Hmdb loader
Identification
HMDB Protein ID HMDBP08053
Secondary Accession Numbers
  • 13764
Name Testican-2
Synonyms
  1. SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2
Gene Name SPOCK2
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function May participate in diverse steps of neurogenesis. Binds calcium
Pathways Not Available
Reactions Not Available
GO Classification
Component
extracellular region part
extracellular matrix
proteinaceous extracellular matrix
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
Cellular Location
  1. Secreted
  2. extracellular space
  3. extracellular matrix (Probable)
Gene Properties
Chromosome Location Chromosome:1
Locus 10pter-q25.3
SNPs SPOCK2
Gene Sequence
>1275 bp
ATGCGCGCCCCGGGCTGCGGGCGGCTGGTGCTGCCGCTGCTGCTCCTGGCCGCGGCAGCC
CTGGCCGAAGGCGACGCCAAGGGGCTCAAGGAGGGCGAGACCCCCGGCAATTTCATGGAG
GACGAGCAATGGCTGTCGTCCATCTCGCAGTACAGCGGCAAGATCAAGCACTGGAACCGC
TTCCGAGACGAAGTGGAGGATGACTATATCAAGAGCTGGGAGGACAATCAGCAAGGAGAT
GAAGCCCTGGATACCACCAAGGACCCCTGCCAGAAGGTGAAGTGCAGCCGCCACAAGGTG
TGCATTGCCCAGGGCTACCAGCGGGCCATGTGCATCAGTCGCAAGAAGCTGGAGCACAGG
ATCAAGCAGCCGACCGTGAAACTCCATGGAAACAAAGACTCCATCTGCAAGCCCTGCCAC
ATGGCCCAGCTTGCCTCTGTCTGCGGCTCAGATGGCCACACTTACAGCTCTGTGTGTAAG
CTGGAGCAACAGGCGTGCCTGAGCAGCAAGCAGCTGGCGGTGCGATGCGAGGGCCCCTGC
CCCTGCCCCACGGAGCAGGCTGCCACCTCCACCGCCGATGGCAAACCAGAGACTTGCACC
GGTCAGGACCTGGCTGACCTGGGAGATCGGCTGCGGGACTGGTTCCAGCTCCTTCATGAG
AACTCCAAGCAGAATGGCTCAGCCAGCAGTGTAGCCGGCCCGGCCAGCGGGCTGGACAAG
AGCCTGGGGGCCAGCTGCAAGGACTCCATTGGCTGGATGTTCTCCAAGCTGGACACCAGT
GCTGACCTCTTCCTGGACCAGACGGAGCTGGCCGCCATCAACCTGGACAAGTACGAGGTC
TGCATCCGTCCCTTCTTCAACTCCTGTGACACCTACAAGGATGGCCGGGTCTCTACTGCT
GAGTGGTGCTTCTGCTTCTGGAGGGAGAAGCCCCCCTGCCTGGCAGAGCTGGAGCGCATC
CAGATCCAGGAGGCCGCCAAGAAGAAGCCAGGCATCTTCATCCCGAGCTGCGACGAGGAT
GGCTACTACCGGAAGATGCAGTGTGACCAGAGCAGCGGTGACTGCTGGTGTGTGGACCAG
CTGGGCCTGGAGCTGACTGGCACGCGCACGCATGGGAGCCCCGACTGCGATGACATCGTG
GGCTTCTCGGGGGACTTTGGAAGCGGTGTCGGCTGGGAGGATGAGGAGGAGAAGGAGACG
GAGGAAGCAGGCGAGGAGGCCGAGGAGGAGGAGGGCGAGGCAGGCGAGGCTGACGACGGG
GGCTACATCTGGTAG
Protein Properties
Number of Residues 424
Molecular Weight 46778.7
Theoretical pI 4.45
Pfam Domain Function
Signals
  • 1-22
Transmembrane Regions
  • None
Protein Sequence
>Testican-2
MRAPGCGRLVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNR
FRDEVEDDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHR
IKQPTVKLHGNKDSICKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRCEGPC
PCPTEQAATSTADGKPETCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGPASGLDK
SLGASCKDSIGWMFSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDGRVSTA
EWCFCFWREKPPCLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSSGDCWCVDQ
LGLELTGTRTHGSPDCDDIVGFSGDFGSGVGWEDEEEKETEEAGEEAEEEEGEAGEADDG
GYIW
GenBank ID Protein 3581968
UniProtKB/Swiss-Prot ID Q92563
UniProtKB/Swiss-Prot Entry Name TICN2_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ001453
GeneCard ID SPOCK2
GenAtlas ID SPOCK2
HGNC ID HGNC:13564
References
General References
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  2. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
  3. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]
  4. Zhang Z, Henzel WJ: Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. 2004 Oct;13(10):2819-24. Epub 2004 Aug 31. [PubMed:15340161 ]
  5. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. DNA Res. 1996 Oct 31;3(5):321-9, 341-54. [PubMed:9039502 ]
  6. Vannahme C, Schubel S, Herud M, Gosling S, Hulsmann H, Paulsson M, Hartmann U, Maurer P: Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain. J Neurochem. 1999 Jul;73(1):12-20. [PubMed:10386950 ]