| Identification |
|---|
| HMDB Protein ID
| HMDBP07848 |
| Secondary Accession Numbers
| |
| Name
| Neuropeptide FF receptor 2 |
| Synonyms
|
- G-protein coupled receptor 74
- G-protein coupled receptor HLWAR77
- Neuropeptide G-protein coupled receptor
|
| Gene Name
| NPFFR2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| neuropeptide receptor activity |
| receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| peptide receptor activity, g-protein coupled |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q21 |
| SNPs
| NPFFR2 |
| Gene Sequence
|
>1569 bp
ATGAATAGCTTCTTCGGAACCCCAGCGGCCAGCTGGTGCCTCCTGGAAAGTGACGTCTCA
TCTGCACCGGACAAGGAGGCGGGGAGGGAGCGCAGAGCACTCAGCGTCCAGCAGCGCGGC
GGGCCAGCCTGGAGCGGAAGCCTGGAGTGGAGCAGGCAGTCCGCGGGGGACAGACGTCGG
CTGGGATTGAGCCGGCAGACTGCGAAAAGTAGCTGGAGCCGGAGCAGGGACAGAACCTGT
TGCTGCAGACGGGCTTGGTGGATTCTGGTTCCTGCCGCCGACAGGGCTCGCCGGGAGAGG
TTCATCATGAATGAGAAATGGGACACAAACTCTTCAGAAAACTGGCATCCCATCTGGAAT
GTCAATGACACAAAGCATCATCTGTACTCAGATATTAATATTACCTATGTGAACTACTAT
CTTCACCAGCCTCAAGTGGCAGCAATCTTCATTATTTCCTACTTTCTGATCTTCTTTTTG
TGCATGATGGGAAATACTGTGGTTTGCTTTATTGTAATGAGGAACAAACATATGCACACA
GTCACTAATCTCTTCATCTTAAACCTGGCCATAAGTGATTTACTAGTTGGCATATTCTGC
ATGCCTATAACACTGCTGGACAATATTATAGCAGGATGGCCATTTGGAAACACGATGTGC
AAGATCAGTGGATTGGTCCAGGGAATATCTGTCGCAGCTTCAGTCTTTACGTTAGTTGCA
ATTGCTGTAGATAGGTTCCAGTGTGTGGTCTACCCTTTTAAACCAAAGCTCACTATCAAG
ACAGCGTTTGTCATTATTATGATCATCTGGGTCCTAGCCATCACCATTATGTCTCCATCT
GCAGTAATGTTACATGTGCAAGAAGAAAAATATTACCGAGTGAGACTCAACTCCCAGAAT
AAAACCAGTCCAGTCTACTGGTGCCGGGAAGACTGGCCAAATCAGGAAATGAGGAAGATC
TACACCACTGTGCTGTTTGCCAACATCTACCTGGCTCCCCTCTCCCTCATTGTCATCATG
TATGGAAGGATTGGAATTTCACTCTTCAGGGCTGCAGTTCCTCACACAGGCAGGAAGAAC
CAGGAGCAGTGGCACGTGGTGTCCAGGAAAAAGCAGAAGATCATTAAGATGCTCCTGATT
GTGGCCCTGCTTTTTATTCTCTCATGGCTGCCCCTGTGGACTCTAATGATGCTCTCAGAC
TACGCTGACCTTTCTCCAAATGAACTGCAGATCATCAACATCTACATCTACCCTTTTGCA
CACTGGCTGGCATTCGGCAACAGCAGTGTCAATCCCATCATTTATGGTTTCTTCAACGAG
AATTTCCGCCGTGGTTTCCAAGAAGCTTTCCAGCTCCAGCTCTGCCAAAAAAGAGCAAAG
CCTATGGAAGCTTATACCCTAAAAGCTAAAAGCCATGTGCTCATAAACACATCTAATCAG
CTTGTCCAGGAATCTACATTTCAAAACCCTCATGGGGAAACCTTGCTTTATAGGAAAAGT
GCTGAAAAACCCCAACAGGAATTAGTGATGGAAGAATTAAAAGAAACTACTAACAGCAGT
GAGATTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 522 |
| Molecular Weight
| 60269.7 |
| Theoretical pI
| 9.69 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 148-168
- 185-205
- 222-242
- 263-283
- 320-340
- 378-398
- 414-434
|
| Protein Sequence
|
>Neuropeptide FF receptor 2
MNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRR
LGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWN
VNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHT
VTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVA
IAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQN
KTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKN
QEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFA
HWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQ
LVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
|
| External Links |
|---|
| GenBank ID Protein
| 4530469 |
| UniProtKB/Swiss-Prot ID
| Q9Y5X5 |
| UniProtKB/Swiss-Prot Entry Name
| NPFF2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF119815 |
| GeneCard ID
| NPFFR2 |
| GenAtlas ID
| NPFFR2 |
| HGNC ID
| HGNC:4525 |
| References |
|---|
| General References
| - Bonini JA, Jones KA, Adham N, Forray C, Artymyshyn R, Durkin MM, Smith KE, Tamm JA, Boteju LW, Lakhlani PP, Raddatz R, Yao WJ, Ogozalek KL, Boyle N, Kouranova EV, Quan Y, Vaysse PJ, Wetzel JM, Branchek TA, Gerald C, Borowsky B: Identification and characterization of two G protein-coupled receptors for neuropeptide FF. J Biol Chem. 2000 Dec 15;275(50):39324-31. [PubMed:11024015 ]
- Cikos S, Gregor P, Koppel J: Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta. Biochem Biophys Res Commun. 1999 Mar 16;256(2):352-6. [PubMed:10079187 ]
- Elshourbagy NA, Ames RS, Fitzgerald LR, Foley JJ, Chambers JK, Szekeres PG, Evans NA, Schmidt DB, Buckley PT, Dytko GM, Murdock PR, Milligan G, Groarke DA, Tan KB, Shabon U, Nuthulaganti P, Wang DY, Wilson S, Bergsma DJ, Sarau HM: Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J Biol Chem. 2000 Aug 25;275(34):25965-71. [PubMed:10851242 ]
- Parker RM, Copeland NG, Eyre HJ, Liu M, Gilbert DJ, Crawford J, Couzens M, Sutherland GR, Jenkins NA, Herzog H: Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family. Brain Res Mol Brain Res. 2000 May 5;77(2):199-208. [PubMed:10837915 ]
|
