Hmdb loader
Identification
HMDB Protein ID HMDBP07693
Secondary Accession Numbers
  • 13402
Name FRAS1-related extracellular matrix protein 3
Synonyms Not Available
Gene Name FREM3
Protein Type Unknown
Biological Properties
General Function Involved in cell communication
Specific Function Extracellular matrix protein which may play a role in cell adhesion
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Process
cellular process
cell communication
Cellular Location
  1. Secreted
  2. extracellular space
  3. extracellular matrix
Gene Properties
Chromosome Location Chromosome:4
Locus 4q31.21
SNPs FREM3
Gene Sequence
>6420 bp
ATGGCGGGGGCTTCTCGGCACCCGACTGGGACGCCCCGGCAGCTCCTTGTGGCGCTCGCC
TGCCTGCTCTTGAGTCGCCCCGCGCTGCAGGGACGGGCATCCTCACTTGGGACCGAGCCC
GACCCGGCGCTTTACCTGCCCGCCCGGGGTGCGCTTGACGGCACTCGCCCCGACGGCCCC
AGCGTGCTGATTGCCAACCCTGGACTCCGGGTGCCCCTGGGTCGTTCCCTTTGGCTCGAC
CCGCTCCGGGATCTGGTGATTGGAGTGCAGCCGGGGGACCGGTGCGAAGTCACGGTACTG
GACGCCCTGCCGCGGCTCAAGGGCGCGCTCTCCCCGCGCCGCTTCCCCTGCACCTTCGGG
CCCCGCCAAGTCCAGTACACTCACTTCGGCTCCCACAGCCCCGGACGCGCCCGGGTGCTG
CTGCAGCTGCGCTACGACGCCCCGACTCACACTCTGGTGCTGCCCTTCACGCTGGCGGTG
GACTTGGTCTTCTCCCAGCTGGAGCTGGTGACGCGTAACAGGCCTTTGGTAGTGGAGAAG
CTGCGAAGCTGGAGCCGCGCCATAGACAGGAGAGTGCTGGACTTCGCCTCCCTGAAGTCT
GGAGCCACGGCCACCCGCAGGTGCCGGCTTACCCCACTTCCTCACGAGGACGGCCCCCTG
CCCAAGTACGGGCGCTTGGTGGACGCGGTGGGGGCCCCTCTCCCCAGGGGCAAGGGCGTA
GACTGTGAGGCTTTCCTCCGTGCTGGGGTGCGCTATCAGCACACAGCCACCTCCTCGCCC
AACCGTGACTACGTGCCCATGATGGTGGAGCTGCTGGGGCCTGAGGGCCAAGACGCTGGG
TCCGCGGGTGTGCTGGTCCGCGAGCACTTCCAGCTGCTCGTGAGGATCCGCGGCGGAGCC
GAGAACACACCGCCCAGGCCCAGCTTCATGGCCACGATGATGATGGAGGTGGATCCACTG
GTGCTGACAGCCCTGACGCCTGACGCACTGGCCGCGGAGGACGTCGAGTCAGACCCTGGT
GACCTGGTGTTCAACATTCTGAACGCCCCCACTCACCCACCAGGGCACCCGGGGCAACAG
GGCTACGTGGTCAGCACCGACGACCCTCTAGGGCTTCCAGTCTCCTTCTTCACCCAGCAG
GAGCTGAGGGAGCTGAAGATTGCCTATCAGCCCCCTGCAGAGAACTCCCATGGGGAGCGC
CTCTTTCAGCTGGAGCTGGAGGTGGTGGACGGAGACGGCGCCGCCTCAGACCCCTTTGCC
TTCATGGTGACAGTGAAATCCATGAATACTCTGGTCCCAGTGGCTAGCCATAACAGGGGA
CTTGTGCTTTTTGAAGGTCAGTCAAGGCCCTTGTCCAGCACCCACAGCATTCCTATCAGT
GATAAAGATAACCTGGAAGAGGTGAAAATGGCTGCAGTCAGGGGCTTGAGACATGGGCAG
CTGGTGGTGTTTGGGGCACCTGCTGGGTGCAAGTATTTCACACCAGCGGACCTGGCAGCA
GGGCGAGTGGTGTATCAGCATGATGGCAGCAACACCTACAGTGACAATATCATCTTCCGG
ATGGAGGACGGGCACCACCAAGTGGACTTCCTCTTTCCCCTCACCATCCTACCTGTGGAT
GATGAACCACCAATGGTCAATACTAACACAGGACTCTCACTCACTGAAGGGCAGGTGGTC
CAGATCTCTCCCTTTGTACTGAGTGCTACTGATATTGACTCTGAGGACTCAACCATCCAC
TTTGTGCTGGAGAACCAGCCCCTAAAAGGAAATGAGGAAGAGCCTCAGTGGGAGTTGGCC
CCTGGTTCCTCCCACTCAGGCCACTACCTGGGGGACCTGTTGCTGCAGCAGGCTGAACTA
