Human Metabolome Database: Showing Protein Protocadherin alpha-13 (HMDBP07890)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07890

Secondary Accession Numbers

13601

Name

Protocadherin alpha-13

Synonyms

PCDH-alpha-13

Gene Name

PCDHA13

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q31

SNPs

PCDHA13

Gene Sequence

>2853 bp
ATGCTGTCTTCCTGGCAAGGAGGCCCAAGACCGCGGCAACTACTGCTCTGGCTTCTGATC
CTCGCAGCCTGGGAGACGGGTAGTGGCCAGCTCCACTACTCCGTCCCCGAGGAAGCAAAA
CACGGCACCTTCGTGGGCCGCATCGCTCAGGACCTGGGGCTGGAGCTGGCGGAGCTGGTG
CCGCGCCTGTTCCGGGTGGCGTCCAAAAGACACGGGGACCTTCTGGAGGTAAATCTGCAG
AATGGCATTTTGTTTGTGAATTCTCGGATCGACCGCGAGGAGCTGTGTGGGCGGAGCGCG
GAGTGCAGCATCCACCTGGAGGTGATCGTGGACAGGCCTCTGCAGGTTTTCCATGTGGAG
GTGAAGGTGAGGGACATTAACGACAACCCGCCCATATTCCCTGAAAGCAAGAAACGAATA
ATCATTGCAGAATCTAGACCTCCGGAAACTCGATTTCCACTAGATGGCGCATCCGATGCA
GATATTGGAGTAAACTCGGCATTGACCTACCGACTGGATCCCAACGATTATTTCACTTTG
GACGCACAAAACAGTCTTGAGCAAATGTCTTCATTATCACTTGTACTGAGGAAAACACTG
GACAGAGAGGAAATTCAGGAACATAGTTTATTACTGACAGCCAGTGATGGAGGTAAACCC
GAGCTGACTGGCACAGTTCAGCTGCTCATCACGATTCTGGACGTGAATGACAACGCCCCG
GAATTTTACCAATCCGTTTATAAAGTGACGGTGTTAGAGAACGCCTTCAATGGAACATTA
GTGATCAAGCTAAATGCCACAGATCCTGATGATGGTACAAATGGAGATATAGTTTACTCA
TTTAGAAGGCCTGTATGGCCTGCAGTGGTATATGCATTTACCATAAATCCGAACAATGGA
GAAATTAGGACAAAAGGCAAACTAGATTTCGAAGAAAAGAAATTATATGAAATATCCGTG
GAGGCAGTTGACAAAGGAAATATTCCAATGGCGGGTCATTGTACCCTTTTGGTGGAAGTA
CTAGATGTAAATGATAACGCCCCAGAGGTTACCATCACTTCTTTGTCACTCCCCATCAGA
GAAGACACTCAGCCTAGCGCCATTATTGCCCTAATCAGTGTGTCCGATCGTGACTCTGGC
TCAAATGGACAGGTCACCTGCACCTTGACGCCGCATGTCCCCTTCAAGCTGGTGTCCACC
TACAAGAACTACTACTCATTAGTGCTGGACAGCGCCCTGGACCGCGAGAGCGTATCAGCC
TATGAACTGGTGGTGACCGCGCGGGACGGGGGCTCGCCTTCGCTGTGGGCCACGGCCAGC
GTGTCGGTGGGGGTGGCCGACGTGAACGACAACGCGCCGGCGTTCGCGCAGCCCGAGTAC
ACGGTGTTCGTGAAGGAAAACAATCCGCCGGGCTGCCACATCTTCACGGTGTCTGCTCAG
GACGCGGACGCACAGGAGAACGCGCTGGTCTCCTACTCGCTGGTGGAGCGGCGGGTGGGC
GAGCGTGCGCTGTCGAGCTACGTGTCGGTGCACGCGGAGAGCGGCAAGGTGTACGCGCTG
CAGCCGTTGGACCACGAGGAGCTGGAGCTGTTGCAGTTCCAGGTGAGCGCGCGCGACTCT
GGCGTGCCGCCTCTGGGCAGCAACGTGACGCTGCAGGTGTTCGTGCTGGACGAGAACGAC
AACGCTCCGGCGCTGCTGACGCCCGGGGCTGGCAGCGCGGGAGGCACAGTGAGCGAGCTG
ATGCCGCGGTCGGTGGGTGCAGGCCACGTGGTGGCGAAGGTGCGCGCGGTGGACGCCGAT
TCGGGCTACAATGCGTGGCTTTCGTATGAATTGCAGCTGGCGGCGGTCGGCGCGCGCATC
CCGTTCCGCGTGGGGCTGTACACTGGCGAGATCAGCACGACGCGCCCTCTGGACGAGGTG
GACGCGCCGCACCACCGCCTTCTGGTGCTGGTGAAGGACCACGGTGAGCCCGCGCTGACG
GCCACGGCAACGGTGCTGTTGTCGCTGGTGGAGAGCGGCCAAGCGCCACAGGCTTCGTCG
