Human Metabolome Database: Showing Protein Ryanodine receptor 2 (HMDBP07975)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 metabolites

Identification

HMDB Protein ID

HMDBP07975

Secondary Accession Numbers

13686

Name

Ryanodine receptor 2

Synonyms

Cardiac muscle ryanodine receptor-calcium release channel
Cardiac muscle-type ryanodine receptor
RYR-2
RyR2
hRYR-2

Gene Name

RYR2

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium channel activity

Specific Function

Communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T- tubules

Pathways

Acebutolol Action Pathway
Alprenolol Action Pathway
Amiodarone Action Pathway
Amlodipine Action Pathway
Arbutamine Action Pathway
Atenolol Action Pathway
Betaxolol Action Pathway
Bevantolol Action Pathway
Bisoprolol Action Pathway
Bopindolol Action Pathway
Bupranolol Action Pathway
Carteolol Action Pathway
Carvedilol Action Pathway
Diltiazem Action Pathway
Disopyramide Action Pathway
Dobutamine Action Pathway
Epinephrine Action Pathway
Esmolol Action Pathway
Felodipine Action Pathway
Flecainide Action Pathway
Fosphenytoin (Antiarrhythmic) Action Pathway
Ibutilide Action Pathway
Isoprenaline Action Pathway
Isradipine Action Pathway
Labetalol Action Pathway
Levobunolol Action Pathway
Lidocaine (Antiarrhythmic) Action Pathway
Metipranolol Action Pathway
Metoprolol Action Pathway
Mexiletine Action Pathway
Muscle/Heart Contraction
Nadolol Action Pathway
Nebivolol Action Pathway
Nifedipine Action Pathway
Nimodipine Action Pathway
Nisoldipine Action Pathway
Nitrendipine Action Pathway
Oxprenolol Action Pathway
Penbutolol Action Pathway
Phenytoin (Antiarrhythmic) Action Pathway
Pindolol Action Pathway
Practolol Action Pathway
Procainamide (Antiarrhythmic) Action Pathway
Propranolol Action Pathway
Quinidine Action Pathway
Sotalol Action Pathway
Timolol Action Pathway
Tocainide Action Pathway
Verapamil Action Pathway

Reactions

Not Available

GO Classification

Component
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
ion binding
cation binding
metal ion binding
binding
intracellular ligand-gated calcium channel activity
ryanodine-sensitive calcium-release channel activity
intracellular ligand-gated ion channel activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
cation channel activity
calcium ion binding
calcium channel activity
ligand-gated ion channel activity
Process
di-, tri-valent inorganic cation transport
divalent metal ion transport
calcium ion transport
cellular metal ion homeostasis
cellular calcium ion homeostasis
establishment of localization
transport
biological regulation
transmembrane transport
ion transport
cation transport
regulation of biological quality
homeostatic process
chemical homeostasis
ion homeostasis
cellular ion homeostasis
cellular cation homeostasis

Cellular Location

Membrane
Multi-pass membrane protein (Probable)