CCTCTCTCAACTGAAGATGAAGACTGGCACTACATGGAAAAGGAAGGGCTTTATGAGAAA
GTGGTGACTGAGTGGCTACAGAGAGACATAATGGAAGGGAGACTCTTCTACCGCCATCTT
GGACCACACAGCCCTCAATCTGTAATGGTCCAGCTGGCTTTCCATGTGCAGGATGACCAT
GACCCACCCAATCTCTCCAAACAGCACATTTTCACCATCAAGGTCCAACCAGTGGATATA
CTGAGTCCACAGCTGTATCCAGGAACTACACTAGAAATGACTGTACAAGAATACCAACTC
ACTCACTTCCAGAAGAATTTCCTCCGATACATTGACCAGGACTCTGATGACCAGAACCTA
TGGTACACCCTACTGACACTCCCGACTGACACAGATGGCAACCACCAAGTCCGGGCTGGA
GAAATTGTGCTCACTGATTCACCAGACACACTCATCATGCACTTTACCCAAGCCCAGGTA
AATCAGCATAAAGTTGCCTACCAGCCTCCACAGAAATTGGGTATTGCACCACGGGTTGTG
CAGTTTACTTACCAGGTGGAAGATGCTGCAGGCAATAGCGTGCCAGGCACATTCACATTA
TTCCTGCAACCTGTGGACAACCAGCCCCCAGAAGTCACCAACAGAGGCTTTGCTATCTTA
GAGGGAGGCAGCTTTAACCTCAGCAGTAATGAGCTGCATGTTACAGACCCAGACACAGAC
ATTGACCAAATTGTCTTCATATTAGTCCGGGGTCCCCAACATGGACACTTGCAGTACTTT
AAAAGATGTATGGTCCCAGGGGAATCTTTCATGCAAGCTGATGTTATTAACGGGAGTGTC
TCTTACCAGCATGGCAGAGACCAGACGACTACCAGTGACACTTTCCATCTGGAAGTAAGT
GATGGGGTGCACCATATACCCATCACCATCCCAATTTCTGTGCATCCCAATGTGGCTAAC
AGAAGTCCTAGGATCTCTCTCAGAAGTAGTTCATTATTGGATGTTTCTATAGACGTACTA
GAGAATAAAGCCACTGAAATTACCATGGGTGTCATCCATGGCAAAAGGAAGGATGTAGGT
GACTTGATGCTGTCTTTCATTGTAAAGGACAGCCCCAAACTGGGCACTATTCTGGTAAAT
GGTTTGCCCACAGAACGATTCACCCAAGAGGATCTCATCAATGGGAGAGTAGCCTATGCC
CACACTGCAGGTGAAGTTGGTTTTCAAAAGCAGCACGATGCCTTCAGCCTCATCCTCTCC
AAAGATTCTTACCAATGGGTAGTGGGGAATAGCATAATAGAGAAAGTACAGGTACAAGTA
ACTGTGCTGCCTGTGGACAATGTGGGACCCAAGGTCTTCGTCGGGGAGTCCTTCATTGTC
TATGAAGGTGAGAAGAACTCCTTGACCTTACAACATCTCCATGTTGAAGATGTGGACACT
CATCAAGATGAACTCCTCTGCACAGTGACTAGTCAGCCAGCCTCTGGCTACCTGGAAAAG
ATTGCATCAGCTCCTGGTTCAAAAATGTCCCAGTCTGGTAGCCCTATCAGTGCTTTCTCC
CTCAGAGATATCCAAGTGAGGCATATCAATTATGTACAGAGTATTCACAAGGGAGTAGAG
CCACAAGAGGACCAATTCACCTTTTATTGCTCTGATGGCATCAACTTCTCCCCAAATGTC
TTCTTCCCTATAATCATCCTACCCACCAATGATGAGCAGCCTAAACTTTTTGCCCATGAG
TTTAAGGTACTAGAGGGGATGAGCCTGGTCATAGACACCCAGCTGCTTAATGGAGCAGAT
GCTGACCTGCCACCAAATGAGCTCCACTTTCAACTCACAGCCCTCCCTCGGCATGGACGA
ATCATACAGCAGCTGGCTACAGGCAGCCAGCCCATCCACAGCTTCACCCTCAAGGAGATC
CAGGAGGCCTCCACCATTGTGTATGAGCATGATGACTCAGAGACAAAAGAGGACAGTTTT
GAGGTCTGGCTGAGTGACGGCAAGCACACAACCCACAGGAAGGTACCCATTGTAGTGACC
CTAGTGGATGATGAAACTCCTCACCTGACTGTCAACAATGGGCTGAAGGTAGAGAAAGGA
CACTCTGAGATCATCACAAATCGGATCCTCAAGGCCACAGATCTTGACTCAGATGATAAA
AGCCTCAGTTTTGTCCTCCATTCTGGGCCTCAACAAGGGCTTCTACAGAGGCTGAGAAAA
CCCAGAGGAGAAGTGAGGAACAATCTTACTCTGGGAATGAACTTTACCCAGGATGAGATT
AACAGAGGCCTCATCTGCTATATCCACACAGGCCAAGAAGGGATTGTTGACATTATCAAG
TTTGATGTTACTGATGGGGTTAACACTTTGACAGACCACTACTTCTATGTCACCATTGGC
AACTTAGACAGCGTCTTCCCTGAGGTAATCAGCAAAAGGATCACCTTGATAGAAGGTGCC
