| Identification |
|---|
| HMDB Protein ID
| HMDBP07976 |
| Secondary Accession Numbers
| |
| Name
| Ryanodine receptor 3 |
| Synonyms
|
- Brain ryanodine receptor-calcium release channel
- Brain-type ryanodine receptor
- RYR-3
- RyR3
|
| Gene Name
| RYR3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in calcium channel activity |
| Specific Function
| Communication between transverse-tubules and sarcoplasmic reticulum. Contraction of skeletal muscle is triggered by release of calcium ions from SR following depolarization of T-tubules |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| intracellular ligand-gated calcium channel activity |
| ryanodine-sensitive calcium-release channel activity |
| intracellular ligand-gated ion channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| calcium ion binding |
| calcium channel activity |
| ligand-gated ion channel activity |
| Process |
| di-, tri-valent inorganic cation transport |
| divalent metal ion transport |
| calcium ion transport |
| cellular metal ion homeostasis |
| cellular calcium ion homeostasis |
| establishment of localization |
| transport |
| biological regulation |
| transmembrane transport |
| ion transport |
| cation transport |
| regulation of biological quality |
| homeostatic process |
| chemical homeostasis |
| ion homeostasis |
| cellular ion homeostasis |
| cellular cation homeostasis |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Probable)
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q14-q15 |
| SNPs
| RYR3 |
| Gene Sequence
|
>14613 bp
ATGGCCGAAGGGGGAGAAGGAGGCGAGGACGAGATCCAGTTTCTGAGGACTGAGGATGAA
GTGGTACTCCAGTGCATCGCCACCATTCATAAGGAGCAGAGGAAGTTCTGCCTGGCAGCC
GAGGGACTTGGGAATCGCCTGTGCTTCTTGGAACCCACTTCAGAAGCCAAGTACATTCCT
CCAGATCTCTGCGTCTGCAATTTTGTGCTGGAACAGTCCCTATCTGTCAGAGCCCTGCAG
GAAATGCTTGCCAACACAGGTGAAAATGGCGGCGAAGGGGCAGCACAAGGAGGTGGCCAC
AGGACCCTGTTATACGGCCATGCAGTTCTCCTGAGGCACTCTTTCAGCGGAATGTATCTA
ACATGCTTGACTACATCAAGATCCCAGACAGACAAACTTGCCTTTGATGTAGGTCTACGG
GAACATGCCACAGGAGAAGCCTGTTGGTGGACTATACATCCTGCTTCCAAACAGAGGTCC
GAAGGAGAGAAAGTTCGAATTGGCGATGACCTCATCCTCGTCAGCGTGTCCTCTGAAAGA
TACCTTCATCTCTCAGTATCAAATGGTAACATACAAGTGGATGCCTCCTTTATGCAAACA
CTCTGGAATGTACATCCTACGTGCTCAGGAAGTAGCATCGAAGAAGGATACCTACTTGGT
GGGCATGTAGTACGTCTTTTCCATGGTCATGATGAATGTTTGACGATACCATCTACAGAC
CAGAATGATTCCCAGCACAGGAGGATATTCTACGAAGCTGGGGGAGCTGGGACTCGAGCC
AGTTCTCTTTGGAGAGTGGAACCCCTTCGGATAAGCTGGAGTGGCAGTAACATCAGATGG
GGCCAGGCTTTCCGACTCCGGCATCTCACCACAGGCCACTACCTGGCCTTGACAGAAGAC
CAAGGCCTTATACTGCAAGACCGGGCAAAGTCAGACACCAAGTCCACAGCTTTCTCTTTC
CGGGCATCAAAGGAACTCAAGGAGAAATTAGACTCCAGTCACAAGCGAGACATAGAAGGC
ATGGGAGTTCCAGAAATCAAGTATGGAGATTCTGTCTGCTTTGTGCAGCATATAGCCAGT
GGTCTGTGGGTGACCTACAAAGCACAAGACGCCAAAACTTCCCGCCTGGGACCTCTAAAA
AGAAAGGTCATACTCCATCAGGAAGGCCACATGGATGATGGATTAACACTGCAGAGATGC
CAGCGTGAGGAGTCCCAGGCTGCTCGGATCATCCGGAACACTACAGCCTTATTCAGCCAG
TTTGTCAGTGGAAACAATCGCACAGCTGCCCCCATCACCCTGCCTATAGAAGAAGTCCTG