Gene Properties

Chromosome Location

Chromosome:1

Locus

1q43

SNPs

RYR2

Gene Sequence

>14904 bp
ATGGCCGATGGGGGCGAGGGCGAAGACGAGATCCAGTTCCTGCGAACTGATGATGAAGTG
GTTCTGCAGTGCACCGCAACCATCCACAAAGAACAACAGAAGCTATGCTTGGCAGCAGAA
GGATTTGGCAACAGACTTTGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCA
GACCTCTCCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTGTCCGGGCGCTGCAGGAG
ATGCTGGCTAACACCGTGGAGAAATCAGAAGGGCAAGTTGATGTGGAAAAATGGAAATTC
ATGATGAAGACTGCTCAAGGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTG
CTGCGCCATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCACCTCCCGGTCTTCAACT
GATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGACACCACAGGGGAGGCTTGTTGGTGG
ACCATACACCCTGCCTCTAAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGAC
CTCATCTTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGTCTTATGGCAACGGCAGC
TTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGGAGCGTGGCCCCAATCAGCTCAGGA
AGTGAGGCAGCCCAAGGGTATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACAC
ATGGACGAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAGAGCAGCGGAGAACTGTT
CATTATGAAGGTGGCGCTGTGTCTGTTCATGCACGTTCCCTTTGGAGACTAGAGACGCTA
AGAGTTGCGTGGAGTGGAAGCCACATAAGATGGGGACAGCCATTCCGACTACGCCATGTC
ACAACAGGAAAATACTTGAGTCTCATGGAAGACAAAAACCTTCTACTCATGGACAAAGAG
AAAGCTGATGTAAAATCAACAGCATTTACCTTCCGGTCTTCCAAGGAAAAATTGGATGTA
GGGGTGAGAAAAGAAGTAGATGGCATGGGAACATCTGAAATAAAATACGGTGACTCAGTA
TGCTATATACAACATGTAGACACAGGCCTATGGCTTACTTACCAGTCTGTGGACGTGAAA
TCCGTGAGAATGGGATCTATACAACGTAAGGCTATTATGCATCATGAAGGCCACATGGAT
GATGGCATAAGTTTGTCGAGATCCCAGCATGAAGAATCACGCACAGCCCGAGTTATCCGG
AGCACAGTCTTCCTTTTCAATAGATTTATAAGGGGCCTTGATGCTCTCAGCAAGAAAGCG
AAGGCTTCCACAGTCGATTTGCCTATAGAGTCCGTAAGCCTAAGTCTGCAGGATCTCATT
GGCTACTTCCACCCCCCAGATGAGCATTTAGAGCATGAAGACAAACAGAACAGACTACGA
GCCCTGAAGAATCGGCAAAATCTCTTCCAGGAAGAGGGAATGATCAACCTCGTGCTTGAG
TGCATAGACCGTTTGCACGTCTACAGCAGTGCAGCACACTTTGCTGATGTTGCTGGGCGA
GAAGCAGGAGAGTCTTGGAAATCCATTCTGAATTCTCTGTATGAGTTGCTGGCGGCTCTA
ATTAGAGGAAATCGTAAAAACTGTGCTCAATTTTCTGGCTCCCTCGACTGGTTGATCAGC
AGATTGGAAAGACTGGAAGCTTCTTCAGGCATTCTGGAAGTTTTACACTGTGTTTTAGTA
GAAAGTCCAGAAGCTCTAAATATTATTAAAGAAGGACATATTAAATCTATTATCTCACTT
TTAGACAAACATGGAAGAAATCACAAGGTTCTGGATGTCTTGTGCTCACTCTGTGTTTGC
CACGGGGTTGCAGTCCGTTCTAACCAGCATCTCATCTGTGACAATCTCCTACCAGGAAGA
GACTTGTTATTGCAGACACGTCTTGTGAACCATGTCAGCAGCATGAGACCCAATATTTTT
CTGGGCGTCAGTGAAGGTTCTGCTCAGTATAAGAAATGGTACTATGAATTGATGGTGGAC
CACACAGAGCCCTTTGTGACAGCTGAAGCAACTCACCTGCGAGTGGGCTGGGCTTCCACT
GAAGGATATTCTCCCTACCCTGGAGGGGGCGAAGAGTGGGGTGGAAATGGTGTTGGAGAT
GATCTCTTCTCCTATGGATTTGATGGCCTTCATCTCTGGTCAGGTTGTATTGCTCGTACT
