| Identification |
|---|
| HMDB Protein ID
| HMDBP07763 |
| Secondary Accession Numbers
| |
| Name
| Potassium channel subfamily U member 1 |
| Synonyms
|
- Calcium-activated potassium channel subunit alpha-3
- Calcium-activated potassium channel, subfamily M subunit alpha-3
- KCa5
- Slowpoke homolog 3
|
| Gene Name
| KCNU1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in ion channel activity |
| Specific Function
| Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May be involved in sperm capacitation and/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH and membrane potential are known to occur. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+) |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| calcium activated cation channel activity |
| calcium-activated potassium channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
| monovalent inorganic cation transport |
| potassium ion transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8p11.23 |
| SNPs
| KCNU1 |
| Gene Sequence
|
>3450 bp
ATGTTTCAGACTAAGCTACGAAATGAAACTTGGGAAGACTTGCCAAAAATGTCCTGCACA
ACTGAGATCCAAGCAGCATTCATTCTCTCTTCCTTTGTGACCTTCTTCAGTGGACTCATC
ATCCTGTTGATCTTCAGGCTGATCTGGAGATCTGTTAAAAAATGGCAAATCATCAAGGGA
ACAGGAATTATCTTGGAACTGTTCACATCAGGTACCATCGCTAGGAGCCATGTAAGAAGC
CTCCACTTCCAGGGACAATTTCGTGATCATATAGAAATGTTGCTTTCAGCCCAGACCTTT
GTGGGGCAAGTGTTGGTGATCCTTGTCTTTGTACTAAGCATTGGGTCTCTTATAATCTAT
TTCATCAATTCTGCTGACCCTGTTGGAAGCTGTTCATCATATGAAGACAAAACCATTCCT
ATTGATTTGGTTTTCAATGCTTTCTTTAGTTTCTATTTTGGATTGAGGTTTATGGCAGCT
GATGACAAGATCAAGTTCTGGCTGGAGATGAATTCAATCGTAGACATCTTTACCATCCCA
CCAACCTTTATTTCTTATTATTTGAAGAGCAATTGGCTAGGTTTAAGGTTCCTAAGAGCC
TTGCGCCTGCTAGAACTCCCTCAAATCTTGCAAATTCTACGAGCCATCAAGACCAGTAAC
TCAGTGAAGTTTTCCAAACTGCTGTCAATAATTCTCAGTACCTGGTTCACAGCTGCGGGA
TTCATTCACCTGGTGGAAAATTCTGGTGATCCCTGGCTCAAAGGTAGAAATTCACAGAAT
ATATCATATTTTGAGTCAATTTACCTGGTCATGGCAACAACGTCAACCGTTGGATTTGGA
GATGTGGTAGCCAAGACATCCTTAGGACGGACCTTCATCATGTTCTTCACACTGGGGAGT
TTGATATTATTTGCGAACTATATACCTGAAATGGTGGAACTGTTTGCTAACAAGAGGAAA
TACACCAGTTCCTATGAAGCACTCAAAGGAAAGAAGTTTATTGTGGTCTGTGGAAACATC
ACTGTGGACAGTGTGACCGCTTTCCTGAGGAATTTCCTCCGCGACAAGTCAGGAGAGATC
AACACTGAAATTGTTTTCCTGGGAGAAACCCCTCCTTCTTTGGAACTTGAAACCATATTT
AAATGCTACTTGGCCTACACAACGTTCATTTCTGGATCTGCAATGAAGTGGGAGGATCTG
AGGCGAGTTGCGGTGGAATCTGCAGAGGCATGCCTGATTATAGCCAATCCTTTGTGCAGT
GATTCCCATGCTGAAGATATTTCCAACATTATGAGGGTGCTCTCTATCAAGAACTATGAT
TCTACCACCAGAATCATCATACAGATACTGCAATCCCATAACAAGGTTTATCTGCCAAAG
ATTCCCAGCTGGAACTGGGACACCGGAGACAACATCATCTGCTTTGCTGAATTAAAACTT
GGATTTATCGCCCAAGGCTGTTTGGTGCCAGGCTTGTGTACCTTCCTAACATCTCTATTT
GTGGAGCAAAACAAAAAGGTTATGCCTAAACAGACCTGGAAGAAACACTTCTTGAATAGC
ATGAAAAACAAAATTCTGACCCAACGTCTCTCTGATGACTTTGCTGGAATGAGCTTTCCT
GAAGTTGCCCGGCTCTGCTTTCTGAAGATGCACCTCCTGTTGATAGCCATCGAATACAAG
TCCCTCTTTACGGATGGTTTCTGTGGTCTGATACTAAATCCACCTCCACAAGTGAGGATA
CGTAAGAACACATTAGGGTTCTTTATTGCTGAAACTCCAAAGGACGTCAGAAGAGCCTTG
TTTTACTGTTCAGTCTGTCATGATGATGTGTTCATTCCTGAGCTAATTACAAACTGTGGC
TGCAAAAGCAGAAGCCGGCAGCACATCACAGTGCCATCGGTAAAGAGAATGAAAAAATGT
CTGAAGGGAATCTCCTCTCGTATATCAGGGCAGGATTCTCCGCCAAGGGTATCTGCAAGC
ACTTCGAGCATATCAAACTTCACCACCAGGACTCTTCAACATGATGTAGAACAAGATTCT
GACCAGCTTGATAGCAGTGGGATGTTTCACTGGTGCAAACCAACCTCTTTGGACAAGGTG
ACTCTGAAACGAACTGGCAAGTCAAAGTATAAGTTTCGGAACCATATTGTAGCATGTGTA
TTTGGAGATGCCCACTCAGCCCCGATGGGGCTTCGGAACTTTGTAATGCCCTTGAGAGCC
AGCAACTATACCAGGAAGGAGCTGAAGGACATAGTGTTCATTGGGTCTCTGGACTATCTA
CAGAGAGAATGGCGATTTCTCTGGAATTTTCCCCAGATATACATTCTGCCTGGATGTGCA
