Hmdb loader
Identification
HMDB Protein ID HMDBP08016
Secondary Accession Numbers
  • 13727
Name Striatin-3
Synonyms
  1. Cell cycle autoantigen SG2NA
  2. S/G2 antigen
Gene Name STRN3
Protein Type Unknown
Biological Properties
General Function Involved in armadillo repeat domain binding
Specific Function Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Cytoplasm
  2. Peripheral membrane protein
  3. Membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 14q13-q21
SNPs STRN3
Gene Sequence
>2394 bp
ATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCCCGGCAG
CAGCAGGGACCTGGGGGGAACCTGGGCCTTTCGCCCGGGGGGAACGGAGCGGCGGGCGGC
GGGGGTCCTCCGGCCTCCGAGGGAGCGGGTCCCGCGGCAGGCCCCGAGCTGTCCCGGCCG
CAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGGTTCGAG
ATGGAGCGGGCGCACTGGGAGGTGGAACGGGCCGAACTGCAGGCCCGGATTGCATTTCTA
CAAGGCGAAAGAAAAGGTCAAGAGAACCTGAAGAAGGACTTAGTAAGAAGAATAAAGATG
TTAGAGTATGCATTAAAACAAGAAAGGGCAAAATATCACAAATTAAAATATGGCACGGAA
CTGAACCAAGGTGACTTGAAAATGCCAACCTTTGAGTCAGAAGAAACCAAAGACACAGAG
GCTCCCACAGCACCTCAGAATAGCCAGTTAACGTGGAAGCAAGGCAGACAGCTTTTAAGA
CAGTATCTTCAGGAAGTAGGTTATACAGATACAATATTAGATGTACGGTCTCAGCGGGTA
AGGTCATTACTTGGACTATCTAATTCAGAACCAAATGGATCAGTAGAAACAAAGAATTTA
GAACAGATCCTGAATGGAGGTGAATCTCCTAAGCAAAAGGGACAAGAAATAAAAAGGTCC
TCTGGTGATGTTCTTGAGACGTTCAATTTCTTAGAAAATGCCGATGACAGTGATGAAGAT
GAGGAAAATGACATGATCGAAGGCATCCCAGAAGGAAAAGACAAACATCGGATGAATAAA
CATAAAATAGGTAATGAAGGTTTAGCTGCTGACCTAACTGACGATCCTGATACTGAGGAA
GCACTGAAAGAATTTGATTTTTTAGTGACTGCTGAAGATGGTGAAGGAGCTGGAGAAGCA
CGGAGTTCGGGGGATGGCACAGAATGGGATAAAGATGACCTCTCCCCAACTGCTGAGGTT
TGGGATGTAGACCAGGGACTAATAAGTAAACTGAAGGAACAGTACAAGAAGGAACGAAAG
GGGAAGAAAGGGGTGAAGAGGGCCAACAGGACAAAACTCTACGACATGATAGCTGATCTG
GGAGATGATGAGCTGCCCCACATCCCTTCAGGAATCATTAATCAGTCTAGGTCAGCCTCT
ACTAGAATGACTGATCATGAAGGTGCAAGAGCAGAGGAAGCTGAACCAATAACGTTTCCA
TCTGGAGGAGGCAAGTCATTTATTATGGGTTCTGATGATGTTTTGTTAAGTGTACTGGGC
CTTGGAGACCTTGCAGACTTGACGGTAACAAATGATGCAGACTATAGTTATGATTTGCCT
GCTAATAAAGATGCCTTTCGAAAGACATGGAATCCCAAGTATACACTACGTAGCCATTTT
GATGGAGTACGGGCATTAGCTTTTCATCCTGTAGAACCTGTGCTGGTTACTGCTTCTGAG
GACCATACCCTGAAACTTTGGAACCTGCAAAAAACAGTTCCTGCCAAAAAGAGTGCCTCT
TTAGATGTAGAGCCTATCTACACATTTAGGGCCCACATCGGCCCTGTTCTGTCATTAGCT
ATTAGTTCTAATGGAGAACAGTGTTTTAGTGGTGGTATTGATGCAACCATCCAGTGGTGG
AATATGCCGAGTCCCAGTGTAGATCCATATGATACATATGAGCCAAATGTTCTAGCTGGC
ACTTTAGTTGGTCATACAGATGCAGTTTGGGGTCTTGCTTATAGTGGCATAAAAAATCAA
TTACTGTCTTGTTCAGCAGATGGCACTGTTAGGTTATGGAATCCACAAGAAAAATTGCCA
TGTATTTGCACTTACAATGGAGATAAAAAGCATGGAATACCTACATCAGTTGACTTTATA
GGCTGTGATCCAGCTCATATGGTAACCTCTTTCAACACTGGTAGTGCAGTAATTTATGAT
TTAGAAACATCACAGTCATTGGTGATACTTTCATCACAGGTAGATTCTGGTTTACAATCT
AATAATCATATCAACAGAGTAGTAAGTCATCCCACACTTCCTGTTACAATAACTGCTCAT
GAAGATAGACACATCAAATTTTTTGACAATAAAACGGGTAAAATGATCCATTCTATGGTA
GCTCACTTGGATGCTGTTACAAGTCTAGCAGTAGATCCTAATGGAATCTATTTGATGTCT
GGAAGCCATGACTGTTCCATCAGATTATGGAATTTAGACAGCAAGACATGTGTGCAAGAA
ATAACAGCTCACAGAAAGAAATTGGATGAATCAATTTATGATGTTGCTTTCCACTCGTCA
AAAGCATATATAGCTAGTGCAGGAGCTGATGCTCTTGCCAAAGTATTTGTATGA
Protein Properties
Number of Residues 797
Molecular Weight 87208.6
Theoretical pI 5.0
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Striatin-3
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRP
QQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKM
LEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLR
QYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRS
SGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEE
ALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLISKLKEQYKKERK
GKKGVKRANRTKLYDMIADLGDDELPHIPSGIINQSRSASTRMTDHEGARAEEAEPITFP
SGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHF
DGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLA
ISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQ
LLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYD
LETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMV
AHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSS
KAYIASAGADALAKVFV
GenBank ID Protein 142976686
UniProtKB/Swiss-Prot ID Q13033
UniProtKB/Swiss-Prot Entry Name STRN3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001083893.1
GeneCard ID STRN3
GenAtlas ID STRN3
HGNC ID HGNC:15720
References
General References
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
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  6. Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y: Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Anal Sci. 2008 Jan;24(1):161-6. [PubMed:18187866 ]
  7. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  8. Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP: A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol. 2006 Oct;24(10):1285-92. Epub 2006 Sep 10. [PubMed:16964243 ]
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  10. Muro Y, Chan EK, Landberg G, Tan EM: A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells. Biochem Biophys Res Commun. 1995 Feb 27;207(3):1029-37. [PubMed:7864889 ]
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