Human Metabolome Database: Showing Protein Protocadherin alpha-3 (HMDBP07880)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07880

Secondary Accession Numbers

13591

Name

Protocadherin alpha-3

Synonyms

PCDH-alpha-3

Gene Name

PCDHA3

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q31

SNPs

PCDHA3

Gene Sequence

>2853 bp
ATGTTGTTCTCCTGGCGAGAAGATCCTGGAGCCCAGTGCCTGCTGCTTTCTCTTCTGCTC
CTCGCAGCCTCGGAGGTGGGGAGCGGCCAGCTCCACTACTCCGTCTCTGAGGAGGCCAAG
CATGGCACCTTCGTGGGCCGCATCGCGCAGGACCTGGGGCTGGAGCTGGCGGAGCTGGTG
CCGCGCCTGTTCCGGGTGGCGTCCAAAAGACACGGGGACCTTCTGGAGGTAAATCTGCAG
AATGGCATTTTGTTTGTGAATTCTCGGATAGACCGCGAGGAACTGTGCGGGCGGAGCGCG
GAGTGCAGCATCCACCTGGAGGTGATCGTGGACAGGCCGCTGCAGGTTTTCCATGTGGAG
GTGGAAGTGAAGGACATTAATGACAACGCGCCAGTTTTTCCAATGGCTGTAAAGAATCTG
TTTATTTCCGAATCCCGACAGCCTGGCTCTCGGTTTTCGCTAGAGGGCGCATCAGATGCA
GATATCGGAACAAATTCGTTGTTGACTTACAGTCTTGATTCCACTGAATATTTTACCTTG
GACGTTAAAAGAAATGATGAGGAAATTAAATCCCTTGGACTCGTGTTGAAAAAAAATTTA
AATCGAGAGGACACTCCTAAGCATTATTTACTAATAACAGCAATTGATGGTGGGAAACCA
GAGCTCACTGGCACGACTCAACTAAAGATCACTGTTTTAGATGTAAACGACAACGCCCCA
GCGTTTGAGAGGACGATCTATAAAGTCAGATTACTCGAAAATGCACCAAATGGTACCCTA
GTGGTGACCGTTAACGCCACCGATTTGGATGAAGGAGTAAATAAGGATATCGCGTATTCT
TTCAATACGGACATGTCAGCAGATATTCTGTCAAAATTCCATTTAGATCCAGTCAATGGA
CAAATCAGTGTAAAGGGTAACATAGATTTCGAGGAAAGTAAGTCATATGAAATCCAGGTA
GAAGCCACGGATAAAGGAAATCCCCCAATGTCAGATCACTGCACAGTTCTACTCGAAATT
GTGGACATCAATGATAATGTACCTGAGTTAGTTATTCAATCACTATCTTTACCTGTATTA
GAAGACTCTCCACTTAGCACAGTCATCGCTCTGATCAGCGTGTCCGACCGCGACTCAGGA
GTCAATGGACAGGTCACCTGCTCGCTGACGCCCCACGTCCCCTTCAAGCTGGTGTCCACC
TTCAAGAATTACTACTCATTGGTGCTGGACAGCCCTCTGGACCGCGAGAGCGTGTCGGCC
TATGAGCTGGTGGTGACTGCTCGGGACGGGGGCTCGCCTTCACTGTGGGCCACGGCCAGC
GTGTCCGTGGAGGTGGCCGACGTGAACGACAATGCGCCGGCATTCTCGCAGTCCGAGTAC
ACGGTGTTCGTGAAGGAGAACAACCCGCCGGGCTGCCACATCTTCACGGTGTCTGCGCGG
GACGCGGACGCGCAGGAGAACGCCCTGGTGTCCTACTCGCTGGTGGAACGGCGGGTGGGG
GAGCGCGCGCTGTCGAGCTACGTGTCGGTACACGCGGAGAGCGGCAAGGTGTACGCGCTG
CAGCCGCTGGACCACGAGGAGCTAGAGCTGCTGCAGTTCCAGGTGAGTGCGCGCGATGCG
GGCGTGCCGCCTCTGGGCAGCAACGTGACGCTGCAGGTGTTCGTGCTGGACGAGAACGAC
AACGCGCCGGCACTGCTGATGCCTCGGGTGGGTGGCATCGGTGGCGCAGTGAGCGAGCTG
GTGCCGCGGTCAGTGGGTGCGGGCCACGTGGTAGCGAAGGTGCGCGCAGTGGATGCAGAC
TCAGGCTACAACGCGTGGCTTTCGTATGAGCTGCAGCCTGGGACCGGCGGTGCGCGCATC
CCGTTTCGCGTGGGGCTGTACACGGGAGAGATCAGCACGACCCGTGCCCTGGACGAGGTG
GACGCCCCGCGCCATCGCCTACTGGTGCTGGTGAAGGACCACGGTGAACCCTCATTGACC
GCCACGGCCACTGTGCTGGTGTCGCTGGTGGAGAGTGGCCAGGCACCCAAGGCCTCGTCC
