Hmdb loader
Identification
HMDB Protein ID HMDBP07672
Secondary Accession Numbers
  • 13381
Name Extended synaptotagmin-2
Synonyms
  1. Chr2Syt
  2. E-Syt2
Gene Name ESYT2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function May play a role as calcium-regulated intrinsic membrane protein
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:7
Locus 7q36.3
SNPs ESYT2
Gene Sequence
>2766 bp
ATGACCGCAAACAGGGACGCCGCCCTCTCATCCCACCGCCACCCCGGCTGCGCTCAGCGG
CCGCGCACCCCCACGTTTGCCAGCAGCTCCCAGAGGCGGTCAGCCTTTGGGTTTGACGAC
GGCAACTTCCCGGGCCTCGGCGAGCGCAGCCACGCACCCGGAAGCCGCCTCGGGGCGCGA
CGCCGAGCCAAAACCGCCCGCGGGCTCCGAGGCCACAGGCAAAGGGGCGCTGGCGCGGGG
CTGAGCCGCCCGGGATCAGCGCGAGCACCCAGCCCGCCTCGGCCGGGAGGGCCTGAGAAC
CCCGGGGGCGTGCTGAGCGTGGAGCTGCCCGGGCTGCTGGCGCAGCTGGCGCGGAGCTTC
GCGCTGCTGCTGCCCGTGTACGCGCTGGGCTACCTGGGGCTCAGCTTCAGCTGGGTTCTC
CTCGCGCTCGCGCTGCTCGCCTGGTGTCGCCGCAGCCGCGGCCTCAAGGCCCTGCGCCTG
TGCCGCGCGCTGGCGCTGCTGGAAGACGAGGAGCGCGTCGTGCGCCTGGGGGTGCGCGCC
TGCGACCTGCCCGCCTGGGTTCATTTTCCAGACACTGAAAGAGCAGAATGGCTAAATAAG
ACTGTAAAACACATGTGGCCTTTCATTTGCCAATTTATAGAGAAGTTGTTTCGAGAAACT
ATAGAACCAGCCGTGCGGGGAGCAAACACCCACCTTAGCACCTTTAGTTTCACGAAGGTC
GACGTGGGCCAGCAGCCCCTCAGGATCAATGGTGTTAAGGTATACACTGAAAATGTAGAC
AAAAGGCAAATTATTTTGGACCTTCAGATTAGTTTTGTAGGAAATTGTGAGATTGATTTG
GAGATCAAACGATATTTTTGTAGAGCTGGTGTGAAAAGTATCCAGATTCATGGTACCATG
CGGGTGATCCTGGAACCGTTGATTGGAGATATGCCCTTAGTTGGAGCTTTGTCTATCTTC
TTCCTTAGGAAACCACTTTTAGAAATTAACTGGACAGGACTGACGAATCTTCTGGATGTC
CCTGGATTGAATGGTTTATCAGATACTATCATTTTGGATATAATATCAAACTATCTGGTG
CTTCCCAATCGAATCACCGTTCCACTTGTCAGTGAAGTTCAAATAGCTCAGTTGCGGTTT
CCTGTACCAAAGGGTGTTCTAAGGATACATTTTATTGAAGCTCAGGATCTTCAGGGGAAA
GACACTTACCTTAAGGGACTTGTCAAGGGAAAGTCAGACCCCTATGGAATCATTAGAGTT
GGCAACCAAATCTTCCAAAGCAGAGTCATCAAGGAGAACCTCAGTCCAAAGTGGAATGAA
GTCTATGAGGCTTTAGTGTATGAACATCCTGGACAAGAATTAGAGATTGAGCTCTTTGAT
GAAGACCCAGACAAGGATGACTTTTTAGGAAGTCTTATGATTGACCTCATTGAAGTTGAA
AAGGAGCGCCTTTTAGATGAATGGTTCACTCTGGACGAGGTTCCCAAGGGGAAGCTACAC
TTGAGACTGGAGTGGCTCACGTTAATGCCAAATGCGTCAAACCTCGACAAGGTGCTAACA
GACATCAAAGCTGACAAAGACCAAGCCAACGATGGTCTTTCCTCTGCATTGCTGATCTTG
TACTTGGATTCAGCAAGGAACCTTCCGTCAGGGAAGAAAATAAGCAGCAACCCAAATCCT
GTTGTCCAGATGTCAGTTGGGCACAAGGCCCAGGAGAGCAAGATTCGATACAAAACCAAT
GAACCTGTGTGGGAGGAAAACTTCACTTTCTTCATTCACAATCCCAAGCGCCAGGACCTT
GAAGTTGAGGTCAGAGACGAGCAGCACCAGTGTTCCCTGGGGAACCTGAAGGTCCCCCTC
AGCCAGCTGCTCACCAGTGAGGACATGACTGTGAGCCAGCGCTTCCAGCTCAGTAACTCG
GGTCCAAACAGCACCATCAAGATGAAGATTGCCCTGCGGGTGCTCCATCTCGAAAAGCGA
GAAAGGCCTCCAGACCACCAACACTCAGCTCAAGTCAAACGTCCCTCTGTGTCCAAAGAG
GGGAGGAAAACATCCATCAAATCTCATATGTCTGGGTCTCCAGGCCCTGGTGGCAGCAAC
ACAGCTCCATCCACACCAGTCATTGGGGGCAGTGATAAGCCTGGTATGGAAGAAAAGGCC
CAGCCCCCTGAGGCCGGCCCTCAGGGGCTGCACGACCTGGGCAGAAGCTCCTCCAGCCTC
CTGGCCTCCCCAGGCCACATCTCAGTCAAGGAGCCGACCCCCAGCATCGCCTCGGACATC
