| Identification |
|---|
| HMDB Protein ID
| HMDBP07961 |
| Secondary Accession Numbers
| |
| Name
| Pyroglutamylated RFamide peptide receptor |
| Synonyms
|
- AQ27
- G-protein coupled receptor 103
- Orexigenic neuropeptide QRFP receptor
- SP9155
|
| Gene Name
| QRFPR |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| neuropeptide receptor activity |
| receptor activity |
| neuropeptide y receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| peptide receptor activity, g-protein coupled |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q27 |
| SNPs
| QRFPR |
| Gene Sequence
|
>1296 bp
ATGCAGGCGCTTAACATTACCCCGGAGCAGTTCTCTCGGCTGCTGCGGGACCACAACCTG
ACGCGGGAGCAGTTCATCGCAGTTCATCGCCTGCGACCGCTCGTCTACACCCCAGAGCTG
CCGGGACGCGCCAAGCTGGCCCTCGTGCTCACCGGCGTGCTCATCTTCGCCCTGGCGCTC
TTTGGCAATGCTCTGGTGTTCTACGTGGTGACCCGCAGCAAGGCCATGCGCACCGTCACC
AACATCTTTATCTGCTCCTTGGCGCTCAGTGACCTGCTCATCACCTTCTTCTGCATTCCC
GTCACCATGCTCCAGAACATTTCCGACAACTGGCTGGGGGGTGCTTTCATTTGCAAGATG
GTGCCATTTGTCCAGTCTACCGCTGTTGTGACAGAAATCCTCACTATGACCTGCATTGCT
GTGGAAAGGCACCAGGGACTTGTGCATCCTTTTAAAATGAAGTGGCAATACACCAACCGA
AGGGCTTTCACAATGCTAGGTGTGGTCTGGCTGGTGGCAGTCATCGTAGGATCACCCATG
TGGCACGTGCAACAACTTGAGATCAAATATGACTTCCTATATGAAAAGGAACACATCTGC
TGCTTAGAAGAGTGGACCAGCCCTGTGCACCAGAAGATCTACACCACCTTCATCCTTGTC
ATCCTCTTCCTCCTGCCTCTTATGGTGATGCTTATTCTGTACAGTAAAATTGGTTATGAA
CTTTGGATAAAGAAAAGAGTTGGGGATGGTTCAGTGCTTCGAACTATTCATGGAAAAGAA
ATGTCCAAAATAGCCAGGAAGAAGAAACGAGCTGTCATTATGATGGTGACAGTGGTGGCT
CTCTTTGCTGTGTGCTGGGCACCATTCCATGTTGTCCATATGATGATTGAATACAGTAAT
TTTGAAAAGGAATATGATGATGTCACAATCAAGATGATTTTTGCTATCGTGCAAATTATT
GGATTTTCCAACTCCATCTGTAATCCCATTGTCTATGCATTTATGAATGAAAACTTCAAA
AAAAATGTTTTGTCTGCAGTTTGTTATTGCATAGTAAATAAAACCTTCTCTCCAGCACAA
AGGCATGGAAATTCAGGAATTACAATGATGCGGAAGAAAGCAAAGTTTTCCCTCAGAGAG
AATCCAGTGGAGGAAACCAAAGGAGAAGCATTCAGTGATGGCAACATTGAAGTCAAATTG
TGTGAACAGACAGAGGAGAAGAAAAAGCTCAAACGACATCTTGCTCTCTTTAGGTCTGAA
CTGGCTGAGAATTCTCCTTTAGACAGTGGGCATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 431 |
| Molecular Weight
| 49487.4 |
| Theoretical pI
| 9.51 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 47-67
- 82-102
- 121-141
- 163-183
- 213-233
- 272-292
- 312-332
|
| Protein Sequence
|
>Pyroglutamylated RFamide peptide receptor
MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALAL
FGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKM
VPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPM
WHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYE
LWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSN
FEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQ
RHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSE
LAENSPLDSGH
|
| External Links |
|---|
| GenBank ID Protein
| 37651191 |
| UniProtKB/Swiss-Prot ID
| Q96P65 |
| UniProtKB/Swiss-Prot Entry Name
| QRFPR_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB109629 |
| GeneCard ID
| QRFPR |
| GenAtlas ID
| QRFPR |
| HGNC ID
| HGNC:15565 |
| References |
|---|
| General References
| - Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF: Discovery and mapping of ten novel G protein-coupled receptor genes. Gene. 2001 Sep 5;275(1):83-91. [PubMed:11574155 ]
- Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F Jr, Zhang FL: Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. J Biol Chem. 2003 Jul 25;278(30):27652-7. Epub 2003 Apr 24. [PubMed:12714592 ]
- Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M: A new peptidic ligand and its receptor regulating adrenal function in rats. J Biol Chem. 2003 Nov 21;278(47):46387-95. Epub 2003 Sep 5. [PubMed:12960173 ]
|
