Hmdb loader

Showing Protein Trichohyalin (HMDBP08074)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP08074
Secondary Accession Numbers
  • 13785
Name Trichohyalin
Synonyms Not Available
Gene Name TCHH
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 1q21.3
SNPs TCHH
Gene Sequence 
>5832 bp
ATGTCTCCACTTCTGAGAAGCATCTGTGACATCACTGAAATTTTCAATCAGTATGTCTCT
CATGATTGTGATGGAGCAGCATTAACTAAGAAAGACCTGAAGAACCTCCTTGAAAGGGAA
TTTGGAGCTGTGCTTCGGAGACCACATGACCCTAAGACGGTAGATCTGATCCTGGAACTT
CTGGATCTTGACAGTAATGGGCGTGTCGATTTCAACGAATTCCTCCTATTTATTTTCAAA
GTGGCTCAAGCTTGTTACTATGCTCTCGGCCAGGCCACGGGACTGGATGAGGAGAAGCGA
GCCCGGTGTGACGGAAAGGAGAGCCTGTTACAAGATCGCAGGCAAGAAGAAGACCAAAGG
AGATTCGAGCCCCGGGACAGACAACTGGAAGAAGAACCTGGGCAACGACGCAGGCAGAAG
AGGCAGGAACAGGAGAGGGAGCTAGCTGAGGGAGAGGAGCAAAGTGAGAAACAAGAGCGA
CTTGAACAGCGCGACAGGCAGCGCCGCGACGAGGAGCTGTGGCGGCAAAGGCAAGAATGG
CAAGAACGGGAAGAGCGCCGTGCAGAGGAAGAGCAGCTGCAGAGTTGCAAAGGTCACGAA
ACTGAGGAGTTTCCAGACGAAGAGCAACTGCGAAGGCGGGAGCTGCTGGAGCTGAGGAGG
AAGGGCCGCGAGGAGAAACAGCAGCAAAGGCGAGAGCGGCAAGACAGAGTGTTCCAGGAG
GAAGAAGAGAAAGAGTGGAGGAAGCGCGAGACAGTGCTCCGGAAGGAAGAAGAGAAGTTG
CAGGAAGAGGAGCCGCAGCGGCAAAGAGAGCTCCAGGAGGAAGAAGAGCAGCTACGGAAG
CTGGAGCGGCAAGAGCTGAGGAGGGAGCGCCAGGAGGAAGAGCAGCAGCAGCAAAGGCTG
AGGCGCGAGCAGCAACTAAGGCGCAAGCAGGAGGAGGAGAGGCGCGAGCAGCAGGAGGAG
AGGCGCGAGCAGCAGGAGAGGCGCGAGCAGCAGGAGGAGAGGCGCGAGCAGCAGCTGAGG
CGCGAGCAGGAGGAGAGGCGCGAGCAGCAGCTGAGGCGCGAGCAGGAGGAGGAGAGGCGC
GAGCAGCAGCTGAGGCGCGAGCAGGAGGAGGAGAGGCGCGAGCAGCAGCTGAGGCGCGAG
CAGCAGCTGAGGCGCGAGCAGCAGCTGAGGCGCGAGCAGCAGCTGAGGCGCGAGCAGCAG
CTGAGGCGCGAGCAGCAGCTGAGGCGCGAGCAGCAGCTGAGGCGCGAGCAGCAGCTGAGG
CGCGAGCAGCAGCTGAGGCGCGAGCAGGAGGAGGAGAGGCACGAGCAGAAGCACGAGCAG
GAGAGGCGCGAGCAGCGGCTGAAGCGCGAGCAGGAGGAGAGGCGCGATTGGCTGAAGCGC
GAGGAGGAGACGGAGAGGCACGAGCAGGAGAGGCGCAAGCAGCAGCTGAAGCGCGACCAG
GAGGAGGAGAGGCGCGAACGTTGGCTGAAGCTCGAGGAGGAGGAGAGGCGCGAGCAGCAG
GAGAGGCGCGAGCAGCAACTAAGGCGGGAGCAAGAGGAGAGGCGCGAGCAGCGGCTGAAG
CGCCAGGAGGAGGAAGAGAGGCTCCAGCAGCGGTTGAGGAGCGAGCAACAACTAAGACGC
GAGCAGGAGGAGAGGCGCGAGCAGCTGCTGAAGCGCGAGGAGGAGAAGAGGCTCGAGCAG
GAGAGGCGAGAGCAGCGGCTGAAGCGCGAGCAGGAGGAGAGGCGCGATCAGCTGCTGAAG
CGCGAGGAGGAGAGGCGCCAGCAGCGGCTGAAGCGCGAGCAGGAAGAGAGGCTCGAGCAG
CGACTGAAGCGCGAGGAGGTGGAGAGACTCGAGCAGGAGGAGAGGCGCGAGCAGCGGCTG
AAGCGCGAGGAGCCGGAGGAAGAGAGGCGCCAGCAGCTGCTGAAGAGCGAGGAGCAGGAG