CTTTATTCTGGAGACCTCCATGCGGCCAACATAGAGCAATGCTCCATGTGTGCTGTCTTG
TCCCCCCCACCCCAGCCATCAAGCAACCAGACTTTGGTAGACACAGAAGCCATCATGGCA
ACCCTCACCATCGGATCCTTGCAAATTGACTCCTCCTCTGACCCGTCACCCTCAGTGTCA
GAGGAGACTCCAGGTTACACAAATGGACATAATGAGAAATCAAACTGCCGAAAAGTCCCT
ATCCTTACTGAACTGAAAAATCCTTCCAACATTCACTTTATTGAACAGCTTGGTGGACTG
GAAGGGTCCCTCCAAGAAACAAATCTGCATCTCAGCACTGCCTTTTCTACGGGCACTGTT
TTTTCCGGCAGCTTCTTGGATTCTCTGCTGGCCACGGCCTTCTACAATTATCATGTCCTG
GAATTGCTTCAGATGCTGGTGACAGGAGGAGTAAGTTCTCAGCTGGAACAACATTTAGAT
AAGGATAAAGTCTATGGTGTGGCAGATAGCTGCACGTCGCTCTTGTCTGGAAGAAACCGG
TGTAAGCTGGGGCTTCTGTCCTTACACGAAACCATTTTATCAGACGTTAATCCAAGAAAC
ACCTTTGGACAACTGTTCTGTGGCTCATTAGATCTTTTTGGAATCCTGTGTGTTGGCTTA
TACCGAATAATTGATGAAGAGGAGCTCAACCCAGAAAACAAAAGGTTTGTGATCACCCGG
CCAGCCAATGAGTTCAAGCTGCTGCCTTCAGATCTTGTGTTTTGTGCCATACCCTTCAGC
ACTGCTTGTTATAAAAGGAATGAAGAGTTCTCATTGCAAAAGTCATATGAAATTGTAAAT
AAAGCATCACAGACAACAGAGACACATTCAGACACAAATTGTCCTCCCACCATTGATTCA
GTTACTGAGACATTGTATTCACCAGTCTATTCTTACCAGCCGAGAACTAACTCCCTCTCT
TTTCCTAAGCAAATAGCATGGAATCAGAGTAGAACAAACAGTATTATATCATCTCAGATA
CCTTTAGGTGACAATGCAAAAGAAAATGAAAGGAAAACTTCAGATGAGGTTTATGATGAG
GATCCCTTTGCATATTCAGAGCCACTATAG
|
| Protein Properties |
|---|
| Number of Residues
| 1149 |
| Molecular Weight
| 129542.0 |
| Theoretical pI
| 7.87 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 25-45
- 102-122
- 139-159
- 164-184
- 189-209
- 227-247
- 292-312
|
| Protein Sequence
|
>Potassium channel subfamily U member 1
MFQTKLRNETWEDLPKMSCTTEIQAAFILSSFVTFFSGLIILLIFRLIWRSVKKWQIIKG
TGIILELFTSGTIARSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIY
FINSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIP
PTFISYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAG
FIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGS
LILFANYIPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEI
NTEIVFLGETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCS
DSHAEDISNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKL
GFIAQGCLVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFP
EVARLCFLKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRAL
FYCSVCHDDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSPPRVSAS
TSSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKYKFRNHIVACV
FGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGCA
LYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVS
EETPGYTNGHNEKSNCRKVPILTELKNPSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTV
FSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTSLLSGRNR
CKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEEELNPENKRFVITR
PANEFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQTTETHSDTNCPPTIDS
VTETLYSPVYSYQPRTNSLSFPKQIAWNQSRTNSIISSQIPLGDNAKENERKTSDEVYDE
DPFAYSEPL
|
| External Links |
|---|
| GenBank ID Protein
| 157074214 |
| UniProtKB/Swiss-Prot ID
| A8MYU2 |
| UniProtKB/Swiss-Prot Entry Name
| KCNU1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001031836.2 |
| GeneCard ID
| KCNU1 |
| GenAtlas ID
| KCNU1 |
| HGNC ID
| HGNC:18867 |
| References |
|---|
| General References
| - Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L 3rd, Engels R, Glockner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES: DNA sequence and analysis of human chromosome 8. Nature. 2006 Jan 19;439(7074):331-5. [PubMed:16421571 ]
- Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L: Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes. J Biol Chem. 1998 Feb 6;273(6):3509-16. [PubMed:9452476 ]
|