CAGACCCTACAGGACTTGATCGCCTACTTCCAGCCCCCAGAGGAGGAGATGCGACATGAA
GACAAGCAGAACAAGCTCCGCTCACTCAAAAACAGACAAAATCTTTTCAAGGAAGAGGGA
ATGTTGGCCCTTGTCTTAAATTGCATTGACCGCTTAAATATCTACAATAGCGTAGCACAC
TTTGCAGGGATTGCAAGGGAAGAGAGTGGCATGGCCTGGAAAGAAATTCTGAACCTCCTC
TACAAATTGCTGGCTGCTCTCATTCGCGGAAACAGAAACAATTGCGCTCAATTCTCCAAT
AACCTTGATTGGCTCATCAGTAAATTGGACAGACTAGAATCTTCCTCAGGTATCTTGGAA
GTTTTGCACTGCATCTTAACTGAAAGCCCAGAAGCCTTAAATCTGATAGCGGAGGGCCAC
ATCAAGTCGATCATCTCCCTGTTGGATAAGCACGGGCGGAATCACAAGGTTCTGGATATC
CTGTGCTCCCTCTGTCTCTGCAATGGGGTTGCAGTGAGAGCCAACCAGAATCTGATCTGT
GACAACTTGCTGCCCCGGAGAAACCTACTCCTGCAGACACGACTGATTAACGATGTAACC
AGTATCCGGCCAAACATCTTCCTGGGAGTCGCGGAGGGCTCAGCCCAGTACAAGAAGTGG
TACTTCGAGCTGATTATCGACCAGGTGGACCCCTTCCTAACAGCAGAGCCCACACATCTG
CGGGTGGGCTGGGCCTCTTCTTCAGGCTATGCCCCATGCCCAGGAGGTGGAGAAGGATGG
GGAGGCAATGGTGTTGGTGACGACCTGTACTCCTATGGCTTTGATGGACTTCACCTTTGG
TCAGGCCGGATACCCAGAGCTGTGGCTTCCGTCAACCAGCACCTCCTGAGATCGGATGAC
GTGGTAAGCTGCTGCCTGGACCTCGGGGTGCCCAGCATCTCATTCCGCATCAATGGGCAG
CCCGTGCAGGGGATGTTTGAGAACTTCAACACAGACGGGCTCTTCTTCCCTGTGATGAGC
TTTTCAGCAGGTGTCAAAGTACGTTTCCTGATGGGTGGACGTCATGGAGAGTTTAAGTTC
CTGCCTCCCTCTGGCTATGCCCCTTGCTATGAAGCCTTACTTCCAAAAGAGAAGATGAGA
TTGGAGCCTGTCAAAGAATATAAACGTGATGCTGATGGCATTAGAGATCTCTTGGGTACC
ACCCAGTTCCTCTCCCAAGCCTCTTTCATCCCATGCCCCGTAGACACCAGTCAGGTTATT
TTGCCACCTCACCTAGAAAAGATCCGAGACAGACTAGCTGAAAACATCCATGAGCTTTGG
GGAATGAATAAAATAGAACTTGGCTGGACTTTCGGCAAGATACGAGATGACAATAAAAGA
CAACACCCTTGCCTTGTGGAGTTTTCAAAGCTCCCAGAAACTGAGAAGAACTATAACCTG
CAAATGTCAACTGAAACCTTAAAAACCCTCTTGGCCCTGGGGTGCCACATTGCTCATGTT
AACCCAGCTGCTGAGGAGGATCTCAAGAAGGTCAAACTGCCCAAAAACTATATGATGTCC
AACGGCTATAAGCCAGCCCCTTTGGATTTGTCTGATGTGAAGCTGTTACCTCCTCAAGAA
ATTTTAGTGGATAAGCTTGCAGAAAATGCACACAATGTTTGGGCAAAAGACAGAATAAAA
CAAGGATGGACCTATGGCATCCAACAGGATTTGAAGAACAAAAGAAATCCCCGTCTGGTG
CCATATGCATTACTGGATGAGCGTACCAAGAAGTCAAACAGGGACAGCCTGCGGGAAGCT
GTGCGCACTTTTGTTGGTTACGGGTATAACATTGAGCCATCAGACCAAGAACTAGCTGAC
TCGGCTGTGGAGAAGGTCAGCATAGACAAGATCCGATTTTTCCGGGTAGAGCGATCTTAT
GCAGTGAGATCTGGAAAGTGGTATTTTGAGTTTGAAGTGGTGACTGGAGGAGACATGCGA
GTCGGCTGGGCGAGGCCAGGCTGTCGACCTGATGTCGAGCTGGGGGCCGATGACCAAGCC
TTTGTGTTTGAAGGCAACAGGGGCCAGCGTTGGCATCAAGGAAGTGGGTATTTTGGGCGT
ACCTGGCAGCCAGGGGATGTGGTCGGATGTATGATTAACCTGGATGATGCTTCAATGATC
TTCACACTGAATGGGGAGCTGCTGATCACCAACAAAGGCTCTGAACTTGCCTTCGCTGAC
TACGAGATTGAGAATGGCTTCGTGCCCATCTGCTGTCTGGGTCTATCTCAGATCGGCCGC
ATGAATCTCGGGACAGATGCCAGTACCTTCAAGTTTTATACCATGTGCGGTCTCCAAGAG
GGCTTTGAGCCTTTTGCTGTCAACATGAACAGAGATGTTGCTATGTGGTTCAGCAAGCGC
CTCCCGACGTTTGTCAACGTGCCAAAGGATCATCCACACATAGAGGTCATGAGGATTGAT
GGCACCATGGACAGCCCTCCGTGTCTCAAGGTGACGCATAAGACATTTGGCACACAGAAT
AGCAATGCCGACATGATCTATTGCCGCTTGAGCATGCCTGTCGAGTGCCACTCCTCCTTC
AGCCACAGCCCCTGTCTGGACAGTGAAGCTTTCCAGAAAAGGAAACAGATGCAAGAAATA
CTCTCTCATACAACAACACAGTGCTACTACGCCATCCGCATCTTTGCTGGACAGGATCCA
TCCTGTGTCTGGGTCGGATGGGTGACTCCAGACTATCACTTGTACAGTGAAAAGTTTGAC
CTGAATAAAAACTGCACAGTGACTGTCACCCTAGGGGATGAAAGAGGCCGGGTCCATGAA
AGTGTGAAACGCAGCAACTGCTACATGGTCTGGGGTGGAGACATTGTAGCCAGTTCCCAG
