| Identification |
|---|
| HMDB Protein ID
| HMDBP07921 |
| Secondary Accession Numbers
| |
| Name
| Protocadherin gamma-A12 |
| Synonyms
|
- Cadherin-21
- Fibroblast cadherin-3
- PCDH-gamma-A12
|
| Gene Name
| PCDHGA12 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q31 |
| SNPs
| PCDHGA12 |
| Gene Sequence
|
>2799 bp
ATGATTCCTGCGCGACTGCACCGGGACTACAAAGGGCTTGTCCTGCTGGGAATCCTCCTG
GGGACTCTGTGGGAGACCGGATGCACCCAGATACGCTATTCAGTTCCGGAAGAGCTGGAG
AAAGGCTCTAGGGTGGGCGACATCTCCAGGGACCTGGGGCTGGAGCCCCGGGAGCTCGCG
GAGCGCGGAGTCCGCATCATCCCCAGAGGTAGGACGCAGCTTTTCGCCCTGAATCCGCGC
AGCGGCAGCTTGGTCACGGCGGGCAGGATAGACCGGGAGGAGCTCTGTATGGGGGCCATC
AAGTGTCAATTAAATCTAGACATTCTGATGGAGGATAAAGTGAAAATATATGGAGTAGAA
GTAGAAGTAAGGGACATTAACGACAATGCGCCTTACTTTCGTGAAAGTGAATTAGAAATA
AAAATTAGTGAAAATGCAGCCACTGAGATGCGGTTCCCTCTACCCCACGCCTGGGATCCG
GATATCGGGAAGAACTCTCTGCAGAGCTACGAGCTCAGCCCGAACACTCACTTCTCCCTC
ATCGTGCAAAATGGAGCCGACGGTAGTAAGTACCCCGAATTGGTGCTGAAACGCGCCCTG
GACCGCGAAGAAAAGGCTGCTCACCACCTGGTCCTTACGGCCTCCGACGGGGGCGACCCG
GTGCGCACAGGCACCGCGCGCATCCGCGTGATGGTTCTGGATGCGAACGACAACGCACCA
GCGTTTGCTCAGCCCGAGTACCGCGCGAGCGTTCCGGAGAATCTGGCCTTGGGCACGCAG
CTGCTTGTAGTCAACGCTACCGACCCTGACGAAGGAGTCAATGCGGAAGTGAGGTATTCC
TTCCGGTATGTGGACGACAAGGCGGCCCAAGTTTTCAAACTAGATTGTAATTCAGGGACA
ATATCAACAATAGGGGAGTTGGACCACGAGGAGTCAGGATTCTACCAGATGGAAGTGCAA
GCAATGGATAATGCAGGATATTCTGCGCGAGCCAAAGTCCTGATCACTGTTCTGGACGTG
AACGACAATGCCCCAGAAGTGGTCCTCACCTCTCTCGCCAGCTCGGTTCCCGAAAACTCT
CCCAGAGGGACATTAATTGCCCTTTTAAATGTAAATGACCAAGATTCTGAGGAAAACGGA
CAGGTGATCTGTTTCATCCAAGGAAATCTGCCCTTTAAATTAGAAAAATCTTACGGAAAT
TACTATAGTTTAGTCACAGACATAGTCTTGGATAGGGAACAGGTTCCTAGCTACAACATC
ACAGTGACCGCCACTGACCGGGGAACCCCGCCCCTATCCACGGAAACTCATATCTCGCTG
AACGTGGCAGACACCAACGACAACCCGCCGGTCTTCCCTCAGGCCTCCTATTCCGCTTAT
ATCCCAGAGAACAATCCCAGAGGAGTTTCCCTCGTCTCTGTGACCGCCCACGACCCCGAC
TGTGAAGAGAACGCCCAGATCACTTATTCCCTGGCTGAGAACACCATCCAAGGGGCAAGC
CTATCGTCCTACGTGTCCATCAACTCCGACACTGGGGTACTGTATGCGCTGAGCTCCTTC
GACTACGAGCAGTTCCGAGACTTGCAAGTGAAAGTGATGGCGCGGGACAACGGGCACCCG
CCCCTCAGCAGCAACGTGTCGTTGAGCCTGTTCGTGCTGGACCAGAACGACAATGCGCCC
GAGATCCTGTACCCCGCCCTCCCCACGGACGGTTCCACTGGCGTGGAGCTGGCTCCCCGC
TCCGCAGAGCCCGGCTACCTGGTGACCAAGGTGGTGGCGGTGGACAGAGACTCCGGCCAG
AACGCCTGGCTGTCCTACCGTCTGCTCAAGGCCAGCGAGCCGGGACTCTTCTCGGTGGGT
CTGCACACGGGCGAGGTGCGCACGGCGCGAGCCCTGCTGGACAGAGACGCGCTCAAGCAG
AGCCTCGTAGTGGCCGTCCAGGACCACGGCCAGCCCCCTCTCTCCGCCACTGTCACGCTC
ACCGTGGCCGTGGCCGACAGCATCCCCCAAGTCCTGGCGGACCTCGGCAGCCTCGAGTCT
CCAGCTAACTCTGAAACCTCAGACCTCACTCTGTACCTGGTGGTAGCGGTGGCCGCGGTC
TCCTGCGTCTTCCTGGCCTTCGTCATCTTGCTGCTGGCGCTCAGGCTGCGGCGCTGGCAC