GTAAGCTCACCAAACCAACATCTGTTAAGAACTGATGATGTCATCAGTTGCTGTTTAGAT
CTGAGTGCCCCAAGCATCTCGTTCCGAATTAATGGACAACCTGTTCAAGGAATGTTTGAG
AATTTCAACATCGATGGCCTCTTCTTTCCAGTCGTTAGTTTCTCTGCAGGAATAAAAGTA
CGCTTTCTGCTTGGAGGGCGACATGGAGAATTCAAATTTCTTCCTCCACCTGGGTATGCT
CCTTGTTATGAAGCTGTTCTGCCAAAAGAAAAGTTGAAAGTGGAACACAGCCGAGAGTAC
AAGCAAGAAAGAACTTACACACGCGACCTGCTGGGCCCCACAGTTTCCCTGACGCAAGCT
GCCTTCACACCCATCCCTGTGGATACCAGCCAGATCGTGTTGCCTCCTCATCTAGAAAGA
ATAAGAGAAAAACTGGCAGAGAATATCCATGAACTCTGGGTTATGAATAAAATTGAGCTT
GGCTGGCAGTATGGTCCGGTTAGAGATGACAACAAGAGACAACACCCATGCCTGGTGGAG
TTCTCCAAGCTGCCTGAACAGGAGCGCAATTACAACTTACAAATGTCGCTTGAGACCCTG
AAGACTTTGTTGGCATTAGGATGTCATGTGGGTATATCAGATGAACATGCTGAAGACAAG
GTGAAAAAAATGAAGCTACCCAAGAATTACCAGCTGACAAGTGGATACAAGCCTGCCCCT
ATGGACCTGAGCTTTATCAAACTCACCCCATCGCAAGAAGCAATGGTGGACAAGTTGGCA
GAAAATGCACATAATGTGTGGGCGCGGGATCGAATCCGGCAGGGCTGGACTTATGGCATC
CAACAGGACGTAAAGAACAGAAGAAATCCTCGCCTTGTTCCCTACACTCCTCTGGATGAC
CGAACCAAGAAATCCAACAAGGACAGCCTCCGCGAGGCTGTGCGCACGCTGCTGGGGTAC
GGCTACAACTTGGAAGCACCAGATCAAGATCATGCAGCCAGAGCCGAAGTGTGCAGCGGC
ACCGGGGAAAGGTTCCGAATCTTCCGTGCCGAGAAGACCTATGCAGTGAAGGCCGGACGG
TGGTATTTTGAATTTGAGACGGTCACTGCTGGAGACATGAGGGTTGGTTGGAGTCGTCCT
GGTTGTCAACCGGATCAGGAGCTTGGCTCAGATGAACGTGCCTTTGCCTTTGATGGCTTC
AAGGCCCAGCGGTGGCATCAGGGCAATGAACACTATGGGCGCTCTTGGCAAGCAGGCGAT
GTCGTGGGGTGTATGGTTGACATGAACGAACACACCATGATGTTCACACTGAATGGTGAA
ATCCTTCTTGATGATTCAGGCTCAGAACTGGCTTTCAAGGACTTTGATGTTGGCGATGGA
TTCATACCTGTGTGTAGCCTTGGAGTGGCTCAAGTGGGTAGGATGAACTTTGGAAAGGAT
GTCAGCACCTTGAAATATTTCACCATCTGTGGCTTACAAGAGGGCTATGAACCATTTGCC
GTTAATACAAACAGGGATATTACCATGTGGCTGAGCAAGAGGCTTCCTCAGTTTCTTCAA
GTTCCATCAAACCATGAACATATAGAGGTGACCAGAATAGACGGCACCATAGACAGTTCC
CCATGTTTAAAGGTCACTCAGAAGTCTTTTGGTTCTCAGAACAGCAACACTGATATCATG
TTTTATCGCCTGAGCATGCCGATCGAGTGCGCGGAGGTCTTCTCCAAGACGGTGGCTGGA
GGGCTCCCTGGGGCTGGCCTTTTTGGGCCCAAGAATGACTTGGAAGATTATGATGCTGAT
TCTGACTTTGAGGTTCTGATGAAGACAGCTCATGGCCATCTAGTGCCCGATCGTGTTGAC
AAAGACAAAGAAGCTACTAAACCAGAGTTTAACAACCACAAAGATTATGCCCAGGAAAAG
CCCTCTCGTCTGAAACAAAGATTTTTGCTTAGAAGAACAAAGCCAGATTACAGCACAAGC
CATTCTGCAAGACTCACCGAAGATGTCCTTGCTGATGATCGGGATGACTATGATTTCTTG
ATGCAAACGTCCACGTACTATTACTCAGTGAGAATCTTTCCTGGACAAGAACCTGCTAAT
GTCTGGGTGGGCTGGATTACATCAGATTTCCATCAGTATGACACAGGCTTTGACTTGGAC
AGAGTTCGCACAGTAACAGTTACTCTAGGAGATGAAAAAGGAAAAGTGCATGAAAGCATC
AAACGCAGCAACTGCTATATGGTATGTGCGGGTGAGAGCATGAGCCCCGGGCAAGGACGC
AACAATAATGGACTGGAGATTGGCTGTGTGGTGGATGCTGCCAGCGGGCTGCTCACATTC
ATTGCCAATGGCAAGGAACTGAGCACATACTATCAGGTGGAACCGAGTACAAAATTATTT
CCTGCGGTTTTTGCACAAGCTACAAGTCCCAATGTTTTCCAGTTTGAGTTGGGAAGAATA
AAGAATGTGATGCCTCTCTCGGCGGGATTATTCAAGAGTGAGCACAAGAACCCCGTGCCG
CAGTGCCCCCCGCGCCTCCACGTGCAGTTCCTGTCACACGTCCTGTGGAGCAGAATGCCC
