Human Metabolome Database: Showing Protein Peroxidasin homolog (HMDBP07959)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 metabolites

Identification

HMDB Protein ID

HMDBP07959

Secondary Accession Numbers

13670

Name

Peroxidasin homolog

Synonyms

Melanoma-associated antigen MG50
Vascular peroxidase 1
p53-responsive gene 2 protein

Gene Name

PXDN

Protein Type

Unknown

Biological Properties

General Function

Involved in peroxidase activity

Specific Function

Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation.

Pathways

Not Available

Reactions

phenolic donor + Hydrogen peroxide → phenoxyl radical of the donor + Water

details

GO Classification

Biological Process
extracellular matrix organization
immune response
hydrogen peroxide catabolic process
Cellular Component
endoplasmic reticulum
proteinaceous extracellular matrix
extracellular space
extracellular matrix
Function
peroxidase activity
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
iron ion binding
protein binding
antioxidant activity
heme binding
Molecular Function
metal ion binding
extracellular matrix structural constituent
heme binding
peroxidase activity
interleukin-1 receptor antagonist activity
Process
response to stimulus
response to stress
response to oxidative stress
metabolic process
oxidation reduction

Cellular Location

Secreted
extracellular space
extracellular matrix

Gene Properties

Chromosome Location

Locus

2p25

SNPs

PXDN

Gene Sequence

>4440 bp
ATGGCCAAGCGCTCCAGGGGCCCCGGGCGCCGCTGCCTGTTGGCGCTCGTGCTGTTCTGC
GCCTGGGGGACGCTGGCCGTGGTGGCCCAGAAGCCGGGCGCAGGGTGTCCGAGCCGCTGC
CTGTGCTTCCGCACCACCGTGCGCTGCATGCATCTGCTGCTGGAGGCCGTGCCCGCCGTG
GCGCCGCAGACCTCCATCCTAGATCTTCGCTTTAACAGAATCAGAGAGATCCAACCTGGG
GCATTCAGGCGGCTGAGGAACTTGAACACATTGCTTCTCAATAATAATCAGATCAAGAGG
ATACCTAGTGGAGCATTTGAAGACTTGGAAAATTTAAAATATCTCTATCTGTACAAGAAT
GAGATCCAGTCAATTGACAGGCAAGCATTTAAGGGACTTGCCTCTCTAGAGCAACTATAC
CTGCACTTTAATCAGATAGAAACTTTGGACCCAGATTCGTTCCAGCATCTCCCGAAGCTC
GAGAGGCTATTTTTGCATAACAACCGGATTACACATTTAGTTCCAGGGACATTTAATCAC
TTGGAATCTATGAAGAGATTGCGACTGGACTCAAACACACTTCACTGCGACTGTGAAATC
CTGTGGTTGGCGGATTTGCTGAAAACCTACGCGGAGTCGGGGAACGCGCAGGCAGCGGCC
ATCTGTGAATATCCCAGACGCATCCAGGGACGCTCAGTGGCAACCATCACCCCGGAAGAG
CTGAACTGTGAAAGGCCCCGGATCACCTCCGAGCCCCAGGACGCAGATGTGACCTCGGGG
AACACCGTGTACTTCACCTGCAGAGCCGAAGGCAACCCCAAGCCTGAGATCATCTGGCTG
CGAAACAATAATGAGCTGAGCATGAAGACAGATTCCCGCCTAAACTTGCTGGACGATGGG
ACCCTGATGATCCAGAACACACAGGAGACAGACCAGGGTATCTACCAGTGCATGGCAAAG
AACGTGGCCGGAGAGGTGAAGACGCAAGAGGTGACCCTCAGGTACTTCGGGTCTCCAGCT
CGACCCACTTTTGTAATCCAGCCACAGAATACAGAGGTGCTGGTTGGGGAGAGCGTCACG
CTGGAGTGCAGCGCCACAGGCCACCCCCCGCCGCGGATCTCCTGGACGAGAGGTGACCGC
ACACCCTTGCCAGTTGACCCGCGGGTGAACATCACGCCTTCTGGCGGGCTTTACATACAG
AACGTCGTACAGGGGGACAGCGGAGAGTATGCGTGCTCTGCGACCAACAACATTGACAGC
GTCCATGCCACCGCTTTCATCATCGTCCAGGCTCTTCCTCAGTTCACTGTGACGCCTCAG
GACAGAGTCGTTATTGAGGGCCAGACCGTGGATTTCCAGTGTGAAGCCAAGGGCAACCCG
CCGCCCGTCATCGCCTGGACCAAGGGAGGGAGCCAGCTCTCCGTGGACCGGCGGCACCTG
GTCCTGTCATCGGGAACACTTAGAATCTCTGGTGTTGCCCTCCACGACCAGGGCCAGTAC