AAGTCACGCCTGCTGCAGGCTTCAGGAGGCGGCTTGACAGGAGCGCCGGCGTCGCACTTT
GTGGGCGTGGACGGGGTGCAGGCTTTCCTGCAGACCTATTCCCACGAGGTTTCCCTCACC
ACGGACTCGCGGAAGAGTCACCTGATCTTCCCCCAGCCCAACTATGCAGACATGCTCGTC
AGCCAGGAGAGCTTTGAAAAAAGCGAGCCCCTTTTGCTGTCAGGTGATTCGGTATTTTCT
AAAGACAGTCATGGGTTAATTGAGCAAGCCCCGCCCAACACGGACTGGCGTTTCTCTCAG
GCCCAGAGACCCGGCACCAGCGGCTCCCAAAATGGCGATGACACCGGCACCTGGCCCAAC
AACCAGTTTGACACAGAGATGCTGCAAGCCATGATCTTGGCGTCCGCCAGTGAAGCTGCT
GATGGGAGCTCCACCCTGGGAGGGGGTGCCGGCACCATGGGATTGAGCGCCCGCTACGGA
CCCCAGTTCACCCTGCAGCACGTGCCCGACTACCGCCAGAATGTCTACATCCCAGGCAGC
AATGCCACACTGACCAACGCAGCTGGCAAGCGGGATGGCAAGGCCCCAGCAGGTGGCAAT
GGCAACAAGAAGAAGTCGGGCAAGAAGGAGAAGAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 932 |
| Molecular Weight
| 100954.1 |
| Theoretical pI
| 4.66 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protocadherin gamma-A12
MIPARLHRDYKGLVLLGILLGTLWETGCTQIRYSVPEELEKGSRVGDISRDLGLEPRELA
ERGVRIIPRGRTQLFALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVE
VEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSL
IVQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAP
AFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGT
ISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSVPENS
PRGTLIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNI
TVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPD
CEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHP
PLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQ
NAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTL
TVAVADSIPQVLADLGSLESPANSETSDLTLYLVVAVAAVSCVFLAFVILLLALRLRRWH
KSRLLQASGGGLTGAPASHFVGVDGVQAFLQTYSHEVSLTTDSRKSHLIFPQPNYADMLV
SQESFEKSEPLLLSGDSVFSKDSHGLIEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPN
NQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGS
NATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
|
| External Links |
|---|
| GenBank ID Protein
| 8850232 |
| UniProtKB/Swiss-Prot ID
| O60330 |
| UniProtKB/Swiss-Prot Entry Name
| PCDGC_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_003735.2 |
| GeneCard ID
| PCDHGA12 |
| GenAtlas ID
| PCDHGA12 |
| HGNC ID
| HGNC:8699 |
| References |
|---|
| General References
| - Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]
- Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Feb 28;5(1):31-9. [PubMed:9628581 ]
- Matsuyoshi N, Imamura S: Multiple cadherins are expressed in human fibroblasts. Biochem Biophys Res Commun. 1997 Jun 18;235(2):355-8. [PubMed:9199196 ]
- Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]
|
