Hmdb loader
Identification
HMDB Protein ID HMDBP07778
Secondary Accession Numbers
  • 13487
Name Liprin-beta-1
Synonyms
  1. PTPRF-interacting protein-binding protein 1
  2. Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1
  3. hSGT2
Gene Name PPFIBP1
Protein Type Unknown
Biological Properties
General Function Replication, recombination and repair
Specific Function May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 12p12.1
SNPs PPFIBP1
Gene Sequence
>3036 bp
ATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATA
GCAGGTTCTAAGGCTCTGGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCT
CCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAG
ATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAA
ACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGAT
GTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTA
AGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGT
CTTGAAGAGCACAGAGAGAAGTTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTA
AGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAG
TTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACA
GAGGGGCTGATTCAGGAGATCAATGATTTGAGGTTAAAAGTTAGTGAAATGGACAGTGAG
AGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAATCTTTAATGGCCAAACTTTCTAGC
ATGAAAATCAAGGTGGGTCAGATGCAGTATGAAAAGCAGCGGATGGAACAAAAATGGGAG
TCACTGAAGGATGAACTGGCATCTTTAAAAGAACAACTAGAAGAAAAGGAATCTGAAGTA
AAAAGGCTACAAGAAAAATTGGTTTGCAAGATGAAAGGAGAAGGGGTTGAAATTGTTGAT
AGAGACATCGAAGTACAAAAAATGAAAAAAGCTGTGGAGTCCTTGATGGCAGCAAATGAA
GAAAAGGATCGGAAAATAGAAGATCTTCGACAGTGCCTGAACAGGTACAAGAAAATGCAA
GACACGGTGGTACTGGCCCAAGGCAAAGATGGAGAATATGAAGAGCTGCTCAATTCCAGT
TCCATCTCCTCTTTGCTGGATGCACAGGGTTTCAGTGATCTGGAGAAAAGTCCATCACCC
ACTCCAGTAATGGGATCTCCCAGTTGTGACCCATTTAACACAAGTGTTCCCGAAGAGTTC
CATACTACCATCTTGCAAGTTTCCATCCCTTCATTATTGCCAGCAACTGTAAGCATGGAA
ACTTCTGAAAAATCAAAGTTGACTCCTAAGCCAGAGACTTCATTTGAAGAAAATGATGGA
AACATAATCCTTGGTGCCACTGTTGATACCCAACTGTGTGATAAACTTTTAACTTCAAGT
CTGCAGAAGTCCAGCAGCCTGGGCAATCTGAAGAAAGAGACATCTGATGGGGAAAAGGAA
ACTATTCAGAAGACTTCAGAGGACAGAGCTCCGGCAGAAAGCAGGCCATTTGGGACCCTT
CCTCCCAGGCCCCCAGGGCAGGACACCTCCATGGATGACAACCCCTTCGGCACTCGAAAA
GTCAGATCTTCCTTTGGCCGGGGCTTTTTTAAAATCAAAAGTAACAAGAGAACAGCAAGT
GCACCAAACTTAGCTGAAACAGAAAAAGAGACAGCAGAGCACCTAGATCTGGCTGGTGCT
TCTTCTCGGCCAAAAGATTCACAGAGGAACAGTCCCTTCCAGATACCGCCTCCATCTCCA
GATTCCAAAAAGAAATCCAGAGGTATCATGAAACTCTTTGGAAAACTTAGGAGAAGTCAA
TCAACTACATTCAACCCAGATGACATGTCTGAGCCTGAATTCAAAAGAGGAGGGACAAGG
GCAACCGCGGGGCCCCGATTAGGTTGGTCTCGAGACTTGGGACAGTCTAACAGTGACTTG
GATATGCCATTTGCCAAGTGGACCAAGGAGCAGGTTTGCAATTGGCTGATGGAACAGGGC
TTGGGCTCGTACCTGAATTCTGGCAAGCACTGGATTGCATCTGGCCAAACGCTTTTGCAG
GCTTCTCAACAAGATCTAGAGAAGGAACTTGGAATCAAGCATTCACTTCATCGAAAGAAA
CTCCAGCTAGCACTCCAAGCCCTGGGATCTGAAGAAGAAACCAATCATGGGAAGCTGGAT
TTCAACTGGGTCACTAGATGGTTGGATGACATTGGCCTCCCTCAATATAAGACCCAGTTT
GATGAAGGACGGGTTGATGGTCGAATGCTACATTACATGACTGTTGATGACTTACTGTCT
CTGAAGGTTGTAAGTGTGCTACACCATCTCAGTATCAAAAGGGCCATCCAGGTCCTGAGG
ATCAATAACTTTGAACCAAACTGTCTACGGAGGCGGCCATCTGATGAGAATACCATCGCC
