Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP07873
Secondary Accession Numbers
  • 13584
Name Protocadherin-18
Synonyms Not Available
Gene Name PCDH18
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Potential calcium-dependent cell-adhesion protein
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:4
Locus 4q31
SNPs PCDH18
Gene Sequence
>3408 bp
ATGCACCAAATGAATGCTAAAATGCACTTTAGGTTTGTTTTTGCACTTCTGATAGTATCT
TTCAACCACGATGTACTGGGCAAGAATTTGAAATACAGGATTTATGAGGAACAGAGGGTT
GGATCAGTAATTGCAAGACTATCAGAGGATGTGGCTGATGTTTTATTGAAGCTTCCTAAT
CCTTCTACTGTTCGATTTCGAGCCATGCAGAGGGGAAATTCTCCTCTACTTGTAGTAAAC
GAGGATAATGGGGAAATCAGCATAGGGGCTACAATTGACCGTGAACAACTGTGCCAGAAA
AACTTGAACTGTTCCATAGAGTTTGATGTGATCACTCTACCCACAGAGCATCTGCAGCTT
TTCCATATTGAAGTTGAAGTGCTGGATATTAATGACAATTCTCCCCAGTTTTCAAGATCT
CTCATACCTATTGAGATATCTGAGAGTGCAGCAGTTGGGACTCGCATTCCCCTGGACAGT
GCATTTGATCCAGATGTTGGGGAAAATTCCCTCCACACATACTCGCTCTCTGCCAATGAT
TTTTTTAATATCGAGGTTCGGACCAGGACTGATGGAGCCAAGTATGCAGAACTCATAGTG
GTCAGAGAGTTAGATCGGGAGCTGAAGTCAAGCTACGAGCTTCAGCTCACTGCCTCAGAC
ATGGGAGTACCTCAGAGGTCTGGCTCATCCATACTAAAAATAAGCATTTCAGACTCCAAT
GACAACAGCCCTGCTTTTGAGCAGCAATCTTATATAATACAACTCTTAGAAAACTCCCCG
GTTGGCACTTTGCTCTTAGATCTGAATGCCACGGATCCAGATGAGGGCGCTAATGGGAAA
ATTGTATATTCCTTCAGCAGTCATGTGTCTCCCAAAATTATGGAGACTTTTAAAATTGAT
TCTGAAAGAGGACATTTGACTCTTTTCAAGCAAGTGGATTATGAAATCACCAAATCCTAT
GAGATTGATGTTCAGGCTCAAGATTTGGGTCCAAATTCAATCCCAGCCCATTGCAAAATT
ATAATTAAGGTTGTGGATGTTAATGACAATAAACCTGAAATTAACATCAACCTCATGTCC
CCTGGAAAAGAAGAAATATCTTATATTTTTGAAGGGGATCCTATTGATACATTTGTTGCT
TTGGTCAGAGTTCAGGACAAGGATTCTGGGCTGAATGGAGAAATAGTTTGTAAGCTTCAT
GGACATGGTCACTTTAAACTTCAGAAGACATATGAAAACAATTATTTAATCTTAACTAAT
GCCACACTGGATAGAGAAAAGAGATCTGAGTATAGTTTGACTGTAATCGCTGAGGACAGG
GGGACACCCAGTCTCTCTACAGTGAAACATTTTACAGTTCAAATCAATGATATCAATGAC
AATCCACCCCACTTCCAGAGAAGCCGATATGAATTTGTAATTTCAGAAAATAACTCACCA
GGGGCATATATCACCACTGTTACAGCCACAGATCCTGATCTTGGAGAAAATGGGCAAGTG
ACATACACCATCTTGGAGAGTTTTATTCTAGGAAGTTCCATAACTACATATGTAACCATT
GACCCATCTAATGGAGCCATCTATGCCCTCAGAATCTTTGATCATGAAGAAGTGAGTCAG
ATCACTTTTGTGGTAGAAGCAAGAGATGGAGGAAGCCCGAAGCAACTGGTAAGCAATACC
ACAGTTGTGCTCACCATCATTGACGAAAATGACAACGTTCCTGTGGTTATAGGGCCTGCA
TTGCGTAATAATACGGCAGAAATCACCATTCCCAAAGGGGCTGAAAGTGGCTTTCATGTC
ACAAGAATAAGGGCAATTGACAGAGACTCTGGTGTGAATGCTGAACTCAGCTGCGCCATA
GTAGCAGGTAATGAGGAGAATATCTTCATAATTGATCCACGATCATGTGACATCCATACC
AACGTTAGCATGGATTCTGTTCCCTACACAGAATGGGAGCTGTCAGTTATCATTCAGGAC
AAAGGCAATCCTCAGCTACATACCAAAGTCCTTCTGAAGTGCATGATCTTTGAATATGCA
GAGTCGGTGACAAGTACAGCAATGACTTCAGTAAGCCAGGCATCCTTGGATGTCTCCATG
ATAATAATTATTTCCTTAGGAGCAATTTGTGCAGTGTTGCTGGTTATTATGGTGCTATTT
GCAACTAGGTGTAACCGCGAGAAGAAAGACACTAGATCCTATAACTGCAGGGTGGCCGAA
TCAACTTACCAGCACCACCCAAAAAGGCCATCCCGGCAGATTCACAAAGGGGACATCACA
TTGGTGCCTACCATAAATGGCACTCTGCCCATCAGATCTCATCACAGATCGTCTCCATCT
