Hmdb loader
Identification
HMDB Protein ID HMDBP07920
Secondary Accession Numbers
  • 13631
Name Protocadherin gamma-A11
Synonyms
  1. PCDH-gamma-A11
Gene Name PCDHGA11
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:5
Locus 5q31
SNPs PCDHGA11
Gene Sequence
>2808 bp
ATGGCGAATCGGCTACAGCGCGGGGACCGCAGTCGGCTGCTGCTGCTGCTGTGCATTTTC
CTGGGGACGCTGCGGGGGTTCCGGGCCAGGCAGATCCGATATTCGGTGCCAGAAGAGACC
GAAAAGGGCTCCTTCGTGGGCAATATCTCCAAGGACCTGGGGCTGGAGCCCCGGGAGCTG
GCGAAGCGCGGAGTCCGCATCGTCTCCAGAGGGAAGACACAGCTTTTCGCTGTGAATCCG
CGAAGCGGCAGCTTGATCACGGCAGGCAGGATAGACCGGGAGGAGCTCTGTGAGACGGTG
TCCTCCTGTTTTTTAAATATGGAACTTCTCGTGGAAGACACCTTGAAGATTTACGGAGTG
GAGGTGGAAATAATAGATATTAATGATAACGCCCCCAGCTTCCAGGAGGACGAAGTGGAG
ATAAAAGTCAGTGAGCACGCAATTCCTGGGGCGCGATTTGCTCTTCCTAATGCTAGGGAT
CCAGATGTGGGCGTGAACTCCCTCCAGAGCTACCAGCTCAGCCCTAATAATTACTTTTCC
TTGCAACTGCGGGGCAGAACGGATGGGGCCAAGAATCCAGAGCTAGTACTGGAGGGAAGC
CTGGACCGAGAGAAAGAGGCTGCTCACCTGCTCCTCCTCACAGCTTTAGATGGAGGCGAT
CCCATCCGAAAGGGCGCAGTTCCCATTCGTGTGGTGGTCCTCGATGTAAATGATCACATC
CCAATGTTTACACAGTCCGTATATCGCGTGAGTGTTCCAGAAAACATCAGCTCCGGAACT
CGGGTGCTGATGGTTAATGCAACGGATCCAGACGAGGGAATCAACGGGGAAGTAATGTAT
TCATTTCGGAACATGGAAAGCAAGGCTTCTGAAATATTCCAATTGGATTCACAAACTGGA
GAAGTTCAAGTACGGGGGTCTCTGGATTTTGAAAAATATAGATTCTATGAGATGGAAATT
CAAGGCCAAGATGGTGGAGGTCTCTTTACCACCACGACGATGTTGATCACTGTTGTGGAT
GTGAATGATAACGCTCCAGAAATAACTATCACCTCTTCTATTAATTCAATTCTGGAAAAC
TCTCCTCCAGGTACAGTGATTGCTCTTCTAAATGTGCAAGATCAAGATTCTGGAGAAAAT
GGTCAAGTCTCCTGTTTTATTCCTAACCACCTGCCTTTTAAATTAGAAAAGACTTATGGA
AATTATTACAAATTGATAACAAGCAGAGTGCTGGACAGGGAGTTGGTCCAGAGCTACAAT
ATAACGTTGACAGCCACAGACCAGGGAAGCCCGCCTTTGTCTGCAGAAACTCATGTCTGG
CTGAATGTGGCAGATGACAACGATAACCCTCCCGTTTTTCCTCACTCCTCTTACTCTGCC
TACATTCCCGAAAACAACCCCAGGGGTGCCTCCATCTTCTCAGTGACCGCCCTCGACCCG
GACAGCAAACAGAATGCCCTGGTCACTTACTCTCTGACGGATGACACTGTCCAGGGGGTG
CCTCTGTCCTCCTATGTCTCTATTAACTCCAACACTGGTGTTCTCTATGCCCTACAATCC
TTCGACTATGAGCAGTTTCGAGACTTAGAACTGAGAGTGATAGCACGTGACAGCGGGGAC
CCGCCCCTCAGCAGCAACGTGTCGCTGAGCCTGTTCGTGCTGGACCAGAACGACAATGCG
CCCGAGATCCTGTACCCTGCCCTCCCCACAGACGGCTCCACTGGCGTGGAGCTGGCGCCC
CGCTCTGCGGAACCTGGCTACCTGGTGACCAAGGTGGTTGCGGTGGACAAAGATTCAGGC
CAGAACGCCTGGCTGTCCTATCGCCTGCTTAAGGCCAGCGAGCCGGGACTCTTCGCGGTG
GGGGAGCACACGGGCGAGGTGCGTACAGCGCGGGCACTGCTGGACAGAGACGCGCTCAAG
CAGAGCCTCGTGGTGGCCGTCCAGGACCACGGCCAGCCCCCTCTCTCGGCCACCGTCACG
CTCACCGTGGCTGTGGCCGACAGCATCCCCGAAGTCCTGGCGGACCTCGGCAGCCTCGAG
