Hmdb loader
Identification
HMDB Protein ID HMDBP07892
Secondary Accession Numbers
  • 13603
Name Protocadherin beta-2
Synonyms
  1. PCDH-beta-2
Gene Name PCDHB2
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:5
Locus 5q31
SNPs PCDHB2
Gene Sequence
>2397 bp
ATGGAGGCCGGAGAGGGGAAGGAGCGCGTTCCGAAACAAAGGCAAGTCCTGATATTCTTT
GTTTTGCTGGGCATAGCTCAGGCTAGTTGCCAGCCTAGGCACTATTCAGTGGCCGAGGAA
ACGGAGAGTGGCTCCTTTGTGGCCAATTTGTTAAAAGACCTGGGGCTGGAGATAGGAGAA
CTTGCTGTGAGGGGGGCCAGGGTCGTTTCCAAAGGAAAAAAAATGCATTTGCAGTTCGAT
AGGCAGACCGGGGATTTGTTGTTAAATGAGAAATTGGACCGGGAGGAGCTGTGCGGCCCC
ACAGAGCCCTGTGTCCTACCTTTCCAGGTGTTACTAGAAAATCCCTTGCAGTTTTTTCAG
GCGGAGCTACGGATTAGGGACGTAAATGATCATTCCCCAGTTTTCCTAGACAAAGAAATA
CTTTTGAAAATTCCAGAAAGTATCACTCCTGGAACTACTTTCTTAATAGAACGTGCCCAG
GACTTGGATGTAGGAACCAACAGTCTCCAAAATTACACAATCAGTCCCAATTTCCACTTT
CATCTTAATTTACAAGACAGTCTCGATGGCATAATATTACCACAGCTGGTGCTGAACAGA
GCCCTGGATCGCGAGGAGCAGCCTGAGATCAGGTTAACCCTCACAGCGCTAGATGGCGGG
AGTCCACCCAGGTCCGGCACGGCCCTGGTACGGATTGAAGTTGTGGACATCAATGACAAC
GTCCCAGAGTTTGCAAAGCTGCTCTATGAGGTGCAGATCCCGGAGGACAGCCCCGTTGGA
TCCCAGGTTGCCATCGTCTCTGCCAGGGATTTAGACATTGGAACTAATGGAGAAATATCT
TATGCATTTTCCCAAGCATCTGAAGACATTCGCAAAACGTTTCGATTAAGTGCAAAATCG
GGAGAACTGCTTTTAAGACAGAAACTGGATTTCGAATCCATCCAGACATACACAGTAAAT
ATTCAGGCGACAGATGGTGGGGGCCTATCTGGAACTTGTGTGGTATTTGTCCAAGTGATG
GATTTGAATGACAATCCTCCGGAACTAACTATGTCGACACTTATCAATCAGATCCCAGAA
AACTTGCAGGACACCCTCATTGCTGTATTCAGCGTTTCAGATCCTGACTCCGGAGACAAC
GGAAGGATGGTGTGCTCCATCCAAGATGATCTTCCTTTTTTCTTGAAACCTTCTGTTGAG
AACTTTTACACTCTGGTGATAAGCACGGCCCTGGACCGGGAGACCAGATCCGAATACAAC
ATCACCATCACCGTCACCGACTTCGGGACACCCAGGCTGAAAACCGAGCACAACATAACC
GTGCTGGTCTCCGACGTCAATGACAACGCCCCCGCCTTCACCCAAACCTCCTACACCCTG
TTCGTCCGCGAGAACAACAGCCCCGCCCTGCACATCGGCAGCGTCAGCGCCACAGACAGA
GACTCGGGCACCAACGCCCAGGTCACCTACTCGCTGCTGCCGCCCCAGGACCCGCACCTG
CCCCTCGCCTCCCTGGTCTCCATCAACGCGGACAACGGCCACCTGTTCGCTCTCCAGTCG
CTGGACTACGAGGCCCTGCAGGCGTTCGAGTTCCGCGTGGGCGCCGCAGACCGCGGCTCC
CCGGCGTTGAGCAGCGAGGCGCTGGTGCGCGTGCTGGTGCTGGACGCCAACGACAACTCG
CCCTTCGTGCTGTACCCGCTGCAGAACGGCTCCGCGCCCTGCACCGAGCTGGTGCCCCGG
GCGGCCGAGCCGGGCTACCTGGTGACCAAGGTGGTGGCGGTGGACGGCGACTCGGGCCAG