CAGGCGTCCGCTGGCGCCACGGGCCCGGAAGCTGCACTGGTGGATGTCAACGTGTACTTG
ATCGTCGCCATCTGCGCGGTGTCCAGTCTGTTGGTGCTCACACTGCTGCTATATACTGCT
CTGCGGTGCTCCGCGCCGCCAACCGAAGGCGACTGTGGGCCGGGCAAGCCCACGCTGGTG
TGCTCCAGCGCGGTGGGGAGCTGGTCATACTCGCAGCAGAGGCAGCAGAGGGTGTGCTCT
GGAGAGGGGTTGCCCAAGACCGACCTCATGGCTTTTAGCCCTAGCCTTCCTCCTTGTCCA
ATTAGCCGGGATAGAGAGGAGAAACAGGATGTGGACGTTGATCTCTCAGCCAAACCACGA
CAGCCCAACCCTGACTGGCGTTACTCTGCCTCCCTGAGAGCAGGCATGCACAGCTCTGTG
CACCTAGAGGAGGCTGGCATTCTACGGGCTGGTCCAGGAGGGCCTGATCAGCAGTGGCCA
ACAGTATCCAGTGCAACACCAGAACCAGAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCG
GGTGTCAACAGCAACAGCTGGACCTTTAAATACGGACCAGGCAACCCCAAACAATCCGGT
CCCGGTGAGTTGCCCGACAAATTCATTATCCCAGGATCTCCTGCAATCATCTCCATCCGG
CAGGAGCCTACTAACAGCCAAATTGACAAAAGTGACTTCATAACCTTCGGCAAAAAGGAG
GAGACCAAGAAAAAGAAGAAAAAGAAGAAGGGTAACAAGACCCAGGAGAAAAAAGAGAAA
GGGAACAGCACGACTGACAACAGTGACCAGTGA

Protein Properties

Number of Residues

950

Molecular Weight

102427.3

Theoretical pI

4.7

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_2 (PF08266 )

Signals

1-29

Transmembrane Regions

698-718

Protein Sequence

>Protocadherin alpha-3
MLFSWREDPGAQCLLLSLLLLAASEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV
PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVE
VEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYFTL
DVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAP
AFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNG
QISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVL
EDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSA
YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSAR
DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDA
GVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRAVDAD
SGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLT
ATATVLVSLVESGQAPKASSQASAGATGPEAALVDVNVYLIVAICAVSSLLVLTLLLYTA
LRCSAPPTEGDCGPGKPTLVCSSAVGSWSYSQQRQQRVCSGEGLPKTDLMAFSPSLPPCP
ISRDREEKQDVDVDLSAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWP
TVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIR
QEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ

External Links

GenBank ID Protein

9256586

UniProtKB/Swiss-Prot ID

Q9Y5H8

UniProtKB/Swiss-Prot Entry Name

PCDA3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM: The DNA sequence and comparative analysis of human chromosome 5. Nature. 2004 Sep 16;431(7006):268-74. [PubMed:15372022 ]
Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]