Human Metabolome Database: Showing Protein Troponin I, fast skeletal muscle (HMDBP08060)

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Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification
HMDB Protein ID	HMDBP08060
Secondary Accession Numbers	13771
Name	Troponin I, fast skeletal muscle
Synonyms	Troponin I, fast-twitch isoform
Gene Name	TNNI2
Protein Type	Unknown
Biological Properties
General Function	Involved in actin binding
Specific Function	Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity
Pathways	Acebutolol Action Pathway Alprenolol Action Pathway Amiodarone Action Pathway Amlodipine Action Pathway Arbutamine Action Pathway Atenolol Action Pathway Betaxolol Action Pathway Bevantolol Action Pathway Bisoprolol Action Pathway Bopindolol Action Pathway Bupranolol Action Pathway Carteolol Action Pathway Carvedilol Action Pathway Diltiazem Action Pathway Disopyramide Action Pathway Dobutamine Action Pathway Epinephrine Action Pathway Esmolol Action Pathway Felodipine Action Pathway Flecainide Action Pathway Fosphenytoin (Antiarrhythmic) Action Pathway Ibutilide Action Pathway Isoprenaline Action Pathway Isradipine Action Pathway Labetalol Action Pathway Levobunolol Action Pathway Lidocaine (Antiarrhythmic) Action Pathway Metipranolol Action Pathway Metoprolol Action Pathway Mexiletine Action Pathway Muscle/Heart Contraction Nadolol Action Pathway Nebivolol Action Pathway Nifedipine Action Pathway Nimodipine Action Pathway Nisoldipine Action Pathway Nitrendipine Action Pathway Oxprenolol Action Pathway Penbutolol Action Pathway Phenytoin (Antiarrhythmic) Action Pathway Pindolol Action Pathway Practolol Action Pathway Procainamide (Antiarrhythmic) Action Pathway Propranolol Action Pathway Quinidine Action Pathway Sotalol Action Pathway Timolol Action Pathway Tocainide Action Pathway Verapamil Action Pathway
Reactions	Not Available
GO Classification	Not Available
Cellular Location	Not Available
Gene Properties
Chromosome Location	Chromosome:1
Locus	11p15.5
SNPs	TNNI2
Gene Sequence	>549 bp ATGGGAGATGAGGAGAAGCGGAACAGGGCCATCACGGCCCGCAGGCAGCACCTGAAGAGT GTGATGCTGCAGATAGCGGCCACGGAGCTGGAGAAGGAGGAGAGCCGCCGTGAGGCAGAG AAGCAGAACTACCTGGCGGAGCACTGCCCGCCGCTGCATATCCCGGGCTCCATGTCTGAA GTGCAGGAGCTCTGCAAACAGCTGCACGCCAAGATCGATGCGGCTGAAGAGGAGAAGTAC GACATGGAGGTGAGGGTGCAGAAGACCAGCAAGGAGCTGGAGGACATGAACCAGAAGCTA TTTGATCTGCGGGGCAAGTTCAAGCGGCCCCCACTGCGGAGGGTGCGCATGTCGGCCGAT GCCATGCTCAAGGCCCTGCTGGGCTCGAAGCACAAGGTGTGCATGGACCTGAGGGCCAAC CTGAAGCAGGTCAAGAAGGAGGACACAGAGAAGGAGCGGGACCTGCGAGACGTGGGTGAC TGGAGGAAGAACATCGAGGAGAAGTCTGGCATGGAGGGCCGGAAGAAGATGTTTGAGTCC GAGTCCTAG
Protein Properties
Number of Residues	182
Molecular Weight	21338.4
Theoretical pI	9.17
Pfam Domain Function	Troponin (PF00992 )
Signals	None
Transmembrane Regions	None
Protein Sequence	>Troponin I, fast skeletal muscle MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSE VQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSAD AMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFES ES
External Links
GenBank ID Protein	224967057
UniProtKB/Swiss-Prot ID	P48788
UniProtKB/Swiss-Prot Entry Name	TNNI2_HUMAN
PDB IDs	Not Available
GenBank Gene ID	NM_001145829.1
GeneCard ID	TNNI2
GenAtlas ID	TNNI2
HGNC ID	HGNC:11946
References
General References	Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ] Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [PubMed:16554811 ] Zhu L, Perez-Alvarado G, Wade R: Sequencing of a cDNA encoding the human fast-twitch skeletal muscle isoform of troponin I. Biochim Biophys Acta. 1994 Apr 6;1217(3):338-40. [PubMed:8148383 ] Mullen AJ, Barton PJ: Structural characterization of the human fast skeletal muscle troponin I gene (TNNI2). Gene. 2000 Jan 25;242(1-2):313-20. [PubMed:10721725 ] Sung SS, Brassington AM, Grannatt K, Rutherford A, Whitby FG, Krakowiak PA, Jorde LB, Carey JC, Bamshad M: Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes. Am J Hum Genet. 2003 Mar;72(3):681-90. [PubMed:12592607 ]