GAGAGGCGCCAGCAGCAACTAAGGCGCGAGCAGCAGGAAAGGCGCGAGCAGCGGCTGAAG
CGCGAGGAGGAGGAAGAGAGGCTCGAGCAGCGGCTGAAGCGCGAGCATGAGGAAGAGAGG
CGCGAGCAGGAGCTAGCTGAGGAGGAGCAGGAACAGGCCCGGGAGCGGATTAAGAGCCGC
ATCCCGAAGTGGCAGTGGCAGCTAGAAAGCGAGGCCGACGCACGGCAAAGCAAAGTCTAC
TCGAGGCCCCGCAAGCAGGAAGGGCAGAGGCGCCGCCAAGAGCAGGAGGAAAAGAGGCGG
CGCCGGGAGAGTGAGCTGCAATGGCAGGAGGAGGAACGGGCTCACCGGCAGCAGCAGGAA
GAGGAGCAGCGCCGGGACTTCACATGGCAGTGGCAGGCGGAGGAAAAGAGCGAGAGGGGC
CGTCAGAGGCTGTCGGCCAGGCCCCCATTGCGGGAGCAGCGGGAGAGGCAGCTGAGGGCC
GAGGAGCGCCAGCAGCGGGAACAACGGTTTCTCCCGGAGGAGGAGGAGAAGGAGCAGCGG
CGCCGCCAGCGACGCGAGAGGGAGAAAGAGCTGCAGTTCCTGGAGGAAGAGGAGCAGCTC
CAGCGGCGGGAGCGTGCCCAACAGCTCCAGGAGGAGGAGGACGGCCTCCAGGAGGATCAG
GAGAGGAGGCGAAGCCAGGAGCAGCGCCGCGACCAAAAATGGAGGTGGCAACTAGAAGAA
GAAAGGAAGAGACGCCGCCACACGCTGTACGCCAAGCCAGCCCTACAAGAGCAGCTGAGG
AAGGAACAGCAGCTGCTGCAGGAGGAGGAGGAGGAGCTACAGAGAGAGGAGCGCGAGAAG
AGAAGGCGCCAAGAACAGGAGAGACAATACCGCGAGGAAGAGCAGCTGCAGCAGGAGGAA
GAGCAGCTGCTGAGAGAGGAACGGGAGAAAAGAAGACGCCAGGAGCGGGAAAGGCAATAT
CGGAAGGATAAGAAGCTGCAGCAGAAGGAAGAGCAGCTGCTGGGAGAGGAACCGGAGAAG
AGAAGGCGCCAGGAGCGGGAGAAAAAATACCGCGAGGAAGAGGAGTTGCAGCAGGAGGAA
GAGCAGCTGCTGAGAGAGGAACGGGAGAAGAGAAGGCGCCAGGAGTGGGAGAGGCAGTAC
CGCAAAAAAGACGAGCTGCAGCAGGAAGAAGAGCAGCTGCTGAGAGAGGAACGGGAGAAA
AGAAGACTCCAGGAGCGGGAGAGGCAATATCGGGAGGAAGAGGAGCTGCAGCAGGAGGAA
GAGCAGCTGCTGGGAGAGGAACGGGAGACGAGAAGGCGCCAGGAGCTGGAGAGGCAATAT
CGGAAGGAAGAGGAGCTGCAGCAGGAGGAAGAGCAGCTGCTGAGAGAGGAACCGGAGAAG
AGAAGGCGCCAGGAGCGGGAGAGGCAATGTCGGGAGGAAGAGGAGCTGCAGCAGGAGGAA
GAGCAGCTGCTGAGAGAGGAACGGGAGAAGAGAAGGCGCCAGGAGCTGGAGAGGCAATAT
CGGGAGGAAGAGGAGGTGCAGCAGGAGGAAGAGCAGCTGCTGAGAGAGGAACCGGAGAAG
AGAAGGCGCCAGGAGCTGGAGAGGCAATACCGCGAGGAAGAGGAGCTGCAGCAGGAGGAA
GAGCAGCTGCTGAGAGAGGAACAGGAGAAAAGGCGCCAGGAGCGGGAGAGGCAGTATCGG
GAGGAGGAAGAGCTTCAGCGCCAGAAAAGGAAGCAGCGATACCGGGATGAGGATCAGCGC
AGTGATCTGAAATGGCAGTGGGAACCAGAAAAAGAAAATGCAGTTCGTGATAACAAGGTT
TACTGCAAAGGCAGAGAGAATGAACAGTTCCGGCAGTTGGAAGATTCCCAGCTGCGCGAC
AGACAATCCCAGCAAGATCTGCAGCACCTGCTGGGTGAACAGCAAGAGCGAGATCGTGAG
CAAGAGAGGAGGCGCTGGCAGCAGCGCGACAGGCATTTCCCAGAGGAAGAACAGCTGGAG
CGAGAAGAGCAAAAGGAAGCCAAAAGGCGCGACAGGAAGTCCCAAGAGGAAAAGCAGTTG
CTGAGAGAGGAAAGAGAAGAGAAGAGACGCCGTCAAGAGACAGACAGAAAATTCCGCGAG
GAGGAACAGCTGCTCCAGGAAAGGGAGGAACAGCCGCTGCGCCGCCAAGAGCGTGACAGA
AAATTCCGCGAAGAGGAACTGCGCCATCAGGAACAAGGGAGAAAATTCCTCGAGGAGGAA