GAATGCCAGGCTGTCAACATCATCGGCTCCCAGAAGGTCGTGGCCCACCTGACTGTGCAG
CCCAGAGTCACCCCAGTGTTTGCCAGCATTCCCAGCGACACAACAGTGGAGGTGGGCGCC
AATGTGCAGCTCCCGTGCAGCTCCCAGGGCGAGCCCGAGCCAGCCATCACCTGGAACAAG
GATGGGGTTCAGGTGACAGAAAGTGGAAAATTTCACATCAGCCCTGAAGGATTCTTGACC
ATCAATGACGTTGGCCCTGCAGACGCAGGTCGCTATGAGTGTGTGGCCCGGAACACCATT
GGGTCGGCCTCGGTGAGCATGGTGCTCAGTGTGAATGTTCCTGACGTCAGTCGAAATGGA
GATCCGTTTGTAGCTACCTCCATCGTGGAAGCGATTGCGACTGTTGACAGAGCTATAAAC
TCAACCCGAACACATTTGTTTGACAGCCGTCCTCGTTCTCCAAATGATTTGCTGGCCTTG
TTCCGGTATCCGAGGGATCCTTACACAGTTGAACAGGCACGGGCGGGAGAAATCTTTGAA
CGGACATTGCAGCTCATTCAGGAGCATGTACAGCATGGCTTGATGGTCGACCTCAACGGA
ACAAGTTACCACTACAACGACCTGGTGTCTCCACAGTACCTGAACCTCATCGCAAACCTG
TCGGGCTGTACCGCCCACCGGCGCGTGAACAACTGCTCGGACATGTGCTTCCACCAGAAG
TACCGGACGCACGACGGCACCTGTAACAACCTGCAGCACCCCATGTGGGGCGCCTCGCTG
ACCGCCTTCGAGCGCCTGCTGAAATCCGTGTACGAGAATGGCTTCAACACCCCTCGGGGC
ATCAACCCCCACCGACTGTACAACGGGCACGCCCTTCCCATGCCGCGCCTGGTGTCCACC
ACCCTGATCGGGACGGAGACCGTCACACCCGACGAGCAGTTCACCCACATGCTGATGCAG
TGGGGCCAGTTCCTGGACCACGACCTCGACTCCACGGTGGTGGCCCTGAGCCAGGCACGC
TTCTCCGACGGACAGCACTGCAGCAACGTGTGCAGCAACGACCCCCCCTGCTTCTCTGTC
ATGATCCCCCCCAATGACTCCCGGGCCAGGAGCGGGGCCCGCTGCATGTTCTTCGTGCGC
TCCAGCCCTGTGTGCGGCAGCGGCATGACTTCGCTGCTCATGAACTCCGTGTACCCGCGG
GAGCAGATCAACCAGCTCACCTCCTACATAGACGCATCCAACGTGTACGGGAGCACGGAG
CATGAGGCCCGCAGCATCCGCGACCTGGCCAGCCACCGCGGCCTGCTGCGGCAGGGCATC
GTGCAGCGGTCCGGGAAGCCGCTGCTCCCCTTCGCCACCGGGCCGCCCACGGAGTGCATG
CGGGACGAGAACGAGAGCCCCATCCCCTGCTTCCTGGCCGGGGACCACCGCGCCAACGAG
CAGCTGGGCCTGACCAGCATGCACACGCTGTGGTTCCGCGAGCACAACCGCATTGCCACG
GAGCTGCTCAAGCTGAACCCGCACTGGGACGGCGACACCATCTACTATGAGACCAGGAAG
ATCGTGGGTGCGGAGATCCAGCACATCACCTACCAGCACTGGCTCCCGAAGATCCTGGGG
GAGGTGGGCATGAGGACGCTGGGAGAGTACCACGGCTACGACCCCGGCATCAATGCTGGC
ATCTTCAACGCCTTCGCCACCGCGGCCTTCAGGTTTGGCCACACGCTTGTCAACCCACTG
CTTTACCGGCTGGACGAGAACTTCCAGCCCATTGCACAAGATCACCTCCCCCTTCACAAA
GCTTTCTTCTCTCCCTTCCGGATTGTGAATGAGGGCGGCATCGATCCGCTTCTCAGGGGG
CTGTTCGGGGTGGCGGGGAAAATGCGTGTGCCCTCGCAGCTGCTGAACACGGAGCTCACG
GAGCGGCTGTTCTCCATGGCACACACGGTGGCTCTGGACCTGGCGGCCATCAACATCCAG
CGGGGCCGGGACCACGGGATCCCACCCTACCACGACTACAGGGTCTACTGCAATCTATCG
GCGGCACACACGTTCGAGGACCTGAAAAATGAGATTAAAAACCCTGAGATCCGGGAGAAA
CTGAAAAGGTTGTATGGCTCGACACTCAACATCGACCTGTTTCCGGCGCTCGTGGTGGAG
GACCTGGTGCCTGGCAGCCGGCTGGGCCCCACCCTGATGTGTCTTCTCAGCACACAGTTC
AAGCGCCTGCGAGATGGGGACAGGTTGTGGTATGAGAACCCTGGGGTGTTCTCCCCGGCC
CAGCTGACTCAGATCAAGCAGACGTCGCTGGCCAGGATCCTATGCGACAACGCGGACAAC
ATCACCCGGGTGCAGAGCGACGTGTTCAGGGTGGCGGAGTTCCCTCACGGCTACGGCAGC
TGTGACGAGATCCCCAGGGTAGACCTCCGGGTGTGGCAGGACTGCTGTGAAGACTGTAGG
ACCAGGGGGCAGTTCAATGCCTTTTCCTATCATTTCCGAGGCAGACGGTCTCTTGAGTTC
AGCTACCAGGAGGACAAGCCGACCAAGAAAACAAGACCACGGAAAATACCCAGTGTTGGG
AGACAGGGGGAACATCTCAGCAACAGCACCTCAGCCTTCAGCACACGCTCAGATGCATCT
GGGACAAATGACTTCAGAGAGTTTGTTCTGGAAATGCAGAAGACCATCACAGACCTCAGA
ACACAGATAAAGAAACTTGAATCACGGCTCAGTACCACAGAGTGCGTGGATGCCGGGGGC
GAATCTCACGCCAACAACACCAAGTGGAAAAAAGATGCATGCACCATTTGTGAATGCAAA
GACGGGCAGGTCACCTGCTTCGTGGAAGCTTGCCCCCCTGCCACCTGTGCTGTCCCCGTG
AACATCCCAGGGGCCTGCTGTCCAGTCTGCTTACAGAAGAGGGCGGAGGAAAAGCCCTAG

