Hmdb loader
Identification
HMDB Protein ID HMDBP07930
Secondary Accession Numbers
  • 13641
Name Protocadherin gamma-C4
Synonyms
  1. PCDH-gamma-C4
Gene Name PCDHGC4
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:5
Locus 5q31
SNPs PCDHGC4
Gene Sequence
>2817 bp
ATGCTCCGCAAGGTGAGAAGCTGGACAGAAATCTGGCGGTGGGCTACCCTTTTGTTCCTC
TTTTACCACCTGGGTTACGTTTGTGGGCAGATCCGCTACCCGGTCCCAGAGGAGTCACAG
GAAGGGACTTTTGTAGGGAATGTCGCTCAAGATTTCCTGCTGGATACGGACAGTCTGTCA
GCTCGCAGGCTGCAGGTCGCTGGAGAGGTGAACCAAAGACACTTCCGTGTGGATTTGGAC
AGCGGAGCCCTGCTCATCAAGAACCCAATCGACCGAGAGGCACTGTGTGGGCTCAGTGCC
AGCTGCATCGTGCCCCTGGAGTTTGTCACCGAAGGTCCTTTGGAAATGTACCGAGCAGAG
GTAGAGATCGTAGATGTGAATGATCACGCCCCCCGTTTTCCGCGGCAGCAGCTGGACTTG
GAAATTGGGGAGGCAGCTCCTCCAGGACAGCGTTTCCCGTTGGAAAAGGCTCAGGATGCA
GATGTGGGGAGCAATTCGATTAGCAGCTATAGGCTGAGCTCCAATGAACACTTTGCACTG
GATGTGAAGAAGCGCAGCGACGGCAGCCTGGTCCCAGAGCTGCTCCTGGAGAAGCCTTTG
GATCGAGAGAAGCAATCGGACTACCGCCTGGTGCTGACTGCTGTCGATGGAGGGAACCCG
CCGAGATCTGGCACCGCAGAGCTCCGGGTATCCGTGCTGGACGTAAACGACAACGCCCCA
GCCTTCCAGCAATCCAGCTACAGGATTAGTGTGTTGGAGAGCGCACCAGCGGGCATGGTG
CTCATCCAGCTCAATGCCTCAGACCCGGACCTGGGTCCCAGTGGTAACGTCACCTTTTAT
TTCAGTGGTCATACCCCTGATCGTGTAAGAAACCTCTTTAGCCTGCACCCCACTACTGGA
AAGCTTACTCTTTTGGGGCCCCTAGACTTTGAGAGTGAGAATTACTATGAATTTGATGTG
CGGGCTCGCGATGGGGGTTCTCCAGCCATGGAGCAACATTGCAGCCTTCGAGTGGATCTG
CTGGACGTAAATGACAATGCCCCTTACATCACAGTGACCTCAGAGCTTGGAACCCTCCCC
GAGAGTGCAGAACCTGGCACTGTGGTGGCACTTATCAGTGTGCAGGATCCAGACTCAGGG
TCAAACGGAGATGTGAGCCTCCGCATTCCTGACCACTTGCCATTTGCCCTCAAGTCTGCC
TTCAGGAACCAGTTCTCCCTGGTGACTGCTGGACCCTTGGATCGAGAGGCCAAATCTAGC
TATGACATCATGGTCACTGCTTCTGATGCTGGGAACCCTCCTCTCAGTACCCACAGAACT
ATTTTCCTCAATATTTCAGATGTGAATGATAATCCACCCTCTTTCTTTCAGAGGTCACAT
GAGGTGTTTGTTCCTGAGAACAATCGCCCAGGGGACCTGCTTTGCTCCCTTGCAGCCTCT
GACCCAGACTCTGGCTTGAATGCGCTTATCTCCTACTCACTCCTGGAGCCCAGGAATCGA
GATGTATCAGCTTCCTCTTTCATCTCTCTGAACCCCCAGACAGGAGCTGTTCATGCTACT
CGATCCTTTGACTATGAGCAAACCCAGACACTGCAGTTTGAGGTGCAGGCCCGGGATCGG
GGCAACCCACCCCTTAGCAGCACTGTAACAGTTCGTCTATTTGTGCTGGACCTCAATGAC
AATGCTCCAGCTGTGCTCCGTCCTCGGGCCCGGCCTGGTTCCTTATGTCCCCAAGCACTG
CCTCCATCAGTTGGTGCTGGCCACCTAATCACAAAGGTGACTGCTGTGGACTTGGATTCA
GGTTACAATGCTTGGGTTTCCTATCAGCTCCTGGAGGCCCCAGATCCCAGCCTGTTTGCA
GTCTCTCGATATGCTGGGGAGGTGCGGACGGCTGTTCCTATCCCAGCTGACCTCCCACCA
CAGAAGCTGGTCATTGTGGTAAAGGATAGTGGTAGTCCACCACTCTCTACCTCTGTTACT
CTCTTAGTGTCCTTAGAGGAAGACACTCATCCAGTTGTCCCAGATCTTCGAGAATCTTCA