AACCAGTTTTTGAAGGTAGATGTGTCTCGAATAAGTGAACGCCAAGGCTGGTTGGTGCAG
TGTTTGGATCCTCTGCAGTTCATGTCTCTTCATATCCCTGAGGAAAACAGATCTGTTGAC
ATCTTAGAGTTGACAGAGCAGGAGGAATTGCTGAAATTTCACTATCACACTCTCCGGCTC
TACTCAGCCGTCTGTGCTCTTGGGAACCACCGGGTGGCCCATGCCCTGTGCAGCCATGTG
GATGAACCTCAGCTCCTCTATGCCATTGAGAACAAGTACATGCCTGGTTTGCTGCGTGCT
GGCTACTATGACCTGCTGATTGACATCCACCTGAGCTCCTATGCCACTGCCAGGCTCATG
ATGAACAACGAGTACATTGTCCCCATGACGGAGGAGACGAAGAGCATCACCCTGTTCCCT
GATGAGAACAAAAAACACGGCCTTCCAGGGATCGGCCTCAGCACCTCCCTCAGGCCACGG
ATGCAGTTTTCCTCCCCCAGTTTTGTAAGCATTAGTAATGAATGTTACCAGTACAGTCCA
GAGTTCCCACTGGACATCCTCAAGTCCAAAACCATACAGATGCTGACAGAAGCTGTTAAA
GAGGGCAGTCTTCATGCCCGGGACCCAGTTGGAGGGACTACTGAATTCCTCTTTGTACCT
CTCATCAAGCTTTTCTATACCCTGCTGATCATGGGCATCTTTCACAACGAGGACTTGAAG
CACATCTTGCAGTTGATTGAGCCCAGTGTGTTTAAAGAAGCTGCCACTCCGGAGGAGGAG
AGTGACACGCTGGAGAAAGAGCTCAGTGTGGACGATGCAAAGCTGCAAGGAGCTGGTGAG
GAAGAAGCCAAGGGGGGCAAGCGGCCCAAGGAAGGCCTGCTCCAAATGAAACTGCCAGAG
CCAGTTAAATTGCAGATGTGCCTACTGCTTCAGTACCTCTGTGACTGCCAGGTCCGGCAC
CGGATAGAAGCCATTGTAGCCTTTTCAGATGATTTTGTGGCTAAGCTCCAAGACAATCAA
CGTTTCCGATACAACGAAGTCATGCAAGCCTTAAACATGTCAGCTGCACTCACAGCCAGG
AAGACAAAGGAATTTAGATCACCACCTCAAGAACAGATCAATATGCTTCTCAATTTTAAG
GATGACAAAAGTGAATGTCCATGTCCAGAAGAAATTCGTGACCAACTATTGGATTTCCAT
GAAGATTTGATGACACATTGTGGAATTGAGCTGGATGAAGATGGGTCTCTGGATGGAAAC
AGTGATTTAACAATTAGAGGGCGTCTGCTATCCCTGGTAGAAAAGGTGACATATCTGAAG
AAGAAGCAAGCAGAAAAACCAGTTGAGAGTGACTCCAAAAAGTCCTCCACTCTGCAGCAG
CTGATTTCTGAGACCATGGTCCGATGGGCTCAGGAGTCTGTCATTGAAGACCCCGAGCTG
GTGAGGGCCATGTTTGTGTTGCTCCATCGGCAGTATGACGGCATTGGGGGTCTTGTTCGG
GCCCTGCCAAAGACCTACACGATAAATGGTGTGTCCGTGGAGGACACCATCAACCTGCTG
GCATCCCTTGGTCAGATTCGGTCCCTGCTGAGTGTGAGAATGGGCAAAGAAGAAGAGAAG
CTCATGATTCGTGGATTAGGGGATATTATGAATAACAAAGTGTTTTACCAGCACCCTAAT
CTCATGAGGGCACTGGGGATGCACGAGACTGTGATGGAGGTCATGGTGAACGTCCTTGGA
GGTGGAGAGTCCAAGGAAATCACCTTTCCCAAGATGGTGGCCAACTGTTGCCGTTTTCTC
TGTTACTTCTGTCGTATAAGTAGGCAGAATCAAAAAGCTATGTTTGATCATCTCAGTTAT
TTACTGGAAAACAGCAGTGTTGGTCTTGCCTCCCCAGCTATGAGAGGTTCAACACCACTG
GATGTGGCTGCAGCTTCGGTGATGGATAATAATGAACTAGCATTAGCTCTGCGTGAGCCG
GATCTAGAAAAGGTAGTTCGTTATTTGGCTGGTTGTGGACTGCAAAGTTGCCAGATGCTG
GTGTCTAAGGGCTATCCAGACATTGGGTGGAACCCAGTTGAAGGAGAGAGATATCTTGAC
TTTCTCAGATTTGCTGTCTTCTGTAATGGGGAGAGTGTGGAGGAAAATGCAAATGTCGTG
GTGAGATTGCTCATTCGGAGGCCTGAGTGTTTTGGTCCTGCTTTGAGAGGAGAAGGTGGG
AATGGGCTTCTTGCAGCAATGGAAGAAGCCATCAAAATCGCCGAGGATCCTTCCCGAGAT
GGTCCCTCACCAAATAGCGGATCCAGTAAAACACTTGACACAGAGGAGGAGGAAGATGAC
ACTATCCACATGGGGAACGCGATCATGACCTTCTATTCAGCTTTGATTGACCTCTTGGGA
CGCTGTGCTCCTGAGATGCATTTGATTCATGCCGGGAAGGGAGAAGCCATCAGAATTAGG
TCCATTTTGAGATCCCTCATTCCCCTGGGAGATTTGGTGGGCGTTATCAGCATCGCTTTT