AGATCAAATCGGAGCAACGTGGACCTGGAGATCGGCTGTCTCGTGGATCTGGCCATGGGC
ATGTTGTCCTTCTCAGCCAATGGAAAGGAACTGGGCACCTGCTACCAGGTGGAGCCTAAT
ACCAAAGTGTTTCCAGCAGTCTTCCTGCAGCCTACAAGTACTTCTTTGTTTCAGTTTGAA
CTTGGAAAGCTGAAGAACGCAATGCCCCTGTCAGCGGCCATATTCAGGAGTGAAGAGAAG
AACCCAGTCCCACAGTGTCCACCTCGGCTGGACGTCCAAACCATCCAGCCCGTGCTCTGG
AGCCGCATGCCCAACAGCTTCCTGAAGGTGGAGACCGAGCGTGTGAGCGAGCGCCACGGC
TGGGTGGTGCAGTGCCTGGAGCCCCTGCAGATGATGGCGCTCCACATCCCCGAGGAGAAC
AGGTGTGTGGATATCCTGGAGCTCTGTGAGCAGGAGGACCTGATGCGGTTCCATTACCAC
ACGCTGAGGCTCTACAGCGCGGTGTGCGCCCTGGGAAACAGCCGCGTGGCCTACGCCCTG
TGCAGCCACGTGGACCTCTCCCAGCTCTTCTATGCCATTGACAACAAGTACCTCCCCGGC
CTCCTTCGATCTGGTTTCTATGACCTGCTCATCAGCATCCACCTGGCCAGCGCCAAGGAG
AGGAAGCTGATGATGAAGAACGAGTACATCATCCCCATTACCAGCACCACCAGGAATATC
TGCCTCTTCCCGGACGAGTCCAAGAGGCATGGACTGCCTGGGGTGGGCCTGAGAACATGT
CTCAAGCCCGGGTTCAGGTTCTCCACCCCTTGCTTTGTTGTGACTGGTGAGGATCACCAA
AAGCAGAGCCCCGAGATTCCCTTGGAGAGTCTCAGGACGAAGGCTCTGAGTATGCTGACA
GAGGCAGTGCAGTGCAGCGGGGCCCACATCCGAGACCCTGTAGGGGGGTCTGTGGAGTTC
CAGTTTGTGCCTGTGCTGAAACTCATTGGAACCCTGCTGGTCATGGGCGTGTTTGATGAT
GATGATGTTCGGCAGATCCTCCTCCTGATTGATCCCTCTGTGTTTGGGGAGCATAGTGCG
GGGACAGAGGAGGGAGCAGAAAAGGAGGAAGTGACCCAGGTGGAGGAGAAGGCTGTGGAG
GCTGGGGAGAAGGCCGGCAAGGAGGCTCCTGTCAAAGGCTTGTTGCAGACTCGATTACCC
GAATCCGTCAAGCTGCAGATGTGTGAGCTCCTCAGCTATCTCTGCGACTGTGAGCTGCAG
CACCGAGTGGAGGCCATTGTGGCATTTGGTGACATTTATGTCTCCAAGCTGCAGGCAAAT
CAGAAGTTCCGCTACAATGAGCTCATGCAGGCCCTGAACATGTCTGCGGCCCTGACTGCC
CGGAAGACCAAGGAGTTCCGCTCACCCCCACAGGAGCAGATCAACATGCTGCTTAACTTT
CAACTGGGAGAGAACTGCCCCTGCCCAGAGGAGATTCGGGAGGAGCTGTATGATTTCCAT
GAGGACCTTCTCCTTCACTGTGGGGTTCCTTTGGAAGAAGAGGAAGAGGAGGAGGAGGAC
ACCTCCTGGACAGGAAAACTCTGTGCCTTGGTTTACAAAATCAAAGGCCCACCCAAGCCA
GAGAAGGAGCAGCCGACGGAGGAGGAGGAGAGATGCCCCACAACATTGAAGGAACTCATC
TCACAGACGATGATCTGCTGGGCCCAGGAGGACCAGATCCAGGATTCAGAGCTGGTCCGA
ATGATGTTCAACCTCCTCCGGAGGCAGTATGACAGCATTGGGGAGCTGCTGCAGGCGCTG
CGGAAGACCTACACCATCAGCCACACCTCTGTAAGCGACACCATCAACCTGCTGGCTGCC
CTGGGCCAAATCCGCTCCCTCCTCAGTGTCAGGATGGGCAAGGAAGAGGAGTTGCTCATG
ATCAATGGGCTGGGAGACATAATGAACAACAAGGTGTTTTACCAGCATCCCAACCTCATG
AGAGTCCTGGGCATGCACGAGACGGTGATGGAGGTGATGGTGAACGTGTTGGGTACAGAG
AAATCTCAGATTGCATTTCCAAAGATGGTTGCTAGCTGCTGCCGTTTCCTTTGCTATTTC
TGTCGAATTAGCCGGCAAAATCAGAAGGCCATGTTTGAGCATCTGAGTTATCTTCTGGAG
AATAGCAGTGTTGGCCTAGCCTCCCCGTCGATGAGGGGATCCACCCCGCTGGATGTGGCA
GCTTCCTCTGTGATGGACAACAATGAGTTAGCGCTGAGCTTAGAGGAACCAGACCTCGAG
AAGGTGGTGACCTACTTGGCAGGCTGTGGCCTACAGAGCTGCCCCATGCTTCTGGCCAAA
GGATACCCTGATGTCGGCTGGAACCCCATTGAAGGGGAACGCTACCTGTCCTTCCTGAGG
TTTGCTGTCTTCGTGAACAGTGAGAGTGTGGAAGAAAACGCCAGCGTTGTGGTCAAGCTG
CTCATCAGACGCCCAGAGTGCTTCGGCCCGGCCCTGCGGGGTGAGGGGGGAAACGGGCTC
TTGGCAGCCATGCAGGGTGCCATTAAGATCTCTGAGAACCCAGCGCTCGACCTCCCCTCT
CAAGGATACAAAAGAGAAGTCAGCACGGAGGACGATGAAGAGGAAGAAGAAATCGTGCAT
ATGGGCAATGCAATTATGTCATTTTATTCGGCCCTTATAGATCTACTGGGCCGCTGTGCT
CCTGAAATGCACCTCATCCAGACAGGAAAGGGGGAAGCCATCCGCATCAGGTCCATCCTG
CGCTCCCTGGTCCCCACAGAAGACCTGGTTGGGATCATCAGCATCCCCTTGAAACTGCCC
TCCCTCAACAAAGATGGGTCGGTCAGTGAGCCAGATATGGCGGCCAATTTCTGCCCTGAC