AGAGTGACCCTTACCAACAATCTGCTTACCAACAGTGACATCAACAGCTCTGATGAACAT
CACTTTAGCATTACACGGGCTCCAAGCCTGGGTCACTTAGAAAGTTCTGACTATGCTGGG
GAACCCATTGCCTCTTTCACTCAACTTCAATTGGCTAGCAACAAAATATCCTATGTCCAT
ACTTCAAATGATGAGAAAAAGATGGACAGCTTCGAATTTCAAGTGATCGGCGAACTCTAC
CCTGTGTTCAGAACCTTCAGGATCTTCATCACTGATGTGGATAATAAGAAACCTATCTTG
ACCATCCATAGACTAACACTACAGAAAGAGGATAGCCAACTGATCACTCTCCTTGAGTTG
ACAGTGGAAGACAGTGATACCCCAGATGACCTTATTCTCTTTACCATCACCCAGGTCCCC
ATGCATGGCAAGATTTTGTACAATGGTAGCCGTCCCGTGACCACTTTCACCAAGCAAGAC
CTGAACAAGAACCTGATTAGCTACAAGCATGACGGCAGTGAGACCACTGAAGATAGTTTC
TCCTTGACTGTGACAGACGGCACTCACACTGATTTCTATGTCCTACCAGACACTGCCCTG
GCGACACACAAACCTCAAGTAATGAGGGTCCAGATAAGATCATTAGACAATAGGCTTCCC
CAGATTACTACCAACAGGGGTGCCCCAGCCTTGAAGCGCCTTCACACTGGACACATGGGC
TTCCTGATTACCAGCAAGTCTCTGAAGGCAGAAGATCAGGACAGTCCCCACAGGCTTCTG
AAGTATAAAGTGACCAGAGGACCAGAGCATGGCTTCATTATCAAAACTGGCCTTGGAAAC
CAGAGCACTCGAGTGTTTACACAAGCTGACATTGATGAGATGAAGATATCCTATGTCTTG
AATGAGGGCAGCAACGCATCAAAGGACATCTTCTATTTCTCTGTTGAAGACAATGGAGGA
AATAAACTAACAAATCAGCCTTTCCATCTAAACTGGGCTTGGATTTGTTTGGAGAAAGAG
TACTACATTGTGGATGAAGATTCCACATTCTTAGAAGTGACCCTTACACGCAGAGGATAC
CTTGGAGAAACATCATTTATCAGCATTGGTACCAAAGATGAAACTGCAAAAAAAGACAAA
GATTTCAAATGGAAGACCAATAAACAGATCCAGTTCAATCCTGGACAGACTACAGCCACA
TGGAGGGTGAGAATTATACCTGACAATGAATATGAGACTTCAGAGACCTTCCAGATCATT
CTGTCTGAACCTCTCATGGCTGTACTGGAGTTTCCAGAAATGGCAACGGTTGAAATTGTA
GACCCTGGAGATGAATCAACAGTTTATATTCCAGAGGCGGAATACAAAATAGAAGAGGAC
ATTGGGGAACTTTTGATTCCAGTAAGACGATCTGGAGATGCAAGCCAGGAACTAATCGTC
ATTTGCTCCACACGTCAAGGTTCTGCCACAGGCACGATTTCTTCCACAGTGTTATTCTCT
GATTACATCTCACGTCCAGAAGACCACACCAGCATCCTCCACTTTGACAAGAATGAGACA
CAGAAGACCTGCCAGGTCCTGATCATTGATGACTCCCTTTATGAAGAGGAGGAATCCTTC
AGCGTTTCACTTAGGCTGCCAGTGGGAGGACAGCTGGGAGCCAGATTCCCCACCACTAAG
GTGACTATTCTGGCTGATCGTTATGATGAACCTGTCCTGCACTTTGGGGATGCTGAATAT
CACGTCAATGAAAGTGCTCGCTACGTGGAGGTTTGTGTTTGGAGAAGAGGCACTGATCTT
TCCCAACCATCATCCATCGCCGTGCGCTCCAGAAAGTCAGAGCAGGAGTCAGCAGAAGCT
GGAACAGATTATGTTGGTATCAGCCGAAACCTGGACTTTGCTCCAGGCGTGCGCATGCAG
ACATTCCAAGTGACCATCCTTGATGACCTGGGACAGCCTACCTTGGAAGGCCCAGAGAAG
TTTGAATTACTTCTTCAGATGCCTATGGGTGCAGTGCTTGGAGAACCAAATAAAACTACC
ATTTTCATCGAGGACACCATCACGGACTGTAAGCAGAGTGCTTGTAGTTCCTTTGATTGA
Protein Properties
Number of Residues 2135
Molecular Weight 237762.4
Theoretical pI 4.98
Pfam Domain Function
Signals
  • 1-30
Transmembrane Regions
  • None
Protein Sequence
>FRAS1-related extracellular matrix protein 3
MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGP
SVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFG
PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK
LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGV
DCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGA
ENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQ
GYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFA
FMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQ
LVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVD
DEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELA
PGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHL
GPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQL
THFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQV
NQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAIL
EGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSV
SYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL
ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYA
HTAGEVGFQKQHDAFSLLSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVFVGESFIVY
EGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSL
RDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEF
KVLEGMSLVIDTQLLNGADADLPPNEHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQE
ASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHS
EIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINR
GLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVIGNLDSVFPEVISKRITLIEGARVT
LTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVHTSN
DEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLELTVE
DSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLIYKHDGSETTEDSFSLTV
TDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMGFLIT
SKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVLNEGS
NASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGYLGET
SFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILSEP
LMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICST
RQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSL
RLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPS
SIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELL
LQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD
GenBank ID Protein 270265871
UniProtKB/Swiss-Prot ID P0C091
UniProtKB/Swiss-Prot Entry Name FREM3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001168235
GeneCard ID FREM3
GenAtlas ID FREM3
HGNC ID HGNC:25172
References
General References
  1. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [PubMed:15815621 ]
  2. Smyth I, Du X, Taylor MS, Justice MJ, Beutler B, Jackson IJ: The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13560-5. Epub 2004 Sep 2. [PubMed:15345741 ]