AACGCCTGGCTGTCGTACCAGCTGCTCAAGGCCACGGAGCCCGGGCTGTTCGGCGTGTGG
GCGCACAATGGCGAGGTGCGCACCGCCAGGCTGCTGAGGGAGCGCGACGCTGCCAAGCAG
AGGCTGGTGGTGCTGGTCAAGGACAATGGCGAGCCTCCGCGCTCGGCCACCGCCACGCTG
CACGTGCTCCTGGTGGACGGCTTCTCCCAGCCCTACCTGCTGCTCCCGGAGGCGGCACCG
GCCCAGGCCCAGGCCGACTTGCTCACCGTCTACCTGGTGGTGGCGTTGGCCTCGGTGTCT
TCGCTCTTCCTCTTCTCGGTGCTCCTGTTCGTGGCGGTGCGGCTGTGCAGGAGGAGCAGG
GCGGCCTCGGTGGGTCGCTGCTCGGTGCCCGAGGGCCCCTTTCCAGGGCAGATGGTGGAC
GTGAGCGGCACCGGGACCCTGTCCCAGAGCTACCAGTACGAGGTGTGTCTGACTGGAGGC
TCCGGGACAAATGAGTTCAAGTTCCTGAAGCCAATTATCCCCAACTTCGTTGCTCAGGGT
GCAGAGAGGGTTAGCGAGGCAAATCCCAGTTTCAGGAAGAGCTTTGAATTCACTTAA
Protein Properties
Number of Residues 798
Molecular Weight 87252.9
Theoretical pI 4.5
Pfam Domain Function
Signals
  • 1-30
Transmembrane Regions
  • 693-713
Protein Sequence
>Protocadherin beta-2
MEAGEGKERVPKQRQVLIFFVLLGIAQASCQPRHYSVAEETESGSFVANLLKDLGLEIGE
LAVRGARVVSKGKKMHLQFDRQTGDLLLNEKLDREELCGPTEPCVLPFQVLLENPLQFFQ
AELRIRDVNDHSPVFLDKEILLKIPESITPGTTFLIERAQDLDVGTNSLQNYTISPNFHF
HLNLQDSLDGIILPQLVLNRALDREEQPEIRLTLTALDGGSPPRSGTALVRIEVVDINDN
VPEFAKLLYEVQIPEDSPVGSQVAIVSARDLDIGTNGEISYAFSQASEDIRKTFRLSAKS
GELLLRQKLDFESIQTYTVNIQATDGGGLSGTCVVFVQVMDLNDNPPELTMSTLINQIPE
NLQDTLIAVFSVSDPDSGDNGRMVCSIQDDLPFFLKPSVENFYTLVISTALDRETRSEYN
ITITVTDFGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDR
DSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALQSLDYEALQAFEFRVGAADRGS
PALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQ
NAWLSYQLLKATEPGLFGVWAHNGEVRTARLLRERDAAKQRLVVLVKDNGEPPRSATATL
HVLLVDGFSQPYLLLPEAAPAQAQADLLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSR
AASVGRCSVPEGPFPGQMVDVSGTGTLSQSYQYEVCLTGGSGTNEFKFLKPIIPNFVAQG
AERVSEANPSFRKSFEFT
GenBank ID Protein 5457039
UniProtKB/Swiss-Prot ID Q9Y5E7
UniProtKB/Swiss-Prot Entry Name PCDB2_HUMAN
PDB IDs Not Available
GenBank Gene ID AF152495
GeneCard ID PCDHB2
GenAtlas ID PCDHB2
HGNC ID HGNC:8687
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  3. Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]
  4. Vanhalst K, Kools P, Vanden Eynde E, van Roy F: The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. FEBS Lett. 2001 Apr 20;495(1-2):120-5. [PubMed:11322959 ]