CAGATGCCAACAATAGCCAAAGATGGGAATGTGGTGGAACCTGACATGTCTGCGGGGTTT
TGCCCAGATCACAAGGCAGCCATGGTTTTATTCCTTGACAGGGTCTATGGGATTGAGGTT
CAAGACTTCCTCCTCCATCTTCTTGAGGTTGGCTTTCTGCCAGATCTCCGGGCGGCTGCT
TCTTTAGATACGGCAGCTTTGAGTGCTACAGACATGGCCTTGGCCCTCAATCGGTACCTT
TGCACAGCCGTCTTGCCATTGTTAACAAGATGTGCTCCTCTCTTTGCTGGCACAGAGCAC
CACGCTTCTCTCATTGACTCATTACTTCATACTGTGTATAGACTTTCTAAGGGCTGTTCA
CTTACCAAAGCTCAGCGGGATTCCATAGAAGTTTGTTTACTCTCTATTTGTGGACAACTG
AGACCTTCTATGATGCAGCACTTACTCAGAAGATTAGTATTTGATGTCCCATTATTAAAT
GAACACGCAAAGATGCCTCTTAAACTGCTGACAAATCATTATGAAAGATGCTGGAAATAT
TACTGCCTGCCTGGAGGGTGGGGAAACTTTGGTGCTGCCTCAGAAGAAGAACTTCATTTA
TCAAGAAAGTTGTTCTGGGGCATTTTTGATGCCCTGTCTCAAAAGAAATATGAACAAGAA
CTTTTCAAACTGGCACTGCCTTGCCTGAGTGCAGTTGCGGGAGCTTTGCCTCCAGACTAC
ATGGAGTCAAATTATGTCAGTATGATGGAAAAACAGTCATCAATGGATTCTGAAGGGAAC
TTTAACCCACAACCTGTTGATACCTCAAATATTACAATTCCTGAGAAATTGGAATACTTC
ATTAACAAATATGCAGAACACTCCCATGACAAATGGTCAATGGACAAGTTGGCAAATGGA
TGGATTTATGGAGAAATATATTCAGACTCTTCTAAGGTTCAGCCATTAATGAAGCCATAT
AAGCTATTGTCTGAAAAGGAAAAAGAAATTTATCGCTGGCCAATCAAAGAATCTTTAAAA
ACTATGCTGGCTAGGACTATGAGAACTGAAAGAACTCGGGAGGGAGACAGCATGGCCCTT
TACAACCGGACTCGTCGTATTTCTCAGACAAGCCAGGTTTCTGTGGACGCTGCCCATGGT
TACAGTCCCCGGGCCATTGACATGAGCAATGTTACACTATCTAGAGACCTGCATGCTATG
GCAGAAATGATGGCTGAAAACTACCATAATATATGGGCAAAGAAAAAGAAAATGGAGTTG
GAGTCCAAAGGAGGAGGAAACCATCCTCTGCTGGTGCCCTATGATACACTGACAGCCAAA
GAGAAAGCCAAGGATAGAGAAAAAGCACAGGACATCCTCAAGTTCTTGCAGATCAATGGA
TATGCTGTATCCAGAGGATTTAAGGACCTGGAACTGGACACGCCTTCTATTGAGAAACGA
TTTGCCTATAGTTTCCTCCAACAACTCATTCGCTATGTGGATGAAGCCCATCAGTATATC
CTGGAGTTTGATGGTGGCAGCAGAGGCAAAGGAGAACATTTCCCTTATGAACAAGAAATC
AAGTTCTTTGCAAAAGTCGTTCTTCCTTTAATTGATCAGTATTTCAAAAACCATCGTTTA
TACTTCTTATCTGCAGCAAGCAGACCTCTCTGCTCTGGAGGACATGCTTCCAACAAAGAG
AAAGAAATGGTGACTAGCCTATTCTGCAAACTTGGAGTTCTTGTCAGGCATAGGATTTCA
CTATTTGGCAATGATGCAACATCAATTGTCAACTGTCTTCATATTTTGGGTCAGACTTTG
GATGCAAGGACAGTGATGAAGACTGGCCTGGAGAGTGTTAAAAGTGCACTCAGAGCTTTT
CTGGACAACGCTGCAGAGGATCTGGAGAAGACCATGGAAAACCTCAAGCAGGGCCAGTTC
ACTCACACCCGAAACCAGCCCAAAGGGGTTACTCAGATTATCAATTACACCACAGTGGCC
CTGCTGCCAATGCTGTCGTCATTATTTGAACATATTGGCCAGCATCAGTTCGGAGAAGAC
CTAATATTGGAAGATGTCCAGGTGTCTTGTTATAGAATTCTGACTAGCTTATATGCTTTG
GGAACCAGCAAGAGTATTTACGTGGAGAGGCAACGTTCTGCATTAGGAGAATGTCTAGCT
GCCTTTGCTGGTGCTTTTCCTGTAGCATTTTTGGAAACTCATCTGGACAAACATAATATT
TACTCCATCTACAATACCAAGTCTTCACGAGAAAGAGCAGCTCTCAGTTTGCCAACTAAT
GTGGAAGATGTTTGTCCAAACATTCCGTCTTTGGAGAAACTCATGGAAGAAATCGTGGAA
TTAGCCGAGTCCGGCATTCGCTACACTCAAATGCCACATGTCATGGAAGTCATACTGCCC
ATGCTTTGCAGCTACATGTCTCGTTGGTGGGAGCATGGACCTGAGAACAATCCAGAACGG
GCCGAGATGTGCTGCACAGCCCTGAACTCAGAGCACATGAACACACTTCTAGGGAACATA
