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Identification
HMDB Protein ID HMDBP07731
Secondary Accession Numbers
  • 13440
Name Histone H2A type 3
Synonyms Not Available
Gene Name HIST3H2A
Protein Type Unknown
Biological Properties
General Function Involved in DNA binding
Specific Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Pathways Not Available
Reactions Not Available
GO Classification
Component
macromolecular complex
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
nucleosome
protein-dna complex
Function
binding
nucleic acid binding
dna binding
Process
cellular process
cellular component organization at cellular level
organelle organization
chromosome organization
chromatin organization
nucleosome assembly
nucleosome organization
Cellular Location
  1. Nucleus
  2. Chromosome
Gene Properties
Chromosome Location Chromosome:1
Locus 1q42.13
SNPs HIST3H2A
Gene Sequence
>393 bp
ATGTCCGGTCGTGGTAAGCAGGGTGGCAAGGCGCGCGCCAAGGCTAAGTCGCGCTCGTCG
CGCGCGGGGCTGCAGTTCCCCGTGGGCCGCGTGCACCGGTTGCTCCGCAAGGGCAACTAT
TCGGAGCGCGTGGGCGCCGGCGCCCCGGTCTATCTGGCCGCGGTGCTCGAGTACTTGACT
GCCGAGATCCTGGAGCTTGCCGGCAACGCGGCGCGCGACAACAAGAAGACGCGCATCATC
CCGCGCCACCTGCAGCTGGCCATCCGCAACGACGAGGAGCTCAACAAGCTGCTGGGCCGC
GTGACCATCGCGCAGGGTGGCGTCCTGCCCAACATCCAGGCCGTACTGCTGCCCAAGAAG
ACGGAGAGCCACCACAAGGCCAAGGGCAAGTGA
Protein Properties
Number of Residues 130
Molecular Weight 14121.4
Theoretical pI 11.66
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Histone H2A type 3
MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKK
TESHHKAKGK
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q7L7L0
UniProtKB/Swiss-Prot Entry Name H2A3_HUMAN
PDB IDs
GenBank Gene ID AK311930
GeneCard ID HIST3H2A
GenAtlas ID HIST3H2A
HGNC ID HGNC:20507
References
General References
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