCTGGGGGTATTT
CGGATCCGGGCCGCACATCGGCGGACCATGCGGGATCAGGACACCGGGAAGGAGAACGAG
ATGGACTGGGACGACTCTGCCCTGACCATCACCGTCAACCCCATGGAGACCTATGAGGAC
CAGCACAGCAGTGAGGAGGAGGAGGAAGAGGAAGAGGAAGAGGAAAGCGAGGACGGCGAA
GAAGAGGATGACATCACCAGCGCCGAGTCGGAGAGCAGCGAGGAGGAGGAGGGGGAGCAG
GGCGACCCCCAGAACGCAACCCGGCAGCAGCAGCTGGAGTGGGATGACTCCACCCTCAGC
TACTGA
Protein Properties
Number of Residues 981
Molecular Weight 109792.0
Theoretical pI 4.55
Pfam Domain Function
Signals
  • 1-28
Transmembrane Regions
  • 860-880
Protein Sequence
>Calsyntenin-1
MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLI
ALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCEL
QKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYD
SILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAY
DCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQ
ATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSD
QVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSL
YVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHE
PFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLA
GLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDK
AMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGV
HHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTC
EVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNW
HARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFV
DLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENE
MDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQ
GDPQNATRQQQLEWDDSTLSY
GenBank ID Protein 57242757
UniProtKB/Swiss-Prot ID O94985
UniProtKB/Swiss-Prot Entry Name CSTN1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001009566.1
GeneCard ID CLSTN1
GenAtlas ID CLSTN1
HGNC ID HGNC:17447
References
General References
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  5. Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T: Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. J Biol Chem. 2003 Dec 5;278(49):49448-58. Epub 2003 Sep 12. [PubMed:12972431 ]
  6. Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T: Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation. J Biol Chem. 2004 Jun 4;279(23):24343-54. Epub 2004 Mar 22. [PubMed:15037614 ]
  7. Hintsch G, Zurlinden A, Meskenaite V, Steuble M, Fink-Widmer K, Kinter J, Sonderegger P: The calsyntenins--a family of postsynaptic membrane proteins with distinct neuronal expression patterns. Mol Cell Neurosci. 2002 Nov;21(3):393-409. [PubMed:12498782 ]
  8. Araki Y, Kawano T, Taru H, Saito Y, Wada S, Miyamoto K, Kobayashi H, Ishikawa HO, Ohsugi Y, Yamamoto T, Matsuno K, Kinjo M, Suzuki T: The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. EMBO J. 2007 Mar 21;26(6):1475-86. Epub 2007 Mar 1. [PubMed:17332754 ]