CCATCAGAAGTTCAGAAGTGGACTAACCATCGAGTGATGGAGTGGCTGCGCTCCGTGGAC
TTGGCAGAATATGCGCCCAATCTCAGAGGCAGTGGTGTCCATGGTGGGCTCATGGTTCTA
GAGCCTCGTTTTAACGTAGAAACAATGGCTCAGTTATTGAACATCCCACCCAATAAGACT
TTGCTGCGAAGACATTTGGCCACTCATTTCAACCTTCTGATTGGGGCTGAGGCACAGCAC
CAGAAGCGAGATGCCATGGAGCTGCCGGATTATGTACTTCTAACAGCTACTGCCAAAGTG
AAGCCAAAGAAACTTGCCTTTAGCAATTTTGGGAATTTGAGAAAGAAGAAACAGGAAGAT
GGTGAAGAATATGTTTGTCCAATGGAATTGGGACAGGCATCAGGAAGTGCATCTAAGAAA
GGATTTAAACCTGGTTTGGATATGCGCCTGTATGAGGAAGATGATTTGGACCGGTTAGAG
CAGATGGAAGATTCAGAAGGGACAGTGAGACAGATAGGTGCATTCTCTGAAGGCATCAAC
AATCTGACGCACATGTTAAAAGAAGATGACATGTTTAAAGATTTTGCTGCCCGTTCCCCC
AGTGCCAGCATTACAGATGAAGACTCAAACGTTTGA
Protein Properties
Number of Residues 1011
Molecular Weight 114023.1
Theoretical pI 5.22
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Liprin-beta-1
MMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLE
MMETDEKEGLRCQIPDSTAETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQV
SVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAEISNLK
LKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMAKLSS
MKIKVGQMQYEKQRMEQKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVD
RDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKDGEYEELLNSS
SISSLLDAQGFSDLEKSPSPTPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSME
TSEKSKLTPKPETSFEENDGNIILGATVDTQLCDKLLTSSLQKSSSLGNLKKETSDGEKE
TIQKTSEDRAPAESRPFGTLPPRPPGQDTSMDDNPFGTRKVRSSFGRGFFKIKSNKRTAS
APNLAETEKETAEHLDLAGASSRPKDSQRNSPFQIPPPSPDSKKKSRGIMKLFGKLRRSQ
STTFNPDDMSEPEFKRGGTRATAGPRLGWSRDLGQSNSDLDMPFAKWTKEQVCNWLMEQG
LGSYLNSGKHWIASGQTLLQASQQDLEKELGIKHSLHRKKLQLALQALGSEEETNHGKLD
FNWVTRWLDDIGLPQYKTQFDEGRVDGRMLHYMTVDDLLSLKVVSVLHHLSIKRAIQVLR
INNFEPNCLRRRPSDENTIAPSEVQKWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVL
EPRFNVETMAQLLNIPPNKTLLRRHLATHFNLLIGAEAQHQKRDAMELPDYVLLTATAKV
KPKKLAFSNFGNLRKKKQEDGEEYVCPMELGQASGSASKKGFKPGLDMRLYEEDDLDRLE
QMEDSEGTVRQIGAFSEGINNLTHMLKEDDMFKDFAARSPSASITDEDSNV
GenBank ID Protein 312032469
UniProtKB/Swiss-Prot ID Q86W92
UniProtKB/Swiss-Prot Entry Name LIPB1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_177444.2
GeneCard ID PPFIBP1
GenAtlas ID PPFIBP1
HGNC ID HGNC:9249
References
General References
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  2. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  5. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
  6. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  7. Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106. [PubMed:12168954 ]
  8. Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM: Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5860-5. Epub 2007 Mar 26. [PubMed:17389395 ]
  9. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Oct 29;6(5):337-45. [PubMed:10574462 ]
  10. Serra-Pages C, Medley QG, Tang M, Hart A, Streuli M: Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. J Biol Chem. 1998 Jun 19;273(25):15611-20. [PubMed:9624153 ]
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