| Identification |
|---|
| HMDB Protein ID
| HMDBP07832 |
| Secondary Accession Numbers
| |
| Name
| NKG2D ligand 3 |
| Synonyms
|
- ALCAN-gamma
- N2DL-3
- NKG2DL3
- Retinoic acid early transcript 1N
|
| Gene Name
| ULBP3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in immune response |
| Specific Function
| Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1 |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| mhc protein complex |
| mhc class i protein complex |
| membrane |
| cell part |
| macromolecular complex |
| protein complex |
| Process |
| antigen processing and presentation |
| immune system process |
| immune response |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q25 |
| SNPs
| ULBP3 |
| Gene Sequence
|
>735 bp
ATGGCAGCGGCCGCCAGCCCCGCGATCCTTCCGCGCCTCGCGATTCTTCCGTACCTGCTA
TTCGACTGGTCCGGGACGGGGCGGGCCGACGCTCACTCTCTCTGGTATAACTTCACCATC
ATTCATTTGCCCAGACATGGGCAACAGTGGTGTGAGGTCCAGAGCCAGGTGGATCAGAAG
AATTTTCTCTCCTATGACTGTGGCAGTGACAAGGTCTTATCTATGGGTCACCTAGAAGAG
CAGCTGTATGCCACAGATGCCTGGGGAAAACAACTGGAAATGCTGAGAGAGGTGGGGCAG
AGGCTCAGACTGGAACTGGCTGACACTGAGCTGGAGGATTTCACACCCAGTGGACCCCTC
ACGCTGCAGGTCAGGATGTCTTGTGAGTGTGAAGCCGATGGATACATCCGTGGATCTTGG
CAGTTCAGCTTCGATGGACGGAAGTTCCTCCTCTTTGACTCAAACAACAGAAAGTGGACA
GTGGTTCACGCTGGAGCCAGGCGGATGAAAGAGAAGTGGGAGAAGGATAGCGGACTGACC
ACCTTCTTCAAGATGGTCTCAATGAGAGACTGCAAGAGCTGGCTTAGGGACTTCCTGATG
CACAGGAAGAAGAGGCTGGAACCCACAGCACCACCCACCATGGCCCCAGGCTTAGCTCAA
CCCAAAGCCATAGCCACCACCCTCAGTCCCTGGAGCTTCCTCATCATCCTCTGCTTCATC
CTCCCTGGCATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 244 |
| Molecular Weight
| 27949.0 |
| Theoretical pI
| 8.13 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>NKG2D ligand 3
MAAAASPAILPRLAILPYLLFDWSGTGRADAHSLWYNFTIIHLPRHGQQWCEVQSQVDQK
NFLSYDCGSDKVLSMGHLEEQLYATDAWGKQLEMLREVGQRLRLELADTELEDFTPSGPL
TLQVRMSCECEADGYIRGSWQFSFDGRKFLLFDSNNRKWTVVHAGARRMKEKWEKDSGLT
TFFKMVSMRDCKSWLRDFLMHRKKRLEPTAPPTMAPGLAQPKAIATTLSPWSFLIILCFI
LPGI
|
| External Links |
|---|
| GenBank ID Protein
| 14530667 |
| UniProtKB/Swiss-Prot ID
| Q9BZM4 |
| UniProtKB/Swiss-Prot Entry Name
| N2DL3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB052908 |
| GeneCard ID
| ULBP3 |
| GenAtlas ID
| ULBP3 |
| HGNC ID
| HGNC:14895 |
| References |
|---|
| General References
| - Cosman D, Mullberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ: ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity. 2001 Feb;14(2):123-33. [PubMed:11239445 ]
- Radosavljevic M, Cuillerier B, Wilson MJ, Clement O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S: A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. Genomics. 2002 Jan;79(1):114-23. [PubMed:11827464 ]
- Steinle A, Li P, Morris DL, Groh V, Lanier LL, Strong RK, Spies T: Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. Immunogenetics. 2001 May-Jun;53(4):279-87. [PubMed:11491531 ]
- Cerwenka A, Lanier LL: NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer. Tissue Antigens. 2003 May;61(5):335-43. [PubMed:12753652 ]
- Radaev S, Rostro B, Brooks AG, Colonna M, Sun PD: Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3. Immunity. 2001 Dec;15(6):1039-49. [PubMed:11754823 ]
|
