Hmdb loader
Identification
HMDB Protein ID HMDBP07809
Secondary Accession Numbers
  • 13518
Name Matrix metalloproteinase-24
Synonyms
  1. MMP-24
  2. MT-MMP 5
  3. MT5-MMP
  4. MT5MMP
  5. MTMMP5
  6. Membrane-type matrix metalloproteinase 5
  7. Membrane-type-5 matrix metalloproteinase
  8. Processed matrix metalloproteinase-24
Gene Name MMP24
Protein Type Unknown
Biological Properties
General Function Involved in metalloendopeptidase activity
Specific Function Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin
Pathways Not Available
Reactions Not Available
GO Classification
Component
extracellular region part
extracellular matrix
Function
endopeptidase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
transition metal ion binding
zinc ion binding
metalloendopeptidase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
metallopeptidase activity
calcium ion binding
Process
metabolic process
macromolecule metabolic process
protein metabolic process
proteolysis
Cellular Location
  1. extracellular space
  2. extracellular matrix
  3. Processed matrix metalloproteinase-24:Secreted
Gene Properties
Chromosome Location Chromosome:2
Locus 20q11.2
SNPs MMP24
Gene Sequence
>1938 bp
ATGCCGAGGAGCCGGGGCGGCCGCGCCGCGCCGGGGCCGCCGCCGCCGCCGCCGCCGCCG
GGCCAGGCCCCGCGCTGGAGCCGCTGGCGGGTCCCTGGGCGGCTGCTGCTGCTGCTGCTG
CCCGCGCTCTGCTGCCTCCCGGGCGCCGCGCGGGCGGCGGCGGCGGCGGCGGGGGCAGGG
AACCGGGCAGCGGTGGCGGTGGCGGTGGCGCGGGCGGACGAGGCGGAGGCGCCCTTCGCC
GGGCAGAACTGGTTAAAGTCCTATGGCTATCTGCTTCCCTATGACTCACGGGCATCTGCG
CTGCACTCAGCGAAGGCCTTGCAGTCGGCAGTCTCCACTATGCAGCAGTTTTACGGGATC
CCGGTCACCGGTGTGTTGGATCAGACAACGATCGAGTGGATGAAGAAACCCCGATGTGGT
GTCCCTGATCACCCCCACTTAAGCCGTAGGCGGAGAAACAAGCGCTATGCCCTGACTGGA
CAGAAGTGGAGGCAAAAACACATCACCTACAGCATTCACAACTATACCCCAAAAGTGGGT
GAGCTAGACACGCGGAAAGCTATTCGCCAGGCTTTCGATGTGTGGCAGAAGGTGACCCCA
CTGACCTTTGAAGAGGTGCCATACCATGAGATCAAAAGTGACCGGAAGGAGGCAGACATC
ATGATCTTTTTTGCTTCTGGTTTCCATGGCGACAGCTCCCCATTTGATGGAGAAGGGGGA
TTCCTGGCCCATGCCTACTTCCCTGGCCCAGGGATTGGAGGAGACACCCACTTTGACTCC
GATGAGCCATGGACGCTAGGAAATGCCAACCATGACGGGAACGACCTCTTCCTGGTGGCT
GTGCATGAGCTGGGCCACGCGCTGGGACTGGAGCACTCCAGCGACCCCAGCGCCATCATG
GCGCCCTTCTACCAGTACATGGAGACGCACAACTTCAAGCTGCCCCAGGACGATCTCCAG
GGCATCCAGAAGATCTATGGACCCCCAGCCGAGCCTCTGGAGCCCACAAGGCCACTCCCT
ACACTCCCCGTCCGCAGGATCCACTCACCATCGGAGAGGAAACACGAGCGCCAGCCCAGG
CCCCCTCGGCCGCCCCTCGGGGACCGGCCATCCACACCAGGCACCAAACCCAACATCTGT
GACGGCAACTTCAACACAGTGGCCCTCTTCCGGGGCGAGATGTTTGTCTTTAAGGATCGC
TGGTTCTGGCGTCTGCGCAATAACCGAGTGCAGGAGGGCTACCCCATGCAGATCGAGCAG
TTCTGGAAGGGCCTGCCTGCCCGCATCGACGCAGCCTATGAAAGGGCCGATGGGAGATTT
GTCTTCTTCAAAGGTGACAAGTATTGGGTGTTTAAGGAGGTGACGGTGGAGCCTGGGTAC
CCCCACAGCCTGGGGGAGCTGGGCAGCTGTTTGCCCCGTGAAGGCATTGACACAGCTCTG
CGCTGGGAACCTGTGGGCAAGACCTACTTTTTCAAAGGCGAGCGGTACTGGCGCTACAGC
GAGGAGCGGCGGGCCACGGACCCTGGCTACCCTAAGCCCATCACCGTGTGGAAGGGCATT
CCACAGGCTCCCCAAGGAGCCTTCATCAGCAAGGAAGGATATTACACCTATTTCTACAAG
GGCCGGGACTACTGGAAGTTTGACAACCAGAAACTGAGCGTGGAGCCAGGCTACCCGCGC
AACATCCTGCGTGACTGGATGGGCTGCAACCAGAAGGAGGTGGAGCGGCGGAAGGAGCGG
CGGCTGCCCCAGGACGACGTGGACATCATGGTGACCATCAACGATGTGCCGGGCTCCGTG
AACGCCGTGGCCGTGGTCATCCCCTGCATCCTGTCCCTCTGCATCCTGGTGCTGGTCTAC
ACCATCTTCCAGTTCAAGAACAAGACAGGCCCTCAGCCTGTCACCTACTATAAGCGGCCA
GTCCAGGAATGGGTGTGA
Protein Properties
Number of Residues 645
Molecular Weight 73230.9
Theoretical pI 9.58
Pfam Domain Function
Signals
  • 1-52
Transmembrane Regions
  • 603-623
Protein Sequence
>Matrix metalloproteinase-24
MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAG
NRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGI
PVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVG
ELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGG
FLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIM
APFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPR
PPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQ
FWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTAL
RWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYK
GRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSV
NAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV
GenBank ID Protein 5381386
UniProtKB/Swiss-Prot ID Q9Y5R2
UniProtKB/Swiss-Prot Entry Name MMP24_HUMAN
PDB IDs Not Available
GenBank Gene ID AF131284
GeneCard ID MMP24
GenAtlas ID MMP24
HGNC ID HGNC:7172
References
General References
  1. Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y: Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Anal Sci. 2008 Jan;24(1):161-6. [PubMed:18187866 ]
  2. Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [PubMed:11780052 ]
  3. Llano E, Pendas AM, Freije JP, Nakano A, Knauper V, Murphy G, Lopez-Otin C: Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors. Cancer Res. 1999 Jun 1;59(11):2570-6. [PubMed:10363975 ]