AGGGCGTCGGCAGGCGCTGTGGGTCCAGAAGCGGCGCTGGTGGATGTCAATGTTTACTTG
ATCATTGCCATCTGCGCGGTGTCCAGCCTGTTGGTGCTCACGTTGCTGCTGTATACTGCG
CTGCGGTGCTCGGCACCGCCCACCGAGGGCGCGTGCGCGCCGGGCAAGCCCACTCTAGTG
TGCTCCAGCGCGGCAGGGAGTTGGTCGTACTCGCAGCAGAGGCGGCCGAGGGTGTGCTCT
GGGGAGGGCCCGCATAAGACGGACCTCATGGCCTTCAGTCCCAGCCTTCCTCCTTGTCTG
GGTTCTGCAGAGGGAACAGGCCAGAGGGAGGAGGACTCAGAATGCTTGAAAGAGCCACGA
CAGCCCAACCCTGACTGGCGTTACTCTGCCTCCCTGAGAGCAGGCATGCACAGCTCTGTG
CACCTAGAGGAGGCTGGCATTCTACGGGCTGGTCCAGGAGGGCCTGATCAGCAGTGGCCA
ACAGTATCCAGTGCAACACCAGAACCAGAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCG
GGTGTCAACAGCAACAGCTGGACCTTTAAATACGGACCAGGCAACCCCAAACAATCCGGT
CCCGGTGAGTTGCCCGACAAATTCATTATCCCAGGATCTCCTGCAATCATCTCCATCCGG
CAGGAGCCTACTAACAGCCAAATTGACAAAAGTGACTTCATAACCTTCGGCAAAAAGGAG
GAGACCAAGAAAAAGAAGAAAAAGAAGAAGGGTAACAAGACCCAGGAGAAAAAAGAGAAA
GGGAACAGCACGACTGACAACAGTGACCAGTGA

Protein Properties

Number of Residues

950

Molecular Weight

102482.4

Theoretical pI

4.85

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_2 (PF08266 )

Signals

1-29

Transmembrane Regions

698-718

Protein Sequence

>Protocadherin alpha-13
MLSSWQGGPRPRQLLLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV
PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVE
VKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTL
DAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAP
EFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNG
EIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIR
EDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSA
YELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQ
DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDS
GVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDAD
SGYNAWLSYELQLAAVGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALT
ATATVLLSLVESGQAPQASSRASAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTA
LRCSAPPTEGACAPGKPTLVCSSAAGSWSYSQQRRPRVCSGEGPHKTDLMAFSPSLPPCL
GSAEGTGQREEDSECLKEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWP
TVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIR
QEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ

External Links

GenBank ID Protein

9256580

UniProtKB/Swiss-Prot ID

Q9Y5I0

UniProtKB/Swiss-Prot Entry Name

PCDAD_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM: The DNA sequence and comparative analysis of human chromosome 5. Nature. 2004 Sep 16;431(7006):268-74. [PubMed:15372022 ]
Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]