Hmdb loader
Identification
HMDB Protein ID HMDBP08022
Secondary Accession Numbers
  • 13733
Name Synaptic vesicle glycoprotein 2C
Synonyms Not Available
Gene Name SV2C
Protein Type Unknown
Biological Properties
General Function Involved in transmembrane transport
Specific Function Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
transporter activity
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Cytoplasmic vesicle
  2. Multi-pass membrane protein
  3. secretory vesicle
  4. synaptic vesicle membrane
Gene Properties
Chromosome Location Chromosome:5
Locus 5q13.3
SNPs SV2C
Gene Sequence
>2184 bp
ATGGAAGACTCTTACAAGGATAGGACTTCACTGATGAAGGGTGCCAAGGACATTGCCAGA
GAGGTGAAGAAACAAACAGTAAAGAAGGTGAATCAAGCTGTGGACCGAGCCCAGGATGAA
TACACCCAGAGGTCCTACAGTCGGTTCCAAGATGAAGAAGATGATGATGACTACTACCCG
GCTGGAGAAACCTATAATGGTGAGGCCAACGATGACGAAGGCTCAAGTGAAGCCACTGAG
GGGCATGATGAAGATGATGAGATCTATGAGGGGGAGTATCAGGGCATCCCCAGTATGAAC
CAAGCGAAGGACAGCATCGTGTCAGTGGGGCAGCCCAAGGGCGATGAGTACAAGGACCGA
CGGGAGCTGGAATCAGAAAGGAGAGCTGACGAGGAAGAGTTAGCCCAGCAGTATGAGCTG
ATAATCCAAGAATGCGGTCATGGTCGTTTTCAGTGGGCCCTTTTCTTCGTCCTGGGCATG
GCTCTTATGGCAGACGGTGTAGAGGTGTTTGTCGTTGGCTTCGTGTTACCCAGTGCTGAG
ACAGACCTCTGCATCCCAAATTCAGGATCTGGATGGCTAGGCAGCATAGTGTACCTCGGG
ATGATGGTGGGGGCGTTCTTCTGGGGAGGACTGGCAGACAAAGTGGGAAGGAAACAGTCT
CTTCTGATTTGCATGTCTGTCAACGGATTCTTTGCCTTCCTTTCTTCATTTGTCCAAGGT
TATGGCTTCTTTCTCTTCTGTCGCTTACTTTCTGGATTCGGGATTGGAGGAGCCATACCC
ACTGTGTTCTCGTACTTTGCTGAAGTCCTGGCCCGGGAAAAGCGGGGCGAACACTTGAGC
TGGCTCTGCATGTTCTGGATGATCGGTGGCATCTACGCCTCTGCCATGGCCTGGGCCATC
ATCCCGCACTACGGGTGGAGCTTCAGCATGGGATCGGCCTACCAGTTTCACAGTTGGCGT
GTGTTTGTCATCGTCTGTGCACTCCCCTGTGTCTCCTCCGTGGTGGCCCTCACATTCATG
CCTGAAAGCCCACGATTCTTGTTGGAGGTTGGAAAACATGATGAAGCTTGGATGATTCTG
AAGTTAATTCATGACACCAACATGAGAGCCCGGGGTCAGCCTGAGAAGGTCTTCACGGTA
AACAAAATAAAAACTCCTAAACAAATAGATGAGCTGATTGAAATTGAGAGTGACACAGGA
ACATGGTATAGGAGGTGTTTTGTTCGGATCCGCACCGAGCTGTACGGAATTTGGTTGACT
TTTATGAGATGTTTCAACTACCCAGTCAGGGATAATACAATAAAGCTTACAATTGTTTGG
TTCACCCTGTCCTTTGGGTACTATGGATTATCCGTTTGGTTCCCTGATGTCATTAAACCT
CTGCAGTCCGATGAATATGCATTGCTAACCAGAAATGTGGAGAGAGATAAATATGCAAAT
TTCACTATTAACTTTACAATGGAAAATCAGATTCATACTGGAATGGAATACGACAATGGC
AGATTCATAGGGGTCAAGTTCAAATCTGTAACTTTCAAAGACTCTGTTTTTAAGTCCTGC
ACCTTTGAGGATGTAACTTCAGTGAACACCTACTTCAAGAACTGCACATTTATTGACACT
GTTTTTGACAACACAGATTTTGAGCCATATAAATTCATTGACAGTGAATTTAAAAACTGC
TCGTTTTTTCACAACAAGACGGGATGTCAGATTACCTTTGATGATGACTATAGTGCCTAC
TGGATTTATTTTGTCAACTTTCTGGGGACATTGGCAGTATTGCCAGGGAACATTGTGTCT
GCTCTGCTGATGGACAGAATTGGGCGCTTAACAATGCTAGGTGGCTCTATGGTGCTTTCG
GGGATCAGCTGTTTCTTCCTTTGGTTCGGCACCAGTGAATCCATGATGATAGGCATGCTG
TGTCTGTACAATGGATTGACCATCTCAGCCTGGAACTCTCTTGACGTGGTCACTGTGGAA
CTGTACCCCACAGACCGGAGGGCAACAGGCTTTGGCTTCTTAAATGCGCTATGCAAGGCA
GCAGCCGTCCTGGGAAACTTAATATTTGGCTCTCTGGTCAGCATCACCAAATCAATCCCC
ATCCTGCTGGCTTCTACTGTGCTCGTGTGTGGAGGACTCGTTGGGCTGTGCCTGCCTGAC
ACACGAACCCAGGTTCTGATGTAA
Protein Properties
Number of Residues 727
Molecular Weight 82341.5
Theoretical pI 4.67
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 155-175
  • 192-212
  • 227-247
  • 249-269
  • 281-301
  • 321-341
  • 438-458
  • 579-599
  • 610-630
  • 637-657
  • 670-690
  • 699-719
Protein Sequence
>Synaptic vesicle glycoprotein 2C
MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDYYP
AGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQAKDSIVSVGQPKGDEYKDR
RELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAE
TDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQG
YGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAI
IPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMIL
KLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLT
FMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYAN
FTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDT
VFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVS
ALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVE
LYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPD
TRTQVLM
GenBank ID Protein 73695465
UniProtKB/Swiss-Prot ID Q496J9
UniProtKB/Swiss-Prot Entry Name SV2C_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_014979.1
GeneCard ID SV2C
GenAtlas ID SV2C
HGNC ID HGNC:30670
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Jun 30;6(3):197-205. [PubMed:10470851 ]