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Identification
HMDB Protein ID HMDBP07711
Secondary Accession Numbers
  • 13420
Name Polypeptide N-acetylgalactosaminyltransferase-like 6
Synonyms
  1. GalNAc-T17
  2. Polypeptide GalNAc transferase 17
  3. Protein-UDP acetylgalactosaminyltransferase 17
  4. Putative polypeptide N-acetylgalactosaminyltransferase 17
  5. UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17
  6. pp-GaNTase 17
Gene Name GALNTL6
Protein Type Unknown
Biological Properties
General Function Involved in metal ion binding
Specific Function Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (By similarity).
Pathways
  • Mucin type O-glycan biosynthesis
  • protein glycosylation
Reactions
UDP-N-acetyl-alpha-D-galactosamine + polypeptide → Uridine 5'-diphosphate + N-acetyl-alpha-D-galactosaminyl-polypeptide details
UDP-N-acetyl-D-galactosamine + Protein serine → UDP + Tn antigen details
GO Classification
Biological Process
protein glycosylation
Cellular Component
integral to membrane
Golgi membrane
Molecular Function
metal ion binding
polypeptide N-acetylgalactosaminyltransferase activity
Cellular Location
  1. Golgi apparatus membrane
  2. Single-pass type II membrane protein
Gene Properties
Chromosome Location 4
Locus 4q34.1
SNPs GALNTL6
Gene Sequence
>1806 bp
ATGAAGAGGAAACAGAAGAGATTTCTGCAGATGACTTTGTTGTTCACGGTGGCTTTAATT
TTCCTGCCTAACGTTGGTCTCTGGTCTCTGTACAAGGATAAGCACCTGGTGAAGTCAGCG
GAGCCCGGGGAGCAGCAGACATTTCCACTGGGCCTGGGAGATGGGCAATTCTATTCATGG
ACAGATGGTTTGAGAAGAAAGGACTGGCATGACTATGAAAGCATTCAGAAAGAGGCTATG
CGCTCAGGGAAAGGTGAACATGGGAAACCTTACCCCCTTACTGAAGAGGACCATGATGAC
TCAGCTTACAGGGAAAATGGTTTTAATATTTTCGTCAGCAACAATATTGCTCTAGAGAGG
TCTCTGCCAGATATTCGTCATGCTAACTGTAAGCATAAGATGTATCTGGAAAGGCTGCCA
AACACCAGCATCATTATCCCATTTCATAATGAAGGTTGGACTTCACTCCTGCGGACCATA
CACAGTATAATTAACCGAACCCCAGGGAGTCTGATAGCAGAAATCATTCTAGTAGATGAC
TTCAGTGAGAGAGAACACCTGAAGGATAAATTGGAAGAATACATGGCCCGATTTTCCAAA
GTGAGGATTGTTCGCACCAAGAAAAGAGAAGGACTCATCCGGACCCGTCTCCTGGGGGCA
TCTATGGCCAGAGGAGAAGTCCTGACATTCCTGGACTCCCACTGCGAGGTCAATGTGAAC
TGGCTGCCCCCACTCCTCAACCAAATTGCACTAAACCACAAAACCATCGTGTGTCCCATG
ATCGATGTCATTGACCACAATCACTTCGGGTATGAGGCACAAGCTGGGGATGCCATGCGA
GGAGCCTTCGACTGGGAAATGTACTACAAAAGAATCCCCATCCCTCCAGAGCTCCAGAGG
GCAGATCCCAGCGACCCTTTTGAGTCTCCTGTTATGGCTGGAGGTCTCTTTGCTGTGGAT
CGGAAATGGTTTTGGGAATTGGGTGGCTATGATCCAGGTTTAGAAATCTGGGGAGGAGAA
CAGTATGAAATCTCTTTTAAGGTTTGGATGTGTGGAGGAGAAATGTTTGATGTTCCATGT
TCTAGAGTTGGTCATATCTACAGGAAGTACGTTCCATACAAAGTTCCATCTGGGACAAGC
CTGGCAAGAAACCTGAAGCGGGTAGCTGAGACCTGGATGGATGAATTTGCCGAGTACATT
TACCAGCGGCGGCCGGAGTACAGGCATCTCTCCACGGGGGACATCTCTGCCCAGAAGGAG
CTGCGCAAGCAGCTCAAGTGCAAGGACTTCAAATGGTTCATGGCTGCTGTGGCCTGGGAC
GTGCCTAAATACTACCCTCCAGTGGAGCCCCCGCCTGCTGCCTGGGGGGAGATCCGAAAT
GTGGCAGCAAATCTCTGTGTGGACAGCAAGCATGGAGCCACCGGAACAGAGCTGAGGCTG
GACATCTGTGTCAAGGATGGTTCTGAAAGAACATGGTCTCATGAACAGCTTTTTACCTTT
GGATGGAGAGAAGATATTCGACCCGGTGAGCCACTGCATACCCGGAAATTCTGCTTTGAT
GCGATCTCACACAACAGCCCCGTTACACTCTATGACTGTCATGGCATGAAGGGGAACCAG
CTCTGGGGATACCGGAAGGACAGAACATTATTCCATCCTGTGAGCAACAGCTGCATGGAT
TGCAACCCCGCAGAGAAGAAGATTTTCATGGCCAGATGTGACCCTCTCTCTGAGACTCAG
CAGTGGATTTTTGAACACATTAATATGACTGTTTTAGAAAAATTTAACCACCATGCCAAC
TCCTAG
Protein Properties
Number of Residues 601
Molecular Weight 69787.21
Theoretical pI 7.455
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Polypeptide N-acetylgalactosaminyltransferase-like 6
MKRKQKRFLQMTLLFTVALIFLPNVGLWSLYKDKHLVKSAEPGEQQTFPLGLGDGQFYSW
TDGLRRKDWHDYESIQKEAMRSGKGEHGKPYPLTEEDHDDSAYRENGFNIFVSNNIALER
SLPDIRHANCKHKMYLERLPNTSIIIPFHNEGWTSLLRTIHSIINRTPGSLIAEIILVDD
FSEREHLKDKLEEYMARFSKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVN
WLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQR
ADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPC
SRVGHIYRKYVPYKVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKE
LRKQLKCKDFKWFMAAVAWDVPKYYPPVEPPPAAWGEIRNVAANLCVDSKHGATGTELRL
DICVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCFDAISHNSPVTLYDCHGMKGNQ
LWGYRKDRTLFHPVSNSCMDCNPAEKKIFMARCDPLSETQQWIFEHINMTVLEKFNHHAN
S
GenBank ID Protein 194018457
UniProtKB/Swiss-Prot ID Q49A17
UniProtKB/Swiss-Prot Entry Name GLTL6_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001034845.2
GeneCard ID GALNTL6
GenAtlas ID GALNTL6
HGNC ID HGNC:33844
References
General References
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