Human Metabolome Database: Showing Protein Protocadherin beta-11 (HMDBP07901)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07901

Secondary Accession Numbers

13612

Name

Protocadherin beta-11

Synonyms

PCDH-beta-11

Gene Name

PCDHB11

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q31

SNPs

PCDHB11

Gene Sequence

>2394 bp
ATGGAGAACCAAGGGACACGCACTCAGCAGATAAGGCAAGTCCTGCTTCTCTTTGTTTTG
CTCGGAATGTCTCAGGCGGGCTCTGAAACCTGGAGCTTTTCTGTGGCAGAAGAAATGCAG
AGCGGGAGTTTTGTAGGCAATCTGGCAAAGGACCTGGGGCTGAAGGTGAGAGAACTGTCC
TCACGGGGGGCTCGGGTGGTCTCTAATGATAAGAAACAGCGTTTGCAGCTGGACATAAAC
ACTGGGGATTTGCTCTTAAGTGAAACACTAGACAGGGAGGAGCTCTGCGGTTCCATCGAG
CCTTGCGTGCTACATTTGCAGGTGTTAATGCAAAACCCCACGCAGTTTTTACAAATTGAG
CTTCAGGTCAGGGATATAAATGATCACTCTCCCATCTTCTCGGAAAAACAAATGCTCCTA
GAAATCCCAGAGAACAGTCCCGTTGGTGCTGTGTTCTTACTAGAAAGTGCGAAGGATTTA
GATGTAGGAATCAATGCTGTAAAAAGCTACACAATAAGCCCCAACTCTCATTTTCACATT
AAAATGAGAGTCATTCCAGACAATAGGAAATACCCCGAGTTAGTTCTGGACAAGGCGCTG
GATTATGAAGAGCTCCCGGAGCTCAGTTTCATCCTCTCTGCTCTGGATGGTGGGTCCCCT
CCCAGGTCTGGAACTGCCTTGGTCAGGGTGGTGGTTGTGGACATTAATGACAACTCCCCT
GAATTTGAGCAGGCTTTTTATGAGGTGAAGATTCGGGAGAATAGCATCCTTGGCTCGCTG
ATTTTGATTGTCTCAGCTTGGGATTTAGACTCTGGAACAAATGGTGAAATATGCTATACC
TTTTCCCATGCCTCAGAAGATATTCGCAAGACATTTGAAATTAATCAAAAGTCTGGAGAA
ATTACTTTAAGAGCACCTCTGGATTTTGAAACGATTGAGTCATACTCAATAATCATTCAA
GCCACAGATGGGGGAGGACTTTTTGGAAAATCTACAGTCATAATTCACGTGATAGATGTA
AATGACAATGCTCCTGAAATCACTGTGTCATCAATTACCAGTCCAATCCCAGAAAATACG
CCAGAGACCGTGGTTATGGTTTTTAGTATCCAAGATATAGACTCTGGGGACAACGGAAGA
ATTGTTTGTTCCATTCCGGAAGACCTCCCATTCGTGCTAAAATCTTCAGTTGAGAATTAC
TACACGTTGGAAACAGAGAGACCACTGGACAGAGAGAGCACAGCCGAGTACAATATCACC
ATCACCGTCACCGACTTGGGGATACCCAGGCTGAAAACCGAGCACAACACAACTGTGTTG
GTCTCTGACGTCAATGACAACGCCCCCACCTTCACCCAAACCTCCTACACCCTGTTCGTC
CGCGAGAACAACAGCCCCGCCCTGCACATCGGCAGTGTCAGCGCTACAGACAGAGACTCA
GGCACCAACGCCCAGGTCAACTACTCGCTACTCCCGCCCCAGGACCTGCACCTGCCCCTC
GCCTCCCTGGTCTCCATCAACACAGACAACGGCCACCTGTTCGCCCTCAGGTCGCTGGAC
TACGAGGCCCTGCAGGCTTTCGACTTCCGCGTGGGCGCCACAGACCGCGGCTCCCCGGCT
TTGAGCAGCGAGGCGCTGGTGCGCGTGCTGGTGCTGGACGCCAACGACAACTCGCCCTTC
GTGCTGTACCCGCTGCAGAACGGCTCCGCGCCCTGCACCGAGCTGGTGCCCCGGGCGGCC
GAGCCGGGCTACCTGGTGACCAAGGTGGTGGCGGTGGACGGCGACTCGGGCCAGAACGCC
TGGCTGTCGTACCAGCTGCTCAAGGCCACGGAGCCCGGGCTATTCGGCGTGTGGGCGCAC
AATGGCGAGGTGCGCACCGCCAGGCTGCTGAGCGAGCGCGACGCGGCCAAGCACAGGCTG
GTGGTGCTGGTCAAGGACAATGGCGAGCCTCCGCGCTCGGCCACCGCCACGCTGCAAGTG
CTCCTGGTGGACGGCTTCTCCCAGCCCTACCTGCCGCTCCCTGAGGCGGCACCGGCCCAG
GCCCAGGCCGACTCGCTCACCGTCTACTTGGTGGTGGCGTTGGCCTCGGTGTCTTCGCTC
TTCCTCTTCTCGGTGCTCCTGTTCGTGGCGGTGCGGCTGTGCAGGAGGAGCAGGGCGGCC
TCGGTGGGAAGCTGCTCGGTGCCTAAGGGCCCCTTTCCAGGGCATCTGGTGGACGTGAGC
GGCACCGGGACCCTTTCCCAGAGCTACCAGTACGAGGTGTGTCTGACGGGAGGTTCCGAG
ACAAATGAATTCAAGTTCCTAAAACCGGTTATCCCTAATATCCAGGCAAAAGGTCTTGGG
AAGAATAGTGAAGAAAACTCCACCTTTCGAAATAGCTTTGGATTTAATTTTTAG

Protein Properties

Number of Residues

797

Molecular Weight

87087.5

Theoretical pI

4.48

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_2 (PF08266 )

Signals

1-26

Transmembrane Regions

691-711

Protein Sequence

>Protocadherin beta-11
MENQGTRTQQIRQVLLLFVLLGMSQAGSETWSFSVAEEMQSGSFVGNLAKDLGLKVRELS
SRGARVVSNDKKQRLQLDINTGDLLLSETLDREELCGSIEPCVLHLQVLMQNPTQFLQIE
LQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTISPNSHFHI
KMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVDINDNSP
EFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASEDIRKTFEINQKSGE
ITLRAPLDFETIESYSIIIQATDGGGLFGKSTVIIHVIDVNDNAPEITVSSITSPIPENT
PETVVMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSVENYYTLETERPLDRESTAEYNIT
ITVTDLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDS
GTNAQVNYSLLPPQDLHLPLASLVSINTDNGHLFALRSLDYEALQAFDFRVGATDRGSPA
LSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNA
WLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLQV
LLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAA
SVGSCSVPKGPFPGHLVDVSGTGTLSQSYQYEVCLTGGSETNEFKFLKPVIPNIQAKGLG
KNSEENSTFRNSFGFNF

External Links

GenBank ID Protein

5457029

UniProtKB/Swiss-Prot ID

Q9Y5F2

UniProtKB/Swiss-Prot Entry Name

PCDBB_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]
Vanhalst K, Kools P, Vanden Eynde E, van Roy F: The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. FEBS Lett. 2001 Apr 20;495(1-2):120-5. [PubMed:11322959 ]