Hmdb loader
Identification
HMDB Protein ID HMDBP07849
Secondary Accession Numbers
  • 13558
Name Neuronal pentraxin-1
Synonyms
  1. NP-I
  2. NP1
  3. Neuronal pentraxin I
Gene Name NPTX1
Protein Type Unknown
Biological Properties
General Function Involved in metal ion binding
Specific Function May mediate uptake of degraded synaptic material which could play an important role in synaptic remodeling. Can mediate the neuronal and glial uptake of the snake venom toxin taipoxin
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Cytoplasmic vesicle
  2. secretory vesicle (Potential)
Gene Properties
Chromosome Location Chromosome:1
Locus 17q25.3
SNPs NPTX1
Gene Sequence
>1299 bp
ATGCCGGCCGGCCGCGCCGCGCGCACCTGTGCGCTGCTCGCCCTCTGCCTCCTGGGCGCC
GGGGCCCAGGATTTCGGGCCGACGCGCTTCATCTGCACCTCGGTGCCCGTGGACGCCGAC
ATGTGCGCCGCGTCCGTGGCCGCCGGCGGCGCCGAGGAGCTCCGGAGCAGCGTGCTGCAG
CTCCGCGAGACGGTGCTGCAGCAGAAGGAGACCATCCTGAGCCAGAAGGAGACCATCCGC
GAGCTGACCGCCAAGCTGGGCCGCTGCGAGAGCCAGAGCACGCTGGACCCCGGAGCCGGC
GAGGCCCGGGCGGGCGGCGGCCGCAAGCAGCCCGGCTCGGGCAAGAACACCATGGGCGAC
CTGTCCCGGACACCGGCCGCCGAGACGCTCAGCCAACTCGGGCAAACTTTGCAATCGCTC
AAAACCCGCCTGGAGAACCTCGAGCAGTACAGCCGCCTCAATTCCTCCAGCCAGACCAAC
AGCCTCAAGGATCTGCTGCAGAGCAAGATCGATGAGCTGGAGAGGCAGGTGCTGTCCCGG
GTGAACACCCTGGAGGAGGGCAAGGGGGGCCCCAGGAACGACACCGAGGAGAGGGTCAAG
ATCGAGACCGCCCTGACCTCCCTGCACCAGCGGATCAGCGAGCTCGAGAAAGGTCAGAAA
GACAACCGCCCTGGAGACAAGTTCCAGCTCACATTCCCACTGCGGACCAACTATATGTAT
GCCAAGGTGAAGAAGAGCCTGCCAGAGATGTACGCCTTCACTGTCTGCATGTGGCTCAAG
TCCAGCGCCACGCCAGGTGTGGGCACGCCCTTCTCCTACGCTGTGCCCGGCCAGGCCAAC
GAGCTGGTCCTCATTGAGTGGGGCAACAACCCCATGGAGATCCTCATCAATGACAAGGTG
GCCAAGCTGCCTTTTGTCATCAATGATGGCAAGTGGCACCACATCTGTGTCACCTGGACC
ACCCGGGACGGGGTCTGGGAGGCCTACCAGGATGGCACGCAGGGTGGCAGTGGCGAGAAC
TTGGCGCCCTATCACCCCATCAAGCCCCAGGGCGTGCTGGTGCTGGGCCAGGAGCAGGAC
ACTCTGGGTGGTGGGTTTGATGCCACCCAGGCATTTGTGGGTGAGCTGGCCCACTTCAAC
ATCTGGGACCGCAAGCTGACCCCCGGGGAGGTGTACAACCTGGCCACCTGCAGCACCAAG
GCTCTGTCCGGCAATGTCATCGCCTGGGCTGAATCCCACATCGAGATCTACGGCGGGGCC
ACCAAGTGGACCTTCGAGGCCTGTCGCCAGATCAACTGA
Protein Properties
Number of Residues 432
Molecular Weight 47122.0
Theoretical pI 6.52
Pfam Domain Function
Signals
  • 1-22
Transmembrane Regions
  • None
Protein Sequence
>Neuronal pentraxin-1
MPAGRAARTCALLALCLLGAGAQDFGPTRFICTSVPVDADMCAASVAAGGAEELRSSVLQ
LRETVLQQKETILSQKETIRELTAKLGRCESQSTLDPGAGEARAGGGRKQPGSGKNTMGD
LSRTPAAETLSQLGQTLQSLKTRLENLEQYSRLNSSSQTNSLKDLLQSKIDELERQVLSR
VNTLEEGKGGPRNDTEERVKIETALTSLHQRISELEKGQKDNRPGDKFQLTFPLRTNYMY
AKVKKSLPEMYAFTVCMWLKSSATPGVGTPFSYAVPGQANELVLIEWGNNPMEILINDKV
AKLPFVINDGKWHHICVTWTTRDGVWEAYQDGTQGGSGENLAPYHPIKPQGVLVLGQEQD
TLGGGFDATQAFVGELAHFNIWDRKLTPGEVYNLATCSTKALSGNVIAWAESHIEIYGGA
TKWTFEACRQIN
GenBank ID Protein 193785332
UniProtKB/Swiss-Prot ID Q15818
UniProtKB/Swiss-Prot Entry Name NPTX1_HUMAN
PDB IDs Not Available
GenBank Gene ID AK127335
GeneCard ID NPTX1
GenAtlas ID NPTX1
HGNC ID HGNC:7952
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Omeis IA, Hsu YC, Perin MS: Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization. Genomics. 1996 Sep 15;36(3):543-5. [PubMed:8884281 ]