CACAAGGCACCTATGGTGCTGTTCTTGGACCGCGTTTATGGCATTAAGGATCAAACTTTT
CTGCTCCACTTACTGGAGGTTGGATTTTTACCTGACCTAAGAGCTTCTGCCTCTCTAGAT
ACAGTTTCCCTAAGCACCACAGAGGCTGCGCTTGCACTAAATAGGTATATATGTTCTGCT
GTGCTCCCGCTCCTCACAAGATGTGCCCCTCTCTTTGCCGGAACAGAACACTGCACCTCT
CTGATTGATTCCACACTGCAGACAATATACAGGCTATCCAAGGGACGTTCCCTCACCAAA
GCACAAAGGGACACTATAGAAGAATGTTTGCTTGCCATTTGCAATCACTTGAGGCCTTCC
ATGTTACAGCAACTCCTGCGACGCCTCGTTTTTGATGTGCCGCAACTCAATGAATACTGC
AAAATGCCTCTCAAGCTTCTGACGAATCACTATGAACAGTGTTGGAAGTATTACTGCCTG
CCTTCAGGATGGGGGAGCTACGGGCTAGCTGTGGAAGAAGAGCTGCACCTAACGGAGAAG
CTTTTCTGGGGGATTTTTGACTCGCTCTCCCATAAGAAATATGACCCAGATCTTTTCCGA
ATGGCCCTGCCTTGTCTCAGTGCTATAGCTGGGGCCTTGCCACCAGATTATTTAGATACC
AGAATCACAGCCACATTGGAGAAACAGATCTCAGTGGATGCGGATGGCAACTTTGACCCA
AAACCTATTAACACCATGAATTTTTCCTTGCCTGAAAAATTGGAATACATCGTCACCAAG
TATGCTGAGCATTCACATGATAAATGGGCCTGTGACAAGAGTCAGAGTGGATGGAAATAT
GGGATTTCCCTGGATGAAAATGTGAAGACCCACCCACTGATAAGGCCTTTCAAGACATTA
ACGGAGAAGGAGAAGGAAATTTATCGCTGGCCTGCGCGAGAGTCCCTGAAAACCATGCTG
GCTGTGGGCTGGACTGTGGAGAGGACCAAAGAGGGAGAAGCTTTGGTTCAACAGCGGGAA
AATGAGAAGCTTCGAAGTGTGTCCCAGGCCAACCAGGGCAACAGCTACAGTCCTGCTCCC
CTCGACCTCTCAAACGTTGTGCTCTCCAGAGAGCTCCAGGGAATGGTGGAGGTCGTGGCT
GAGAACTATCACAATATCTGGGCCAAGAAGAAGAAGCTGGAGCTGGAGAGCAAAGGTGGT
GGCAGCCACCCTCTTCTGGTACCATATGACACCTTGACTGCCAAGGAAAAGTTCAAGGAC
CGGGAGAAGGCACAGGACCTGTTTAAGTTCCTCCAAGTGAATGGCATCATAGTTTCCAGG
GGTATGAAGGATATGGAGCTGGATGCCTCCTCCATGGAGAAGAGGTTTGCCTATAAGTTC
TTGAAGAAGATCCTGAAATACGTTGATTCTGCTCAAGAATTTATTGCCCATTTAGAAGCC
ATTGTCAGCAGTGGGAAAACTGAAAAGTCTCCCCGTGACCAGGAGATCAAATTCTTTGCC
AAAGTTCTCCTCCCGCTGGTTGACCAGTACTTCACCAGTCATTGCCTCTACTTCTTGTCA
TCCCCTCTGAAGCCCCTTAGCAGCAGCGGATATGCCTCCCATAAGGAGAAAGAAATGGTG
GCCGGCCTGTTCTGCAAACTTGCCGCTCTCGTTAGACACAGAATTTCCCTCTTTGGTAGT
GATTCTACTACAATGGTGAGCTGTCTTCACATCTTAGCTCAGACACTTGACACAAGGACT
GTCATGAAGTCAGGCTCAGAGCTGGTGAAGGCTGGGTTACGAGCATTCTTTGAAAATGCT
GCAGAAGATTTGGAGAAGACTTCAGAAAACCTGAAACTTGGGAAGTTCACCCATTCCCGA
ACGCAGATTAAAGGCGTTTCTCAGAATATTAACTACACTACAGTGGCTCTGCTCCCCATC
CTGACGTCCATCTTTGAGCACGTCACTCAGCATCAGTTTGGAATGGATCTACTCTTGGGT
GATGTGCAGATTTCATGCTACCACATACTGTGCAGCCTCTACTCCCTTGGGACGGGAAAG
AACATTTATGTTGAAAGGCAACGCCCTGCCCTTGGAGAATGTCTGGCCTCGCTGGCAGCT
GCCATACCAGTGGCATTCCTGGAGCCCACCCTTAATCGCTACAATCCACTCTCGGTCTTC
AACACCAAAACCCCCAGGGAGAGGTCTATTCTGGGGATGCCAGACACGGTAGAAGACATG
TGTCCTGACATCCCCCAGCTGGAAGGCCTGATGAAGGAAATCAACGACCTGGCCGAGTCA
GGGGCCCGGTACACAGAGATGCCCCATGTCATCGAGGTGATCTTACCCATGCTCTGCAAC
TACTTGTCCTACTGGTGGGAGCGGGGTCCTGAGAACCTGCCCCCCAGCACAGGGCCATGC
TGCACCAAGGTCACCTCTGAACACCTCAGTCTCATCCTGGGCAACATTCTGAAAATCATC
AACAACAACCTGGGCATCGATGAGGCCTCCTGGATGAAGCGCATTGCAGTGTATGCACAG
CCCATCATCAGCAAAGCCAGGCCCGACCTGCTGAGAAGCCACTTCATCCCAACTCTGGAG
AAGCTGAAGAAAAAGGCTGTCAAGACGGTGCAGGAGGAGGAGCAGTTGAAAGCCGATGGC
AAAGGGGACACCCAGGAGGCAGAACTCCTCATCCTGGACGAGTTCGCGGTCCTCTGCAGA
GATCTCTATGCCTTCTACCCCATGCTGATCCGCTACGTGGACAACAACAGATCTAACTGG
CTGAAAAGTCCTGATGCTGATTCTGACCAGCTCTTCCGCATGGTGGCAGAAGTCTTCATT