TCATCTCCTACCTTAGAAAGAGGGCAGATGGGCAGCCGGCAGAGTCACAACAGTCACCAG
TCACTCAACAGTTTGGTGACAATCTCATCAAACCACGTGCCAGAGAATTTCTCATTAGAA
CTCACCCACGCCACTCCTGCTGTTGAGCAGGTCTCTCAGCTTCTTTCAATGCTTCACCAG
GGGCAATATCAGCCAAGACCAAGTTTTCGAGGAAACAAATATTCCAGGAGCTACAGATAT
GCCCTTCAAGACATGGACAAATTTAGCTTGAAAGACAGTGGCCGTGGTGACAGTGAGGCA
GGAGACAGTGATTATGATTTGGGGCGAGATTCTCCAATAGATAGGCTGTTGGGTGAAGGA
TTCAGCGACCTGTTTCTCACAGATGGAAGAATTCCAGCAGCTATGAGACTCTGCACGGAG
GAGTGCAGGGTCCTGGGACACTCTGACCAGTGCTGGATGCCACCACTGCCCTCACCGTCT
TCTGATTATAGGAGTAACATGTTCATTCCAGGGGAAGAATTCCCAACGCAACCCCAGCAG
CAGCATCCACATCAGAGTCTTGAGGATGACGCTCAGCCTGCAGATTCCGGTGAAAAGAAG
AAGAGTTTTTCCACCTTTGGAAAGGACTCCCCAAACGATGAGGACACTGGGGATACCAGC
ACATCATCTCTGCTCTCGGAAATGAGCAGTGTGTTCCAGCGTCTCTTACCGCCTTCCCTG
GACACCTATTCTGAATGCAGTGAGGTGGATCGGTCCAACTCCCTGGAGCGCAGGAAGGGA
CCCTTGCCAGCCAAAACTGTGGGTTACCCACAGGGGGTAGCGGCATGGGCAGCCAGTACG
CATTTTCAAAATCCCACCACCAACTGTGGGCCGCCACTTGGAACTCACTCCAGTGTGCAG
CCTTCTTCAAAATGGCTGCCAGCCATGGAGGAGATCCCTGAAAATTATGAGGAAGATGAT
TTTGACAATGTGCTCAACCACCTCAATGATGGGAAACACGAACTCATGGATGCCAGTGAA
CTGGTGGCAGAGATTAACAAACTGCTTCAAGATGTCCGCCAGAGCTAG
Protein Properties
Number of Residues 1135
Molecular Weight 126148.0
Theoretical pI 4.78
Pfam Domain Function
Signals
  • 1-27
Transmembrane Regions
  • 700-720
Protein Sequence
>Protocadherin-18
MHQMNAKMHFRFVFALLIVSFNHDVLGKNLKYRIYEEQRVGSVIARLSEDVADVLLKLPN
PSTVRFRAMQRGNSPLLVVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQL
FHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSAND
FFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSN
DNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKID
SERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININLMS
PGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTN
ATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISENNSP
GAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQ
ITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHV
TRIRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQD
KGNPQLHTKVLLKCMIFEYAESVTSTAMTSVSQASLDVSMIIIISLGAICAVLLVIMVLF
ATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTINGTLPIRSHHRSSPS
SSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQ
GQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEG
FSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPTQPQQ
QHPHQSLEDDAQPADSGEKKKSFSTFGKDSPNDEDTGDTSTSSLLSEMSSVFQRLLPPSL
DTYSECSEVDRSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPTTNCGPPLGTHSSVQ
PSSKWLPAMEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS
GenBank ID Protein 14589929
UniProtKB/Swiss-Prot ID Q9HCL0
UniProtKB/Swiss-Prot Entry Name PCD18_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_019035.3
GeneCard ID PCDH18
GenAtlas ID PCDH18
HGNC ID HGNC:14268
References
General References
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