Protein Properties

Number of Residues

1479

Molecular Weight

165273.15

Theoretical pI

7.173

Pfam Domain Function

An_peroxidase (PF03098 )
I-set (PF07679 )
VWC (PF00093 )
LRR_1 (PF00560 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Peroxidasin homolog
MAKRSRGPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAV
APQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKN
EIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNH
LESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEE
LNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG
TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVT
LECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDS
VHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHL
VLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGA
NVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTI
GSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLAL
FRYPRDPYTVEQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANL
SGCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRG
INPHRLYNGHALPMPRLVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQAR
FSDGQHCSNVCSNDPPCFSVMIPPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPR
EQINQLTSYIDASNVYGSTEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECM
RDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRK
IVGAEIQHITYQHWLPKILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPL
LYRLDENFQPIAQDHLPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELT
ERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREK
LKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPA
QLTQIKQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQDCCEDCR
TRGQFNAFSYHFRGRRSLEFSYQEDKPTKKTRPRKIPSVGRQGEHLSNSTSAFSTRSDAS
GTNDFREFVLEMQKTITDLRTQIKKLESRLSTTECVDAGGESHANNTKWKKDACTICECK
DGQVTCFVEACPPATCAVPVNIPGACCPVCLQKRAEEKP

External Links

GenBank ID Protein

109150416

UniProtKB/Swiss-Prot ID

Q92626

UniProtKB/Swiss-Prot Entry Name

PXDN_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [PubMed:19159218 ]
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Han G, Ye M, Zhou H, Jiang X, Feng S, Jiang X, Tian R, Wan D, Zou H, Gu J: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. Proteomics. 2008 Apr;8(7):1346-61. doi: 10.1002/pmic.200700884. [PubMed:18318008 ]
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. DNA Res. 1996 Oct 31;3(5):321-9, 341-54. [PubMed:9039502 ]
Horikoshi N, Cong J, Kley N, Shenk T: Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. Biochem Biophys Res Commun. 1999 Aug 11;261(3):864-9. [PubMed:10441517 ]
Mitchell MS, Kan-Mitchell J, Minev B, Edman C, Deans RJ: A novel melanoma gene (MG50) encoding the interleukin 1 receptor antagonist and six epitopes recognized by human cytolytic T lymphocytes. Cancer Res. 2000 Nov 15;60(22):6448-56. [PubMed:11103812 ]
Cheng G, Salerno JC, Cao Z, Pagano PJ, Lambeth JD: Identification and characterization of VPO1, a new animal heme-containing peroxidase. Free Radic Biol Med. 2008 Dec 15;45(12):1682-94. doi: 10.1016/j.freeradbiomed.2008.09.009. Epub 2008 Sep 23. [PubMed:18929642 ]
Peterfi Z, Donko A, Orient A, Sum A, Prokai A, Molnar B, Vereb Z, Rajnavolgyi E, Kovacs KJ, Muller V, Szabo AJ, Geiszt M: Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney. Am J Pathol. 2009 Aug;175(2):725-35. doi: 10.2353/ajpath.2009.080693. Epub 2009 Jul 9. [PubMed:19590037 ]