CTGTGGTGTAAATCTCATAACTTCAAGAGAGAAGAGCAAAATTTTGTGATTCAGAATGAA
ATTAATAATTTGGCATTTTTAACTGGAGACAGCAAAAGCAAGATGTCAAAAGCCATGCAA
GTAAAGTCTGGAGGACAAGACCAGGAGCGGAAGAAGACAAAGCGGCGGGGAGACTTGTAT
TCCATCCAGACCTCCCTCATCGTGGCTGCACTCAAGAAAATGCTGCCCATTGGTTTGAAT
ATGTGTACTCCAGGCGACCAGGAGCTGATCTCCCTCGCAAAATCGCGATACAGCCATAGG
GACACAGATGAAGAGGTCAGAGAACATCTGCGGAACAACTTGCACTTGCAGGAAAAGTCT
GATGACCCAGCTGTAAAATGGCAACTGAACCTCTACAAGGATGTTCTGAAGAGTGAAGAA
CCTTTCAATCCGGAAAAGACAGTGGAGCGTGTGCAGAGAATTTCAGCAGCTGTCTTCCAC
CTGGAACAGGTGGAACAGCCTTTGAGGTCCAAGAAGGCCGTCTGGCACAAACTGTTATCA
AAGCAACGGAAACGGGCAGTGGTGGCCTGTTTCAGGATGGCCCCTCTCTACAACCTGCCC
AGGCACCGCTCTATTAACCTCTTCCTCCATGGCTATCAGAGATTTTGGATAGAAACAGAG
GAGTATTCCTTTGAAGAGAAACTAGTACAGGATTTGGCTAAATCTCCAAAGGTGGAAGAG
GAGGAGGAGGAAGAGACAGAAAAACAACCTGACCCACTACATCAGATCATTCTCTATTTT
AGCCGCAACGCTCTCACGGAGAGGAGCAAATTGGAAGACGACCCTTTGTACACCTCCTAT
TCCAGCATGATGGCCAAGAGTTGTCAAAGTGGTGAGGATGAAGAAGAAGATGAAGACAAG
GAAAAAACATTCGAAGAGAAAGAGATGGAGAAGCAAAAAACCCTCTATCAGCAAGCTCGG
CTGCATGAGCGTGGTGCTGCGGAGATGGTCCTTCAGATGATAAGCGCTAGCAAAGGTGAG
ATGAGCCCCATGGTGGTTGAGACGCTGAAGCTGGGGATCGCCATTCTGAACGGAGGCAAT
GCTGGTGTGCAACAGAAAATGCTAGATTACCTAAAGGAGAAAAAGGATGCTGGATTCTTT
CAAAGCCTTTCTGGTCTTATGCAGTCTTGCAGTGTCCTTGATTTGAATGCATTTGAGAGG
CAGAATAAAGCTGAAGGCCTGGGGATGGTGACTGAAGAAGGAACACTCATTGTTCGGGAA
CGTGGTGAAAAAGTACTCCAGAATGACGAGTTCACGCGTGATCTCTTTAGATTCCTACAG
TTACTTTGTGAGGGACATAACAGTGACTTTCAGAACTTCCTGCGGACTCAGATGGGCAAC
ACCACCACCGTGAATGTCATCATCAGCACTGTGGACTACCTTCTGCGTCTGCAGGAATCA
ATCAGTGATTTCTACTGGTATTATTCAGGGAAGGACATCATTGATGAATCTGGACAGCAC
AATTTTTCCAAAGCTCTGGCAGTCACCAAGCAGATTTTCAATTCTCTTACAGAATACATC
CAGGGCCCTTGCATTGGTAATCAACAGAGCCTGGCTCACAGCAGGCTGTGGGACGCAGTG
GTTGGCTTCCTCCATGTCTTTGCTAATATGCAGATGAAACTCTCTCAGGATTCCAGTCAG
ATCGAGCTGCTGAAGGAACTCTTGGATCTCCTTCAGGACATGGTGGTGATGCTTCTGTCC
CTCCTGGAAGGGAATGTGGTAAATGGCACCATTGGCAAGCAGATGGTTGACACACTGGTA
GAATCATCTACCAATGTAGAAATGATCTTGAAATTCTTTGACATGTTCTTGAAACTTAAA
GACTTAACCAGCTCAGACACCTTCAAAGAATATGACCCAGATGGTAAAGGAATTATCTCC
AAAAAAGAATTCCAGAAGGCCATGGAAGGGCAAAAACAGTACACGCAGTCAGAGATTGAC
TTTCTCCTGTCGTGTGCAGAAGCTGATGAGAATGACATGTTTAATTACGTTGATTTTGTA
GACCGGTTCCATGAGCCAGCCAAGGACATAGGGTTTAATGTGGCTGTGTTATTGACAAAT
CTTTCTGAACACATGCCAAACGATTCCCGCCTGAAGTGTCTGTTGGACCCAGCAGAAAGT
GTGCTAAATTACTTCGAACCCTACCTAGGACGCATCGAGATCATGGGTGGGGCCAAGAAG
ATTGAGCGTGTTTATTTTGAGATCAGTGAATCCAGTCGCACTCAGTGGGAGAAGCCCCAG
GTGAAGGAATCTAAGCGACAGTTCATTTTTGATGTTGTCAATGAAGGTGGGGAGCAGGAA
AAGATGGAGCTGTTTGTGAACTTCTGTGAGGACACCATCTTTGAAATGCAGTTAGCATCT
CAGATCTCTGAATCCGATTCAGCTGACAGGCCAGAAGAGGAGGAAGAAGATGAAGATTCT
TCTTACGTGTTAGAAATTGCGGGTGAAGAGGAAGAAGACGGGTCTCTTGAGCCGGCCTCT
GCATTTGCTATGGCCTGTGCCTCTGTGAAGAGGAATGTCACCGACTTCCTGAAGAGAGCA
ACCCTGAAGAACCTCAGGAAGCAGTACAGGAACGTGAAAAAGATGACTGCGAAGGAGCTG
GTGAAGGTGCTCTTCTCCTTTTTCTGGATGCTGTTCGTGGGGCTATTCCAGTTGCTCTTC
ACCATCCTGGGAGGAATCTTTCAGATCCTCTGGAGCACAGTGTTTGGAGGGGGCCTGGTA
GAAGGGGCAAAGAACATCAGAGTGACCAAGATCCTGGGTGACATGCCTGACCCAACCCAA
TTTGGTATCCATGATGACACTATGGAGGCTGAGAGGGCAGAGGTGATGGAGCCAGGTATC