TCGCTGCCCATCGCCACCCAGGAGCTGCGGCAAAGGCTGAGGCAGCTGGAAAACGGGACG
ACCCTGGGACAGTCTCCACTGGGGCAGATCCAGCTGACCATCCGGCACAGCTCGCAGAGA
AACAAGCTTATCGTGGTCGTGCATGCCTGCAGAAACCTCATTGCCTTCTCTGAAGACGGC
TCTGACCCCTATGTCCGCATGTATTTATTACCAGACAAGAGGCGGTCAGGAAGGAGGAAA
ACACACGTGTCAAAGAAAACATTAAATCCAGTGTTTGATCAAAGCTTTGATTTCAGTGTT
TCGTTACCAGAAGTCCAGAGGAGAACGCTTGACGTTGCCGTGAAGAACAGTGGCGGCTTC
CTGTCCAAAGACAAAGGGCTCCTTGGCAAAGTATTGGTTGCTCTGGCATCTGAAGAACTT
GCCAAAGGCTGGACCCAGTGGTATGACCTCACGGAAGATGGGACGAGGCCTCAGGCGATG
ACATAG
Protein Properties
Number of Residues 921
Molecular Weight 102356.5
Theoretical pI 9.8
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 128-148
  • 302-322
Protein Sequence
>Extended synaptotagmin-2
MTANRDAALSSHRHPGCAQRPRTPTFASSSQRRSAFGFDDGNFPGLGERSHAPGSRLGAR
RRAKTARGLRGHRQRGAGAGLSRPGSARAPSPPRPGGPENPGGVLSVELPGLLAQLARSF
ALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRA
CDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKV
DVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTM
RVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLV
LPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV
GNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVE
KERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLIL
YLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDL
EVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKR
ERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKA
QPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGT
TLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRK
THVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEEL
AKGWTQWYDLTEDGTRPQAMT
GenBank ID Protein 116292891
UniProtKB/Swiss-Prot ID A0FGR8
UniProtKB/Swiss-Prot Entry Name ESYT2_HUMAN
PDB IDs Not Available
GenBank Gene ID DQ993201
GeneCard ID ESYT2
GenAtlas ID ESYT2
HGNC ID HGNC:22211
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  5. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
  6. Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H: Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15. [PubMed:19369195 ]
  7. Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9. [PubMed:17924679 ]
  8. Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106. [PubMed:12168954 ]
  9. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  10. Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC: Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-72. Epub 2003 Apr 10. [PubMed:12690205 ]
  11. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Oct 29;6(5):337-45. [PubMed:10574462 ]
  12. Min SW, Chang WP, Sudhof TC: E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3823-8. Epub 2007 Feb 28. [PubMed:17360437 ]
  13. Craxton M: Genomic analysis of synaptotagmin genes. Genomics. 2001 Sep;77(1-2):43-9. [PubMed:11543631 ]