TTGAAAATCATATATAATAACTTGGGGATTGATGAGGGAGCCTGGATGAAGAGGCTAGCA
GTGTTTTCCCAGCCTATAATAAATAAAGTGAAACCTCAGCTCTTGAAAACTCATTTCTTG
CCGTTAATGGAGAAACTCAAGAAAAAGGCAGCTACGGTGGTGTCTGAGGAAGACCACCTG
AAAGCTGAGGCCAGGGGGGACATGTCGGAGGCAGAACTCCTCATCCTAGATGAGTTCACC
ACACTGGCCAGAGATCTCTATGCCTTCTACCCTCTCTTGATTAGATTTGTGGACTATAAC
AGGGCAAAGTGGCTAAAGGAGCCTAACCCAGAAGCAGAGGAGCTCTTCCGCATGGTGGCT
GAAGTGTTTATCTACTGGTCGAAGTCCCATAATTTCAAAAGAGAAGAGCAGAACTTCGTT
GTACAGAATGAAATCAACAATATGTCTTTCCTTATTACTGATACCAAGTCAAAGATGTCA
AAGGCAGCTGTTTCTGATCAGGAAAGGAAGAAAATGAAGCGCAAAGGAGATCGGTATTCC
ATGCAGACCTCTCTGATTGTAGCAGCTCTGAAGCGGTTACTGCCCATTGGGTTGAACATC
TGTGCCCCTGGGGACCAGGAGCTCATTGCTCTGGCCAAAAATCGATTTAGCCTGAAAGAT
ACTGAGGATGAAGTACGAGATATAATCCGCAGCAATATTCATTTACAAGGCAAGTTGGAG
GATCCTGCTATTAGATGGCAAATGGCTCTTTACAAAGACTTACCAAACAGGACTGATGAT
ACCTCAGATCCAGAGAAGACGGTAGAAAGAGTATTGGATATAGCAAATGTGCTTTTTCAT
CTTGAACAGAAGTCTAAACGTGTGGGTCGAAGACATTACTGTCTGGTGGAACATCCTCAG
AGATCTAAAAAGGCTGTATGGCATAAACTACTGTCTAAGCAGAGGAAAAGGGCTGTTGTA
GCCTGCTTCCGGATGGCCCCCTTATATAATCTGCCAAGGCATCGGGCTGTCAATCTCTTT
CTTCAGGGATATGAAAAGTCTTGGATTGAAACAGAAGAACATTACTTTGAAGATAAACTG
ATAGAAGATTTAGCAAAACCTGGGGCTGAACCTCCAGAAGAAGATGAAGGCACTAAGAGA
GTTGATCCTCTACATCAGCTGATCCTTCTGTTTAGTCGGACAGCTTTAACAGAGAAATGC
AAACTGGAGGAAGATTTTTTATATATGGCCTATGCAGATATTATGGCAAAGAGTTGTCAT
GATGAGGAAGATGACGATGGTGAAGAGGAAGTGAAGAGTTTTGAAGAAAAAGAAATGGAA
AAGCAAAAGCTTCTATACCAGCAAGCCCGACTCCACGATCGTGGCGCGGCTGAGATGGTG
CTACAGACAATCAGTGCCAGCAAAGGTGAAACTGGACCAATGGTAGCAGCTACTCTGAAA
CTTGGAATTGCTATTTTAAATGGTGGGAACTCCACAGTACAGCAGAAAATGCTTGACTAC
CTCAAGGAGAAAAAGGATGTGGGCTTCTTTCAGAGCCTGGCCGGCCTGATGCAGTCATGT
AGTGTCCTTGACCTAAATGCATTTGAGCGACAAAACAAAGCTGAAGGTCTTGGGATGGTG
ACAGAGGAAGGATCAGGAGAAAAGGTTCTGCAGGACGATGAGTTCACCTGTGACCTCTTC
CGATTCCTGCAACTACTCTGTGAGGGACACAACTCAGATTTTCAGAATTATCTGAGAACT
CAGACTGGCAATAATACAACTGTCAACATAATTATCTCCACTGTAGACTACCTACTGAGA
GTTCAGGAATCAATTAGTGACTTTTATTGGTATTACTCTGGGAAAGATGTTATTGATGAA
CAAGGACAACGGAATTTCTCCAAAGCTATCCAAGTGGCAAAACAAGTCTTTAACACTCTT
ACAGAGTATATTCAGGGTCCTTGCACTGGGAATCAACAGAGTTTGGCACACAGCAGGCTG
TGGGATGCTGTGGTCGGCTTTCTTCATGTGTTTGCCCATATGCAGATGAAGCTGTCGCAG
GATTCCAGTCAAATTGAGCTATTAAAAGAATTAATGGATCTGCAGAAGGATATGGTGGTC
ATGTTGCTGTCCATGTTAGAAGGTAATGTTGTTAATGGAACGATTGGCAAACAGATGGTG
GATATGCTTGTGGAATCTTCCAACAACGTGGAGATGATTCTCAAATTTTTTGACATGTTC
TTAAAACTAAAGGATTTGACGTCGTCTGATACTTTTAAAGAATATGACCCCGATGGCAAG
GGAGTCATTTCCAAGAGGGACTTCCACAAAGCGATGGAGAGCCATAAGCACTACACGCAG
TCAGAAACGGAATTTCTTTTGTCTTGTGCGGAGACGGATGAGAATGAAACCCTCGACTAC
GAAGAGTTCGTCAAACGCTTCCACGAACCTGCGAAGGACATCGGCTTCAACGTCGCCGTC
CTTCTGACAAACCTCTCTGAGCACATGCCCAACGATACCCGACTTCAGACTTTTCTGGAA