TCTCTGGCTAACTCTGAAACCTCAGACCTCTCGCTGTACTTGGTGGTGGCGGTGGCCGCA
GTCTCCTGCATCTTCCTGGTCTTTGTCATCGTGCTGCTGGCACTCAGGCTGTGGCGCTGG
CATAAGTCACGCCTGCTGCAGGCTTCTGAAGGCGGGTTGGCAGGTATGCCCACGTCACAT
TTTGTAGGCGTGGACGGGGTACAGGCTTTCCTGCAAACCTATTCCCACGAGGTCTCTCTC
ATTGCGGACTCGCAGAAGAGTCACCTGATTTTCCCCCAGCCCAACTATGGGGACACGCTC
ATCAGCCAGGAGAGCTGTGAGAAAAGCGAGCCACTCTTGATAGCTGAAGACTCAGCTATC
ATTTTAGGCAAATGTGACCCGACAAGTAATCAGCAAGCCCCGCCCAACACGGACTGGCGT
TTCTCTCAGGCCCAGAGACCCGGCACCAGCGGCTCCCAAAATGGCGATGACACCGGCACC
TGGCCCAACAACCAGTTTGACACAGAGATGCTGCAAGCCATGATCTTGGCGTCCGCCAGT
GAAGCTGCTGATGGGAGCTCCACCCTGGGAGGGGGTGCCGGCACCATGGGATTGAGCGCC
CGCTACGGACCCCAGTTCACCCTGCAGCACGTGCCCGACTACCGCCAGAATGTCTACATC
CCAGGCAGCAATGCCACACTGACCAACGCAGCTGGCAAGCGGGATGGCAAGGCCCCAGCA
GGTGGCAATGGCAACAAGAAGAAGTCGGGCAAGAAGGAGAAGAAGTAA
Protein Properties
Number of Residues 935
Molecular Weight 101542.0
Theoretical pI 4.56
Pfam Domain Function
Signals
  • 1-29
Transmembrane Regions
  • 694-714
Protein Sequence
>Protocadherin gamma-A11
MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL
AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV
EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS
LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI
PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG
EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN
SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN
ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP
DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD
PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG
QNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVT
LTVAVADSIPEVLADLGSLESLANSETSDLSLYLVVAVAAVSCIFLVFVIVLLALRLWRW
HKSRLLQASEGGLAGMPTSHFVGVDGVQAFLQTYSHEVSLIADSQKSHLIFPQPNYGDTL
ISQESCEKSEPLLIAEDSAIILGKCDPTSNQQAPPNTDWRFSQAQRPGTSGSQNGDDTGT
WPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYI
PGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
GenBank ID Protein 5456928
UniProtKB/Swiss-Prot ID Q9Y5H2
UniProtKB/Swiss-Prot Entry Name PCDGB_HUMAN
PDB IDs Not Available
GenBank Gene ID AF152320
GeneCard ID PCDHGA11
GenAtlas ID PCDHGA11
HGNC ID HGNC:8698
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y: Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Anal Sci. 2008 Jan;24(1):161-6. [PubMed:18187866 ]
  3. Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]