CAGCGGCTGCGCCGCCAGGAACGGGAGAGAAAATTCCTTAAGGAGGAACAGCAGCTGCGC
TGCCAGGAGCGCGAGCAACAGCTGCGTCAGGACCGCGACAGAAAATTCCGCGAGGAGGAA
CAGCAGCTGAGCCGCCAAGAGCGTGACAGAAAATTCCGTGAAGAGGAACAGCAGGTGCGC
CGCCAGGAACGAGAGAGAAAATTCCTGGAGGAGGAACAGCAGCTGCGCCAGGAGCGTCAC
AGAAAATTCCGCGAAGAGGAACAGCTGCTCCAGGAAAGGGAAGAACAGCAGCTGCACCGC
CAAGAGCGTGACAGAAAATTCCTGGAGGAGGAACAACAGCTGCGCCGCCAAGAGCGTGAC
AGAAAATTCCGCGAACAGGAACTGCGCAGTCAGGAACCAGAGAGAAAATTCCTCGAGGAG
GAACAGCAGCTGCACCGCCAGCAACGGCAGAGAAAATTCCTCCAGGAGGAACAGCAGCTG
CGCCGCCAGGAGCGCGGGCAACAGCGGCGTCAGGACCGTGACAGAAAATTCCGCGAGGAG
GAACAGCTGCGCCAGGAGAGGGAGGAACAGCAGCTGAGCCGCCAAGAGCGTGACAGAAAA
TTCCGTTTAGAGGAACAGAAAGTGCGCCGCCAGGAACAAGAGAGAAAATTCATGGAGGAC
GAACAGCAGCTGCGCCGCCAGGAGGGCCAACAACAGCTGCGCCAGGAGCGCGACAGAAAA
TTCCGCGAAGACGAACAGCTGCTCCAGGAAAGGGAAGAACAGCAGCTGCACCGCCAAGAG
CGTGACAGAAAATTCCTCGAGGAGGAACCGCAGCTGCGCCGCCAGGAGCGCGAACAACAG
CTGCGTCACGACCGCGACAGAAAATTCCGTGAAGAGGAACAGCTGCTCCAGGAAGGGGAG
GAACAGCAGCTGCGCCGCCAAGAGCGTGACAGAAAATTCCGCGAAGAGGAACAGCAGCTC
CGCCGTCAGGAACGAGAGAGAAAATTCCTCCAGGAGGAACAGCAGCTGCGCCGCCAGGAA
CTGGAGAGAAAATTCCGTGAGGAGGAACAGCTGCGCCAAGAAACGGAGCAAGAGCAGCTG
CGCCGCCAAGAACGCTACAGAAAAATCCTAGAGGAAGAGCAGCTCCGTCCGGAAAGGGAA
GAACAGCAGCTGCGCCGCCAGGAGCGCGACAGAAAATTCCGCGAGGAGGAACAGCTCCGC
CAGGAGAGGGAGGAACAGCAGCTGCGCAGCCAAGAGTCTGACAGAAAATTCCGCGAGGAG
GAACAGCTACGCCAGGAGAGGGAAGAACAGCAGCTGCGCCCCCAACAGCGTGACGGAAAG
TATCGCTGGGAAGAAGAGCAGCTCCAACTTGAGGAACAAGAGCAGAGGCTGCGGCAGGAG
CGAGACCGGCAGTACCGGGCGGAGGAGCAGTTTGCCACGCAGGAGAAGAGTCGTCGTGAG
GAACAAGAACTATGGCAAGAAGAGGAGCAGAAACGTCGCCAGGAACGGGAAAGGAAATTA
CGGGAAGAACACATCCGCCGCCAGCAGAAGGAGGAACAGAGGCACCGCCAAGTCGGGGAG
ATAAAATCCCAAGAAGGGAAGGGCCATGGGCGGCTTCTGGAGCCCGGCACTCATCAGTTT
GCCAGTGTCCCAGTGCGCTCCAGCCCTCTCTATGAGTACATCCAAGAGCAGAGATCTCAA
TACCGCCCTTAA
Protein Properties
Number of Residues 1943
Molecular Weight 253924.4
Theoretical pI 5.49
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Trichohyalin
MSPLLRSICDITEIFNQYVSHDCDGAALTKKDLKNLLEREFGAVLRRPHDPKTVDLILEL
LDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQR
RFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEW
QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQE
EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL
RREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERR
EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR
REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ
EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR
EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ
RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK
REEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY
SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG
RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL
QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR
KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY
RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQY
RKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQY
RKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQY
REEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR
EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRD
RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL
LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEE
QRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVR
RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD
RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE
EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK
FREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE
EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL
RRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE
EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRRE
EQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQF
ASVPVRSSPLYEYIQEQRSQYRP
GenBank ID Protein 55665869
UniProtKB/Swiss-Prot ID Q07283
UniProtKB/Swiss-Prot Entry Name TRHY_HUMAN
PDB IDs Not Available
GenBank Gene ID AL589986
GeneCard ID TCHH
GenAtlas ID TCHH
HGNC ID HGNC:11791
References
General References
  1. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. [PubMed:16710414 ]
  2. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
  3. Lee SC, Kim IG, Marekov LN, O'Keefe EJ, Parry DA, Steinert PM: The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein. J Biol Chem. 1993 Jun 5;268(16):12164-76. [PubMed:7685034 ]
  4. O'Keefe EJ, Hamilton EH, Lee SC, Steinert P: Trichohyalin: a structural protein of hair, tongue, nail, and epidermis. J Invest Dermatol. 1993 Jul;101(1 Suppl):65S-71S. [PubMed:7686953 ]