TTAGCAGAGAGCGTCCTGAATTATTTCCAGCCCTTTCTGGGCCGCATCGAAATCATGGGA
AGCGCCAAACGCATCGAGAGGGTCTATTTTGAAATCAGTGAGTCCAGCCGAACCCAGTGG
GAGAAGCCCCAGGTCAAGGAGTCCAAAAGACAGTTCATATTTGACGTGGTCAACGAAGGC
GGAGAGAAAGAGAAGATGGAACTCTTTGTGAACTTCTGCGAGGACACCATCTTTGAAATG
CAGCTGGCGGCTCAGATCTCGGAGTCGGACTTGAACGAGAGGTCAGCGAATAAGGAAGAA
AGCGAGAAGGAGAGGCCGGAAGAGCAGGGGCCGAGGATGGCTTTCTTCTCCATTCTGACG
GTCAGGTCGGCCCTGTTTGCGCTCAGGTACAATATCTTGACCCTTATGCGAATGCTCAGT
CTGAAGAGCCTGAAGAAGCAGATGAAAAAAGTAAAAAAGATGACCGTGAAGGACATGGTC
ACGGCCTTCTTTTCATCCTACTGGAGTATTTTCATGACCCTCTTGCACTTCGTGGCCAGC
GTTTTCAGAGGCTTTTTCCGCATCATTTGCAGCCTGCTGCTTGGGGGAAGCCTCGTCGAA
GGTGCTAAAAAGATCAAAGTTGCAGAACTGTTAGCCAACATGCCAGACCCCACTCAGGAT
GAGGTTAGAGGAGATGGGGAGGAGGGAGAGAGGAAACCCCTGGAAGCCGCCCTGCCCTCC
GAGGATCTGACCGACTTAAAGGAGCTGACAGAGGAAAGTGACCTTCTTTCGGACATCTTT
GGCCTGGATCTGAAGAGAGAAGGAGGACAGTACAAACTGATTCCTCATAATCCAAATGCT
GGGCTCAGTGACCTCATGAGCAACCCAGTCCCCATGCCTGAGGTGCAGGAAAAATTTCAG
GAACAGAAGGCAAAAGAAGAAGAAAAGGAAGAAAAAGAAGAAACCAAATCTGAACCTGAA
AAAGCCGAGGGAGAAGATGGAGAAAAAGAAGAGAAAGCCAAGGAAGACAAGGGCAAACAA
AAGTTGAGGCAGCTTCACACACACAGATACGGAGAACCAGAAGTGCCAGAGTCAGCATTC
TGGAAGAAAATCATAGCATATCAACAGAAACTTCTAAACTATTTTGCTCGCAACTTTTAC
AACATGAGAATGTTAGCCTTATTTGTCGCATTTGCTATCAATTTCATCTTGCTCTTTTAT
AAGGTCTCCACTTCTTCTGTGGTTGAAGGAAAGGAGCTCCCCACGAGAAGTTCAAGTGAA
AATGCCAAAGTGACAAGCCTGGACAGCAGCTCCCATAGAATCATCGCAGTTCACTATGTA
CTAGAGGAGAGCAGCGGCTACATGGAGCCCACGTTGCGTATCTTAGCTATTCTGCACACG
GTCATTTCTTTCTTCTGCATCATTGGATACTACTGCTTGAAAGTCCCATTGGTTATTTTT
AAGCGAGAAAAGGAAGTGGCACGGAAATTGGAATTTGATGGGCTTTATATTACAGAACAG
CCTTCAGAAGATGATATTAAAGGCCAGTGGGATAGACTCGTAATCAACACACAGTCATTT
CCCAACAACTACTGGGACAAATTTGTTAAAAGAAAGGTTATGGATAAATATGGAGAGTTC
TACGGCCGAGACAGAATCAGTGAATTACTTGGCATGGACAAGGCAGCTCTGGACTTCAGT
GATGCCAGAGAAAAGAAGAAGCCAAAGAAAGACAGCTCCTTATCAGCTGTACTGAACTCC
ATTGATGTGAAGTATCAGATGTGGAAACTAGGAGTCGTTTTCACTGACAACTCCTTCCTC
TACCTAGCCTGGTATATGACTATGTCTGTTCTTGGACACTATAACAACTTTTTTTTTGCC
GCTCACCTTCTCGACATTGCTATGGGATTCAAGACATTAAGAACCATCTTGTCCTCAGTA
ACTCACAATGGCAAACAGCTCGTATTAACCGTTGGCTTATTAGCTGTTGTTGTATACCTA
TACACTGTGGTGGCATTCAATTTTTTCCGAAAATTCTACAATAAAAGTGAAGATGGTGAT
ACACCAGATATGAAATGTGACGATATGCTAACATGCTATATGTTCCACATGTATGTTGGA
GTTCGTGCTGGAGGAGGGATCGGGGATGAAATCGAAGACCCAGCAGGAGATGAATATGAG
ATCTATCGAATCATCTTTGACATCACTTTCTTCTTCTTTGTTATTGTCATTCTCTTGGCC
ATAATACAAGGTCTAATTATTGATGCTTTTGGAGAACTAAGAGACCAACAGGAACAAGTC
AAAGAAGACATGGAGACCAAATGCTTCATCTGTGGGATAGGCAATGATTACTTCGACACA
GTGCCACATGGCTTTGAAACCCACACTTTACAGGAGCACAACTTGGCTAATTACTTGTTT
TTTCTGATGTATCTTATAAACAAAGATGAAACAGAACACACAGGACAGGAATCTTATGTC
TGGAAGATGTATCAAGAAAGGTGTTGGGAATTTTTCCCAGCAGGGGATTGCTTCCGGAAA
CAGTATGAAGACCAGCTAAATTAA