GCTCCAAGGGAAGGAGAATCTCGTCTAACCCTCTACTTGGCTGTGTCCCTAGTGGCAATT
TGCTTTGTCTCCTTTGGCTCATTCGTGGCACTACTCTCTAAGTGTCTTCGTGGGGCAGCC
TGTGGAGTCACATGCTTTCCTGCTGGCACCTGTGCCTGTCTCACCAGATCTCGAAGGAGG
GAGGGGCTTCCCCCTTCCAATGGGATCCTCCGAATCCAGCTAGGGTCAGATGACCCTATC
AAGTTTGTTGATGTGGGAGGCCACTCTCATGGCTGTACACCCTTGGCTTCTGCACCCACT
CGGAGTGATAGCTTCATGATGGTGAAGTCACCCAGTGCACCTATGGCAGGGGAGCCTGTT
CGCCCAAGCTGCCCACCCTCTGATCTTCTCTATGGGCTAGAGCAAGCCCCGCCCAACACG
GACTGGCGTTTCTCTCAGGCCCAGAGACCCGGCACCAGCGGCTCCCAAAATGGCGATGAC
ACCGGCACCTGGCCCAACAACCAGTTTGACACAGAGATGCTGCAAGCCATGATCTTGGCG
TCCGCCAGTGAAGCTGCTGATGGGAGCTCCACCCTGGGAGGGGGTGCCGGCACCATGGGA
TTGAGCGCCCGCTACGGACCCCAGTTCACCCTGCAGCACGTGCCCGACTACCGCCAGAAT
GTCTACATCCCAGGCAGCAATGCCACACTGACCAACGCAGCTGGCAAGCGGGATGGCAAG
GCCCCAGCAGGTGGCAATGGCAACAAGAAGAAGTCGGGCAAGAAGGAGAAGAAGTAA
Protein Properties
Number of Residues 938
Molecular Weight 101212.6
Theoretical pI 4.97
Pfam Domain Function
Signals
  • 1-29
Transmembrane Regions
  • 693-713
Protein Sequence
>Protocadherin gamma-C4
MLRKVRSWTEIWRWATLLFLFYHLGYVCGQIRYPVPEESQEGTFVGNVAQDFLLDTDSLS
ARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAE
VEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFAL
DVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAP
AFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTG
KLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLP
ESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSS
YDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAAS
DPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDR
GNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDS
GYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQKLVIVVKDSGSPPLSTSVT
LLVSLEEDTHPVVPDLRESSAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLRGAA
CGVTCFPAGTCACLTRSRRREGLPPSNGILRIQLGSDDPIKFVDVGGHSHGCTPLASAPT
RSDSFMMVKSPSAPMAGEPVRPSCPPSDLLYGLEQAPPNTDWRFSQAQRPGTSGSQNGDD
TGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQN
VYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
GenBank ID Protein 5456982
UniProtKB/Swiss-Prot ID Q9Y5F7
UniProtKB/Swiss-Prot Entry Name PCDGL_HUMAN
PDB IDs Not Available
GenBank Gene ID AF152338
GeneCard ID PCDHGC4
GenAtlas ID PCDHGC4
HGNC ID HGNC:8717
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  3. Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]