Human Metabolome Database: Showing Protein Protocadherin beta-4 (HMDBP07894)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07894

Secondary Accession Numbers

13605

Name

Protocadherin beta-4

Synonyms

PCDH-beta-4

Gene Name

PCDHB4

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q31

SNPs

PCDHB4

Gene Sequence

>2388 bp
ATGAAGAAGCTAGGGAGAATTCATCCAAACAGGCAAGTGTTGGCCTTTATTTTGATGGTG
TTCTTGTCTCAGGTTCGCCTCGAGCCTATTCGTTATTCTGTGTTGGAGGAAACAGAGAGC
GGCTCCTTTGTAGCCCATCTGGCCAAGGATCTGGGCCTGGGAATTGGGGAACTGGCCTCC
CGGTCAGCCCGGGTGCTGTCTGACGATGACAAGCAGCGTTTGCAGCTGGATCGTCAGACT
GGAGATTTGCTTCTGAGGGAGAAACTAGACCGGGAAGAGCTCTGTGGTCCTATTGAACCG
TGTGTACTGCATTTCCAAGTGTTCCTGGAAATGCCGGTGCAATTTTTTCAAGGAGAATTA
TTGATCCAGGACATAAATGATCACTCTCCAATATTCCCTGAAAGGGAAGTGCTCTTGAAA
ATACTAGAAAATAGCCAGCCGGGTACTCTATTTCCGTTGCTAATAGCTGAGGATTTGGAT
GTGGGCAGCAATGGTCTTCAAAAATACACAATCAGCCCCAATTCTCATTTTCACATTCTC
ACTCGAAATCATAGTGAGGGCAAGAAATACCCAGATTTGGTGCAGGACAAACCACTGGAT
CGAGAGGAGCAGCCTGAGTTCAGCTTAACCCTCGTGGCGCTGGATGGTGGGTCACCACCT
AGGTCTGGCACGGTCATGGTTCGAATCCTGATCATGGACATCAATGACAATGCTCCTGAG
TTTGTGCACACTCCATATGGGGTGCAGGTCCTGGAAAACAGCCCCCTAGACTCTCCAATT
GTTAGGGTCTTAGCTAGAGATATAGATGCTGGAAACTTCGGGAGTGTTTCTTATGGCTTA
TTCCAAGCATCAGATGAAATTAAACAAACTTTCTCAATAAATGAAGTCACGGGAGAAATA
CTGTTGAAAAAAAAATTGGATTTCGAAAAAATTAAATCTTACCATGTAGAAATTGAGGCC
ACAGATGGAGGAGGCCTTTCTGGAAAAGGCACTGTAGTCATAGAGGTGGTGGATGTGAAT
GACAATCCCCCAGAACTTATCATATCTTCACTCACCAGCTCCATCCCAGAAAATGCTCCT
GAGACGGTAGTCTCTATCTTCCGAATTCGAGATAGAGATTCCGGAGAAAATGGAAAGATG
ATTTGCTCTATTCCAGATAATCTACCGTTTATTCTAAAACCAACTTTGAAGAATTTTTAC
ACCCTGGTAACAGAGAGACCACTGGACCGAGAGACCAGCGCTGAGTACAACATCACCATC
GCCGTCACTGACTTGGGGACACCCAGGCTGAAAACCCAGCAGAACATAACCGTGCAGGTC
TCCGACGTCAATGACAACGCCCCCGCCTTCACCCAAACCTCCTACACCCTGTTCGTCCGC
GAGAACAACAGCCCCGCCCTGCACATCGGCAGTGTCAGCGCCACAGACAGAGACTCGGGC
ACCAACGCCCAGGTCACCTACTCGCTGCTGCCGCCCCAGGACCCGCACCTGCCCCTCGCC
TCCCTGGTCTCCATCAACGCAGACAACGGCCACCTGTTCGCCCTCAGGTCGCTGGACTAC
GAGGCCCTGCAGGCGTTCGAGTTCCGCGTGGGCGCCTCAGACCGCGGTTCTCCGGCTTTG
AGCAGCGAGGCGCTGGTGCGCGTGCTGGTGCTGGACACCAACGACAACTCGCCCTTCGTG
CTGTACCCGCTGCAGAATGGCTCCGCGCCCTGCACCGAGCTGGTGCCCCGGGCGGCCGAG
CCGGGCTACCTGGTGACCAAGGTGGTGGCGGTGGACGGCGACTCGGGCCAGAACGCCTGG
CTGTCGTACCAGCTGCTCAAGGCCACGGAGCCTGGGCTGTTCGGCGTGTGGGCGCACAAT
GGCGAGGTGCGCACCGCCAGGCTGCTGAGCGAGCGCGACGCAGCCAAGCACAGGCTCGTG
GTGCTTGTCAAGGACAATGGCGAGCCTCCGCGCTCGGCCACCGCCACGCTGCACGTGCTC
CTGGTGGATGGCTTCTCCCAGCCCTACCTGCCTCTCCCTGAGGCGGCCCCGGCCCAGGCC
CAGGCCGACTCTCTCACCGTCTACCTGGTGGTGGCGTTGGCCTCGGTGTCGTCGCTCTTC
CTCTTCTCGGTGCTCCTGTTCGTGGCGGTGCGGCTGTGCAGGAGGAGCAGGGCGGCCTCG
GTGGGTCGCTGCTCGGTGCCCGAGGGCCCCTTTCCAGGGCATCTGGTGGACGTAAGCGGC
ACCGGGACCCTGTCCCAGAGCTACCAGTACGAGGTGTGTCTGACAGGAGACTCTGGGACT
GGTGAGTTCAAGTTCCTGAAGCCAATATTTCCTAATCTCTTGGTTCAGGACACCGGGAGG
GAAGTTAAGGAAAACCCCAAGTTCAGAAATAGCTTGGTATTCAGTTAA

Protein Properties

Number of Residues

795

Molecular Weight

87269.3

Theoretical pI

4.83

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_2 (PF08266 )

Signals

1-27

Transmembrane Regions

690-710

Protein Sequence

>Protocadherin beta-4
MKKLGRIHPNRQVLAFILMVFLSQVRLEPIRYSVLEETESGSFVAHLAKDLGLGIGELAS
RSARVLSDDDKQRLQLDRQTGDLLLREKLDREELCGPIEPCVLHFQVFLEMPVQFFQGEL
LIQDINDHSPIFPEREVLLKILENSQPGTLFPLLIAEDLDVGSNGLQKYTISPNSHFHIL
TRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGGSPPRSGTVMVRILIMDINDNAPE
FVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEI
LLKKKLDFEKIKSYHVEIEATDGGGLSGKGTVVIEVVDVNDNPPELIISSLTSSIPENAP
ETVVSIFRIRDRDSGENGKMICSIPDNLPFILKPTLKNFYTLVTERPLDRETSAEYNITI
AVTDLGTPRLKTQQNITVQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSG
TNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGASDRGSPAL
SSEALVRVLVLDTNDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAW
LSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVL
LVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAAS
VGRCSVPEGPFPGHLVDVSGTGTLSQSYQYEVCLTGDSGTGEFKFLKPIFPNLLVQDTGR
EVKENPKFRNSLVFS

External Links

GenBank ID Protein

5457043

UniProtKB/Swiss-Prot ID

Q9Y5E5

UniProtKB/Swiss-Prot Entry Name

PCDB4_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]
Vanhalst K, Kools P, Vanden Eynde E, van Roy F: The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. FEBS Lett. 2001 Apr 20;495(1-2):120-5. [PubMed:11322959 ]