Protein Properties

Number of Residues

4967

Molecular Weight

564562.7

Theoretical pI

5.98

Pfam Domain Function

MIR (PF02815 )
Ion_trans (PF00520 )
Ins145_P3_rec (PF08709 )
RIH_assoc (PF08454 )
RYDR_ITPR (PF01365 )
SPRY (PF00622 )
RR_TM4-6 (PF06459 )
RyR (PF02026 )

Signals

None

Transmembrane Regions

3090-3109
3153-3171
3940-3959
3978-3995
4233-4256
4294-4314
4500-4520
4578-4600
4720-4740
4768-4786
4810-4827
4845-4867

Protein Sequence

>Ryanodine receptor 2
MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP
DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL
LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD
LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH
MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV
TTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV
CYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIR
STVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR
ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL
IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL
LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF
LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD
DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE
NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY
KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL
GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDK
VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI
QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG
TGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF
KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG
FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ
VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAG
GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK
PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPAN
VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR
NNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI
KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ
CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV
DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFP
DENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVK
EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEE
SDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH
RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK
DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK
KKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR
ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN
LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY
LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML
VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG
NGLLAAMEEAIKIAEDPSRDGPSPNSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLG
RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF
CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL
CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL
RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL
SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN
FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY
KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG
YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK
EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI
LEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE
KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF
LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED
LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI
YSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP
MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA
VFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLILDEFT
TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFV
VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI
CAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDD
TSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKLLSKQRKRAVV
ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKR
VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEME
KQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDY
LKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLF
RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE
QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ
DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF
LKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDY
EEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMG
SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM
QLAAQISESDLNERSANKEESEKERPEEQGPRMAFFSILTVRSALFALRYNILTLMRMLS
LKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRIICSLLLGGSLVE
GAKKIKVAELLANMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIF
GLDLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPE
KAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFY
NMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYV
LEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQ
PSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFS
DAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFA
AHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGD
TPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLA
IIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLF
FLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN

External Links

GenBank ID Protein

1526978

UniProtKB/Swiss-Prot ID

Q92736

UniProtKB/Swiss-Prot Entry Name

RYR2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

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Laitinen PJ, Swan H, Kontula K: Molecular genetics of exercise-induced polymorphic ventricular tachycardia: identification of three novel cardiac ryanodine receptor mutations and two common calsequestrin 2 amino-acid polymorphisms. Eur J Hum Genet. 2003 Nov;11(11):888-91. [PubMed:14571276 ]
Martin C, Chapman KE, Seckl JR, Ashley RH: Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum. Neuroscience. 1998 Jul;85(1):205-16. [PubMed:9607712 ]
Tunwell RE, Wickenden C, Bertrand BM, Shevchenko VI, Walsh MB, Allen PD, Lai FA: The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis. Biochem J. 1996 Sep 1;318 ( Pt 2):477-87. [PubMed:8809036 ]
Tiso N, Stephan DA, Nava A, Bagattin A, Devaney JM, Stanchi F, Larderet G, Brahmbhatt B, Brown K, Bauce B, Muriago M, Basso C, Thiene G, Danieli GA, Rampazzo A: Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). Hum Mol Genet. 2001 Feb 1;10(3):189-94. [PubMed:11159936 ]
Awad SS, Lamb HK, Morgan JM, Dunlop W, Gillespie JI: Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium. Biochem J. 1997 Mar 15;322 ( Pt 3):777-83. [PubMed:9148749 ]
Priori SG, Napolitano C, Tiso N, Memmi M, Vignati G, Bloise R, Sorrentino V, Danieli GA: Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation. 2001 Jan 16;103(2):196-200. [PubMed:11208676 ]
Laitinen PJ, Brown KM, Piippo K, Swan H, Devaney JM, Brahmbhatt B, Donarum EA, Marino M, Tiso N, Viitasalo M, Toivonen L, Stephan DA, Kontula K: Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia. Circulation. 2001 Jan 30;103(4):485-90. [PubMed:11157710 ]
Priori SG, Napolitano C, Memmi M, Colombi B, Drago F, Gasparini M, DeSimone L, Coltorti F, Bloise R, Keegan R, Cruz Filho FE, Vignati G, Benatar A, DeLogu A: Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation. 2002 Jul 2;106(1):69-74. [PubMed:12093772 ]
Bauce B, Rampazzo A, Basso C, Bagattin A, Daliento L, Tiso N, Turrini P, Thiene G, Danieli GA, Nava A: Screening for ryanodine receptor type 2 mutations in families with effort-induced polymorphic ventricular arrhythmias and sudden death: early diagnosis of asymptomatic carriers. J Am Coll Cardiol. 2002 Jul 17;40(2):341-9. [PubMed:12106942 ]
Choi G, Kopplin LJ, Tester DJ, Will ML, Haglund CM, Ackerman MJ: Spectrum and frequency of cardiac channel defects in swimming-triggered arrhythmia syndromes. Circulation. 2004 Oct 12;110(15):2119-24. Epub 2004 Oct 4. [PubMed:15466642 ]
Bagattin A, Veronese C, Rampazzo A, Danieli GA: Gene symbol: RYR2. Disease: Effort-induced polymorphic ventricular arrhythmias. Hum Genet. 2004 Mar;114(4):404. [PubMed:15046072 ]
Bagattin A, Veronese C, Rampazzo A, Danieli GA: Gene symbol: RYR2. Disease: Effort-induced polymorphic ventricular arrhythmias. Hum Genet. 2004 Mar;114(4):405. [PubMed:15046073 ]
Tester DJ, Spoon DB, Valdivia HH, Makielski JC, Ackerman MJ: Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: a molecular autopsy of 49 medical examiner/coroner's cases. Mayo Clin Proc. 2004 Nov;79(11):1380-4. [PubMed:15544015 ]
Jiang D, Chen W, Wang R, Zhang L, Chen SR: Loss of luminal Ca2+ activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18309-14. Epub 2007 Nov 1. [PubMed:17984046 ]