ACCACTGAACTAGTACACTTCATAAAGGGGGAGAAGGGAGATACAGATATCATGTCAGAC
CTCTTTGGACTCCACCCAAAGAAAGAGGGCAGCTTAAAGCATGGGCCTGAAGTGGGTTTG
GGTGACCTCTCAGAAATTATTGGCAAGGATGAACCCCCTACATTAGAGAGTACTGTACAG
AAGAAGAGGAAAGCTCAGGCAGCAGAAATGAAAGCAGCAAATGAAGCAGAAGGAAAAGTA
GAATCCGAGAAGGCAGACATGGAAGATGGAGAGAAGGAAGACAAAGACAAAGAAGAGGAG
CAAGCTGAGTACCTGTGGACAGAAGTGACAAAAAAGAAGAAGCGGCGGTGTGGTCAGAAG
GTTGAGAAGCCGGAAGCTTTCACAGCCAATTTCTTTAAAGGGCTGGAAATCTATCAGACC
AAGTTACTGCATTACCTGGCCAGGAATTTCTACAACCTGAGGTTCCTTGCTCTGTTTGTA
GCCTTCGCTATCAACTTCATCCTGCTTTTTTATAAGGTCACTGAAGAACCTTTAGAAGAA
GAGACAGAGGATGTTGCAAACCTATGGAATTCCTTTAATGACGAGGAAGAGGAAGAAGCG
ATGGTATTCTTTGTCCTTCAGGAGAGCACCGGGTATATGGCACCAACCCTGCGTGCCCTG
GCCATCATCCATACCATCATCTCTCTAGTCTGTGTGGTGGGCTACTACTGCCTGAAGGTG
CCTTTGGTGGTTTTCAAAAGGGAAAAAGAAATCGCCAGGAAGCTGGAGTTTGATGGCCTA
TATATCACCGAACAGCCATCTGAAGATGACATCAAGGGGCAGTGGGACCGCTTGGTGATC
AACACACCATCTTTTCCTAATAACTACTGGGACAAGTTTGTAAAGAGAAAGGTGATCAAC
AAGTATGGAGATCTCTACGGAGCAGAACGCATTGCTGAACTTCTGGGTTTGGACAAAAAT
GCTCTTGACTTTAGCCCAGTAGAAGAGACCAAAGCAGAAGCGGCTTCTCTGGTGTCATGG
CTAAGTTCCATAGACATGAAGTACCATATCTGGAAGCTTGGAGTTGTTTTTACTGACAAC
TCCTTTCTCTACCTTGCCTGGTATACAACCATGTCAGTCCTGGGCCACTACAATAACTTC
TTCTTTGCTGCTCACCTATTGGACATCGCAATGGGCTTCAAGACACTGAGGACCATTCTG
TCATCTGTAACTCACAATGGCAAACAGTTGGTTCTGACTGTCGGTCTCCTGGCCGTGGTG
GTTTATCTCTATACTGTGGTGGCTTTCAACTTCTTCCGCAAGTTCTACAACAAAAGCGAA
GACGATGACGAGCCCGATATGAAGTGCGACGACATGATGACGTGTTACCTTTTCCACATG
TACGTGGGAGTGAGAGCAGGAGGTGGCATTGGTGATGAAATTGAAGACCCTGCTGGTGAT
CCTTATGAAATGTATCGCATTGTCTTTGACATTACCTTTTTCTTCTTCGTCATTGTCATC
TTGCTGGCCATCATTCAAGGTCTTATTATTGATGCTTTCGGAGAGCTAAGAGACCAGCAG
GAACAAGTACGAGAAGATATGGAGACTAAATGTTTCATCTGTGGGATTGGCAATGACTAC
TTTGACACAACCCCTCATGGTTTTGAAACACATACATTACAAGAGCACAACTTAGCCAAC
TACTTGTTCTTTCTGATGTATTTGATTAATAAAGATGAAACAGAGCACACGGGTCAGGAA
TCTTATGTCTGGAAGATGTACCAAGAAAGGTGTTGGGATTTCTTCCCAGCCGGTGACTGC
TTTCGTAAACAATATGAAGATCAGCTTGGATAA
|
| Protein Properties |
|---|
| Number of Residues
| 4870 |
| Molecular Weight
| 551927.0 |
| Theoretical pI
| 5.38 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 2985-3005
- 3049-3067
- 3836-3855
- 3874-3892
- 4132-4153
- 4195-4215
- 4410-4431
- 4482-4505
- 4622-4642
- 4670-4689
- 4712-4731
- 4756-4770
|
| Protein Sequence
|
>Ryanodine receptor 3
MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP
PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYL
TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER
YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD
QNDSQHRRIFYEAGGAGTRASSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED
QGLILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS
GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ
FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEG
MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN
NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDI
LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW
YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPCPGGGEGWGGNGVGDDLYSYGFDGLHLW
SGRIPRAVASVNQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS
FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGIRDLLGT
TQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR
QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS
NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV
PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVSIDKIRFFRVERSY
AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWHQGSGYFGR
TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGR
MNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVMRID
GTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI
LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE
SVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEPN
TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSEEKNPVPQCPPRLDVQTIQPVLW
SRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYH
TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKE
RKLMMKNEYIIPITSTTRNICLFPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTGEDHQ
KQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD
DDVRQILLLIDPSVFGEHSAGTEEGAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLP
ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA
RKTKEFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEED
TSWTGKLCALVYKIKGPPKPEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDSELVR
MMFNLLRRQYDSIGELLQALRKTYTISHTSVSDTINLLAALGQIRSLLSVRMGKEEELLM
INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF
CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALSLEEPDLE
KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL
LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTEDDEEEEEIVH
MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP
SLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD
TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTK
AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL
PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDT
RITATLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKY
GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRE
NEKLRSVSQANQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG
GSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKF
LKKILKYVDSAQEFIAHLEAIVSSGKTEKSPRDQEIKFFAKVLLPLVDQYFTSHCLYFLS
SPLKPLSSSGYASHKEKEMVAGLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT
VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPI
LTSIFEHVTQHQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA
AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAES
GARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILKII
NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADG
KGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFI
LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLY
SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKS
DDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLS
KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEE
EEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEDEDK
EKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGN
AGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE
RGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQES
ISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV
VGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV
ESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEID
FLLSCAEADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAES
VLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQE
KMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLEPAS
AFAMACASVKRNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLF
TILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGI
TTELVHFIKGEKGDTDIMSDLFGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLESTVQ
KKRKAQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRCGQK
VEKPEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEE
ETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKV
PLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVIN
KYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDN
SFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV
VYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD
PYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY
FDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDC
FRKQYEDQLG
|
| External Links |
|---|
| GenBank ID Protein
| 3123584 |
| UniProtKB/Swiss-Prot ID
| Q15413 |
| UniProtKB/Swiss-Prot Entry Name
| RYR3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ001515 |
| GeneCard ID
| RYR3 |
| GenAtlas ID
| RYR3 |
| HGNC ID
| HGNC:10485 |
| References |
|---|
| General References
| - Lynn S, Morgan JM, Lamb HK, Meissner G, Gillespie JI: Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle. FEBS Lett. 1995 Sep 18;372(1):6-12. [PubMed:7556644 ]
- Martin C, Chapman KE, Seckl JR, Ashley RH: Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum. Neuroscience. 1998 Jul;85(1):205-16. [PubMed:9607712 ]
- Leeb T, Brenig B: cDNA cloning and sequencing of the human ryanodine receptor type 3 (RYR3) reveals a novel alternative splice site in the RYR3 gene. FEBS Lett. 1998 Feb 27;423(3):367-70. [PubMed:9515741 ]
- Nakashima Y, Nishimura S, Maeda A, Barsoumian EL, Hakamata Y, Nakai J, Allen PD, Imoto K, Kita T: Molecular cloning and characterization of a human brain ryanodine receptor. FEBS Lett. 1997 Nov 3;417(1):157-62. [PubMed:9395096 ]
- Hakamata Y, Nishimura S, Nakai J, Nakashima Y, Kita T, Imoto K: Involvement of the brain type of ryanodine receptor in T-cell proliferation. FEBS Lett. 1994 Sep 26;352(2):206-10. [PubMed:7523185 ]
- Sorrentino V, Giannini G, Malzac P, Mattei MG: Localization of a novel ryanodine receptor gene (RYR3) to human chromosome 15q14-q15 by in situ hybridization. Genomics. 1993 Oct;18(1):163-5. [PubMed:8276408 ]
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